Acrylonitrile-induced oxidative DNA damage in rat astrocytes

Environmental and Molecular Mutagenesis

Volumn 47, Issue 8, 2006, Pages 631-638

  Pu, Xinzhu ^a   Kamendulis, Lisa M ^a   Klaunig, James E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acrylonitrile; Astrocytes; Comet assay; Oxidative DNA damage; Oxidative stress

Indexed keywords

1 AMINOBENZOTRIAZOLE; 2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; ACRYLONITRILE; ALPHA TOCOPHEROL; BUTHIONINE SULFOXIMINE; CYANIDE; CYTOCHROME P450; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; EPIGALLOCATECHIN GALLATE; GLUTATHIONE; TROLOX C;

ANIMAL CELL; ARTICLE; ASTROCYTE; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME METABOLISM; NONHUMAN; OXIDATIVE STRESS; RAT;

ACRYLONITRILE; ANIMALS; ANTIOXIDANTS; ASTROCYTES; CELLS, CULTURED; COMET ASSAY; CYANIDES; CYTOCHROME P-450 ENZYME SYSTEM; DNA DAMAGE; GLUTATHIONE; OXIDATIVE STRESS; RATS;

EID: 33750725754     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20249     Document Type: Article

References (46)

1. Abreu ME, Ahmed AE. 1980. Metabolism of acrylonitrile to cyanide: In vitro studies. Drug Metab Dispos 8:376-379.
2. Bigner DD, Bigner SH, Burger JD, Shelburne TJD, Friedman HS. 1986. Primary brain tumors in Fisher 344 rats chronically exposed to acrylonitrile in their drinking-water. Food Chem Toxicol 24:129-137.
3. Bio/dynamics, Inc. 1980. A twenty-four month oral toxicity/ carcinogenicity study of acrylonitrile administered in drinking water to Fisher 344 rats. St. Louis, MO: Monsanto Company. Final Report, VoI I.
4. Chanas B, Wang H, Ghanayem BI. 2003. Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs female mice: Role of CPY2E1 and epoxide hydrolases. Toxicol Appl Pharm 193:293-302.
5. Chang TKH, Crespi CL, Waxman DJ. 2005. Spectrophotometric analysis of human Cyp2E1-catalyzed p-nitrophenol hydroxylation. Methods Mol Biol 320:127-131.
6. Collins AR. 2004. The Comet assay for DNA damage and repair: Principles, applications, and limitations. Mol Biotech 26:249-261.
7. 13C nuclear magnetic resonance spectroscopy. Chem Res Toxicol 4:678-687.
8. Frederick FJ, Levinskas GJ. 2002. Chronic toxicity and oncogenic dose-response effects of lifetime oral acrylonitrile exposure to Fisher 344 rats. Toxicol Lett 132:221-247.
9. 14C-acrylonitrile in rats. Arch Toxicol 50:175-185.
10. Ghanayem BI, Burka LT. 1996. Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats. Drug Metab Dispos 24:390-394.
11. Griffith OW. 1982. Mechanisms of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem 257:13704-13712.
12. Guengerich, FP. 1989. Analysis and characterization of enzymes. In: Hayes AW, editor. Principles and Methods of Toxicology. New York: Raven Press. pp 777-814.
13. Guengerich FP, Geiger LE, Hogy LL, Wright PL. 1981. In vitro metabolism of acrylonitrile to 2-cyanoethylene oxide, reaction with glutathione, and irreversible binding to proteins and nucleic acid. Cancer Res 41:4925-4933.
14. Hadri LE, Chanas B, Ghanayem BI. 2005. Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice. Toxicol Appl Pharm 205:116-125.
15. Hogy LL, Guengerich FP. 1986. In vitro interaction of acrylonitrile and 2-cyanoethylene oxide with DNA in rats. Cancer Res 46:3932-3938.
16. IARC. 1999. Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans. Lyon, France: International Agency for Research on Cancer.
17. Jacob S, Ahmed AE. 2003. Acrylonitrile-induced neurotoxicity in normal human astrocytes: Oxidative stress and 8-hydroxy-2′-deoxyguanosine formation. Toxicol Mech Methods 13:169-179.
18. Jiang J, Xu Y, Klaunig JE. 1998. Induction of oxidative stress in rat brain by acrylonitrile. Toxicol Sci 46:333-341.
19. Johnson JD, Conroy WG, Burns KD, Isom GE. 1987. Peroxidation of brain lipids following cyanide intoxication in mice. Toxicology 46:21-28.
20. Kamendulis LM, Jiang J, Xu Y, Klaunig JE. 1999. Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile. Carcinogenesis 20:1555-1560.
21. Kamendulis LM, Zhang H, Wang Y, Klaunig JE. 2002. Morphological transformation and oxidative stress induced by cyanide in Syrian hamster embryo (SHE) cells. Toxicol Sci 68:437-443.
22. Kanthasamy AG, Ardelt B, Malave A, Mills EM, Powley TL, Borowitz JL, Isom GE. 1997. Reactive oxygen species generated by cyanide mediate toxicity in rat pheochromocytoma cells. Toxicol Lett 93:47-54.
23. Kedderis GL, Batra R, Turner MJ Jr. 1995. Conjugation of acrylonitrile and 2-cyanoethylene oxide with hepatic glutathione. Toxicol Appl Pharm 135:9-17.
24. Kensler TW, Thrush MA. 1986. Role of oxygen radicals in tumor promotion. Environ Mutagen 6:593-616.
25. Kensler TW, Egner PA, Taffe BG, Thrush MA. 1989. Role of free radicals in tumor promotion and progression. Prog Clin Biol Res 298:233-248.
26. Klaunig JE, Kamendulis LM. 2004. The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44:239-267.
27. Lai KP, Wong MH, Wong CK. 2004. Modulation of AhR-mediated CYP1A1 mRNA and EROD activities by 17 β-estradiol and dexamethasone in TCDD-induced H411E cells. Toxicol Sci 78:41-49.
28. Melnyk S, Progribna M, Pogribny I, Hine RJ, James SJ. 1999. A new HPLC method for the simultaneously determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection. J Nutr Biochem 10:490-497.
29. Mikstacka R, Gnojkowski J, Baer-Dubowska W. 2002. Effect of natural phenols on the catalytic activity of cytochrome P450 2E1. Acta Biochim Pol 39:917-925.
30. Mills EM, Gunasekar PG, Pavlakovic G, Isom GE. 1996. Cyanide-induced apoptosis and oxidative stress in differentiated PC12 cells. J Neurochem 67:1039-1046.
31. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
32. Quast JF, Wade CE, Humiston CG, Gushow TS, Park CN, Mckenna MJ. 1980. A Two-Year Toxicity and Oncogenicity Study with Acrylonitrile Incorporated in Drinking Water of Rats. Midland, Mt Dow Chemical.
33. Radany EH, Brenner M, Besnard F, Bigomia V, Bishop M, Deschepper CF. 1992. Directed establishment of rat brain cell lines with the phenotypic characteristics of type I astrocytes. Proc Natl Acad Sci USA 89:6467-6471.
34. Roberts AE, Kedderis GL, Turner MJ, Rickert DE, Swenberg JA. 1991. Species comparison of acrylonitrile epoxidation by microsomes from mice, rats and humans: Relationship to epoxide concentrations in mouse and rat blood. Carcinogenesis 12:401-404.
35. Rojas E, Lopez MC, Valverde M. 1999. Single cell gel electrophoresis assay: Methodology and applications. J Chromatogr B Biomed Sci Appl 722:225-254.
36. Sies H. 1991. Oxidative stress: From basic research to clinical application. Am J Med 91:31S-38S
37. Singh PN, McCoy MT, Tice RR, Schneider EL. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191.
38. Sumner SC, Fennell TR, Moore TA, Chanas B, Gonzalez F, Ghanayem BI. 1999. Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice. Chem Res Toxicol 12:1110-1116.
39. Tice RR, Andrews PW, Hirai O, Singh NP. 1991. The single cell gel (SCG) assay: An electrophoretic technique for the detection of DNA damage in individual cells. Adv Exp Med Biol 283:157-164.
40. Townsend DM, Tew KD, Tapiero H. 2003. The importance of glutathione in human disease. Biomed Pharmcother 57:145-155.
41. Wang H, Chanas B, Ghanayem BI. 2002. Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to cyanide: Comparative studies using CYP2E1-null and wild-type mice. Drug Metab Dispos 30:911-917.
42. Whysner J, Robert ES, Chen D, Conaway CC, Verna LK, Richie JP, Ali N, Williams GM. 1998a. Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile. Arch Toxicol 72:429-438.
43. Whysner J, Ross PM, Conaway CC, Verna LK, Williams GM. 1998b. Evaluation of possible genotoxic mechanisms for acrylonitrile tumorigenicity. Regul Toxicol Pharm 27:217-239.
44. Xia E, Rao G, Remmen HV, Heydari AR, Richardson A. 1995. Activities of antioxidant enzymes in various tissues of male Fisher 344 rats are altered by food restriction. J Nutr 125:195-201.
45. Zhang H, Kamendulis LM, Jiang J, Xu Y, Klaunig JE. 2000. Acrylonitrile-induced morphological transformation in Syrian hamster embryo (SHE) cells. Carcinogenesis 21:727-733.
46. Zhang H, Kamendulis LM, Klaunig JE. 2002. Mechanisms for the induction of oxidative stress in Syrian hamster embryo (SHE) cells by acrylonitrile. Toxicol Sci 67:247-255.