Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

Acta Neuropathologica

Volumn 131, Issue 2, 2016, Pages 267-280

  Taniguchi Watanabe, Sayuri ^a,b   Arai, Tetsuaki ^c   Kametani, Fuyuki ^a   Nonaka, Takashi ^a   Masuda Suzukake, Masami ^a   Tarutani, Airi ^a   Murayama, Shigeo ^d   Saito, Yuko ^e   Arima, Kunimasa ^e   Yoshida, Mari ^f   Akiyama, Haruhiko ^a   Robinson, Andrew ^g   Mann, David M A ^g   Iwatsubo, Takeshi ^b   Hasegawa, Masato ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^f AICHI MEDICAL UNIVERSITY   (Japan)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Alzheimer; CBD; MAPT; Pick; PSP; Strains; Tau

Indexed keywords

ALKALINE PHOSPHATASE; ARGININE; LYSINE; SODIUM DERIVATIVE; TAU PROTEIN; TRYPSIN; MAPT PROTEIN, HUMAN; SARCOSINE; SARKOSYL;

ADULT; AGED; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BIOCHEMICAL ANALYSIS; CARBOXY TERMINAL SEQUENCE; CLINICAL FEATURE; CORTICOBASAL DEGENERATION; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; LIQUID CHROMATOGRAPHY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MIDDLE AGED; MOLECULAR SIZE; MOLECULAR WEIGHT; MORPHOLOGY; NEUROPATHOLOGY; PAIRED HELICAL FILAMENT; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEPHOSPHORYLATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; TANDEM MASS SPECTROMETRY; TAUOPATHY; VERY ELDERLY; ANALOGS AND DERIVATIVES; BRAIN; BRAIN CHEMISTRY; CHEMISTRY; CLASSIFICATION; MASS SPECTROMETRY; METABOLISM; PATHOLOGY; PROCEDURES; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; BRAIN; BRAIN CHEMISTRY; FEMALE; HUMANS; IMMUNOBLOTTING; MALE; MASS SPECTROMETRY; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; PROTEIN CONFORMATION; SARCOSINE; SEQUENCE ANALYSIS, PROTEIN; TAU PROTEINS; TAUOPATHIES; TRYPSIN;

EID: 84954385047     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1503-3     Document Type: Article

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