-
1
-
-
0000179727
-
Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection
-
Ames B.N. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. U.S.A. 70 (1973) 2281-2285
-
(1973)
Proc. Natl. Acad. Sci. U.S.A.
, vol.70
, pp. 2281-2285
-
-
Ames, B.N.1
-
2
-
-
33747335918
-
Risk assessment of substances that are both genotoxic and carcinogenic report of an International Conference organized by EFSA and WHO with support of ILSI Europe
-
Barlow S., Renwick A.G., Kleiner J., Bridges J.W., Busk L., Dybing E., Edler L., Eisenbrand G., Fink-Gremmels J., Knaap A., Kroes R., Liem D., Muller D.J., Page S., Rolland V., Schlatter J., Tritscher A., Tueting W., and Wurtzen G. Risk assessment of substances that are both genotoxic and carcinogenic report of an International Conference organized by EFSA and WHO with support of ILSI Europe. Food Chem.Toxicol. 44 (2006) 1636-1650
-
(2006)
Food Chem.Toxicol.
, vol.44
, pp. 1636-1650
-
-
Barlow, S.1
Renwick, A.G.2
Kleiner, J.3
Bridges, J.W.4
Busk, L.5
Dybing, E.6
Edler, L.7
Eisenbrand, G.8
Fink-Gremmels, J.9
Knaap, A.10
Kroes, R.11
Liem, D.12
Muller, D.J.13
Page, S.14
Rolland, V.15
Schlatter, J.16
Tritscher, A.17
Tueting, W.18
Wurtzen, G.19
-
3
-
-
0032450381
-
Can the concept of hormesis be generalized to carcinogenesis?
-
Calabrese E.J., and Baldwin L.A. Can the concept of hormesis be generalized to carcinogenesis?. Regul. Toxicol. Pharmacol. 28 (1998) 230-241
-
(1998)
Regul. Toxicol. Pharmacol.
, vol.28
, pp. 230-241
-
-
Calabrese, E.J.1
Baldwin, L.A.2
-
4
-
-
0032930665
-
32P-postlabeling for tamoxifen-DNA adducts in the human endometrium
-
32P-postlabeling for tamoxifen-DNA adducts in the human endometrium. Carcinogenesis 20 (1999) 339-342
-
(1999)
Carcinogenesis
, vol.20
, pp. 339-342
-
-
Carmichael, P.L.1
Sardar, S.2
Crooks, N.3
Neven, P.4
Van Hoof, I.5
Ugwumadu, A.6
Bourne, T.7
Tomas, E.8
Hellberg, P.9
Hewer, A.J.10
Phillips, D.H.11
-
5
-
-
0025287177
-
Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the EDO1 study
-
Cohen S.M., and Ellwein L.B. Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the EDO1 study. Toxicol. Appl. Pharmacol. 104 (1990) 79-93
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.104
, pp. 79-93
-
-
Cohen, S.M.1
Ellwein, L.B.2
-
6
-
-
0346156025
-
The human relevance of information on carcinogenic modes of action: overview
-
Cohen S.M., Meek M.E., Klaunig J.E., Patton D.E., and Fenner-Crisp P.A. The human relevance of information on carcinogenic modes of action: overview. Crit. Rev. Toxicol. 33 6 (2003) 581-589
-
(2003)
Crit. Rev. Toxicol.
, vol.33
, Issue.6
, pp. 581-589
-
-
Cohen, S.M.1
Meek, M.E.2
Klaunig, J.E.3
Patton, D.E.4
Fenner-Crisp, P.A.5
-
7
-
-
34248577471
-
Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens
-
Doak S.H., Jenkins G.J.S., Johnson G.E., Quick E., Parry E.M., and Parry J.M. Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens. Cancer Res. 67 8 (2007) 3904-3911
-
(2007)
Cancer Res.
, vol.67
, Issue.8
, pp. 3904-3911
-
-
Doak, S.H.1
Jenkins, G.J.S.2
Johnson, G.E.3
Quick, E.4
Parry, E.M.5
Parry, J.M.6
-
8
-
-
0036122484
-
Hazard characterization of chemicals in food and diet. Dose response, mechanisms and extrapolation issues
-
237-2-82
-
Dybing E., Doe J., Groten J., Kleiner J., Renwick A.G., Schlatter J., Steinberg P., Tritscher A., Walker R., and Younes M. Hazard characterization of chemicals in food and diet. Dose response, mechanisms and extrapolation issues. Food Chem. Toxicol. 40 (2002) 237-2-82
-
(2002)
Food Chem. Toxicol.
, vol.40
-
-
Dybing, E.1
Doe, J.2
Groten, J.3
Kleiner, J.4
Renwick, A.G.5
Schlatter, J.6
Steinberg, P.7
Tritscher, A.8
Walker, R.9
Younes, M.10
-
9
-
-
48649092126
-
-
Ehrenberg, L., Brookes, P., Druckrey, H., Lagerlof, B., Litwin, J. Williams, G. 1973. The relation of cancer induction and genetic damage. In: Evaluation of Genetic Risks of Environmental Chemicals, Ed. C. Ramel, University of Stockholm, Stockholm, Ambio Special Report No. 3, pp. 15-16.
-
Ehrenberg, L., Brookes, P., Druckrey, H., Lagerlof, B., Litwin, J. Williams, G. 1973. The relation of cancer induction and genetic damage. In: Evaluation of Genetic Risks of Environmental Chemicals, Ed. C. Ramel, University of Stockholm, Stockholm, Ambio Special Report No. 3, pp. 15-16.
-
-
-
-
10
-
-
48649100787
-
-
European Food Safety Authority, 2005. Opinion of the Scientific Committee on a request from EFSA related to a harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. (Request No EFSA-Q-2004-020). Adopted on 18 October 2005. Available at: http://efsa.europa.eu./science/sc_committee/sc_opinions1201/sc_op_ej282_gentox_en3.pdf.
-
European Food Safety Authority, 2005. Opinion of the Scientific Committee on a request from EFSA related to a harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. (Request No EFSA-Q-2004-020). Adopted on 18 October 2005. Available at: http://efsa.europa.eu./science/sc_committee/sc_opinions1201/sc_op_ej282_gentox_en3.pdf.
-
-
-
-
11
-
-
48649097213
-
-
European Food Safety Authority (EFSA), 2006. EFA Meeting Summary Report. EFSA/WHO International Conference with Support of ILSI Europe on Risk Assessment of Compounds that are both Genotoxic and Carcinogenic, European Food Safety Authority, Parma, Italy.
-
European Food Safety Authority (EFSA), 2006. EFA Meeting Summary Report. EFSA/WHO International Conference with Support of ILSI Europe on Risk Assessment of Compounds that are both Genotoxic and Carcinogenic, European Food Safety Authority, Parma, Italy.
-
-
-
-
12
-
-
0029008910
-
Effects of low doses of N-nitrosomorpholine on the development of early states of hepatocarcinogenesis
-
Enzmann H., Zerban H., Kopp-Schneider A., Löser A., and Bannasch P. Effects of low doses of N-nitrosomorpholine on the development of early states of hepatocarcinogenesis. Carcinogenesis 16 (1995) 1418-1513
-
(1995)
Carcinogenesis
, vol.16
, pp. 1418-1513
-
-
Enzmann, H.1
Zerban, H.2
Kopp-Schneider, A.3
Löser, A.4
Bannasch, P.5
-
13
-
-
0018909042
-
Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously
-
Farmer J.H., Kodell R.L., Greenman D.L., and Shaw G.W. Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously. J. Environ. Pathol. Toxicol. 3 (1980) 55-68
-
(1980)
J. Environ. Pathol. Toxicol.
, vol.3
, pp. 55-68
-
-
Farmer, J.H.1
Kodell, R.L.2
Greenman, D.L.3
Shaw, G.W.4
-
14
-
-
0032805849
-
Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment
-
Fukushima S. Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment. Cancer Lett. 143 (1999) 157-159
-
(1999)
Cancer Lett.
, vol.143
, pp. 157-159
-
-
Fukushima, S.1
-
15
-
-
0036808143
-
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidaz[4,5f]quinoxaline or N-nitrosodiethylamine
-
Fukushima S., Wanibuchi H., Morimura K., Wei M., Nakae D., Konishi Y., Tsuda H., Uehara N., Imaida K., Shirai T., Tatematsu M., Tsukamoto T., Hirose M., Furukawa F., Wakabayashi K., and Totsuka Y. Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidaz[4,5f]quinoxaline or N-nitrosodiethylamine. Jpn. J. Cancer Res. 93 (2002) 1076-1082
-
(2002)
Jpn. J. Cancer Res.
, vol.93
, pp. 1076-1082
-
-
Fukushima, S.1
Wanibuchi, H.2
Morimura, K.3
Wei, M.4
Nakae, D.5
Konishi, Y.6
Tsuda, H.7
Uehara, N.8
Imaida, K.9
Shirai, T.10
Tatematsu, M.11
Tsukamoto, T.12
Hirose, M.13
Furukawa, F.14
Wakabayashi, K.15
Totsuka, Y.16
-
16
-
-
27744450279
-
Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens
-
Fukushima S., Kinoshita A., Puatanachokchai R., Kushida M., Wanibuchi H., and Morimura K. Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. Carcinogenesis 26 (2005) 1835-1845
-
(2005)
Carcinogenesis
, vol.26
, pp. 1835-1845
-
-
Fukushima, S.1
Kinoshita, A.2
Puatanachokchai, R.3
Kushida, M.4
Wanibuchi, H.5
Morimura, K.6
-
17
-
-
0021667179
-
A carcinogenic potency database of the standardized results of animal bioassays
-
Gold L.S., Sawyer C.B., Magaw R., Backman G.M., de Veciana M., Levinson R., Hooper N.K., Havender W.R., Bernstein L., Peto R., Pike M.C., and Ames B.N. A carcinogenic potency database of the standardized results of animal bioassays. Environ. Health Perspect. 58 (1984) 9-319
-
(1984)
Environ. Health Perspect.
, vol.58
, pp. 9-319
-
-
Gold, L.S.1
Sawyer, C.B.2
Magaw, R.3
Backman, G.M.4
de Veciana, M.5
Levinson, R.6
Hooper, N.K.7
Havender, W.R.8
Bernstein, L.9
Peto, R.10
Pike, M.C.11
Ames, B.N.12
-
19
-
-
0019870862
-
Existence of a practical threshold dose for the haptocarcinogen 3′-methyl-4-(dimethylamino)azobenzene in rat liver
-
Hino O., and Kitagawa T. Existence of a practical threshold dose for the haptocarcinogen 3′-methyl-4-(dimethylamino)azobenzene in rat liver. Gann 72 (1981) 637-638
-
(1981)
Gann
, vol.72
, pp. 637-638
-
-
Hino, O.1
Kitagawa, T.2
-
20
-
-
48649083378
-
-
International Agency for Research on Cancer, 1996. IARC monographs on the evaluation of carcinogenic risks to humans: some pharmaceutical drugs, 'Tamoxifen', IARC, Lyon, vol. 66, pp. 253-365.
-
International Agency for Research on Cancer, 1996. IARC monographs on the evaluation of carcinogenic risks to humans: some pharmaceutical drugs, 'Tamoxifen', IARC, Lyon, vol. 66, pp. 253-365.
-
-
-
-
21
-
-
48649094122
-
-
International Agency for Research on Cancer, 2003. Predictive value of rodent forestomach and gastric neuroendocrine tumours in evaluating carcinogenic risks to humans. 'Summary Report', IARC, Lyon, Technical publication 39, pp. 7-14.
-
International Agency for Research on Cancer, 2003. Predictive value of rodent forestomach and gastric neuroendocrine tumours in evaluating carcinogenic risks to humans. 'Summary Report', IARC, Lyon, Technical publication 39, pp. 7-14.
-
-
-
-
22
-
-
0029780851
-
-
International Expert Panel on Carcinogen Risk Assessment, 1996. The use of mechanistic data in the risk assessments of ten chemicals: an introduction to the chemical-specific reviews. Pharmacol. Ther. 71 (Special Issue):1-5.
-
International Expert Panel on Carcinogen Risk Assessment, 1996. The use of mechanistic data in the risk assessments of ten chemicals: an introduction to the chemical-specific reviews. Pharmacol. Ther. 71 (Special Issue):1-5.
-
-
-
-
23
-
-
24644476629
-
-
Jeffrey, A.M. and Williams, G.M., 2005. Risk assessment of DNA-reactive carcinogens in food. Proceedings 10th International Congress of Toxicology. Toxicology and Applied Pharmacology, 207; s628-s635.
-
Jeffrey, A.M. and Williams, G.M., 2005. Risk assessment of DNA-reactive carcinogens in food. Proceedings 10th International Congress of Toxicology. Toxicology and Applied Pharmacology, 207; s628-s635.
-
-
-
-
24
-
-
48649104176
-
-
Joint FAO/WHO Expert Committee on Food Additives (2005). JECFA Sixty-fourth meting, Rome, 8-17 February 2005. Summary and Conclusions. FAO/WHO. Available at ftp://ftp.fao.org/es/en/jecfa/jecfa64_summary.pdf.
-
Joint FAO/WHO Expert Committee on Food Additives (2005). JECFA Sixty-fourth meting, Rome, 8-17 February 2005. Summary and Conclusions. FAO/WHO. Available at ftp://ftp.fao.org/es/en/jecfa/jecfa64_summary.pdf.
-
-
-
-
25
-
-
0033960141
-
Concepts of threshold in mutagenesis and carcinogenesis
-
Kirsch-Volders M., Aardema M., and Elhajouji A. Concepts of threshold in mutagenesis and carcinogenesis. Mutat. Res. 464 (2000) 3-11
-
(2000)
Mutat. Res.
, vol.464
, pp. 3-11
-
-
Kirsch-Volders, M.1
Aardema, M.2
Elhajouji, A.3
-
27
-
-
0037186896
-
Threshold of toxicological concern (TTC) in food safety assessment
-
Kroes R., and Kozianowski G. Threshold of toxicological concern (TTC) in food safety assessment. Toxicol. Lett. 127 (2002) 43-46
-
(2002)
Toxicol. Lett.
, vol.127
, pp. 43-46
-
-
Kroes, R.1
Kozianowski, G.2
-
28
-
-
0015362694
-
Early appearance of serum alpha-fetoprotein during hepatocarcinogenesis as a function of age of rats and extent of treatment with 3′-methyl-4-dimethylaminoazobenzene
-
Kroes R., Williams G.M., and Weisburger J.H. Early appearance of serum alpha-fetoprotein during hepatocarcinogenesis as a function of age of rats and extent of treatment with 3′-methyl-4-dimethylaminoazobenzene. Cancer Res. 32 (1972) 1526-1532
-
(1972)
Cancer Res.
, vol.32
, pp. 1526-1532
-
-
Kroes, R.1
Williams, G.M.2
Weisburger, J.H.3
-
29
-
-
0015701279
-
On the precocious induction of alpha-foetoprotein by several hepatocarcinogens, including aflatoxin B1 in rats
-
Doll R., and Vodopija I. (Eds), International Agency for Research on Cancer, Lyon
-
Kroes R., Williams G.M., and Weisburger J.H. On the precocious induction of alpha-foetoprotein by several hepatocarcinogens, including aflatoxin B1 in rats. In: Doll R., and Vodopija I. (Eds). Host Environment Interactions in the Etiology of Cancer in Man. IARC Scientific Publication, No. 7 (1973), International Agency for Research on Cancer, Lyon 307-309
-
(1973)
Host Environment Interactions in the Etiology of Cancer in Man. IARC Scientific Publication, No. 7
, pp. 307-309
-
-
Kroes, R.1
Williams, G.M.2
Weisburger, J.H.3
-
30
-
-
0034010667
-
Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing
-
Kroes R., Galli C., Munro I., Schliter B., Tran L.-A., Walker R., and Würtzen G. Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing. Food Chem. Toxicol. 38 (2000) 255-312
-
(2000)
Food Chem. Toxicol.
, vol.38
, pp. 255-312
-
-
Kroes, R.1
Galli, C.2
Munro, I.3
Schliter, B.4
Tran, L.-A.5
Walker, R.6
Würtzen, G.7
-
32
-
-
10744227159
-
Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet
-
Kroes R., Renwick A.G., Cheeseman M., Kleiner J., Mangelsdorf I., Piersma A., Schilter B., Schlatter J., van Schothorst F., Vos J.G., and Würtzen G. Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet. Food Chem. Toxicol. 42 (2004) 65-83
-
(2004)
Food Chem. Toxicol.
, vol.42
, pp. 65-83
-
-
Kroes, R.1
Renwick, A.G.2
Cheeseman, M.3
Kleiner, J.4
Mangelsdorf, I.5
Piersma, A.6
Schilter, B.7
Schlatter, J.8
van Schothorst, F.9
Vos, J.G.10
Würtzen, G.11
-
33
-
-
0023884624
-
Dose-response study with N-nitrosomorpholine in drinking water of F-344 rats
-
Lijinsky W., Kovatch R.M., Riggs C.W., and Walters P.T. Dose-response study with N-nitrosomorpholine in drinking water of F-344 rats. Cancer Res. 48 (1988) 2089-2095
-
(1988)
Cancer Res.
, vol.48
, pp. 2089-2095
-
-
Lijinsky, W.1
Kovatch, R.M.2
Riggs, C.W.3
Walters, P.T.4
-
34
-
-
3242889428
-
Exploration of low-dose estrogen effects: identification of No Observed Transcriptional Effect Level (NOTEL)
-
Lobenhofer E.K., Cui X., Bennett L., Cable P.L., Merrick B.A., Churchill G.A., and Afshari C.A. Exploration of low-dose estrogen effects: identification of No Observed Transcriptional Effect Level (NOTEL). Toxicol. Pathol. 32 (2004) 482-492
-
(2004)
Toxicol. Pathol.
, vol.32
, pp. 482-492
-
-
Lobenhofer, E.K.1
Cui, X.2
Bennett, L.3
Cable, P.L.4
Merrick, B.A.5
Churchill, G.A.6
Afshari, C.A.7
-
35
-
-
0025773554
-
Mutator phenotype may be required for multistage carcinogenesis
-
Loeb L.A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51 (1991) 3075-3079
-
(1991)
Cancer Res.
, vol.51
, pp. 3075-3079
-
-
Loeb, L.A.1
-
36
-
-
0024784488
-
Dose-response carcinogenicity in rats on low-dose levels of N-ethyl-N-nitosourethane
-
Maekawa A., Onodera H., Matsushima Y., Nagaoka T., Todate A., Shibutani M., Kodama Y., and Hayashi Y. Dose-response carcinogenicity in rats on low-dose levels of N-ethyl-N-nitosourethane. Jpn. J. Cancer Res. 80 (1989) 632-636
-
(1989)
Jpn. J. Cancer Res.
, vol.80
, pp. 632-636
-
-
Maekawa, A.1
Onodera, H.2
Matsushima, Y.3
Nagaoka, T.4
Todate, A.5
Shibutani, M.6
Kodama, Y.7
Hayashi, Y.8
-
37
-
-
34948828480
-
Aspartame: a safety evaluation based on current use levels, regulations, toxicological and epidemiological studies
-
Magnuson B.A., Burdock G.A., Doull J., Kroes R.M., Marsh G.M., Pariza M.W., Spencer P.S., Waddell W.J., Walker R., and Williams G.M. Aspartame: a safety evaluation based on current use levels, regulations, toxicological and epidemiological studies. Crit. Rev. Toxicol. 37 (2007) 627-727
-
(2007)
Crit. Rev. Toxicol.
, vol.37
, pp. 627-727
-
-
Magnuson, B.A.1
Burdock, G.A.2
Doull, J.3
Kroes, R.M.4
Marsh, G.M.5
Pariza, M.W.6
Spencer, P.S.7
Waddell, W.J.8
Walker, R.9
Williams, G.M.10
-
38
-
-
10744221981
-
Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry
-
Martin E.A., Brown K., Gaskell M., Al-Azzawi F., Garner R.C., Boocock D.J., Mattock E., Pring D.W., Dingley K., Turteltaub K.W., Smith L.L., and White I.N.H. Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry. Cancer Res. 63 (2003) 8461-8465
-
(2003)
Cancer Res.
, vol.63
, pp. 8461-8465
-
-
Martin, E.A.1
Brown, K.2
Gaskell, M.3
Al-Azzawi, F.4
Garner, R.C.5
Boocock, D.J.6
Mattock, E.7
Pring, D.W.8
Dingley, K.9
Turteltaub, K.W.10
Smith, L.L.11
White, I.N.H.12
-
39
-
-
9144238300
-
A framework for human relevance analysis of information on carcinogenic modes of action
-
Meek M.E., Bucher J.R., Cohen S.M., DeMarco V., Hill R.N., Lehman-McKeeman L.D., Longfellow D.G., Pastorr T., Seed J., and Patton D.E. A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 33 (2003) 591-654
-
(2003)
Crit. Rev. Toxicol.
, vol.33
, pp. 591-654
-
-
Meek, M.E.1
Bucher, J.R.2
Cohen, S.M.3
DeMarco, V.4
Hill, R.N.5
Lehman-McKeeman, L.D.6
Longfellow, D.G.7
Pastorr, T.8
Seed, J.9
Patton, D.E.10
-
40
-
-
0018577895
-
Milestones in chemical carcinogenesis
-
Miller E.C., and Miller J.A. Milestones in chemical carcinogenesis. Sem. Oncol. 6 (1979) 445-460
-
(1979)
Sem. Oncol.
, vol.6
, pp. 445-460
-
-
Miller, E.C.1
Miller, J.A.2
-
41
-
-
0030250802
-
Correlation of structural class with no-observed -effect levels: a proposal for establishing a threshold of concern
-
Munro I.C., Ford R.A., Kennepohl E., and Sprenger J.G. Correlation of structural class with no-observed -effect levels: a proposal for establishing a threshold of concern. Food Chem. Toxicol. 34 (1996) 829-867
-
(1996)
Food Chem. Toxicol.
, vol.34
, pp. 829-867
-
-
Munro, I.C.1
Ford, R.A.2
Kennepohl, E.3
Sprenger, J.G.4
-
43
-
-
48649083119
-
-
National Research Council, 1994. Science and Judgement in Risk Assessment, Washington, D.C.: National Academy Press.
-
National Research Council, 1994. Science and Judgement in Risk Assessment, Washington, D.C.: National Academy Press.
-
-
-
-
44
-
-
48649101961
-
-
National Research Council, 2006. Health risks from dioxin and related compounds, Evaluation of the EPA Reassessment, Washington DC.: National Academy Press.
-
National Research Council, 2006. Health risks from dioxin and related compounds, Evaluation of the EPA Reassessment, Washington DC.: National Academy Press.
-
-
-
-
45
-
-
0029857622
-
Toxicological significance of DNA adducts. Report of an expert panel
-
Nestmann E.R., Bryant D.W., Carr C.J., Fennell T.T., Gallagher J.E., Gorelick N.J., Swenberg J.A., and Williams G.M. Toxicological significance of DNA adducts. Report of an expert panel. Regul. Toxicol. Pharma. 24 (1996) 9-18
-
(1996)
Regul. Toxicol. Pharma.
, vol.24
, pp. 9-18
-
-
Nestmann, E.R.1
Bryant, D.W.2
Carr, C.J.3
Fennell, T.T.4
Gallagher, J.E.5
Gorelick, N.J.6
Swenberg, J.A.7
Williams, G.M.8
-
46
-
-
0026347782
-
Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine; a detailed dose-response study
-
Peto R., Gray R., Brantom P., and Grasso P. Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine; a detailed dose-response study. Cancer Res. 51 (1991) 6415-6451
-
(1991)
Cancer Res.
, vol.51
, pp. 6415-6451
-
-
Peto, R.1
Gray, R.2
Brantom, P.3
Grasso, P.4
-
47
-
-
0026353166
-
Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine
-
Peto R., Gray R., Brantom P., and Grasso P. Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine. Cancer Res. 51 (1991) 6452-6469
-
(1991)
Cancer Res.
, vol.51
, pp. 6452-6469
-
-
Peto, R.1
Gray, R.2
Brantom, P.3
Grasso, P.4
-
48
-
-
2342439267
-
On the application of data on mode of action to carcinogenic risk assessment
-
Rice J.M. On the application of data on mode of action to carcinogenic risk assessment. Toxicol. Sci. 78 (2004) 175-177
-
(2004)
Toxicol. Sci.
, vol.78
, pp. 175-177
-
-
Rice, J.M.1
-
49
-
-
0034767406
-
Scientific analysis of the proposed uses of the T25 dose descriptor in chemical carcinogen regulation
-
Roberts R.A., Crump K.S., Lutz W.K., Wiegand H.-J., Williams G.M., Harrison P.T.C., and Purchase I.F.H. Scientific analysis of the proposed uses of the T25 dose descriptor in chemical carcinogen regulation. Arch. Toxicol. 75 (2001) 507-512
-
(2001)
Arch. Toxicol.
, vol.75
, pp. 507-512
-
-
Roberts, R.A.1
Crump, K.S.2
Lutz, W.K.3
Wiegand, H.-J.4
Williams, G.M.5
Harrison, P.T.C.6
Purchase, I.F.H.7
-
50
-
-
0030776986
-
Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver
-
Root M., Lanage T., and Campbell T.C. Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver. Chem. Biol. Interact. 106 (1997) 213-227
-
(1997)
Chem. Biol. Interact.
, vol.106
, pp. 213-227
-
-
Root, M.1
Lanage, T.2
Campbell, T.C.3
-
51
-
-
0002296799
-
-
De minimis and the threshold of regulation. Felix C.W. (Ed), Chelsea/Lewis, Michigan
-
Rulis A.M. De minimis and the threshold of regulation. In: Felix C.W. (Ed). Food Protection Technology (1986), Chelsea/Lewis, Michigan 29-37
-
(1986)
Food Protection Technology
, pp. 29-37
-
-
Rulis, A.M.1
-
52
-
-
24744458369
-
-
Sander, M., Cadet, J., Casciano, D.A., Galloway, S.M., Marnett, L.J., Novak, R.F., Pettit, S.D., Preston, R.J., Skare, J., Williams, G.M., Van Houten, B. Gollapudi, B.B., 2005. Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004. Toxicol. Appl. Pharmacol. 208:1-20.
-
Sander, M., Cadet, J., Casciano, D.A., Galloway, S.M., Marnett, L.J., Novak, R.F., Pettit, S.D., Preston, R.J., Skare, J., Williams, G.M., Van Houten, B. Gollapudi, B.B., 2005. Proceedings of a workshop on DNA adducts: biological significance and applications to risk assessment Washington, DC, April 13-14, 2004. Toxicol. Appl. Pharmacol. 208:1-20.
-
-
-
-
53
-
-
0034950342
-
A simple method for quantitative risk assessment of non-threshold carcinogens based on the dose descriptor T25
-
Sanner T., Dybing E., Willems M.I., and Krosese E.D. A simple method for quantitative risk assessment of non-threshold carcinogens based on the dose descriptor T25. Pharmalcol. Toxicol. 88 (2001) 331-341
-
(2001)
Pharmalcol. Toxicol.
, vol.88
, pp. 331-341
-
-
Sanner, T.1
Dybing, E.2
Willems, M.I.3
Krosese, E.D.4
-
54
-
-
0037258612
-
Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis; evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work
-
Tsuda H., Fukushima S., Wanibuchi H., Morimura K., Nakae D., Imaida K., Tatematsu M., Hirose M., Wakabayashi K., and Moore M.A. Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis; evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work. Toxicol. Pathol. 31 (2003) 80-86
-
(2003)
Toxicol. Pathol.
, vol.31
, pp. 80-86
-
-
Tsuda, H.1
Fukushima, S.2
Wanibuchi, H.3
Morimura, K.4
Nakae, D.5
Imaida, K.6
Tatematsu, M.7
Hirose, M.8
Wakabayashi, K.9
Moore, M.A.10
-
55
-
-
48649094276
-
-
2u-globulin association with chemically induced renal toxicity and neoplasia in the male rat. Prepared for the Risk Assessment Forum of the US EPA, Washington DC. EPA/625/3-91/019F.
-
2u-globulin association with chemically induced renal toxicity and neoplasia in the male rat. Prepared for the Risk Assessment Forum of the US EPA, Washington DC. EPA/625/3-91/019F.
-
-
-
-
56
-
-
48649102128
-
-
U.S. Environmental Protection Agency (EPA), 2005. Guidelines for carcinogen risk assessment. Risk Assessment Forum, Washington, DC. EPA/630/P-03001F. Available from: http://www.epa.gov/ttn/atw/cancer_guidelines_final_3-25-05.pdf.
-
U.S. Environmental Protection Agency (EPA), 2005. Guidelines for carcinogen risk assessment. Risk Assessment Forum, Washington, DC. EPA/630/P-03001F. Available from: http://www.epa.gov/ttn/atw/cancer_guidelines_final_3-25-05.pdf.
-
-
-
-
57
-
-
0027401607
-
The multistep nature of cancer
-
Vogelstein B., and Kinzler K.W. The multistep nature of cancer. Trends Genet. 9 (1993) 138-141
-
(1993)
Trends Genet.
, vol.9
, pp. 138-141
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
58
-
-
33646540449
-
Concordance of thresholds for carcinogenicity of nitrosodiethylamine
-
Waddell W.J., Fukushima S., and Williams G.M. Concordance of thresholds for carcinogenicity of nitrosodiethylamine. Arch. Toxicol. 80 (2006) 305-309
-
(2006)
Arch. Toxicol.
, vol.80
, pp. 305-309
-
-
Waddell, W.J.1
Fukushima, S.2
Williams, G.M.3
-
59
-
-
0019792758
-
Carcinogen testing: current problems and new approaches
-
Weisburger J.H., and Williams G.M. Carcinogen testing: current problems and new approaches. Science 214 (1981) 401-407
-
(1981)
Science
, vol.214
, pp. 401-407
-
-
Weisburger, J.H.1
Williams, G.M.2
-
60
-
-
0002067439
-
Causes of cancer
-
Murphy G.P., Lawrence Jr. W., and Lenhard Jr. R.E. (Eds), American Cancer Society, Inc, Atlanta, GA
-
Weisburger J.H., and Williams G.M. Causes of cancer. In: Murphy G.P., Lawrence Jr. W., and Lenhard Jr. R.E. (Eds). American Cancer Society Textbook of Clinical Oncology (1995), American Cancer Society, Inc, Atlanta, GA 10-39
-
(1995)
American Cancer Society Textbook of Clinical Oncology
, pp. 10-39
-
-
Weisburger, J.H.1
Williams, G.M.2
-
61
-
-
0029769309
-
Butylated hydroxyanisole mechanistic data and risk assessment: Conditional species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion
-
Whysner J., and Williams G.M. Butylated hydroxyanisole mechanistic data and risk assessment: Conditional species-specific cytotoxicity, enhanced cell proliferation, and tumor promotion. Pharmacol. Ther. 71 (1996) 137-152
-
(1996)
Pharmacol. Ther.
, vol.71
, pp. 137-152
-
-
Whysner, J.1
Williams, G.M.2
-
62
-
-
0029762765
-
Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion
-
Whysner J., Ross P.M., and Williams G.M. Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion. Pharm. Ther. 71 (1996) 153-192
-
(1996)
Pharm. Ther.
, vol.71
, pp. 153-192
-
-
Whysner, J.1
Ross, P.M.2
Williams, G.M.3
-
63
-
-
0019226768
-
Classification of genotoxic and epigenetic hepatocarcinogens using liver culture assays
-
Williams G.M. Classification of genotoxic and epigenetic hepatocarcinogens using liver culture assays. Annals New York Academy of Sciences 349 (1980) 273-282
-
(1980)
Annals New York Academy of Sciences
, vol.349
, pp. 273-282
-
-
Williams, G.M.1
-
64
-
-
0000273376
-
Epigenetic mechanisms of liver tumor promotion
-
Stevenson D.E., McClain R.M., Popp J.A., Slaga T.J., Ward J.M., and Pitot H.C. (Eds), Alan R. Liss, Inc, New York
-
Williams G.M. Epigenetic mechanisms of liver tumor promotion. In: Stevenson D.E., McClain R.M., Popp J.A., Slaga T.J., Ward J.M., and Pitot H.C. (Eds). Mouse Liver Carcinogenesis (1990), Alan R. Liss, Inc, New York 121-145
-
(1990)
Mouse Liver Carcinogenesis
, pp. 121-145
-
-
Williams, G.M.1
-
65
-
-
0025168709
-
-
Williams, G.M., 1990b. Screening procedures for evaluating the potential carcinogenicity of food packaging chemicals. Regul. Toxicol. Pharmacol., 12:30-40, 1990.
-
Williams, G.M., 1990b. Screening procedures for evaluating the potential carcinogenicity of food packaging chemicals. Regul. Toxicol. Pharmacol., 12:30-40, 1990.
-
-
-
-
66
-
-
0027048538
-
DNA reactive and epigenetic carcinogens
-
Williams G.M. DNA reactive and epigenetic carcinogens. Exp. Toxicol. Pathol. 44 (1992) 457-464
-
(1992)
Exp. Toxicol. Pathol.
, vol.44
, pp. 457-464
-
-
Williams, G.M.1
-
67
-
-
0032861974
-
Mechanistic considerations in cancer risk assessment
-
Williams G.M. Mechanistic considerations in cancer risk assessment. Inhal. Toxicol. 11 (1999) 549-554
-
(1999)
Inhal. Toxicol.
, vol.11
, pp. 549-554
-
-
Williams, G.M.1
-
68
-
-
0035860642
-
Mechanisms of chemical carcinogenesis and application to human cancer risk assessment
-
Williams G.M. Mechanisms of chemical carcinogenesis and application to human cancer risk assessment. Toxicology 166 (2001) 3-10
-
(2001)
Toxicology
, vol.166
, pp. 3-10
-
-
Williams, G.M.1
-
69
-
-
0036186764
-
Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity
-
Williams G.M., and Iatropoulos M.J. Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity. Toxicol. Pathol. 30 (2002) 41-53
-
(2002)
Toxicol. Pathol.
, vol.30
, pp. 41-53
-
-
Williams, G.M.1
Iatropoulos, M.J.2
-
70
-
-
0029455988
-
Mechansitic considerations in risk assessment for epigenetic tumor-promoting arcinogens
-
McClain R.M., Slaga T.J., LeBoeuf R., and Pitot H. (Eds), John Wiley and Sons, Inc., New York
-
Williams G.M., and Whysner J. Mechansitic considerations in risk assessment for epigenetic tumor-promoting arcinogens. In: McClain R.M., Slaga T.J., LeBoeuf R., and Pitot H. (Eds). Growth Factors and Tumor Promotion: Implications for Risk Assessment (1995), John Wiley and Sons, Inc., New York 369-383
-
(1995)
Growth Factors and Tumor Promotion: Implications for Risk Assessment
, pp. 369-383
-
-
Williams, G.M.1
Whysner, J.2
-
71
-
-
0029873622
-
Epigenetic carcinogens: evaluation and risk assessment
-
Williams G.M., and Whysner J. Epigenetic carcinogens: evaluation and risk assessment. Exp. Toxicol. Pathol. 48 (1996) 189-195
-
(1996)
Exp. Toxicol. Pathol.
, vol.48
, pp. 189-195
-
-
Williams, G.M.1
Whysner, J.2
-
72
-
-
0015820230
-
Cytochemical and ultrastructural alterations associated with confluent growth in cell cultures of epithelial-like cells from rat liver
-
Williams G.M., Stromberg K., and Kroes R. Cytochemical and ultrastructural alterations associated with confluent growth in cell cultures of epithelial-like cells from rat liver. Lab. Invest. 29 (1973) 293-303
-
(1973)
Lab. Invest.
, vol.29
, pp. 293-303
-
-
Williams, G.M.1
Stromberg, K.2
Kroes, R.3
-
73
-
-
0000931687
-
A comparison of the animal and human carcinogenicity of several environmental, occupation and therapeutic chemicals
-
Flamm G., and Lorentzen R. (Eds), Princeton Scientific Publishers, Princeton, NJ
-
Williams G.M., Reiss B., and Weisburger J.H. A comparison of the animal and human carcinogenicity of several environmental, occupation and therapeutic chemicals. In: Flamm G., and Lorentzen R. (Eds). Mechanisms and Toxicity of Chemical Carcinogens and Mutagens. Advances in Environmental Toxicology, Vol IX (1985), Princeton Scientific Publishers, Princeton, NJ 207-248
-
(1985)
Mechanisms and Toxicity of Chemical Carcinogens and Mutagens. Advances in Environmental Toxicology, Vol IX
, pp. 207-248
-
-
Williams, G.M.1
Reiss, B.2
Weisburger, J.H.3
-
74
-
-
0029874523
-
Risk assessment of carcinogens in food with special consideration of non-genotoxic carcinogens: scientific arguments for use of risk assessment and for changing the Delaney Clause specifically
-
Williams G.M., Karbe E., Fenner-Crisp P., Iatropoulos M.J., and Weisburger J.H. Risk assessment of carcinogens in food with special consideration of non-genotoxic carcinogens: scientific arguments for use of risk assessment and for changing the Delaney Clause specifically. Exp. Toxicol. Pathol. 48 (1996) 119-125
-
(1996)
Exp. Toxicol. Pathol.
, vol.48
, pp. 119-125
-
-
Williams, G.M.1
Karbe, E.2
Fenner-Crisp, P.3
Iatropoulos, M.J.4
Weisburger, J.H.5
-
75
-
-
0034042794
-
Mechanistic basis for non-linearity and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine
-
Williams G.M., Iatropoulos M.J., and Jeffrey A.M. Mechanistic basis for non-linearity and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine. Toxicol. Pathol. 28 (2000) 388-395
-
(2000)
Toxicol. Pathol.
, vol.28
, pp. 388-395
-
-
Williams, G.M.1
Iatropoulos, M.J.2
Jeffrey, A.M.3
-
76
-
-
0034070443
-
Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans
-
Williams G.M., Kroes R., and Munro I.C. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Pharmacol. Toxicol. 31 (2000) 117-165
-
(2000)
Regul. Pharmacol. Toxicol.
, vol.31
, pp. 117-165
-
-
Williams, G.M.1
Kroes, R.2
Munro, I.C.3
-
78
-
-
58749103576
-
-
Wallace Hayes A. (Ed), Taylor and Francis, Philadelphia, PA
-
Williams G.M., Iatropoulos M.J., and Enzmann H.G. In: Wallace Hayes A. (Ed). Principles of testing for carcinogenic activity Principles and Methods of Toxicology (2008), Taylor and Francis, Philadelphia, PA 1271-1322
-
(2008)
Principles of testing for carcinogenic activity Principles and Methods of Toxicology
, pp. 1271-1322
-
-
Williams, G.M.1
Iatropoulos, M.J.2
Enzmann, H.G.3
-
79
-
-
48649097060
-
-
World Health Organization (1999) Principles for the assessment of risk to human health from exposure to chemicals. Environmental Health Criteria No. 210, WHO, Geneva.
-
World Health Organization (1999) Principles for the assessment of risk to human health from exposure to chemicals. Environmental Health Criteria No. 210, WHO, Geneva.
-
-
-
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