hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII

Mutagenesis

Volumn 21, Issue 3, 2006, Pages 185-190

  Smith, Catherine C ^a   O'Donovan, Michael R ^a   Martin, Elizabeth A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; 8 HYDROXYGUANINE DNA GLYCOSYLASE; DIMETHYL SULFOXIDE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; ENDONUCLEASE III; ETHYLNITROSOUREA; GUANINE DERIVATIVE; MESYLIC ACID METHYL ESTER; POTASSIUM BROMATE; SOLVENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA ALKYLATION; DNA DAMAGE; DNA STRAND BREAKAGE; GAMMA IRRADIATION; GENOTOXICITY; INTERMETHOD COMPARISON; LYMPHOMA CELL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIATION RESPONSE; SENSITIVITY AND SPECIFICITY;

ANIMALS; BROMATES; COMET ASSAY; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DIMETHYL SULFOXIDE; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR ENZYMES; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ESCHERICHIA COLI PROTEINS; ETHYLNITROSOUREA; GAMMA RAYS; GUANINE; HUMANS; LEUKEMIA L5178; METHYL METHANESULFONATE; MICE; OXIDATION-REDUCTION; SENSITIVITY AND SPECIFICITY;

EID: 33745107265     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gel019     Document Type: Article

References (19)

1. Tice,R.R., Agurell,E., Anderson,D., Burlinson,B., Hartmann,A., Kobayashi,H., Miyamae,Y., Rojas,A., Rye,J.-C. and Sasaki,Y.F. (2000) Single cell Gel/Comet assay: guidelines for in vivo and in vitro genetic toxicology testing. Environ. Mol. Mutagen., 35, 206-221.
2. Karakaya,A., Jaruga,P., Bohr,V.A., Grollman,A.P. and Dizdaroglu,M. (1997) Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein. Nucleic Acids Res., 25, 474-479.
3. Dušinská,M. and Collins,A. (1996) Detection of oxidised purines and UV-induced photoproducts in DNA of single cells, by inclusion of lesion-specific enzymes in the comet assay. Altern. Lab Anim. 24, 405-411.
4. Dizdaroglu,M. (2005) Base-excision repair of oxidative DNA damage by DNA glycosylases. Mutat. Res., 591, 45-59.
5. Collins,A.R., Duthie,S.J. and Dobson,V.L. (1993) Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis, 14, 1733-1735.
6. Gedik,C.M. and Collins,A. and ESCODD (European Standards Committee on Oxidative DNA Damage). (2005) Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. FASEB J., 19, 82-84.
7. Speit,G., Schutz,P., Bonzheim,I., Trenz,K. and Hoffmann,H. (2004) Sensitivity of the FPG protein towards alkylation damage in the comet assay. Toxicol. Lett., 146, 151-158.
8. Rosenquist,T.A., Zharkov,D.O. and Grollman,A.P. (1997) Cloning and characterization of mammalian 8-oxoguanine DNA glycosylase. Proc. Natl Acad. Sci. USA, 94, 7429-7434.
9. Radicella,J.P., Dherin,C., Desmaze,C., Fox,M.S. and Boiteux,S.F. (1997) Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 94, 8010-8015.
10. Collins,A.R. (2000) Measurement of oxidant DNA damage using the comet assay. In: Lunec,J. and Griffiths,H.R. (eds), Measuring In Vivo Oxidative Damage: A Practical Approach. John Wiley Chichester, UK, pp. 83-94.
11. Cadet,J., Douki,T., Gasparutto,D. and Ravanat,J.-L. (2003) Oxidative damage to DNA: formation, measurement and biochemical features. Mutat. Res., 531, 5-23.
12. David,S.S. and Williams,S.D. (1998) Chemistry of glycosylases and endonucleases involved in base-excision repair. Chem. Rev., 98, 1221-1261.
13. Kasai,H., Nishimura,S., Kurokawa,Y. and Hayashi,Y. (1987) Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis, 8, 1959-1961.
14. Sai,K., Takagi,A., Umemura,T., Hasegawa,R. and Kurokawa,Y. (1991) Relation of 8-hydroxydeoxyguanosine formation in rat kidney to lipid peroxidation, glutathione level and relative organ weight after a single administration of potassium bromate. Jpn. J. Cancer Res., 82, 165-169.
15. Ballmaier,D. and Epe,B. (1995) Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cells. Carcinogenesis, 16, 335-342.
16. Ono,Y., Matsumoto,K., Furuta,T., Ohmoto,T., Akiyama,K. and Seki,S. (1995) Relationship between expression of a major apurinic/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines. J. Neurooncol., 25, 183-192.
17. Collins,A.R., Dusinska,M. and Horska,A. (2001) Detection of alkylation damage in human lymphocyte DNA with the comet assay. Acta Biochim. Pol., 48, 611-614.
18. Horvathovd,E., Slamenova,D., Hlincikova,L., Mandal,T.K., Gabelova,A. and Collins,A.R. (1998) The nature and origin of DNA single-strand breaks determined with the comet assay. Mutat. Res., 409, 163-171.
19. Beranek,D.T. (1990) Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res., 231, 11-30.