Assessment of DNA Binding and Oxidative DNA Damage by Acrylonitrile in Two Rat Target Tissues of Carcinogenicity: Implications for the Mechanism of Action

Chemical Research in Toxicology

Volumn 30, Issue 7, 2017, Pages 1470-1480

  Williams, Gary M ^a   Kobets, Tetyana ^a   Duan, Jian Dong ^a   Iatropoulos, Michael J ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLONITRILE; BENZO[A]PYRENE DERIVATIVE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; DRINKING WATER; PYRIMIDINE DERIVATIVE; DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CARCINOGENESIS; CARCINOGENICITY; COMET ASSAY; CONTROLLED STUDY; COVALENT BOND; DNA ADDUCT; DNA BINDING; DNA DAMAGE; DNA STRAND BREAKAGE; FEMALE; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MASS SPECTROMETRY; NONHUMAN; OXIDATIVE STRESS; RADIOACTIVITY; RAT; RAT STRAIN; TARGET TISSUE; ANIMAL; BINDING SITE; CARCINOGEN TESTING; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FISCHER 344 RAT; ORAL DRUG ADMINISTRATION; OXIDATION REDUCTION REACTION; SPRAGUE DAWLEY RAT;

ACRYLONITRILE; ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CARCINOGENICITY TESTS; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; OXIDATION-REDUCTION; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY;

EID: 85024482244     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.7b00105     Document Type: Article

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