Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats

Toxicological Sciences

Volumn 111, Issue 1, 2009, Pages 64-71

  Pu, Xinzhu ^a   Kamendulis, Lisa M ^a   Klaunig, James E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acrylonitrile; Brain; Comet assay; Oxidative DNA damage; White blood cells

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETYLCYSTEINE; ACRYLONITRILE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; DRINKING WATER; GLUTATHIONE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; BODY WEIGHT; BRAIN CORTEX; CANCER INCIDENCE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ELECTROCHEMICAL ANALYSIS; ENZYME BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEUKOCYTE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SPRAGUE DAWLEY RAT; WEIGHT GAIN;

ACRYLONITRILE; ANIMALS; BIOLOGICAL MARKERS; CARCINOGENS; COMET ASSAY; DEOXYGUANOSINE; DNA DAMAGE; GLUTATHIONE; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 69049112943     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp133     Document Type: Article

References (37)

1. Abreu, M. E., and Ahmed, A. E. (1980). Metabolism of acrylonitrile to cyanide: In vitro studies. Drug. Metab. Dispos. 8, 376-379.
2. Bigner,D. D., Bigner, S.H., Burger, J. D., Shelburne, T. J.D., and Friedman, H. S. (1986). Primary brain tumors in Fisher 344 rats chronically exposed to acrylonitrile in their drinking-water. Food Chem. Toxicol. 24, 129-137.
3. Bio/dynamics Inc. (1980). A Twenty-our Month Oral Toxicity/ Carcinogenicity Study of Acrylonitrile Administered in Drinking Water to Fisher 344 Rats Final Report, Vol. I. Monsanto Company, St. Louis, MO.
4. Chanas, B., Wang, H., and Ghanayem, B. I. (2003). Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs female mice: Role of CPY2E1 and epoxide hydrolases. Toxicol. Appl. Pharm. 193, 293-302.
5. Cole, P., Mandel, J. S., and Collins, J. J. (2008). Acrylonitrile and cancer: A review of the epidemiology. Regul. Toxicol. Pharmacol. 52, 342-351.
6. Collins, A. R. (2004). The comet assay for DNA damage and repair: Principles, applications, and limitations. Mol. Biotech. 26, 249-261.
7. Dennog, C., Gedik, C., Wood, S., and Speit, G. (1999). Analysis of oxidative DNA damage and HPRT mutations in humans after hyperbaric oxygen treatment. Mutat. Res. 431, 351-359.
8. El-Sayed, el-S. M., Abo-Salem, O. M., Abd-Ellah, M. F., and Abd-Alla, G. M. (2008). Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain. J. Biochem. Mol. Toxicol. 22, 268-273.
9. Esmat, A., El-Demerdash, E., El-Mesallamy, H., and Abdel-Naim, A. B. (2007). Toxicity and oxidative stress of acrylonitrile in rat primary glial cells: Preventive effects N-acetylcysteine. Toxicol. Lett. 171, 111-118.
10. 13C nuclear magnetic resonance spectroscopy. Chem. Res. Toxicol. 4, 678-687.
11. Frederick, F. J., and Levinskas, G. J. (2002). Chronic toxicity and oncogenic dose-response effects of lifetime oral acrylonitrile exposure to Fisher 344 rats. Toxicol. Lett. 132, 221-247.
12. Guengerich, F. P., Geiger, L. E., Hogy, L. L., and Wright, P. L. (1981). In vitro metabolism of acrylonitrile to 2-cyanoethylene oxide, reaction with glutathione, and irreversible binding to proteins and nucleic acid. Cancer Res. 41, 4925-4933.
13. Helbock, H. J., Bechman, K. B., and Ames, B. (1999). 8-hydroxydeoxyguanosine and 8-Hydroxyguanine as biomarkers of oxidative DNA damage. Methods Enzymol. 300, 156-166.
14. Hogy, L. L., and Guengerich, F. P. (1986). In vitro interaction of acrylonitrile and 2-cyanoethylene oxide with DNA in rats. Cancer Res. 46, 3932-3938.
15. IARC. (1999). Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans. International Agency for Research on Cancer, Lyon, France.
16. Jacob, S., and Ahmed, A. E. (2003). Acrylonitrile-induced neurotoxicity in normal human astrocytes: Oxidative stress and 8-hydroxy-2′-deoxyguanosine formation. Toxicol. Mech. Method 13, 169-179.
17. Jiang, J., Xu, Y., and Klaunig, J. E. (1998). Induction of oxidative stress in rat brain by acrylonitrile. Toxicol. Sci. 46, 333-341.
18. Kamendulis, L. M., Jiang, J., Xu, Y., and Klaunig, J. E. (1999). Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile. Carcinogenesis 20, 1555-1560.
19. Kedderis, G. L., Batra, R., and Turner, M. J., Jr. (1995). Conjugation of acrylonitrile and 2-cyanoethylene oxide with hepatic glutathione. Toxicol. Appl. Pharm. 135, 9-17.
20. Kensler, T. W., Egner, P. A., Taffe, B. G., and Thrush, M. A. (1989). Role of free radicals in tumor promotion and progression. Prog. Clin. Biol. Res. 298, 233-248.
21. Kensler, T. W., and Thrush, M. A. (1986). Role of oxygen radicals in tumor promotion. Environ. Mutagen. 6, 593-616.
22. Klaunig, J. E., and Kamendulis, L. M. (2004). The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 44, 239-267.
23. McCabe, D. R., Maher, T. J., and Acworth, I. N. (1997). Improved method for the estimation of hydroxyl free radical levels in vivo based on liquid chromatography with electrochemical detection. J. Chromatogr. B: Biomed. Sci. Appl. 691, 23-32.
24. Melnyk, S., Progribna, M., Pogribny, I., Hine, R. J., and James, S. J. (1999). A new HPLC method for the simultaneously determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection. J. Nutr. Biochem. 10, 490-497.
25. Nerland, D. E., Cai, J., and Benz, F. W. (2003). Selective covalent binding of acrylonitrile to cys 186 in rat liver carbonic anhydrase III in vivo. Chem. Res. Toxicol. 16, 583-589.
26. Pu, X., Kamendulis, L. M., and Klaunig, J. E. (2006). Acrylonitrile-induced oxidative DNA damage in rat astrocytes. J. Environ. Mol. Mutagen. 47, 631-638.
27. Quast, J. F., and Friedman, M. A. (2002). Two-year toxicity and oncogenicity study with acrylonitrile incorporated in drinking water of rats. Toxicol. Lett. 132, 153-196.
28. Quast, J. F., Wade, C. E., Humiston, C. G., Gushow, T. S., Park, C. N., and Mckenna, M. J. (1980). In A Two-year Toxicity and Oncogenicity Study with Acrylonitrile Incorporated in Drinking Water of Rats. Dow Chemical Co., Midland, MI.
29. Roberts, A. E., Kedderis, G. L., Turner, M. J., Rickert, D. E., and Swenberg, J. A. (1991). Species comparison of acrylonitrile epoxidation by microsomes from mice, rats and humans: Relationship to epoxide concentrations in mouse and rat blood. Carcinogenesis 12, 401-404.
30. Rojas, E., Lopez, M. C., and Valverde, M. (1999). Single cell gel electrophoresis assay: Methodology and applications. J. Chromatogr. B: Biomed. Sci. Appl. 722, 225-254.
31. Sies, H. (1991). Oxidative stress: From basic research to clinical application. Am. J. Med. 91, 31s-38s.
32. Singh, P. N., McCoy, M. T., Tice, R. R., and Schneider, E. L. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell. Res. 175, 184-191.
33. Speit, G., Schutz, P., Trenz, K., and Rothfuss, A. (2002). Oxygenated water does not induce genotoxic effects in comet assay. Toxicol. Lett. 133, 203-210.
34. Tice, R. R., Andrews, P. W., Hirai, O., and Singh, N. P. (1991). The single cell gel (SCG) assay: An electrophoretic technique for the detection of DNA damage in individual cells. Adv. Exp. Med. Biol. 283, 157-164.
35. Whysner, J., Robert, E. S., Chen, D., Conaway, C. C., Verna, L. K., Richie, J. P., Ali, N., and Williams, G. M. (1998a). Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile. Arch. Toxicol. 72, 429-438.
36. Whysner, J., Ross, P. M., Conaway, C. C., Verna, L. K., and Williams, G. M. (1998b). Evaluation of possible genotoxic mechanisms for acrylonitrile tumorigenicity. Regul. Toxicol. Pharm. 27, 217-239.
37. Xia, E., Rao, G., Remmen, H. V., Heydari, A. R., and Richardson, A. (1995). Activities of antioxidant enzymes in various tissues of male Fisher 344 rats are altered by food restriction. J. Nutr. 125 195-201.