Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 482, Issue 1-2, 2001, Pages 41-46

  Thier, Ricarda ^a,d   Balkenhol, Heiko ^a   Lewalter, Jürgen ^b   Selinski, Silvia ^c   Dommermuth, Anja ^a   Bolt, Hermann M ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^b BAYER AG   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Acrylonitrile; GST polymorphisms; Haemoglobin adducts

Indexed keywords

ACRYLONITRILE; CYTOCHROME P450 2E1; ETHYLENE OXIDE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M3; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; HEMOGLOBIN; ISOENZYME; ISOLEUCINE; N (CYANOETHYL)VALINE; N (HYDROXYETHYL)VALINE; NUCLEOTIDE; UNCLASSIFIED DRUG; VALINE;

ALLELE; ARTICLE; CODON; COHORT ANALYSIS; CONTROLLED STUDY; DETOXIFICATION; DNA POLYMORPHISM; ENZYME POLYMORPHISM; EVALUATION; GENETIC VARIABILITY; HUMAN; INDUSTRIAL WORKER; INTOXICATION; MAJOR CLINICAL STUDY; METABOLISM; MONITORING; PERIODIC MEDICAL EXAMINATION; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TOXICITY;

EID: 0035479511     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00208-1     Document Type: Article

References (32)

1. Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile
2. N-Acetyl-cystein als antidot bei akzidenteller acrylnitril-intoxikation
3. Behandlung von patienten mit vergiftungen durch aliphatische und olefinische nitrile, arbeitsmed
4. Species differences in acrylonitrile metabolism and toxicity between experimental animals and humans based on observations in human accidental poisonings
5. Epoxidation of acrylonitrile by rat and human cytochromes P450
6. Intestinal toxicity of acrylonitrile: In vitro metabolism by intestinal cytochrome P450 2E1
7. Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice
8. Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1
9. Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: Evidence for linkage with GSTM1*A
10. Concise review of the glutathione S-transferases and their significance to toxicology
11. Detection and characterization of novel polymorphisms in the CYP2E1 gene
12. A simple salting out procedure for extracting DNA from human nucleated cells
13. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer
14. Polymorphism of the Pi class glutathione S-transferase in normal populations and cancer patients
15. CYP2E1 genotyping in renal cell/urothelial cancer patients in comparison with control populations
16. Experimental pharmacokinetics and toxicology of acrylonitrile
17. 13C nuclear magnetic resonance spectroscopy
18. Dose-dependent urinary excretion of acrylonitrile metabolites by rats and mice
19. Biological markers of acute acrylonitrile intoxication in rats as a function of dose and time
20. Irreversible binding of acrylonitrile to nucleic acids
21. A note on synthesis and reactivity towards DNA of glycidonitrile, the epoxide of acrylonitrile
22. Evaluation of possible genotoxic mechanisms for acrylonitrile tumorigenicity
23. Carcinogen adducts: Use in diagnosis and risk assessment
24. N-alkylvaline levels in globin as a new type of biomarker in risk assessment of alkylating agents
25. Molecular cloning, characterization and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants: Evidence for differential catalytic activity of the encoded proteins
26. Polymorphic GSTs and cancer predisposition
27. Naturally occurring human glutathione S-transferase GSTP1 isoform with isoleucine and valine at position 104 differ in enzymatic properties
28. Human glutathione S-transferase P1 polymorphisms: Relationship to lung tissue enzyme activity and population frequency distribution
29. Activity of four allelic forms of glutathione S-transferase hGSTP1-1 for diol epoxides of polycyclic aromatic hydrocarbons
30. Catalytic efficiencies of allelic variants of human glutathione S-transferase Pi in the glutathione conjugation of alpha-, beta-unsaturated aldehydes
31. Carcinogenicity and genotoxicity of ethylene oxide: New aspects and recent advances