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Volumn 109, Issue , 2018, Pages 209-218

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

Author keywords

Dementia with Lewy body; Multiple system atrophy; Parkinson's disease; Protein aggregates; Synuclein strains; Synucleinopathy

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID PROTEIN;

EID: 85026252066     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2017.07.018     Document Type: Review
Times cited : (125)

References (167)
  • 1
    • 0037335814 scopus 로고    scopus 로고
    • Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study
    • Aarsland, D., et al. Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. Arch. Neurol. 60 (2003), 387–392.
    • (2003) Arch. Neurol. , vol.60 , pp. 387-392
    • Aarsland, D.1
  • 2
    • 0034077041 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    • Abeliovich, A., et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25 (2000), 239–252.
    • (2000) Neuron , vol.25 , pp. 239-252
    • Abeliovich, A.1
  • 3
    • 34250796761 scopus 로고    scopus 로고
    • Insights into prion strains and neurotoxicity
    • Aguzzi, A., et al. Insights into prion strains and neurotoxicity. Nat. Rev. Mol. Cell. Biol. 8 (2007), 552–561.
    • (2007) Nat. Rev. Mol. Cell. Biol. , vol.8 , pp. 552-561
    • Aguzzi, A.1
  • 4
    • 84855477917 scopus 로고    scopus 로고
    • The neuropathology, pathophysiology and genetics of multiple system atrophy
    • Ahmed, Z., et al. The neuropathology, pathophysiology and genetics of multiple system atrophy. Neuropathol. Appl. Neurobiol. 38 (2012), 4–24.
    • (2012) Neuropathol. Appl. Neurobiol. , vol.38 , pp. 4-24
    • Ahmed, Z.1
  • 5
    • 0036142959 scopus 로고    scopus 로고
    • Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response
    • Apaydin, H., et al. Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response. Arch. Neurol. 59 (2002), 102–112.
    • (2002) Arch. Neurol. , vol.59 , pp. 102-112
    • Apaydin, H.1
  • 6
    • 84879605541 scopus 로고    scopus 로고
    • Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
    • Appel-Cresswell, S., et al. Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. Mov. Disord. 28 (2013), 811–813.
    • (2013) Mov. Disord. , vol.28 , pp. 811-813
    • Appel-Cresswell, S.1
  • 7
    • 84898046790 scopus 로고    scopus 로고
    • Alpha-synuclein mRNA expression in oligodendrocytes in MSA
    • Asi, Y.T., et al. Alpha-synuclein mRNA expression in oligodendrocytes in MSA. Glia 62 (2014), 964–970.
    • (2014) Glia , vol.62 , pp. 964-970
    • Asi, Y.T.1
  • 8
    • 0003652388 scopus 로고    scopus 로고
    • DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, Text Revision
    • American Psychiatric Association Washington, DC
    • Association, A.P., Association, A.P., DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, Text Revision. 2000, American Psychiatric Association, Washington, DC, 75.
    • (2000) , pp. 75
    • Association, A.P.1    Association, A.P.2
  • 9
    • 1642289188 scopus 로고    scopus 로고
    • Role of tau protein in both physiological and pathological conditions
    • Avila, J., et al. Role of tau protein in both physiological and pathological conditions. Physiol. Rev. 84 (2004), 361–384.
    • (2004) Physiol. Rev. , vol.84 , pp. 361-384
    • Avila, J.1
  • 10
    • 84959200902 scopus 로고    scopus 로고
    • Review: the spectrum of clinical features seen with alpha synuclein pathology
    • Barker, R.A., Williams-Gray, C.H., Review: the spectrum of clinical features seen with alpha synuclein pathology. Neuropathol. Appl. Neurobiol. 42 (2016), 6–19.
    • (2016) Neuropathol. Appl. Neurobiol. , vol.42 , pp. 6-19
    • Barker, R.A.1    Williams-Gray, C.H.2
  • 11
    • 80052398365 scopus 로고    scopus 로고
    • alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
    • Bartels, T., et al. alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 477 (2011), 107–110.
    • (2011) Nature , vol.477 , pp. 107-110
    • Bartels, T.1
  • 12
    • 0031029831 scopus 로고    scopus 로고
    • Survival of patients with pathologically proven multiple system atrophy: a meta-analysis
    • Ben-Shlomo, Y., et al. Survival of patients with pathologically proven multiple system atrophy: a meta-analysis. Neurology 48 (1997), 384–393.
    • (1997) Neurology , vol.48 , pp. 384-393
    • Ben-Shlomo, Y.1
  • 13
    • 84964853990 scopus 로고    scopus 로고
    • Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein
    • Bernis, M.E., et al. Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein. Acta Neuropathol. Commun., 3, 2015, 75.
    • (2015) Acta Neuropathol. Commun. , vol.3 , pp. 75
    • Bernis, M.E.1
  • 14
    • 24744461907 scopus 로고    scopus 로고
    • Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation
    • Bertoncini, C.W., et al. Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation. J. Biol. Chem. 280 (2005), 30649–30652.
    • (2005) J. Biol. Chem. , vol.280 , pp. 30649-30652
    • Bertoncini, C.W.1
  • 15
    • 10444240976 scopus 로고    scopus 로고
    • Epidemiological evidence of higher susceptibility to vCJD in the young
    • Boelle, P.Y., et al. Epidemiological evidence of higher susceptibility to vCJD in the young. BMC Infect. Dis., 4, 2004, 26.
    • (2004) BMC Infect. Dis. , vol.4 , pp. 26
    • Boelle, P.Y.1
  • 16
    • 84929709813 scopus 로고    scopus 로고
    • Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains
    • Boluda, S., et al. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta Neuropathol. 129 (2015), 221–237.
    • (2015) Acta Neuropathol. , vol.129 , pp. 221-237
    • Boluda, S.1
  • 17
    • 84892150877 scopus 로고    scopus 로고
    • Structural and functional characterization of two alpha-synuclein strains
    • Bousset, L., et al. Structural and functional characterization of two alpha-synuclein strains. Nat. Commun., 4, 2013, 2575.
    • (2013) Nat. Commun. , vol.4 , pp. 2575
    • Bousset, L.1
  • 18
    • 0030695277 scopus 로고    scopus 로고
    • Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Minnesota, 1976 to 1990
    • Bower, J.H., et al. Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Minnesota, 1976 to 1990. Neurology 49 (1997), 1284–1288.
    • (1997) Neurology , vol.49 , pp. 1284-1288
    • Bower, J.H.1
  • 19
    • 79451471618 scopus 로고    scopus 로고
    • The pathological process underlying Alzheimer's disease in individuals under thirty
    • Braak, H., Del Tredici, K., The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol. 121 (2011), 171–181.
    • (2011) Acta Neuropathol. , vol.121 , pp. 171-181
    • Braak, H.1    Del Tredici, K.2
  • 20
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak, H., et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24 (2003), 197–211.
    • (2003) Neurobiol. Aging , vol.24 , pp. 197-211
    • Braak, H.1
  • 21
    • 17644426053 scopus 로고    scopus 로고
    • Cognitive status correlates with neuropathologic stage in Parkinson disease
    • Braak, H., et al. Cognitive status correlates with neuropathologic stage in Parkinson disease. Neurology 64 (2005), 1404–1410.
    • (2005) Neurology , vol.64 , pp. 1404-1410
    • Braak, H.1
  • 23
    • 84952645933 scopus 로고    scopus 로고
    • The synaptic function of alpha-synuclein
    • Burre, J., The synaptic function of alpha-synuclein. J. Park. Dis. 5 (2015), 699–713.
    • (2015) J. Park. Dis. , vol.5 , pp. 699-713
    • Burre, J.1
  • 24
    • 77957347060 scopus 로고    scopus 로고
    • Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro
    • Burre, J., et al. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 329 (2010), 1663–1667.
    • (2010) Science , vol.329 , pp. 1663-1667
    • Burre, J.1
  • 25
    • 0037109727 scopus 로고    scopus 로고
    • Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
    • Cabin, D.E., et al. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J. Neurosci. 22 (2002), 8797–8807.
    • (2002) J. Neurosci. , vol.22 , pp. 8797-8807
    • Cabin, D.E.1
  • 26
    • 27544507306 scopus 로고    scopus 로고
    • Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
    • Chandra, S., et al. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123 (2005), 383–396.
    • (2005) Cell , vol.123 , pp. 383-396
    • Chandra, S.1
  • 27
    • 67650077008 scopus 로고    scopus 로고
    • Transmission and spreading of tauopathy in transgenic mouse brain
    • Clavaguera, F., et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat. Cell Biol. 11 (2009), 909–913.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 909-913
    • Clavaguera, F.1
  • 28
    • 84878723720 scopus 로고    scopus 로고
    • Brain homogenates from human tauopathies induce tau inclusions in mouse brain
    • Clavaguera, F., et al. Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 9535–9540.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 9535-9540
    • Clavaguera, F.1
  • 29
    • 84929119663 scopus 로고    scopus 로고
    • Rapidly progressive Alzheimer's disease features distinct structures of amyloid-beta
    • Cohen, M.L., et al. Rapidly progressive Alzheimer's disease features distinct structures of amyloid-beta. Brain 138 (2015), 1009–1022.
    • (2015) Brain , vol.138 , pp. 1009-1022
    • Cohen, M.L.1
  • 30
    • 21344445937 scopus 로고    scopus 로고
    • Molecular neurology of prion disease
    • Collinge, J., Molecular neurology of prion disease. J. Neurol. Neurosurg. Psychiatry 76 (2005), 906–919.
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , pp. 906-919
    • Collinge, J.1
  • 31
    • 0029831213 scopus 로고    scopus 로고
    • Molecular analysis of prion strain variation and the aetiology of ‘new variant’ CJD
    • Collinge, J., et al. Molecular analysis of prion strain variation and the aetiology of ‘new variant’ CJD. Nature 383 (1996), 685–690.
    • (1996) Nature , vol.383 , pp. 685-690
    • Collinge, J.1
  • 32
    • 79957453213 scopus 로고    scopus 로고
    • Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
    • Compta, Y., et al. Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?. Brain 134 (2011), 1493–1505.
    • (2011) Brain , vol.134 , pp. 1493-1505
    • Compta, Y.1
  • 33
    • 0037195109 scopus 로고    scopus 로고
    • Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTP
    • Dauer, W., et al. Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTP. Proc. Natl. Acad. Sci. U. S. A. 99 (2002), 14524–14529.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 14524-14529
    • Dauer, W.1
  • 34
    • 0032540327 scopus 로고    scopus 로고
    • Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
    • Davidson, W.S., et al. Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 273 (1998), 9443–9449.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9443-9449
    • Davidson, W.S.1
  • 35
    • 0036094576 scopus 로고    scopus 로고
    • Where does Parkinson disease pathology begin in the brain?
    • Del Tredici, K., et al. Where does Parkinson disease pathology begin in the brain?. J. Neuropathol. Exp. Neurol. 61 (2002), 413–426.
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , pp. 413-426
    • Del Tredici, K.1
  • 36
    • 84875990438 scopus 로고    scopus 로고
    • alpha-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers
    • DeWitt, D.C., Rhoades, E., alpha-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers. Biochemistry 52 (2013), 2385–2387.
    • (2013) Biochemistry , vol.52 , pp. 2385-2387
    • DeWitt, D.C.1    Rhoades, E.2
  • 37
    • 0032778175 scopus 로고    scopus 로고
    • Multiple prion types in the same brain: is a molecular diagnosis of CJD possible?
    • Dickson, D.W., Brown, P., Multiple prion types in the same brain: is a molecular diagnosis of CJD possible?. Neurology 53 (1999), 1903–1904.
    • (1999) Neurology , vol.53 , pp. 1903-1904
    • Dickson, D.W.1    Brown, P.2
  • 38
    • 71849092190 scopus 로고    scopus 로고
    • Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria
    • Dickson, D.W., et al. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria. Lancet Neurol. 8 (2009), 1150–1157.
    • (2009) Lancet Neurol. , vol.8 , pp. 1150-1157
    • Dickson, D.W.1
  • 39
    • 0027178571 scopus 로고
    • A comparison of familial and sporadic Alzheimer's disease
    • Duara, R., et al. A comparison of familial and sporadic Alzheimer's disease. Neurology 43 (1993), 1377–1384.
    • (1993) Neurology , vol.43 , pp. 1377-1384
    • Duara, R.1
  • 40
    • 0003753983 scopus 로고    scopus 로고
    • The Neuropathology of Dementia
    • Cambridge University Press
    • Esiri, M.M., et al. The Neuropathology of Dementia. 2004, Cambridge University Press.
    • (2004)
    • Esiri, M.M.1
  • 42
    • 14644415031 scopus 로고    scopus 로고
    • The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
    • Fernandez-Chacon, R., et al. The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron 42 (2004), 237–251.
    • (2004) Neuron , vol.42 , pp. 237-251
    • Fernandez-Chacon, R.1
  • 43
    • 3342951965 scopus 로고    scopus 로고
    • Lipid rafts mediate the synaptic localization of alpha-synuclein
    • Fortin, D.L., et al. Lipid rafts mediate the synaptic localization of alpha-synuclein. J. Neurosci. 24 (2004), 6715–6723.
    • (2004) J. Neurosci. , vol.24 , pp. 6715-6723
    • Fortin, D.L.1
  • 44
    • 0015550206 scopus 로고
    • Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation
    • Fraser, H., Dickinson, A.G., Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation. J. Comp. Pathol. 83 (1973), 29–40.
    • (1973) J. Comp. Pathol. , vol.83 , pp. 29-40
    • Fraser, H.1    Dickinson, A.G.2
  • 45
    • 67649273927 scopus 로고    scopus 로고
    • Propagation of tau misfolding from the outside to the inside of a cell
    • Frost, B., et al. Propagation of tau misfolding from the outside to the inside of a cell. J. Biol. Chem. 284 (2009), 12845–12852.
    • (2009) J. Biol. Chem. , vol.284 , pp. 12845-12852
    • Frost, B.1
  • 46
    • 34147109175 scopus 로고    scopus 로고
    • Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication
    • Fuchs, J., et al. Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. Neurology 68 (2007), 916–922.
    • (2007) Neurology , vol.68 , pp. 916-922
    • Fuchs, J.1
  • 47
    • 84887903040 scopus 로고    scopus 로고
    • Update on novel familial forms of Parkinson's disease and multiple system atrophy
    • Fujioka, S., et al. Update on novel familial forms of Parkinson's disease and multiple system atrophy. Parkinsonism Relat. Disord. 20:Suppl. 1 (2014), S29–34.
    • (2014) Parkinsonism Relat. Disord. , vol.20 , pp. S29-34
    • Fujioka, S.1
  • 48
    • 78651041685 scopus 로고
    • Degenerative disease of the central nervous system in New Guinea; the endemic occurrence of kuru in the native population
    • Gajdusek, D.C., Zigas, V., Degenerative disease of the central nervous system in New Guinea; the endemic occurrence of kuru in the native population. N. Engl. J. Med. 257 (1957), 974–978.
    • (1957) N. Engl. J. Med. , vol.257 , pp. 974-978
    • Gajdusek, D.C.1    Zigas, V.2
  • 49
    • 0141514771 scopus 로고    scopus 로고
    • Sporadic and familial CJD: classification and characterisation
    • Gambetti, P., et al. Sporadic and familial CJD: classification and characterisation. Br. Med. Bull. 66 (2003), 213–239.
    • (2003) Br. Med. Bull. , vol.66 , pp. 213-239
    • Gambetti, P.1
  • 50
    • 0032980493 scopus 로고    scopus 로고
    • Neurofibrillary pathology in Alzheimer disease with Lewy bodies: two subgroups
    • Gearing, M., et al. Neurofibrillary pathology in Alzheimer disease with Lewy bodies: two subgroups. Arch. Neurol. 56 (1999), 203–208.
    • (1999) Arch. Neurol. , vol.56 , pp. 203-208
    • Gearing, M.1
  • 52
    • 0035951869 scopus 로고    scopus 로고
    • A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
    • Giasson, B.I., et al. A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J. Biol. Chem. 276 (2001), 2380–2386.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2380-2386
    • Giasson, B.I.1
  • 53
    • 27744600040 scopus 로고    scopus 로고
    • The North American multiple system atrophy study group
    • Gilman, S., et al. The North American multiple system atrophy study group. J. Neural. Transm. (Vienna) 112 (2005), 1687–1694.
    • (2005) J. Neural. Transm. (Vienna) , vol.112 , pp. 1687-1694
    • Gilman, S.1
  • 54
    • 52449086856 scopus 로고    scopus 로고
    • Second consensus statement on the diagnosis of multiple system atrophy
    • Gilman, S., et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71 (2008), 670–676.
    • (2008) Neurology , vol.71 , pp. 670-676
    • Gilman, S.1
  • 55
    • 0029806563 scopus 로고    scopus 로고
    • Clinical genetic analysis of Parkinson's disease in the Contursi kindred
    • Golbe, L.I., et al. Clinical genetic analysis of Parkinson's disease in the Contursi kindred. Ann. Neurol. 40 (1996), 767–775.
    • (1996) Ann. Neurol. , vol.40 , pp. 767-775
    • Golbe, L.I.1
  • 56
    • 0034531645 scopus 로고    scopus 로고
    • Clinical and neuropathological correlates of dementia with Lewy bodies
    • Gomez-Tortosa, E., et al. Clinical and neuropathological correlates of dementia with Lewy bodies. Ann. N. Y. Acad. Sci. 920 (2000), 9–15.
    • (2000) Ann. N. Y. Acad. Sci. , vol.920 , pp. 9-15
    • Gomez-Tortosa, E.1
  • 57
    • 78650431984 scopus 로고    scopus 로고
    • alphabetagamma-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
    • Greten-Harrison, B., et al. alphabetagamma-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 19573–19578.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 19573-19578
    • Greten-Harrison, B.1
  • 58
    • 79955441814 scopus 로고    scopus 로고
    • Seeding of normal tau by pathological tau conformers drives pathogenesis of Alzheimer-like tangles
    • Guo, J.L., Lee, V.M., Seeding of normal tau by pathological tau conformers drives pathogenesis of Alzheimer-like tangles. J. Biol. Chem. 286 (2011), 15317–15331.
    • (2011) J. Biol. Chem. , vol.286 , pp. 15317-15331
    • Guo, J.L.1    Lee, V.M.2
  • 59
    • 84879895467 scopus 로고    scopus 로고
    • Distinct alpha-synuclein strains differentially promote tau inclusions in neurons
    • Guo, J.L., et al. Distinct alpha-synuclein strains differentially promote tau inclusions in neurons. Cell 154 (2013), 103–117.
    • (2013) Cell , vol.154 , pp. 103-117
    • Guo, J.L.1
  • 60
    • 79956224885 scopus 로고    scopus 로고
    • Striatal beta-amyloid in dementia with Lewy bodies but not Parkinson's disease
    • Halliday, G.M., et al. Striatal beta-amyloid in dementia with Lewy bodies but not Parkinson's disease. J. Neural. Transm. (Vienna) 118 (2011), 713–719.
    • (2011) J. Neural. Transm. (Vienna) , vol.118 , pp. 713-719
    • Halliday, G.M.1
  • 61
    • 0033919992 scopus 로고    scopus 로고
    • Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry
    • Hamilton, R.L., Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol. 10 (2000), 378–384.
    • (2000) Brain Pathol. , vol.10 , pp. 378-384
    • Hamilton, R.L.1
  • 62
    • 79955759823 scopus 로고    scopus 로고
    • Diagnosing variant Creutzfeldt–Jakob disease: a retrospective analysis of the first 150 cases in the UK
    • Heath, C.A., et al. Diagnosing variant Creutzfeldt–Jakob disease: a retrospective analysis of the first 150 cases in the UK. J. Neurol. Neurosurg. Psychiatry 82 (2011), 646–651.
    • (2011) J. Neurol. Neurosurg. Psychiatry , vol.82 , pp. 646-651
    • Heath, C.A.1
  • 63
    • 84887031600 scopus 로고    scopus 로고
    • Seeded strain-like transmission of beta-amyloid morphotypes in APP transgenic mice
    • Heilbronner, G., et al. Seeded strain-like transmission of beta-amyloid morphotypes in APP transgenic mice. EMBO Rep. 14 (2013), 1017–1022.
    • (2013) EMBO Rep. , vol.14 , pp. 1017-1022
    • Heilbronner, G.1
  • 64
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years
    • Hely, M.A., et al. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov. Disord. 23 (2008), 837–844.
    • (2008) Mov. Disord. , vol.23 , pp. 837-844
    • Hely, M.A.1
  • 65
    • 84872346089 scopus 로고    scopus 로고
    • Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy
    • Iba, M., et al. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. J. Neurosci. 33 (2013), 1024–1037.
    • (2013) J. Neurosci. , vol.33 , pp. 1024-1037
    • Iba, M.1
  • 66
    • 0033757475 scopus 로고    scopus 로고
    • Clinical aspects of argyrophilic grain disease
    • Ikeda, K., et al. Clinical aspects of argyrophilic grain disease. Clin. Neuropathol. 19 (2000), 278–284.
    • (2000) Clin. Neuropathol. , vol.19 , pp. 278-284
    • Ikeda, K.1
  • 67
    • 84857620173 scopus 로고    scopus 로고
    • Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
    • Irwin, D.J., et al. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain 135 (2012), 807–818.
    • (2012) Brain , vol.135 , pp. 807-818
    • Irwin, D.J.1
  • 68
    • 84868200922 scopus 로고    scopus 로고
    • Neuropathologic substrates of Parkinson disease dementia
    • Irwin, D.J., et al. Neuropathologic substrates of Parkinson disease dementia. Ann. Neurol. 72 (2012), 587–598.
    • (2012) Ann. Neurol. , vol.72 , pp. 587-598
    • Irwin, D.J.1
  • 69
    • 84883174947 scopus 로고    scopus 로고
    • Parkinson's disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies
    • Irwin, D.J., et al. Parkinson's disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies. Nat. Rev. Neurosci. 14 (2013), 626–636.
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 626-636
    • Irwin, D.J.1
  • 70
    • 0031922290 scopus 로고    scopus 로고
    • Dementia with grains (argyrophilic grain disease)
    • Jellinger, K.A., Dementia with grains (argyrophilic grain disease). Brain Pathol. 8 (1998), 377–386.
    • (1998) Brain Pathol. , vol.8 , pp. 377-386
    • Jellinger, K.A.1
  • 71
    • 38449089639 scopus 로고    scopus 로고
    • Morphological substrates of parkinsonism with and without dementia: a retrospective clinico-pathological study
    • Jellinger, K.A., Morphological substrates of parkinsonism with and without dementia: a retrospective clinico-pathological study. J. Neural Transm. Suppl., 2007, 91–104.
    • (2007) J. Neural Transm. Suppl. , pp. 91-104
    • Jellinger, K.A.1
  • 72
    • 33747762262 scopus 로고    scopus 로고
    • Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?
    • Jellinger, K.A., Attems, J., Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?. Acta Neuropathol. 112 (2006), 253–260.
    • (2006) Acta Neuropathol. , vol.112 , pp. 253-260
    • Jellinger, K.A.1    Attems, J.2
  • 73
    • 41149152169 scopus 로고    scopus 로고
    • Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease
    • Jellinger, K.A., Attems, J., Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease. Acta Neuropathol. 115 (2008), 427–436.
    • (2008) Acta Neuropathol. , vol.115 , pp. 427-436
    • Jellinger, K.A.1    Attems, J.2
  • 74
    • 0036202684 scopus 로고    scopus 로고
    • Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease
    • Jellinger, K.A., et al. Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease. J. Neural. Transm. (Vienna) 109 (2002), 329–339.
    • (2002) J. Neural. Transm. (Vienna) , vol.109 , pp. 329-339
    • Jellinger, K.A.1
  • 75
    • 26444610170 scopus 로고    scopus 로고
    • Grading of neuropathology in multiple system atrophy: proposal for a novel scale
    • Jellinger, K.A., et al. Grading of neuropathology in multiple system atrophy: proposal for a novel scale. Mov. Disord. 20:Suppl. 12 (2005), S29–36.
    • (2005) Mov. Disord. , vol.20 , pp. S29-36
    • Jellinger, K.A.1
  • 76
    • 0032500599 scopus 로고    scopus 로고
    • Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
    • Jensen, P.H., et al. Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J. Biol. Chem. 273 (1998), 26292–26294.
    • (1998) J. Biol. Chem. , vol.273 , pp. 26292-26294
    • Jensen, P.H.1
  • 77
    • 82755176258 scopus 로고    scopus 로고
    • Membrane curvature sensing by amphipathic helices: a single liposome study using alpha-synuclein and annexin B12
    • Jensen, M.B., et al. Membrane curvature sensing by amphipathic helices: a single liposome study using alpha-synuclein and annexin B12. J. Biol. Chem. 286 (2011), 42603–42614.
    • (2011) J. Biol. Chem. , vol.286 , pp. 42603-42614
    • Jensen, M.B.1
  • 78
    • 0032585594 scopus 로고    scopus 로고
    • Creutzfeldt-Jakob disease and related transmissible spongiform encephalopathies
    • Johnson, R.T., Gibbs, C.J. Jr., Creutzfeldt-Jakob disease and related transmissible spongiform encephalopathies. N. Engl. J. Med. 339 (1998), 1994–2004.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1994-2004
    • Johnson, R.T.1    Gibbs, C.J.2
  • 79
    • 0034280435 scopus 로고    scopus 로고
    • Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain
    • Kahle, P.J., et al. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain. J. Neurosci. 20 (2000), 6365–6373.
    • (2000) J. Neurosci. , vol.20 , pp. 6365-6373
    • Kahle, P.J.1
  • 80
    • 77953011321 scopus 로고    scopus 로고
    • Relationships between age and late progression of Parkinson's disease: a clinico-pathological study
    • Kempster, P.A., et al. Relationships between age and late progression of Parkinson's disease: a clinico-pathological study. Brain 133 (2010), 1755–1762.
    • (2010) Brain , vol.133 , pp. 1755-1762
    • Kempster, P.A.1
  • 81
    • 84885461450 scopus 로고    scopus 로고
    • alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
    • Kiely, A.P., et al. alpha-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?. Acta Neuropathol. 125 (2013), 753–769.
    • (2013) Acta Neuropathol. , vol.125 , pp. 753-769
    • Kiely, A.P.1
  • 82
    • 79955096039 scopus 로고    scopus 로고
    • Survival of Korean patients with multiple system atrophy
    • Kim, H.J., et al. Survival of Korean patients with multiple system atrophy. Mov. Disord. 26 (2011), 909–912.
    • (2011) Mov. Disord. , vol.26 , pp. 909-912
    • Kim, H.J.1
  • 83
    • 84989160282 scopus 로고    scopus 로고
    • Alpha-synuclein biology in Lewy body diseases
    • Kim, W.S., et al. Alpha-synuclein biology in Lewy body diseases. Alzheimers Res. Ther., 6, 2014, 73.
    • (2014) Alzheimers Res. Ther. , vol.6 , pp. 73
    • Kim, W.S.1
  • 84
    • 84982797304 scopus 로고    scopus 로고
    • Exposure to bacterial endotoxin generates a distinct strain of alpha-synuclein fibril
    • Kim, C., et al. Exposure to bacterial endotoxin generates a distinct strain of alpha-synuclein fibril. Sci Rep, 6, 2016, 30891.
    • (2016) Sci Rep , vol.6 , pp. 30891
    • Kim, C.1
  • 85
    • 78349241725 scopus 로고    scopus 로고
    • Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry
    • Kollensperger, M., et al. Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry. Mov. Disord. 25 (2010), 2604–2612.
    • (2010) Mov. Disord. , vol.25 , pp. 2604-2612
    • Kollensperger, M.1
  • 86
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower, J.H., et al. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat. Med. 14 (2008), 504–506.
    • (2008) Nat. Med. , vol.14 , pp. 504-506
    • Kordower, J.H.1
  • 87
    • 84867390597 scopus 로고    scopus 로고
    • Pathologic accumulation of alpha-synuclein and Abeta in Parkinson disease patients with dementia
    • Kotzbauer, P.T., et al. Pathologic accumulation of alpha-synuclein and Abeta in Parkinson disease patients with dementia. Arch. Neurol. 69 (2012), 1326–1331.
    • (2012) Arch. Neurol. , vol.69 , pp. 1326-1331
    • Kotzbauer, P.T.1
  • 88
    • 0037744714 scopus 로고    scopus 로고
    • Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease
    • Kovari, E., et al. Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease. Acta Neuropathol. 106 (2003), 83–88.
    • (2003) Acta Neuropathol. , vol.106 , pp. 83-88
    • Kovari, E.1
  • 89
    • 21144441564 scopus 로고    scopus 로고
    • Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both
    • Kraybill, M.L., et al. Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both. Neurology 64 (2005), 2069–2073.
    • (2005) Neurology , vol.64 , pp. 2069-2073
    • Kraybill, M.L.1
  • 90
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • Kruger, R., et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18 (1998), 106–108.
    • (1998) Nat. Genet. , vol.18 , pp. 106-108
    • Kruger, R.1
  • 91
    • 0035932936 scopus 로고    scopus 로고
    • Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers
    • Kruger, R., et al. Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers. Neurology 56 (2001), 1355–1362.
    • (2001) Neurology , vol.56 , pp. 1355-1362
    • Kruger, R.1
  • 92
    • 84868269943 scopus 로고    scopus 로고
    • Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
    • Lasagna-Reeves, C.A., et al. Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci Rep, 2, 2012, 700.
    • (2012) Sci Rep , vol.2 , pp. 700
    • Lasagna-Reeves, C.A.1
  • 93
    • 41149152243 scopus 로고    scopus 로고
    • Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients
    • Lashley, T., et al. Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients. Acta Neuropathol. 115 (2008), 417–425.
    • (2008) Acta Neuropathol. , vol.115 , pp. 417-425
    • Lashley, T.1
  • 94
    • 0034940160 scopus 로고    scopus 로고
    • Neurodegenerative tauopathies
    • Lee, V.M., et al. Neurodegenerative tauopathies. Annu. Rev. Neurosci. 24 (2001), 1121–1159.
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 1121-1159
    • Lee, V.M.1
  • 95
    • 84878405578 scopus 로고    scopus 로고
    • G51D alpha-synuclein mutation causes a novel parkinsonian-pyramidal syndrome
    • Lesage, S., et al. G51D alpha-synuclein mutation causes a novel parkinsonian-pyramidal syndrome. Ann. Neurol. 73 (2013), 459–471.
    • (2013) Ann. Neurol. , vol.73 , pp. 459-471
    • Lesage, S.1
  • 96
    • 0036264105 scopus 로고    scopus 로고
    • Combined effect of age and severity on the risk of dementia in Parkinson's disease
    • Levy, G., et al. Combined effect of age and severity on the risk of dementia in Parkinson's disease. Ann. Neurol. 51 (2002), 722–729.
    • (2002) Ann. Neurol. , vol.51 , pp. 722-729
    • Levy, G.1
  • 97
    • 14544303625 scopus 로고    scopus 로고
    • Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
    • Lewis, S.J., et al. Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach. J. Neurol. Neurosurg. Psychiatry 76 (2005), 343–348.
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , pp. 343-348
    • Lewis, S.J.1
  • 98
    • 43249110200 scopus 로고    scopus 로고
    • Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    • Li, J.Y., et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat. Med. 14 (2008), 501–503.
    • (2008) Nat. Med. , vol.14 , pp. 501-503
    • Li, J.Y.1
  • 99
    • 84859514120 scopus 로고    scopus 로고
    • Kuru: the first prion disease
    • Liberski, P.P., et al. Kuru: the first prion disease. Adv. Exp. Med. Biol. 724 (2012), 143–153.
    • (2012) Adv. Exp. Med. Biol. , vol.724 , pp. 143-153
    • Liberski, P.P.1
  • 100
    • 34047223232 scopus 로고    scopus 로고
    • DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers
    • Lippa, C.F., et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology 68 (2007), 812–819.
    • (2007) Neurology , vol.68 , pp. 812-819
    • Lippa, C.F.1
  • 101
    • 0033634080 scopus 로고    scopus 로고
    • Phenotypes and prognosis: clinicopathologic studies of corticobasal degeneration
    • Litvan, I., et al. Phenotypes and prognosis: clinicopathologic studies of corticobasal degeneration. Adv. Neurol. 82 (2000), 183–196.
    • (2000) Adv. Neurol. , vol.82 , pp. 183-196
    • Litvan, I.1
  • 102
    • 84884217594 scopus 로고    scopus 로고
    • Molecular structure of beta-amyloid fibrils in Alzheimer's disease brain tissue
    • Lu, J.X., et al. Molecular structure of beta-amyloid fibrils in Alzheimer's disease brain tissue. Cell 154 (2013), 1257–1268.
    • (2013) Cell , vol.154 , pp. 1257-1268
    • Lu, J.X.1
  • 103
    • 72149119358 scopus 로고    scopus 로고
    • Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
    • Luk, K.C., et al. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 20051–20056.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 20051-20056
    • Luk, K.C.1
  • 104
    • 84869109864 scopus 로고    scopus 로고
    • Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk, K.C., et al. Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338 (2012), 949–953.
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1
  • 105
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice
    • Luk, K.C., et al. Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice. J. Exp. Med. 209 (2012), 975–986.
    • (2012) J. Exp. Med. , vol.209 , pp. 975-986
    • Luk, K.C.1
  • 106
    • 84951276856 scopus 로고    scopus 로고
    • Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy
    • Manix, M., et al. Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy. Neurosurg. Focus., 39, 2015, E2.
    • (2015) Neurosurg. Focus. , vol.39
    • Manix, M.1
  • 107
    • 68249141880 scopus 로고    scopus 로고
    • Lewy body pathology in normal elderly subjects
    • Markesbery, W.R., et al. Lewy body pathology in normal elderly subjects. J. Neuropathol. Exp. Neurol. 68 (2009), 816–822.
    • (2009) J. Neuropathol. Exp. Neurol. , vol.68 , pp. 816-822
    • Markesbery, W.R.1
  • 108
    • 0025943571 scopus 로고
    • The rat brain synucleins; family of proteins transiently associated with neuronal membrane
    • Maroteaux, L., Scheller, R.H., The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res. Mol. Brain Res. 11 (1991), 335–343.
    • (1991) Brain Res. Mol. Brain Res. , vol.11 , pp. 335-343
    • Maroteaux, L.1    Scheller, R.H.2
  • 109
    • 84876057762 scopus 로고    scopus 로고
    • Prion-like spreading of pathological alpha-synuclein in brain
    • Masuda-Suzukake, M., et al. Prion-like spreading of pathological alpha-synuclein in brain. Brain 136 (2013), 1128–1138.
    • (2013) Brain , vol.136 , pp. 1128-1138
    • Masuda-Suzukake, M.1
  • 110
    • 0034979314 scopus 로고    scopus 로고
    • Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter
    • Matsuoka, Y., et al. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiol. Dis. 8 (2001), 535–539.
    • (2001) Neurobiol. Dis. , vol.8 , pp. 535-539
    • Matsuoka, Y.1
  • 111
    • 0033923545 scopus 로고    scopus 로고
    • Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease
    • Mattila, P.M., et al. Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. Acta Neuropathol. 100 (2000), 285–290.
    • (2000) Acta Neuropathol. , vol.100 , pp. 285-290
    • Mattila, P.M.1
  • 112
    • 84887921166 scopus 로고    scopus 로고
    • alpha-Synucleinopathy phenotypes
    • McCann, H., et al. alpha-Synucleinopathy phenotypes. Parkinsonism Relat. Disord. 20:Suppl. 1 (2014), S62–7.
    • (2014) Parkinsonism Relat. Disord. , vol.20 , pp. S62-7
    • McCann, H.1
  • 113
    • 33645147707 scopus 로고    scopus 로고
    • Prion disease genetics
    • Mead, S., Prion disease genetics. Eur. J. Hum. Genet. 14 (2006), 273–281.
    • (2006) Eur. J. Hum. Genet. , vol.14 , pp. 273-281
    • Mead, S.1
  • 114
    • 33749020837 scopus 로고    scopus 로고
    • Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
    • Meyer-Luehmann, M., et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 313 (2006), 1781–1784.
    • (2006) Science , vol.313 , pp. 1781-1784
    • Meyer-Luehmann, M.1
  • 115
    • 14844333173 scopus 로고    scopus 로고
    • Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)
    • Mikolaenko, I., et al. Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). J. Neuropathol. Exp. Neurol. 64 (2005), 156–162.
    • (2005) J. Neuropathol. Exp. Neurol. , vol.64 , pp. 156-162
    • Mikolaenko, I.1
  • 116
    • 27744455451 scopus 로고    scopus 로고
    • Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia
    • Miller, D.W., et al. Absence of alpha-synuclein mRNA expression in normal and multiple system atrophy oligodendroglia. J. Neural. Transm. (Vienna) 112 (2005), 1613–1624.
    • (2005) J. Neural. Transm. (Vienna) , vol.112 , pp. 1613-1624
    • Miller, D.W.1
  • 117
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan, M., et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat. Genet. 1 (1992), 345–347.
    • (1992) Nat. Genet. , vol.1 , pp. 345-347
    • Mullan, M.1
  • 118
    • 79952743365 scopus 로고    scopus 로고
    • Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
    • Munch, C., et al. Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 3548–3553.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 3548-3553
    • Munch, C.1
  • 119
    • 0034193399 scopus 로고    scopus 로고
    • Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
    • Murphy, D.D., et al. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 20 (2000), 3214–3220.
    • (2000) J. Neurosci. , vol.20 , pp. 3214-3220
    • Murphy, D.D.1
  • 120
    • 67649856863 scopus 로고    scopus 로고
    • Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity
    • Nekooki-Machida, Y., et al. Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 9679–9684.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 9679-9684
    • Nekooki-Machida, Y.1
  • 121
    • 32044453611 scopus 로고    scopus 로고
    • Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease
    • Nishioka, K., et al. Clinical heterogeneity of alpha-synuclein gene duplication in Parkinson's disease. Ann. Neurol. 59 (2006), 298–309.
    • (2006) Ann. Neurol. , vol.59 , pp. 298-309
    • Nishioka, K.1
  • 122
    • 84885484356 scopus 로고    scopus 로고
    • Prion-like properties of pathological TDP-43 aggregates from diseased brains
    • Nonaka, T., et al. Prion-like properties of pathological TDP-43 aggregates from diseased brains. Cell Rep. 4 (2013), 124–134.
    • (2013) Cell Rep. , vol.4 , pp. 124-134
    • Nonaka, T.1
  • 123
    • 84961034678 scopus 로고
    • Scrapie produced experimentally in goats with special reference to the clinical syndrome
    • Pattison, I.H., Millson, G.C., Scrapie produced experimentally in goats with special reference to the clinical syndrome. J. Comp. Pathol. 71 (1961), 101–109.
    • (1961) J. Comp. Pathol. , vol.71 , pp. 101-109
    • Pattison, I.H.1    Millson, G.C.2
  • 124
    • 84934955012 scopus 로고    scopus 로고
    • Intrastriatal injection of pre-formed mouse alpha-synuclein fibrils into rats triggers alpha-synuclein pathology and bilateral nigrostriatal degeneration
    • Paumier, K.L., et al. Intrastriatal injection of pre-formed mouse alpha-synuclein fibrils into rats triggers alpha-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiol. Dis. 82 (2015), 185–199.
    • (2015) Neurobiol. Dis. , vol.82 , pp. 185-199
    • Paumier, K.L.1
  • 125
    • 84934983329 scopus 로고    scopus 로고
    • alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration
    • Peelaerts, W., et al. alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature 522 (2015), 340–344.
    • (2015) Nature , vol.522 , pp. 340-344
    • Peelaerts, W.1
  • 126
    • 12244249201 scopus 로고    scopus 로고
    • Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils
    • Petkova, A.T., et al. Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science 307 (2005), 262–265.
    • (2005) Science , vol.307 , pp. 262-265
    • Petkova, A.T.1
  • 127
    • 85011664709 scopus 로고    scopus 로고
    • Modulating membrane binding of alpha-synuclein as a therapeutic strategy
    • Pineda, A., Burre, J., Modulating membrane binding of alpha-synuclein as a therapeutic strategy. Proc. Natl. Acad. Sci. U. S. A. 114 (2017), 1223–1225.
    • (2017) Proc. Natl. Acad. Sci. U. S. A. , vol.114 , pp. 1223-1225
    • Pineda, A.1    Burre, J.2
  • 128
    • 27744459883 scopus 로고    scopus 로고
    • Coexistence of multiple PrPSc types in individuals with Creutzfeldt–Jakob disease
    • Polymenidou, M., et al. Coexistence of multiple PrPSc types in individuals with Creutzfeldt–Jakob disease. Lancet Neurol. 4 (2005), 805–814.
    • (2005) Lancet Neurol. , vol.4 , pp. 805-814
    • Polymenidou, M.1
  • 129
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos, M.H., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997), 2045–2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 130
    • 84944452191 scopus 로고    scopus 로고
    • MDS clinical diagnostic criteria for Parkinson's disease
    • Postuma, R.B., et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov. Disord. 30 (2015), 1591–1601.
    • (2015) Mov. Disord. , vol.30 , pp. 1591-1601
    • Postuma, R.B.1
  • 131
    • 84876226920 scopus 로고    scopus 로고
    • A novel alpha-synuclein missense mutation in Parkinson disease
    • Proukakis, C., et al. A novel alpha-synuclein missense mutation in Parkinson disease. Neurology 80 (2013), 1062–1064.
    • (2013) Neurology , vol.80 , pp. 1062-1064
    • Proukakis, C.1
  • 132
    • 84942860108 scopus 로고    scopus 로고
    • Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism
    • Prusiner, S.B., et al. Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), E5308–17.
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. E5308-17
    • Prusiner, S.B.1
  • 133
    • 0032763817 scopus 로고    scopus 로고
    • Sporadic Creutzfeldt-Jakob disease: co-occurrence of different types of PrP(Sc) in the same brain
    • Puoti, G., et al. Sporadic Creutzfeldt-Jakob disease: co-occurrence of different types of PrP(Sc) in the same brain. Neurology 53 (1999), 2173–2176.
    • (1999) Neurology , vol.53 , pp. 2173-2176
    • Puoti, G.1
  • 135
    • 59649095699 scopus 로고    scopus 로고
    • Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
    • Ren, P.H., et al. Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat. Cell Biol. 11 (2009), 219–225.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 219-225
    • Ren, P.H.1
  • 136
    • 0002450017 scopus 로고
    • Supranuclear ophthalmoplegia, pseudobulbar palsy, nuchal dystonia and dementia. A clinical report on eight cases of “heterogenous system degeneration”
    • Richardson, J.C., et al. Supranuclear ophthalmoplegia, pseudobulbar palsy, nuchal dystonia and dementia. A clinical report on eight cases of “heterogenous system degeneration”. Trans. Am. Neurol. Assoc. 88 (1963), 25–29.
    • (1963) Trans. Am. Neurol. Assoc. , vol.88 , pp. 25-29
    • Richardson, J.C.1
  • 137
    • 4344641972 scopus 로고    scopus 로고
    • Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease
    • Rochet, J.C., et al. Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. J. Mol. Neurosci. 23 (2004), 23–34.
    • (2004) J. Mol. Neurosci. , vol.23 , pp. 23-34
    • Rochet, J.C.1
  • 138
    • 84941235726 scopus 로고    scopus 로고
    • Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years
    • Rudge, P., et al. Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years. Brain 138 (2015), 3386–3399.
    • (2015) Brain , vol.138 , pp. 3386-3399
    • Rudge, P.1
  • 139
    • 77951694945 scopus 로고    scopus 로고
    • Correlating familial Alzheimer's disease gene mutations with clinical phenotype
    • Ryan, N.S., Rossor, M.N., Correlating familial Alzheimer's disease gene mutations with clinical phenotype. Biomark. Med 4 (2010), 99–112.
    • (2010) Biomark. Med , vol.4 , pp. 99-112
    • Ryan, N.S.1    Rossor, M.N.2
  • 140
    • 70349151839 scopus 로고    scopus 로고
    • Parkinson disease with dementia: comparing patients with and without Alzheimer pathology
    • Sabbagh, M.N., et al. Parkinson disease with dementia: comparing patients with and without Alzheimer pathology. Alzheimer Dis. Assoc. Disord. 23 (2009), 295–297.
    • (2009) Alzheimer Dis. Assoc. Disord. , vol.23 , pp. 295-297
    • Sabbagh, M.N.1
  • 141
    • 84904636970 scopus 로고    scopus 로고
    • Intramuscular injection of alpha-synuclein induces CNS alpha-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
    • Sacino, A.N., et al. Intramuscular injection of alpha-synuclein induces CNS alpha-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 10732–10737.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 10732-10737
    • Sacino, A.N.1
  • 142
    • 84902486430 scopus 로고    scopus 로고
    • Distinct tau prion strains propagate in cells and mice and define different tauopathies
    • Sanders, D.W., et al. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron 82 (2014), 1271–1288.
    • (2014) Neuron , vol.82 , pp. 1271-1288
    • Sanders, D.W.1
  • 143
    • 33748795816 scopus 로고    scopus 로고
    • Self-management of fatal familial insomnia. Part 2: case report
    • Schenkein, J., Montagna, P., Self-management of fatal familial insomnia. Part 2: case report. MedGenMed., 8, 2006, 66.
    • (2006) MedGenMed. , vol.8 , pp. 66
    • Schenkein, J.1    Montagna, P.2
  • 144
    • 42549125512 scopus 로고    scopus 로고
    • Review: familial Parkinson's disease—genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease
    • Schiesling, C., et al. Review: familial Parkinson's disease—genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease. Neuropathol. Appl. Neurobiol. 34 (2008), 255–271.
    • (2008) Neuropathol. Appl. Neurobiol. , vol.34 , pp. 255-271
    • Schiesling, C.1
  • 145
    • 70350643450 scopus 로고    scopus 로고
    • A clinico-pathological study of subtypes in Parkinson's disease
    • Selikhova, M., et al. A clinico-pathological study of subtypes in Parkinson's disease. Brain 132 (2009), 2947–2957.
    • (2009) Brain , vol.132 , pp. 2947-2957
    • Selikhova, M.1
  • 146
    • 84863595757 scopus 로고    scopus 로고
    • Purified and synthetic Alzheimer's amyloid beta (Abeta) prions
    • Stohr, J., et al. Purified and synthetic Alzheimer's amyloid beta (Abeta) prions. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 11025–11030.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 11025-11030
    • Stohr, J.1
  • 147
    • 1642633056 scopus 로고    scopus 로고
    • Conformational variations in an infectious protein determine prion strain differences
    • Tanaka, M., et al. Conformational variations in an infectious protein determine prion strain differences. Nature 428 (2004), 323–328.
    • (2004) Nature , vol.428 , pp. 323-328
    • Tanaka, M.1
  • 148
    • 84954385047 scopus 로고    scopus 로고
    • Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau
    • Taniguchi-Watanabe, S., et al. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathol. 131 (2016), 267–280.
    • (2016) Acta Neuropathol. , vol.131 , pp. 267-280
    • Taniguchi-Watanabe, S.1
  • 149
    • 12644272790 scopus 로고    scopus 로고
    • Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity
    • Telling, G.C., et al. Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science 274 (1996), 2079–2082.
    • (1996) Science , vol.274 , pp. 2079-2082
    • Telling, G.C.1
  • 150
    • 33947210032 scopus 로고    scopus 로고
    • Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein
    • Tsigelny, I.F., et al. Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J. 274 (2007), 1862–1877.
    • (2007) FEBS J. , vol.274 , pp. 1862-1877
    • Tsigelny, I.F.1
  • 151
    • 38949132572 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology
    • Tsuboi, Y., et al. Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology. Parkinsonism Relat. Disord. 13:Suppl. 3 (2007), S221–4.
    • (2007) Parkinsonism Relat. Disord. , vol.13 , pp. S221-4
    • Tsuboi, Y.1
  • 152
    • 0031713491 scopus 로고    scopus 로고
    • Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein
    • Tu, P.H., et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Ann. Neurol. 44 (1998), 415–422.
    • (1998) Ann. Neurol. , vol.44 , pp. 415-422
    • Tu, P.H.1
  • 153
    • 0027489773 scopus 로고
    • Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
    • Ueda, K., et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 90 (1993), 11282–11286.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 11282-11286
    • Ueda, K.1
  • 154
    • 0035800097 scopus 로고    scopus 로고
    • Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease
    • Volles, M.J., et al. Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry 40 (2001), 7812–7819.
    • (2001) Biochemistry , vol.40 , pp. 7812-7819
    • Volles, M.J.1
  • 155
    • 80053613574 scopus 로고    scopus 로고
    • Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
    • Volpicelli-Daley, L.A., et al. Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72 (2011), 57–71.
    • (2011) Neuron , vol.72 , pp. 57-71
    • Volpicelli-Daley, L.A.1
  • 156
    • 0036241996 scopus 로고    scopus 로고
    • Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients
    • Watanabe, H., et al. Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. Brain 125 (2002), 1070–1083.
    • (2002) Brain , vol.125 , pp. 1070-1083
    • Watanabe, H.1
  • 157
    • 84888349390 scopus 로고    scopus 로고
    • Transmission of multiple system atrophy prions to transgenic mice
    • Watts, J.C., et al. Transmission of multiple system atrophy prions to transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 19555–19560.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 19555-19560
    • Watts, J.C.1
  • 158
    • 84904322386 scopus 로고    scopus 로고
    • Serial propagation of distinct strains of Abeta prions from Alzheimer's disease patients
    • Watts, J.C., et al. Serial propagation of distinct strains of Abeta prions from Alzheimer's disease patients. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 10323–10328.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 10323-10328
    • Watts, J.C.1
  • 159
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
    • Weinreb, P.H., et al. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35 (1996), 13709–13715.
    • (1996) Biochemistry , vol.35 , pp. 13709-13715
    • Weinreb, P.H.1
  • 160
    • 84940969467 scopus 로고    scopus 로고
    • Propagation of prions causing synucleinopathies in cultured cells
    • Woerman, A.L., et al. Propagation of prions causing synucleinopathies in cultured cells. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), E4949–58.
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. E4949-58
    • Woerman, A.L.1
  • 161
    • 85006022171 scopus 로고    scopus 로고
    • Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells
    • Woerman, A.L., et al. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), E8187–E8196.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , pp. E8187-E8196
    • Woerman, A.L.1
  • 162
    • 10944243102 scopus 로고    scopus 로고
    • Role of alpha-synuclein in presynaptic dopamine recruitment
    • Yavich, L., et al. Role of alpha-synuclein in presynaptic dopamine recruitment. J. Neurosci. 24 (2004), 11165–11170.
    • (2004) J. Neurosci. , vol.24 , pp. 11165-11170
    • Yavich, L.1
  • 163
    • 33750041624 scopus 로고    scopus 로고
    • Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice
    • Yavich, L., et al. Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice. J. Neurochem. 99 (2006), 724–732.
    • (2006) J. Neurochem. , vol.99 , pp. 724-732
    • Yavich, L.1
  • 164
    • 34648813113 scopus 로고    scopus 로고
    • Multiple system atrophy: alpha-synuclein and neuronal degeneration
    • Yoshida, M., Multiple system atrophy: alpha-synuclein and neuronal degeneration. Neuropathology 27 (2007), 484–493.
    • (2007) Neuropathology , vol.27 , pp. 484-493
    • Yoshida, M.1
  • 165
    • 30344438495 scopus 로고    scopus 로고
    • Detection of type 1 prion protein in variant Creutzfeldt–Jakob disease
    • Yull, H.M., et al. Detection of type 1 prion protein in variant Creutzfeldt–Jakob disease. Am. J. Pathol. 168 (2006), 151–157.
    • (2006) Am. J. Pathol. , vol.168 , pp. 151-157
    • Yull, H.M.1
  • 166
    • 10744230149 scopus 로고    scopus 로고
    • The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
    • Zarranz, J.J., et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55 (2004), 164–173.
    • (2004) Ann. Neurol. , vol.55 , pp. 164-173
    • Zarranz, J.J.1
  • 167
    • 84936818605 scopus 로고    scopus 로고
    • shRNA targeting alpha-synuclein prevents neurodegeneration in a Parkinson's disease model
    • Zharikov, A.D., et al. shRNA targeting alpha-synuclein prevents neurodegeneration in a Parkinson's disease model. J. Clin. Invest. 125 (2015), 2721–2735.
    • (2015) J. Clin. Invest. , vol.125 , pp. 2721-2735
    • Zharikov, A.D.1


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