Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike

Nature

Volumn 547, Issue 7663, 2017, Pages 360-361

  Ozorowski, Gabriel ^a   Pallesen, Jesper ^a   De Val, Natalia ^a,d   Lyumkis, Dmitry ^b   Cottrell, Christopher A ^a   Torres, Jonathan L ^a   Copps, Jeffrey ^a   Stanfield, Robyn L ^a   Cupo, Albert ^c   Pugach, Pavel ^c   Moore, John P ^c   Wilson, Ian A ^a   Ward, Andrew B ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d Nano Imaging Services   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CCR5 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 41; IMMUNOGLOBULIN F(AB) FRAGMENT; LIGAND; VIRUS ENVELOPE PROTEIN; VIRUS RECEPTOR;

ANTIBODY; CELLS AND CELL COMPONENTS; CHEMICAL BINDING; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITOR; LIGAND; MEMBRANE; MUTATION; PEPTIDE; PROTEIN; VACCINE;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PLIABILITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BINDING; VIRUS CELL INTERACTION; VIRUS ENTRY; VIRUS ENVELOPE; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR MODEL; ULTRASTRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANTIBODIES; BINDING SITES; CD4 ANTIGENS; CRYOELECTRON MICROSCOPY; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV ENVELOPE PROTEIN GP41; HIV-1; IMMUNOGLOBULIN FAB FRAGMENTS; LIGANDS; MODELS, MOLECULAR; RECEPTORS, CCR5; RECEPTORS, HIV;

EID: 85025476641     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature23010     Document Type: Article

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