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Volumn 180, Issue 2, 2008, Pages 75-80

Application of mode-of-action considerations in human cancer risk assessment

Author keywords

Bioindicator; Cancer risk assessment; DNA reactive carcinogen; Epigenetic carcinogen; Insignificant daily intake; Toxicologically

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALKENE; ALPHA 2U GLOBULIN; AROMATIC AMINE; BENZIDINE; BIOLOGICAL MARKER; BUTYLATED HYDROXYANISOLE; CARCINOGEN; CYTOTOXIN; DIETHYLNITROSAMINE; DNA; FOOD ADDITIVE; FORMALDEHYDE; IMMUNOMODULATING AGENT; LIMONENE; MYCOTOXIN; N (2 FLUORENYL)ACETAMIDE; NITROSAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHENOBARBITAL; POLYCYCLIC AROMATIC HYDROCARBON; SACCHARIN; VINYL CHLORIDE;

EID: 48649110206     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.05.021     Document Type: Article
Times cited : (36)

References (79)
  • 1
    • 0000179727 scopus 로고
    • Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection
    • Ames B.N. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. U.S.A. 70 (1973) 2281-2285
    • (1973) Proc. Natl. Acad. Sci. U.S.A. , vol.70 , pp. 2281-2285
    • Ames, B.N.1
  • 3
    • 0032450381 scopus 로고    scopus 로고
    • Can the concept of hormesis be generalized to carcinogenesis?
    • Calabrese E.J., and Baldwin L.A. Can the concept of hormesis be generalized to carcinogenesis?. Regul. Toxicol. Pharmacol. 28 (1998) 230-241
    • (1998) Regul. Toxicol. Pharmacol. , vol.28 , pp. 230-241
    • Calabrese, E.J.1    Baldwin, L.A.2
  • 5
    • 0025287177 scopus 로고
    • Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the EDO1 study
    • Cohen S.M., and Ellwein L.B. Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the EDO1 study. Toxicol. Appl. Pharmacol. 104 (1990) 79-93
    • (1990) Toxicol. Appl. Pharmacol. , vol.104 , pp. 79-93
    • Cohen, S.M.1    Ellwein, L.B.2
  • 7
    • 34248577471 scopus 로고    scopus 로고
    • Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens
    • Doak S.H., Jenkins G.J.S., Johnson G.E., Quick E., Parry E.M., and Parry J.M. Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens. Cancer Res. 67 8 (2007) 3904-3911
    • (2007) Cancer Res. , vol.67 , Issue.8 , pp. 3904-3911
    • Doak, S.H.1    Jenkins, G.J.S.2    Johnson, G.E.3    Quick, E.4    Parry, E.M.5    Parry, J.M.6
  • 9
    • 48649092126 scopus 로고    scopus 로고
    • Ehrenberg, L., Brookes, P., Druckrey, H., Lagerlof, B., Litwin, J. Williams, G. 1973. The relation of cancer induction and genetic damage. In: Evaluation of Genetic Risks of Environmental Chemicals, Ed. C. Ramel, University of Stockholm, Stockholm, Ambio Special Report No. 3, pp. 15-16.
    • Ehrenberg, L., Brookes, P., Druckrey, H., Lagerlof, B., Litwin, J. Williams, G. 1973. The relation of cancer induction and genetic damage. In: Evaluation of Genetic Risks of Environmental Chemicals, Ed. C. Ramel, University of Stockholm, Stockholm, Ambio Special Report No. 3, pp. 15-16.
  • 10
    • 48649100787 scopus 로고    scopus 로고
    • European Food Safety Authority, 2005. Opinion of the Scientific Committee on a request from EFSA related to a harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. (Request No EFSA-Q-2004-020). Adopted on 18 October 2005. Available at: http://efsa.europa.eu./science/sc_committee/sc_opinions1201/sc_op_ej282_gentox_en3.pdf.
    • European Food Safety Authority, 2005. Opinion of the Scientific Committee on a request from EFSA related to a harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. (Request No EFSA-Q-2004-020). Adopted on 18 October 2005. Available at: http://efsa.europa.eu./science/sc_committee/sc_opinions1201/sc_op_ej282_gentox_en3.pdf.
  • 11
    • 48649097213 scopus 로고    scopus 로고
    • European Food Safety Authority (EFSA), 2006. EFA Meeting Summary Report. EFSA/WHO International Conference with Support of ILSI Europe on Risk Assessment of Compounds that are both Genotoxic and Carcinogenic, European Food Safety Authority, Parma, Italy.
    • European Food Safety Authority (EFSA), 2006. EFA Meeting Summary Report. EFSA/WHO International Conference with Support of ILSI Europe on Risk Assessment of Compounds that are both Genotoxic and Carcinogenic, European Food Safety Authority, Parma, Italy.
  • 12
    • 0029008910 scopus 로고
    • Effects of low doses of N-nitrosomorpholine on the development of early states of hepatocarcinogenesis
    • Enzmann H., Zerban H., Kopp-Schneider A., Löser A., and Bannasch P. Effects of low doses of N-nitrosomorpholine on the development of early states of hepatocarcinogenesis. Carcinogenesis 16 (1995) 1418-1513
    • (1995) Carcinogenesis , vol.16 , pp. 1418-1513
    • Enzmann, H.1    Zerban, H.2    Kopp-Schneider, A.3    Löser, A.4    Bannasch, P.5
  • 13
    • 0018909042 scopus 로고
    • Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously
    • Farmer J.H., Kodell R.L., Greenman D.L., and Shaw G.W. Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously. J. Environ. Pathol. Toxicol. 3 (1980) 55-68
    • (1980) J. Environ. Pathol. Toxicol. , vol.3 , pp. 55-68
    • Farmer, J.H.1    Kodell, R.L.2    Greenman, D.L.3    Shaw, G.W.4
  • 14
    • 0032805849 scopus 로고    scopus 로고
    • Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment
    • Fukushima S. Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment. Cancer Lett. 143 (1999) 157-159
    • (1999) Cancer Lett. , vol.143 , pp. 157-159
    • Fukushima, S.1
  • 16
    • 27744450279 scopus 로고    scopus 로고
    • Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens
    • Fukushima S., Kinoshita A., Puatanachokchai R., Kushida M., Wanibuchi H., and Morimura K. Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. Carcinogenesis 26 (2005) 1835-1845
    • (2005) Carcinogenesis , vol.26 , pp. 1835-1845
    • Fukushima, S.1    Kinoshita, A.2    Puatanachokchai, R.3    Kushida, M.4    Wanibuchi, H.5    Morimura, K.6
  • 18
  • 19
    • 0019870862 scopus 로고
    • Existence of a practical threshold dose for the haptocarcinogen 3′-methyl-4-(dimethylamino)azobenzene in rat liver
    • Hino O., and Kitagawa T. Existence of a practical threshold dose for the haptocarcinogen 3′-methyl-4-(dimethylamino)azobenzene in rat liver. Gann 72 (1981) 637-638
    • (1981) Gann , vol.72 , pp. 637-638
    • Hino, O.1    Kitagawa, T.2
  • 20
    • 48649083378 scopus 로고    scopus 로고
    • International Agency for Research on Cancer, 1996. IARC monographs on the evaluation of carcinogenic risks to humans: some pharmaceutical drugs, 'Tamoxifen', IARC, Lyon, vol. 66, pp. 253-365.
    • International Agency for Research on Cancer, 1996. IARC monographs on the evaluation of carcinogenic risks to humans: some pharmaceutical drugs, 'Tamoxifen', IARC, Lyon, vol. 66, pp. 253-365.
  • 21
    • 48649094122 scopus 로고    scopus 로고
    • International Agency for Research on Cancer, 2003. Predictive value of rodent forestomach and gastric neuroendocrine tumours in evaluating carcinogenic risks to humans. 'Summary Report', IARC, Lyon, Technical publication 39, pp. 7-14.
    • International Agency for Research on Cancer, 2003. Predictive value of rodent forestomach and gastric neuroendocrine tumours in evaluating carcinogenic risks to humans. 'Summary Report', IARC, Lyon, Technical publication 39, pp. 7-14.
  • 22
    • 0029780851 scopus 로고    scopus 로고
    • International Expert Panel on Carcinogen Risk Assessment, 1996. The use of mechanistic data in the risk assessments of ten chemicals: an introduction to the chemical-specific reviews. Pharmacol. Ther. 71 (Special Issue):1-5.
    • International Expert Panel on Carcinogen Risk Assessment, 1996. The use of mechanistic data in the risk assessments of ten chemicals: an introduction to the chemical-specific reviews. Pharmacol. Ther. 71 (Special Issue):1-5.
  • 23
    • 24644476629 scopus 로고    scopus 로고
    • Jeffrey, A.M. and Williams, G.M., 2005. Risk assessment of DNA-reactive carcinogens in food. Proceedings 10th International Congress of Toxicology. Toxicology and Applied Pharmacology, 207; s628-s635.
    • Jeffrey, A.M. and Williams, G.M., 2005. Risk assessment of DNA-reactive carcinogens in food. Proceedings 10th International Congress of Toxicology. Toxicology and Applied Pharmacology, 207; s628-s635.
  • 24
    • 48649104176 scopus 로고    scopus 로고
    • Joint FAO/WHO Expert Committee on Food Additives (2005). JECFA Sixty-fourth meting, Rome, 8-17 February 2005. Summary and Conclusions. FAO/WHO. Available at ftp://ftp.fao.org/es/en/jecfa/jecfa64_summary.pdf.
    • Joint FAO/WHO Expert Committee on Food Additives (2005). JECFA Sixty-fourth meting, Rome, 8-17 February 2005. Summary and Conclusions. FAO/WHO. Available at ftp://ftp.fao.org/es/en/jecfa/jecfa64_summary.pdf.
  • 25
    • 0033960141 scopus 로고    scopus 로고
    • Concepts of threshold in mutagenesis and carcinogenesis
    • Kirsch-Volders M., Aardema M., and Elhajouji A. Concepts of threshold in mutagenesis and carcinogenesis. Mutat. Res. 464 (2000) 3-11
    • (2000) Mutat. Res. , vol.464 , pp. 3-11
    • Kirsch-Volders, M.1    Aardema, M.2    Elhajouji, A.3
  • 26
    • 0034509118 scopus 로고    scopus 로고
    • Epigenetic mechanisms of chemical carcinogenesis
    • Klaunig J.E., Kamendulis L.M., and Xu Y. Epigenetic mechanisms of chemical carcinogenesis. Human Exp. Toxicol. 19 (2000) 543-555
    • (2000) Human Exp. Toxicol. , vol.19 , pp. 543-555
    • Klaunig, J.E.1    Kamendulis, L.M.2    Xu, Y.3
  • 27
    • 0037186896 scopus 로고    scopus 로고
    • Threshold of toxicological concern (TTC) in food safety assessment
    • Kroes R., and Kozianowski G. Threshold of toxicological concern (TTC) in food safety assessment. Toxicol. Lett. 127 (2002) 43-46
    • (2002) Toxicol. Lett. , vol.127 , pp. 43-46
    • Kroes, R.1    Kozianowski, G.2
  • 28
    • 0015362694 scopus 로고
    • Early appearance of serum alpha-fetoprotein during hepatocarcinogenesis as a function of age of rats and extent of treatment with 3′-methyl-4-dimethylaminoazobenzene
    • Kroes R., Williams G.M., and Weisburger J.H. Early appearance of serum alpha-fetoprotein during hepatocarcinogenesis as a function of age of rats and extent of treatment with 3′-methyl-4-dimethylaminoazobenzene. Cancer Res. 32 (1972) 1526-1532
    • (1972) Cancer Res. , vol.32 , pp. 1526-1532
    • Kroes, R.1    Williams, G.M.2    Weisburger, J.H.3
  • 29
    • 0015701279 scopus 로고
    • On the precocious induction of alpha-foetoprotein by several hepatocarcinogens, including aflatoxin B1 in rats
    • Doll R., and Vodopija I. (Eds), International Agency for Research on Cancer, Lyon
    • Kroes R., Williams G.M., and Weisburger J.H. On the precocious induction of alpha-foetoprotein by several hepatocarcinogens, including aflatoxin B1 in rats. In: Doll R., and Vodopija I. (Eds). Host Environment Interactions in the Etiology of Cancer in Man. IARC Scientific Publication, No. 7 (1973), International Agency for Research on Cancer, Lyon 307-309
    • (1973) Host Environment Interactions in the Etiology of Cancer in Man. IARC Scientific Publication, No. 7 , pp. 307-309
    • Kroes, R.1    Williams, G.M.2    Weisburger, J.H.3
  • 30
    • 0034010667 scopus 로고    scopus 로고
    • Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing
    • Kroes R., Galli C., Munro I., Schliter B., Tran L.-A., Walker R., and Würtzen G. Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing. Food Chem. Toxicol. 38 (2000) 255-312
    • (2000) Food Chem. Toxicol. , vol.38 , pp. 255-312
    • Kroes, R.1    Galli, C.2    Munro, I.3    Schliter, B.4    Tran, L.-A.5    Walker, R.6    Würtzen, G.7
  • 33
    • 0023884624 scopus 로고
    • Dose-response study with N-nitrosomorpholine in drinking water of F-344 rats
    • Lijinsky W., Kovatch R.M., Riggs C.W., and Walters P.T. Dose-response study with N-nitrosomorpholine in drinking water of F-344 rats. Cancer Res. 48 (1988) 2089-2095
    • (1988) Cancer Res. , vol.48 , pp. 2089-2095
    • Lijinsky, W.1    Kovatch, R.M.2    Riggs, C.W.3    Walters, P.T.4
  • 35
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistage carcinogenesis
    • Loeb L.A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51 (1991) 3075-3079
    • (1991) Cancer Res. , vol.51 , pp. 3075-3079
    • Loeb, L.A.1
  • 40
    • 0018577895 scopus 로고
    • Milestones in chemical carcinogenesis
    • Miller E.C., and Miller J.A. Milestones in chemical carcinogenesis. Sem. Oncol. 6 (1979) 445-460
    • (1979) Sem. Oncol. , vol.6 , pp. 445-460
    • Miller, E.C.1    Miller, J.A.2
  • 41
    • 0030250802 scopus 로고    scopus 로고
    • Correlation of structural class with no-observed -effect levels: a proposal for establishing a threshold of concern
    • Munro I.C., Ford R.A., Kennepohl E., and Sprenger J.G. Correlation of structural class with no-observed -effect levels: a proposal for establishing a threshold of concern. Food Chem. Toxicol. 34 (1996) 829-867
    • (1996) Food Chem. Toxicol. , vol.34 , pp. 829-867
    • Munro, I.C.1    Ford, R.A.2    Kennepohl, E.3    Sprenger, J.G.4
  • 43
    • 48649083119 scopus 로고    scopus 로고
    • National Research Council, 1994. Science and Judgement in Risk Assessment, Washington, D.C.: National Academy Press.
    • National Research Council, 1994. Science and Judgement in Risk Assessment, Washington, D.C.: National Academy Press.
  • 44
    • 48649101961 scopus 로고    scopus 로고
    • National Research Council, 2006. Health risks from dioxin and related compounds, Evaluation of the EPA Reassessment, Washington DC.: National Academy Press.
    • National Research Council, 2006. Health risks from dioxin and related compounds, Evaluation of the EPA Reassessment, Washington DC.: National Academy Press.
  • 46
    • 0026347782 scopus 로고
    • Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine; a detailed dose-response study
    • Peto R., Gray R., Brantom P., and Grasso P. Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine; a detailed dose-response study. Cancer Res. 51 (1991) 6415-6451
    • (1991) Cancer Res. , vol.51 , pp. 6415-6451
    • Peto, R.1    Gray, R.2    Brantom, P.3    Grasso, P.4
  • 47
    • 0026353166 scopus 로고
    • Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine
    • Peto R., Gray R., Brantom P., and Grasso P. Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine. Cancer Res. 51 (1991) 6452-6469
    • (1991) Cancer Res. , vol.51 , pp. 6452-6469
    • Peto, R.1    Gray, R.2    Brantom, P.3    Grasso, P.4
  • 48
    • 2342439267 scopus 로고    scopus 로고
    • On the application of data on mode of action to carcinogenic risk assessment
    • Rice J.M. On the application of data on mode of action to carcinogenic risk assessment. Toxicol. Sci. 78 (2004) 175-177
    • (2004) Toxicol. Sci. , vol.78 , pp. 175-177
    • Rice, J.M.1
  • 50
    • 0030776986 scopus 로고    scopus 로고
    • Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver
    • Root M., Lanage T., and Campbell T.C. Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver. Chem. Biol. Interact. 106 (1997) 213-227
    • (1997) Chem. Biol. Interact. , vol.106 , pp. 213-227
    • Root, M.1    Lanage, T.2    Campbell, T.C.3
  • 51
    • 0002296799 scopus 로고
    • De minimis and the threshold of regulation. Felix C.W. (Ed), Chelsea/Lewis, Michigan
    • Rulis A.M. De minimis and the threshold of regulation. In: Felix C.W. (Ed). Food Protection Technology (1986), Chelsea/Lewis, Michigan 29-37
    • (1986) Food Protection Technology , pp. 29-37
    • Rulis, A.M.1
  • 52
    • 24744458369 scopus 로고    scopus 로고
    • Sander, M., Cadet, J., Casciano, D.A., Galloway, S.M., Marnett, L.J., Novak, R.F., Pettit, S.D., Preston, R.J., Skare, J., Williams, G.M., Van Houten, B. Gollapudi, B.B., 2005. Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004. Toxicol. Appl. Pharmacol. 208:1-20.
    • Sander, M., Cadet, J., Casciano, D.A., Galloway, S.M., Marnett, L.J., Novak, R.F., Pettit, S.D., Preston, R.J., Skare, J., Williams, G.M., Van Houten, B. Gollapudi, B.B., 2005. Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004. Toxicol. Appl. Pharmacol. 208:1-20.
  • 53
    • 0034950342 scopus 로고    scopus 로고
    • A simple method for quantitative risk assessment of non-threshold carcinogens based on the dose descriptor T25
    • Sanner T., Dybing E., Willems M.I., and Krosese E.D. A simple method for quantitative risk assessment of non-threshold carcinogens based on the dose descriptor T25. Pharmalcol. Toxicol. 88 (2001) 331-341
    • (2001) Pharmalcol. Toxicol. , vol.88 , pp. 331-341
    • Sanner, T.1    Dybing, E.2    Willems, M.I.3    Krosese, E.D.4
  • 54
    • 0037258612 scopus 로고    scopus 로고
    • Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis; evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work
    • Tsuda H., Fukushima S., Wanibuchi H., Morimura K., Nakae D., Imaida K., Tatematsu M., Hirose M., Wakabayashi K., and Moore M.A. Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis; evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work. Toxicol. Pathol. 31 (2003) 80-86
    • (2003) Toxicol. Pathol. , vol.31 , pp. 80-86
    • Tsuda, H.1    Fukushima, S.2    Wanibuchi, H.3    Morimura, K.4    Nakae, D.5    Imaida, K.6    Tatematsu, M.7    Hirose, M.8    Wakabayashi, K.9    Moore, M.A.10
  • 55
    • 48649094276 scopus 로고    scopus 로고
    • 2u-globulin association with chemically induced renal toxicity and neoplasia in the male rat. Prepared for the Risk Assessment Forum of the US EPA, Washington DC. EPA/625/3-91/019F.
    • 2u-globulin association with chemically induced renal toxicity and neoplasia in the male rat. Prepared for the Risk Assessment Forum of the US EPA, Washington DC. EPA/625/3-91/019F.
  • 56
    • 48649102128 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency (EPA), 2005. Guidelines for carcinogen risk assessment. Risk Assessment Forum, Washington, DC. EPA/630/P-03001F. Available from: http://www.epa.gov/ttn/atw/cancer_guidelines_final_3-25-05.pdf.
    • U.S. Environmental Protection Agency (EPA), 2005. Guidelines for carcinogen risk assessment. Risk Assessment Forum, Washington, DC. EPA/630/P-03001F. Available from: http://www.epa.gov/ttn/atw/cancer_guidelines_final_3-25-05.pdf.
  • 57
    • 0027401607 scopus 로고
    • The multistep nature of cancer
    • Vogelstein B., and Kinzler K.W. The multistep nature of cancer. Trends Genet. 9 (1993) 138-141
    • (1993) Trends Genet. , vol.9 , pp. 138-141
    • Vogelstein, B.1    Kinzler, K.W.2
  • 58
    • 33646540449 scopus 로고    scopus 로고
    • Concordance of thresholds for carcinogenicity of nitrosodiethylamine
    • Waddell W.J., Fukushima S., and Williams G.M. Concordance of thresholds for carcinogenicity of nitrosodiethylamine. Arch. Toxicol. 80 (2006) 305-309
    • (2006) Arch. Toxicol. , vol.80 , pp. 305-309
    • Waddell, W.J.1    Fukushima, S.2    Williams, G.M.3
  • 59
    • 0019792758 scopus 로고
    • Carcinogen testing: current problems and new approaches
    • Weisburger J.H., and Williams G.M. Carcinogen testing: current problems and new approaches. Science 214 (1981) 401-407
    • (1981) Science , vol.214 , pp. 401-407
    • Weisburger, J.H.1    Williams, G.M.2
  • 60
    • 0002067439 scopus 로고
    • Causes of cancer
    • Murphy G.P., Lawrence Jr. W., and Lenhard Jr. R.E. (Eds), American Cancer Society, Inc, Atlanta, GA
    • Weisburger J.H., and Williams G.M. Causes of cancer. In: Murphy G.P., Lawrence Jr. W., and Lenhard Jr. R.E. (Eds). American Cancer Society Textbook of Clinical Oncology (1995), American Cancer Society, Inc, Atlanta, GA 10-39
    • (1995) American Cancer Society Textbook of Clinical Oncology , pp. 10-39
    • Weisburger, J.H.1    Williams, G.M.2
  • 61
    • 0029769309 scopus 로고    scopus 로고
    • Butylated hydroxyanisole mechanistic data and risk assessment: Conditional species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion
    • Whysner J., and Williams G.M. Butylated hydroxyanisole mechanistic data and risk assessment: Conditional species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion. Pharmacol. Ther. 71 (1996) 137-152
    • (1996) Pharmacol. Ther. , vol.71 , pp. 137-152
    • Whysner, J.1    Williams, G.M.2
  • 62
    • 0029762765 scopus 로고    scopus 로고
    • Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion
    • Whysner J., Ross P.M., and Williams G.M. Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion. Pharm. Ther. 71 (1996) 153-192
    • (1996) Pharm. Ther. , vol.71 , pp. 153-192
    • Whysner, J.1    Ross, P.M.2    Williams, G.M.3
  • 63
    • 0019226768 scopus 로고
    • Classification of genotoxic and epigenetic hepatocarcinogens using liver culture assays
    • Williams G.M. Classification of genotoxic and epigenetic hepatocarcinogens using liver culture assays. Annals New York Academy of Sciences 349 (1980) 273-282
    • (1980) Annals New York Academy of Sciences , vol.349 , pp. 273-282
    • Williams, G.M.1
  • 64
    • 0000273376 scopus 로고
    • Epigenetic mechanisms of liver tumor promotion
    • Stevenson D.E., McClain R.M., Popp J.A., Slaga T.J., Ward J.M., and Pitot H.C. (Eds), Alan R. Liss, Inc, New York
    • Williams G.M. Epigenetic mechanisms of liver tumor promotion. In: Stevenson D.E., McClain R.M., Popp J.A., Slaga T.J., Ward J.M., and Pitot H.C. (Eds). Mouse Liver Carcinogenesis (1990), Alan R. Liss, Inc, New York 121-145
    • (1990) Mouse Liver Carcinogenesis , pp. 121-145
    • Williams, G.M.1
  • 65
    • 0025168709 scopus 로고    scopus 로고
    • Williams, G.M., 1990b. Screening procedures for evaluating the potential carcinogenicity of food packaging chemicals. Regul. Toxicol. Pharmacol., 12:30-40, 1990.
    • Williams, G.M., 1990b. Screening procedures for evaluating the potential carcinogenicity of food packaging chemicals. Regul. Toxicol. Pharmacol., 12:30-40, 1990.
  • 66
    • 0027048538 scopus 로고
    • DNA reactive and epigenetic carcinogens
    • Williams G.M. DNA reactive and epigenetic carcinogens. Exp. Toxicol. Pathol. 44 (1992) 457-464
    • (1992) Exp. Toxicol. Pathol. , vol.44 , pp. 457-464
    • Williams, G.M.1
  • 67
    • 0032861974 scopus 로고    scopus 로고
    • Mechanistic considerations in cancer risk assessment
    • Williams G.M. Mechanistic considerations in cancer risk assessment. Inhal. Toxicol. 11 (1999) 549-554
    • (1999) Inhal. Toxicol. , vol.11 , pp. 549-554
    • Williams, G.M.1
  • 68
    • 0035860642 scopus 로고    scopus 로고
    • Mechanisms of chemical carcinogenesis and application to human cancer risk assessment
    • Williams G.M. Mechanisms of chemical carcinogenesis and application to human cancer risk assessment. Toxicology 166 (2001) 3-10
    • (2001) Toxicology , vol.166 , pp. 3-10
    • Williams, G.M.1
  • 69
    • 0036186764 scopus 로고    scopus 로고
    • Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity
    • Williams G.M., and Iatropoulos M.J. Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity. Toxicol. Pathol. 30 (2002) 41-53
    • (2002) Toxicol. Pathol. , vol.30 , pp. 41-53
    • Williams, G.M.1    Iatropoulos, M.J.2
  • 70
    • 0029455988 scopus 로고
    • Mechansitic considerations in risk assessment for epigenetic tumor-promoting arcinogens
    • McClain R.M., Slaga T.J., LeBoeuf R., and Pitot H. (Eds), John Wiley and Sons, Inc., New York
    • Williams G.M., and Whysner J. Mechansitic considerations in risk assessment for epigenetic tumor-promoting arcinogens. In: McClain R.M., Slaga T.J., LeBoeuf R., and Pitot H. (Eds). Growth Factors and Tumor Promotion: Implications for Risk Assessment (1995), John Wiley and Sons, Inc., New York 369-383
    • (1995) Growth Factors and Tumor Promotion: Implications for Risk Assessment , pp. 369-383
    • Williams, G.M.1    Whysner, J.2
  • 71
    • 0029873622 scopus 로고    scopus 로고
    • Epigenetic carcinogens: evaluation and risk assessment
    • Williams G.M., and Whysner J. Epigenetic carcinogens: evaluation and risk assessment. Exp. Toxicol. Pathol. 48 (1996) 189-195
    • (1996) Exp. Toxicol. Pathol. , vol.48 , pp. 189-195
    • Williams, G.M.1    Whysner, J.2
  • 72
    • 0015820230 scopus 로고
    • Cytochemical and ultrastructural alterations associated with confluent growth in cell cultures of epithelial-like cells from rat liver
    • Williams G.M., Stromberg K., and Kroes R. Cytochemical and ultrastructural alterations associated with confluent growth in cell cultures of epithelial-like cells from rat liver. Lab. Invest. 29 (1973) 293-303
    • (1973) Lab. Invest. , vol.29 , pp. 293-303
    • Williams, G.M.1    Stromberg, K.2    Kroes, R.3
  • 73
    • 0000931687 scopus 로고
    • A comparison of the animal and human carcinogenicity of several environmental, occupation and therapeutic chemicals
    • Flamm G., and Lorentzen R. (Eds), Princeton Scientific Publishers, Princeton, NJ
    • Williams G.M., Reiss B., and Weisburger J.H. A comparison of the animal and human carcinogenicity of several environmental, occupation and therapeutic chemicals. In: Flamm G., and Lorentzen R. (Eds). Mechanisms and Toxicity of Chemical Carcinogens and Mutagens. Advances in Environmental Toxicology, Vol IX (1985), Princeton Scientific Publishers, Princeton, NJ 207-248
    • (1985) Mechanisms and Toxicity of Chemical Carcinogens and Mutagens. Advances in Environmental Toxicology, Vol IX , pp. 207-248
    • Williams, G.M.1    Reiss, B.2    Weisburger, J.H.3
  • 74
    • 0029874523 scopus 로고    scopus 로고
    • Risk assessment of carcinogens in food with special consideration of non-genotoxic carcinogens: scientific arguments for use of risk assessment and for changing the Delaney Clause specifically
    • Williams G.M., Karbe E., Fenner-Crisp P., Iatropoulos M.J., and Weisburger J.H. Risk assessment of carcinogens in food with special consideration of non-genotoxic carcinogens: scientific arguments for use of risk assessment and for changing the Delaney Clause specifically. Exp. Toxicol. Pathol. 48 (1996) 119-125
    • (1996) Exp. Toxicol. Pathol. , vol.48 , pp. 119-125
    • Williams, G.M.1    Karbe, E.2    Fenner-Crisp, P.3    Iatropoulos, M.J.4    Weisburger, J.H.5
  • 75
    • 0034042794 scopus 로고    scopus 로고
    • Mechanistic basis for non-linearity and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine
    • Williams G.M., Iatropoulos M.J., and Jeffrey A.M. Mechanistic basis for non-linearity and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine. Toxicol. Pathol. 28 (2000) 388-395
    • (2000) Toxicol. Pathol. , vol.28 , pp. 388-395
    • Williams, G.M.1    Iatropoulos, M.J.2    Jeffrey, A.M.3
  • 76
    • 0034070443 scopus 로고    scopus 로고
    • Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans
    • Williams G.M., Kroes R., and Munro I.C. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Pharmacol. Toxicol. 31 (2000) 117-165
    • (2000) Regul. Pharmacol. Toxicol. , vol.31 , pp. 117-165
    • Williams, G.M.1    Kroes, R.2    Munro, I.C.3
  • 79
    • 48649097060 scopus 로고    scopus 로고
    • World Health Organization (1999) Principles for the assessment of risk to human health from exposure to chemicals. Environmental Health Criteria No. 210, WHO, Geneva.
    • World Health Organization (1999) Principles for the assessment of risk to human health from exposure to chemicals. Environmental Health Criteria No. 210, WHO, Geneva.


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