메뉴 건너뛰기




Volumn 18, Issue 11, 2017, Pages 1227-1242

Human brown adipose tissue as a target for obesity management; beyond cold-induced thermogenesis

Author keywords

Adaptive thermogenesis; brown adipose tissue; cold induced thermogenesis; diet induced thermogenesis

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADRENERGIC RECEPTOR STIMULATING AGENT; CAPSAICIN; GLUCOCORTICOID; THYROID HORMONE;

EID: 85023607732     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.12584     Document Type: Review
Times cited : (68)

References (145)
  • 1
    • 84901634469 scopus 로고    scopus 로고
    • Twelve-year weight change, waist circumference change and incident obesity: the Australian diabetes, obesity and lifestyle study
    • Tanamas SK, Shaw JE, Backholer K, Magliano DJ, Peeters A. Twelve-year weight change, waist circumference change and incident obesity: the Australian diabetes, obesity and lifestyle study. Obesity (Silver Spring) 2014; 22(6): 1538–1545.
    • (2014) Obesity (Silver Spring) , vol.22 , Issue.6 , pp. 1538-1545
    • Tanamas, S.K.1    Shaw, J.E.2    Backholer, K.3    Magliano, D.J.4    Peeters, A.5
  • 2
    • 84978112129 scopus 로고    scopus 로고
    • Diabetes mellitus statistics on prevalence and mortality: facts and fallacies
    • Zimmet P, Alberti KG, Magliano DJ, Bennett PH. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nat Rev Endocrinol 2016; 12(10): 616–622.
    • (2016) Nat Rev Endocrinol , vol.12 , Issue.10 , pp. 616-622
    • Zimmet, P.1    Alberti, K.G.2    Magliano, D.J.3    Bennett, P.H.4
  • 3
    • 69949162866 scopus 로고    scopus 로고
    • Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with ‘exercise mimetics’
    • Carey AL, Kingwell BA. Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with ‘exercise mimetics’. Diabetologia 2009; 52(10): 2015–2026.
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2015-2026
    • Carey, A.L.1    Kingwell, B.A.2
  • 4
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84(1): 277–359.
    • (2004) Physiol Rev , vol.84 , Issue.1 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 5
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess AM, Lehman S, Williams G et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360(15): 1509–1517.
    • (2009) N Engl J Med , vol.360 , Issue.15 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 6
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity
    • Saito M, Okamatsu-Ogura Y, Matsushita M et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009; 58(7): 1526–1531.
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1526-1531
    • Saito, M.1    Okamatsu-Ogura, Y.2    Matsushita, M.3
  • 8
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen KA, Lidell ME, Orava J et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360(15): 1518–1525.
    • (2009) N Engl J Med , vol.360 , Issue.15 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 9
    • 70349334680 scopus 로고    scopus 로고
    • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti MC, Crosta F, Vitali A et al. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 2009; 23(9): 3113–3120.
    • (2009) FASEB J , vol.23 , Issue.9 , pp. 3113-3120
    • Zingaretti, M.C.1    Crosta, F.2    Vitali, A.3
  • 10
    • 84936771989 scopus 로고    scopus 로고
    • Genetic and functional characterization of clonally derived adult human brown adipocytes
    • Shinoda K, Luijten IH, Hasegawa Y et al. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med 2015; 21(4): 389–394.
    • (2015) Nat Med , vol.21 , Issue.4 , pp. 389-394
    • Shinoda, K.1    Luijten, I.H.2    Hasegawa, Y.3
  • 11
    • 84936773588 scopus 로고    scopus 로고
    • Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes
    • Xue R, Lynes MD, Dreyfuss JM et al. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med 2015; 21(7): 760–768.
    • (2015) Nat Med , vol.21 , Issue.7 , pp. 760-768
    • Xue, R.1    Lynes, M.D.2    Dreyfuss, J.M.3
  • 13
    • 85012867080 scopus 로고    scopus 로고
    • Factors involved in white-to-brown adipose tissue conversion and in thermogenesis: a review
    • Montanari T, Poscic N, Colitti M. Factors involved in white-to-brown adipose tissue conversion and in thermogenesis: a review. Obes Rev 2017.
    • (2017) Obes Rev
    • Montanari, T.1    Poscic, N.2    Colitti, M.3
  • 14
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu J, Bostrom P, Sparks LM et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012; 150(2): 366–376.
    • (2012) Cell , vol.150 , Issue.2 , pp. 366-376
    • Wu, J.1    Bostrom, P.2    Sparks, L.M.3
  • 15
    • 84890234667 scopus 로고    scopus 로고
    • UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic
    • Shabalina IG, Petrovic N, de Jong JM et al. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Rep 2013; 5(5): 1196–1203.
    • (2013) Cell Rep , vol.5 , Issue.5 , pp. 1196-1203
    • Shabalina, I.G.1    Petrovic, N.2    de Jong, J.M.3
  • 18
    • 33745966038 scopus 로고    scopus 로고
    • Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
    • Atit R, Sgaier SK, Mohamed OA et al. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev Biol 2006; 296(1): 164–176.
    • (2006) Dev Biol , vol.296 , Issue.1 , pp. 164-176
    • Atit, R.1    Sgaier, S.K.2    Mohamed, O.A.3
  • 19
    • 34248372084 scopus 로고    scopus 로고
    • Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
    • Timmons JA, Wennmalm K, Larsson O et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A 2007; 104(11): 4401–4406.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.11 , pp. 4401-4406
    • Timmons, J.A.1    Wennmalm, K.2    Larsson, O.3
  • 20
    • 84943402947 scopus 로고    scopus 로고
    • Brown and beige fat: physiological roles beyond heat generation
    • Kajimura S, Spiegelman BM, Seale P. Brown and beige fat: physiological roles beyond heat generation. Cell Metab 2015; 22(4): 546–559.
    • (2015) Cell Metab , vol.22 , Issue.4 , pp. 546-559
    • Kajimura, S.1    Spiegelman, B.M.2    Seale, P.3
  • 21
    • 84878525220 scopus 로고    scopus 로고
    • Bi-directional interconversion of brite and white adipocytes
    • Rosenwald M, Perdikari A, Rulicke T, Wolfrum C. Bi-directional interconversion of brite and white adipocytes. Nat Cell Biol 2013; 15(6): 659–667.
    • (2013) Nat Cell Biol , vol.15 , Issue.6 , pp. 659-667
    • Rosenwald, M.1    Perdikari, A.2    Rulicke, T.3    Wolfrum, C.4
  • 22
    • 84887502374 scopus 로고    scopus 로고
    • Tracking adipogenesis during white adipose tissue development, expansion and regeneration
    • Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med 2013; 19(10): 1338–1344.
    • (2013) Nat Med , vol.19 , Issue.10 , pp. 1338-1344
    • Wang, Q.A.1    Tao, C.2    Gupta, R.K.3    Scherer, P.E.4
  • 23
    • 33847768085 scopus 로고    scopus 로고
    • Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
    • Almind K, Manieri M, Sivitz WI, Cinti S, Kahn CR. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A 2007; 104(7): 2366–2371.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.7 , pp. 2366-2371
    • Almind, K.1    Manieri, M.2    Sivitz, W.I.3    Cinti, S.4    Kahn, C.R.5
  • 24
    • 84874377962 scopus 로고    scopus 로고
    • The genetics of brown adipocyte induction in white fat depots
    • Kozak LP. The genetics of brown adipocyte induction in white fat depots. Front Endocrinol (Lausanne) 2011; 2: 64.
    • (2011) Front Endocrinol (Lausanne) , vol.2 , pp. 64
    • Kozak, L.P.1
  • 25
    • 84893586190 scopus 로고    scopus 로고
    • Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice
    • Okamatsu-Ogura Y, Fukano K, Tsubota A et al. Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. PLoS One 2013; 8(12) e84229.
    • (2013) PLoS One , vol.8 , Issue.12
    • Okamatsu-Ogura, Y.1    Fukano, K.2    Tsubota, A.3
  • 26
    • 84983749205 scopus 로고    scopus 로고
    • Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male mice
    • Labbe SM, Caron A, Chechi K et al. Metabolic activity of brown, “beige,” and white adipose tissues in response to chronic adrenergic stimulation in male mice. Am J Physiol Endocrinol Metab 2016; 311(1): E260–E268.
    • (2016) Am J Physiol Endocrinol Metab , vol.311 , Issue.1 , pp. E260-E268
    • Labbe, S.M.1    Caron, A.2    Chechi, K.3
  • 27
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 2009; 9(2): 203–209.
    • (2009) Cell Metab , vol.9 , Issue.2 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 28
    • 84859465056 scopus 로고    scopus 로고
    • In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding
    • Lee YH, Petkova AP, Mottillo EP, Granneman JG. In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding. Cell Metab 2012; 15(4): 480–491.
    • (2012) Cell Metab , vol.15 , Issue.4 , pp. 480-491
    • Lee, Y.H.1    Petkova, A.P.2    Mottillo, E.P.3    Granneman, J.G.4
  • 29
    • 0000452512 scopus 로고
    • Non-shivering thermogenesis and brown adipose tissue in the human new-born infant
    • Dawkins MJ, Scopes JW. Non-shivering thermogenesis and brown adipose tissue in the human new-born infant. Nature 1965; 206(980): 201–202.
    • (1965) Nature , vol.206 , Issue.980 , pp. 201-202
    • Dawkins, M.J.1    Scopes, J.W.2
  • 30
    • 0013873889 scopus 로고
    • Brown adipose tissue and heat production in the newborn infant
    • Aherne W, Hull D. Brown adipose tissue and heat production in the newborn infant. J Pathol Bacteriol 1966; 91(1): 223–234.
    • (1966) J Pathol Bacteriol , vol.91 , Issue.1 , pp. 223-234
    • Aherne, W.1    Hull, D.2
  • 31
    • 84877340732 scopus 로고    scopus 로고
    • Evidence for two types of brown adipose tissue in humans
    • Lidell ME, Betz MJ, Dahlqvist Leinhard O et al. Evidence for two types of brown adipose tissue in humans. Nat Med 2013; 19(5): 631–634.
    • (2013) Nat Med , vol.19 , Issue.5 , pp. 631-634
    • Lidell, M.E.1    Betz, M.J.2    Dahlqvist Leinhard, O.3
  • 32
    • 84856529575 scopus 로고    scopus 로고
    • Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
    • Ouellet V, Labbe SM, Blondin DP et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 2012; 122(2): 545–552.
    • (2012) J Clin Invest , vol.122 , Issue.2 , pp. 545-552
    • Ouellet, V.1    Labbe, S.M.2    Blondin, D.P.3
  • 33
    • 0035672507 scopus 로고    scopus 로고
    • Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis
    • Virtanen KA, Peltoniemi P, Marjamaki P et al. Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis. Diabetologia 2001; 44(12): 2171–2179.
    • (2001) Diabetologia , vol.44 , Issue.12 , pp. 2171-2179
    • Virtanen, K.A.1    Peltoniemi, P.2    Marjamaki, P.3
  • 34
    • 77951092882 scopus 로고    scopus 로고
    • Multiple thermoregulatory effectors with independent central controls
    • McAllen RM, Tanaka M, Ootsuka Y, McKinley MJ. Multiple thermoregulatory effectors with independent central controls. Eur J Appl Physiol 2010; 109(1): 27–33.
    • (2010) Eur J Appl Physiol , vol.109 , Issue.1 , pp. 27-33
    • McAllen, R.M.1    Tanaka, M.2    Ootsuka, Y.3    McKinley, M.J.4
  • 35
    • 84895792999 scopus 로고    scopus 로고
    • Increased brown adipose tissue oxidative capacity in cold-acclimated humans
    • Blondin DP, Labbe SM, Tingelstad HC et al. Increased brown adipose tissue oxidative capacity in cold-acclimated humans. J Clin Endocrinol Metab 2014; 99(3): E438–E446.
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.3 , pp. E438-E446
    • Blondin, D.P.1    Labbe, S.M.2    Tingelstad, H.C.3
  • 36
    • 79961055484 scopus 로고    scopus 로고
    • Implications of nonshivering thermogenesis for energy balance regulation in humans
    • van Marken Lichtenbelt WD, Schrauwen P. Implications of nonshivering thermogenesis for energy balance regulation in humans. Am J Physiol Regul Integr Comp Physiol 2011; 301(2): R285–R296.
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.301 , Issue.2 , pp. R285-R296
    • van Marken Lichtenbelt, W.D.1    Schrauwen, P.2
  • 37
    • 84883792727 scopus 로고    scopus 로고
    • Brown adipose tissue in humans: therapeutic potential to combat obesity
    • Carey AL, Kingwell BA. Brown adipose tissue in humans: therapeutic potential to combat obesity. Pharmacol Ther 2013; 140(1): 26–33.
    • (2013) Pharmacol Ther , vol.140 , Issue.1 , pp. 26-33
    • Carey, A.L.1    Kingwell, B.A.2
  • 38
    • 84875794383 scopus 로고    scopus 로고
    • 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat
    • Muzik O, Mangner TJ, Leonard WR et al. 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat. J Nucl Med 2013; 54(4): 523–531.
    • (2013) J Nucl Med , vol.54 , Issue.4 , pp. 523-531
    • Muzik, O.1    Mangner, T.J.2    Leonard, W.R.3
  • 40
    • 84921850478 scopus 로고    scopus 로고
    • Brown adipose tissue – not as hot as we thought
    • Jensen MD. Brown adipose tissue – not as hot as we thought. J Physiol 2015; 593(3): 489.
    • (2015) J Physiol , vol.593 , Issue.3 , pp. 489
    • Jensen, M.D.1
  • 41
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • Bartelt A, Bruns OT, Reimer R et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011; 17(2): 200–205.
    • (2011) Nat Med , vol.17 , Issue.2 , pp. 200-205
    • Bartelt, A.1    Bruns, O.T.2    Reimer, R.3
  • 42
    • 79960945989 scopus 로고    scopus 로고
    • Different metabolic responses of human brown adipose tissue to activation by cold and insulin
    • Orava J, Nuutila P, Lidell ME et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab 2011; 14(2): 272–279.
    • (2011) Cell Metab , vol.14 , Issue.2 , pp. 272-279
    • Orava, J.1    Nuutila, P.2    Lidell, M.E.3
  • 43
    • 84962028277 scopus 로고    scopus 로고
    • Brown adipose tissue exhibits a glucose-responsive thermogenic biorhythm in humans
    • Lee P, Bova R, Schofield L et al. Brown adipose tissue exhibits a glucose-responsive thermogenic biorhythm in humans. Cell Metab 2016; 23(4): 602–609.
    • (2016) Cell Metab , vol.23 , Issue.4 , pp. 602-609
    • Lee, P.1    Bova, R.2    Schofield, L.3
  • 44
    • 84962076500 scopus 로고    scopus 로고
    • Brown and beige fat: molecular parts of a thermogenic machine
    • Cohen P, Spiegelman BM. Brown and beige fat: molecular parts of a thermogenic machine. Diabetes 2015; 64(7): 2346–2351.
    • (2015) Diabetes , vol.64 , Issue.7 , pp. 2346-2351
    • Cohen, P.1    Spiegelman, B.M.2
  • 45
    • 0015332110 scopus 로고
    • The distribution of brown adipose tissue in the human
    • Heaton JM. The distribution of brown adipose tissue in the human. J Anat 1972; 112(Pt 1): 35–39.
    • (1972) J Anat , vol.112 , pp. 35-39
    • Heaton, J.M.1
  • 46
    • 0030717887 scopus 로고    scopus 로고
    • Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans
    • Oberkofler H, Dallinger G, Liu YM et al. Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans. J Lipid Res 1997; 38(10): 2125–2133.
    • (1997) J Lipid Res , vol.38 , Issue.10 , pp. 2125-2133
    • Oberkofler, H.1    Dallinger, G.2    Liu, Y.M.3
  • 47
    • 84921941748 scopus 로고    scopus 로고
    • Brown adipose tissue: what have we learned since its recent identification in human adults
    • Halpern B, Mancini MC, Halpern A. Brown adipose tissue: what have we learned since its recent identification in human adults. Arq Bras Endocrinol Metabol 2014; 58(9): 889–899.
    • (2014) Arq Bras Endocrinol Metabol , vol.58 , Issue.9 , pp. 889-899
    • Halpern, B.1    Mancini, M.C.2    Halpern, A.3
  • 48
    • 84913586856 scopus 로고    scopus 로고
    • The browning of white adipose tissue: some burning issues
    • Nedergaard J, Cannon B. The browning of white adipose tissue: some burning issues. Cell Metab 2014; 20(3): 396–407.
    • (2014) Cell Metab , vol.20 , Issue.3 , pp. 396-407
    • Nedergaard, J.1    Cannon, B.2
  • 49
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell 2014; 156(1–2): 20–44.
    • (2014) Cell , vol.156 , Issue.1-2 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 50
    • 84877331455 scopus 로고    scopus 로고
    • Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    • Cypess AM, White AP, Vernochet C et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 2013; 19(5): 635–639.
    • (2013) Nat Med , vol.19 , Issue.5 , pp. 635-639
    • Cypess, A.M.1    White, A.P.2    Vernochet, C.3
  • 51
    • 84877263632 scopus 로고    scopus 로고
    • A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans
    • Jespersen NZ, Larsen TJ, Peijs L et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab 2013; 17(5): 798–805.
    • (2013) Cell Metab , vol.17 , Issue.5 , pp. 798-805
    • Jespersen, N.Z.1    Larsen, T.J.2    Peijs, L.3
  • 52
    • 84869233588 scopus 로고    scopus 로고
    • Human BAT possesses molecular signatures that resemble beige/brite cells
    • Sharp LZ, Shinoda K, Ohno H et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One 2012; 7(11) e49452.
    • (2012) PLoS One , vol.7 , Issue.11
    • Sharp, L.Z.1    Shinoda, K.2    Ohno, H.3
  • 53
    • 84862515329 scopus 로고    scopus 로고
    • Cold but not sympathomimetics activates human brown adipose tissue in vivo
    • Cypess AM, Chen YC, Sze C et al. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci U S A 2012; 109(25): 10001–10005.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.25 , pp. 10001-10005
    • Cypess, A.M.1    Chen, Y.C.2    Sze, C.3
  • 54
    • 84881260642 scopus 로고    scopus 로고
    • Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
    • van der Lans AA, Hoeks J, Brans B et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest 2013; 123(8): 3395–3403.
    • (2013) J Clin Invest , vol.123 , Issue.8 , pp. 3395-3403
    • van der Lans, A.A.1    Hoeks, J.2    Brans, B.3
  • 55
    • 84881221754 scopus 로고    scopus 로고
    • Recruited brown adipose tissue as an antiobesity agent in humans
    • Yoneshiro T, Aita S, Matsushita M et al. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 2013; 123(8): 3404–3408.
    • (2013) J Clin Invest , vol.123 , Issue.8 , pp. 3404-3408
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3
  • 56
    • 84907973405 scopus 로고    scopus 로고
    • Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans
    • Lee P, Smith S, Linderman J et al. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes 2014; 63(11): 3686–3698.
    • (2014) Diabetes , vol.63 , Issue.11 , pp. 3686-3698
    • Lee, P.1    Smith, S.2    Linderman, J.3
  • 57
    • 84938974401 scopus 로고    scopus 로고
    • Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
    • Hanssen MJ, Hoeks J, Brans B et al. Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat Med 2015; 21(8): 863–865.
    • (2015) Nat Med , vol.21 , Issue.8 , pp. 863-865
    • Hanssen, M.J.1    Hoeks, J.2    Brans, B.3
  • 58
    • 84955710844 scopus 로고    scopus 로고
    • Characterization of brown adipose tissue by water-fat separated magnetic resonance imaging
    • Romu T, Elander L, Leinhard OD et al. Characterization of brown adipose tissue by water-fat separated magnetic resonance imaging. J Magn Reson Imaging 2015; 42(6): 1639–1645.
    • (2015) J Magn Reson Imaging , vol.42 , Issue.6 , pp. 1639-1645
    • Romu, T.1    Elander, L.2    Leinhard, O.D.3
  • 59
    • 84963945834 scopus 로고    scopus 로고
    • Short-term cold acclimation recruits brown adipose tissue in obese humans
    • Hanssen MJ, van der Lans AA, Brans B et al. Short-term cold acclimation recruits brown adipose tissue in obese humans. Diabetes 2016; 65(5): 1179–1189.
    • (2016) Diabetes , vol.65 , Issue.5 , pp. 1179-1189
    • Hanssen, M.J.1    van der Lans, A.A.2    Brans, B.3
  • 60
    • 70350443275 scopus 로고    scopus 로고
    • Transdifferentiation properties of adipocytes in the adipose organ
    • Cinti S. Transdifferentiation properties of adipocytes in the adipose organ. Am J Physiol Endocrinol Metab 2009; 297(5): E977–E986.
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , Issue.5 , pp. E977-E986
    • Cinti, S.1
  • 61
    • 0035787319 scopus 로고    scopus 로고
    • The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis
    • Collins S, Surwit RS. The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog Horm Res 2001; 56: 309–328.
    • (2001) Recent Prog Horm Res , vol.56 , pp. 309-328
    • Collins, S.1    Surwit, R.S.2
  • 62
    • 0036011136 scopus 로고    scopus 로고
    • Beta3-adrenoceptors in human detrusor muscle
    • Yamaguchi O. Beta3-adrenoceptors in human detrusor muscle. Urology 2002; 59(5 Suppl 1): 25–29.
    • (2002) Urology , vol.59 , Issue.5 , pp. 25-29
    • Yamaguchi, O.1
  • 63
    • 85009727793 scopus 로고    scopus 로고
    • Mirabegron for the treatment of overactive bladder: a review of efficacy, safety and tolerability with a focus on male, elderly and antimuscarinic poor-responder populations, and patients with OAB in Asia
    • Chapple CR, Siddiqui E. Mirabegron for the treatment of overactive bladder: a review of efficacy, safety and tolerability with a focus on male, elderly and antimuscarinic poor-responder populations, and patients with OAB in Asia. Expert Rev Clin Pharmacol 2017; 10(2): 131–151.
    • (2017) Expert Rev Clin Pharmacol , vol.10 , Issue.2 , pp. 131-151
    • Chapple, C.R.1    Siddiqui, E.2
  • 64
    • 84920627180 scopus 로고    scopus 로고
    • Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist
    • Cypess AM, Weiner LS, Roberts-Toler C et al. Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist. Cell Metab 2015; 21(1): 33–38.
    • (2015) Cell Metab , vol.21 , Issue.1 , pp. 33-38
    • Cypess, A.M.1    Weiner, L.S.2    Roberts-Toler, C.3
  • 65
    • 33947678206 scopus 로고    scopus 로고
    • Thermogenic and metabolic antiobesity drugs: rationale and opportunities
    • Clapham JC, Arch JR. Thermogenic and metabolic antiobesity drugs: rationale and opportunities. Diabetes Obes Metab 2007; 9(3): 259–275.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.3 , pp. 259-275
    • Clapham, J.C.1    Arch, J.R.2
  • 66
    • 0027392074 scopus 로고
    • Tissue distribution of beta 3-adrenergic receptor mRNA in man
    • Krief S, Lonnqvist F, Raimbault S et al. Tissue distribution of beta 3-adrenergic receptor mRNA in man. J Clin Invest 1993; 91(1): 344–349.
    • (1993) J Clin Invest , vol.91 , Issue.1 , pp. 344-349
    • Krief, S.1    Lonnqvist, F.2    Raimbault, S.3
  • 67
    • 0031040576 scopus 로고    scopus 로고
    • Brown adipose tissue, beta 3-adrenergic receptors, and obesity
    • Lowell BB, Flier JS. Brown adipose tissue, beta 3-adrenergic receptors, and obesity. Annu Rev Med 1997; 48: 307–316.
    • (1997) Annu Rev Med , vol.48 , pp. 307-316
    • Lowell, B.B.1    Flier, J.S.2
  • 68
    • 34547900257 scopus 로고    scopus 로고
    • Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity
    • Lafontaine JA, Day RF, Dibrino J et al. Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity. Bioorg Med Chem Lett 2007; 17(18): 5245–5250.
    • (2007) Bioorg Med Chem Lett , vol.17 , Issue.18 , pp. 5245-5250
    • Lafontaine, J.A.1    Day, R.F.2    Dibrino, J.3
  • 69
    • 47149118684 scopus 로고    scopus 로고
    • The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists
    • Arch JR. The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol 2008; 378(2): 225–240.
    • (2008) Naunyn Schmiedebergs Arch Pharmacol , vol.378 , Issue.2 , pp. 225-240
    • Arch, J.R.1
  • 70
    • 84869491480 scopus 로고    scopus 로고
    • Proarrhythmic safety of repeat doses of mirabegron in healthy subjects: a randomized, double-blind, placebo-, and active-controlled thorough QT study
    • Malik M, van Gelderen EM, Lee JH et al. Proarrhythmic safety of repeat doses of mirabegron in healthy subjects: a randomized, double-blind, placebo-, and active-controlled thorough QT study. Clin Pharmacol Ther 2012; 92(6): 696–706.
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.6 , pp. 696-706
    • Malik, M.1    van Gelderen, E.M.2    Lee, J.H.3
  • 71
    • 84884410199 scopus 로고    scopus 로고
    • Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes
    • Murholm M, Isidor MS, Basse AL et al. Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes. BMC Cell Biol 2013; 14: 41.
    • (2013) BMC Cell Biol , vol.14 , pp. 41
    • Murholm, M.1    Isidor, M.S.2    Basse, A.L.3
  • 72
    • 0021327437 scopus 로고
    • Prolonged beta-adrenoceptor stimulation increases the amount of GDP-binding protein in brown adipose tissue mitochondria
    • Young P, Wilson S, Arch JR. Prolonged beta-adrenoceptor stimulation increases the amount of GDP-binding protein in brown adipose tissue mitochondria. Life Sci 1984; 34(12): 1111–1117.
    • (1984) Life Sci , vol.34 , Issue.12 , pp. 1111-1117
    • Young, P.1    Wilson, S.2    Arch, J.R.3
  • 73
    • 84939951899 scopus 로고    scopus 로고
    • Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity
    • Carey AL, Pajtak R, Formosa MF et al. Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity. Diabetologia 2015; 58(5): 1045–1054.
    • (2015) Diabetologia , vol.58 , Issue.5 , pp. 1045-1054
    • Carey, A.L.1    Pajtak, R.2    Formosa, M.F.3
  • 74
    • 84992437294 scopus 로고    scopus 로고
    • Glucocorticoids acutely increase brown adipose tissue activity in humans, revealing species-specific differences in UCP-1 regulation
    • Ramage LE, Akyol M, Fletcher AM et al. Glucocorticoids acutely increase brown adipose tissue activity in humans, revealing species-specific differences in UCP-1 regulation. Cell Metab 2016; 24(1): 130–141.
    • (2016) Cell Metab , vol.24 , Issue.1 , pp. 130-141
    • Ramage, L.E.1    Akyol, M.2    Fletcher, A.M.3
  • 75
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Bostrom P, Wu J, Jedrychowski MP et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481(7382): 463–468.
    • (2012) Nature , vol.481 , Issue.7382 , pp. 463-468
    • Bostrom, P.1    Wu, J.2    Jedrychowski, M.P.3
  • 76
    • 84902097377 scopus 로고    scopus 로고
    • Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
    • Rao RR, Long JZ, White JP et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 2014; 157(6): 1279–1291.
    • (2014) Cell , vol.157 , Issue.6 , pp. 1279-1291
    • Rao, R.R.1    Long, J.Z.2    White, J.P.3
  • 77
    • 84949626813 scopus 로고    scopus 로고
    • Low brown adipose tissue activity in endurance-trained compared with lean sedentary men
    • Vosselman MJ, Hoeks J, Brans B et al. Low brown adipose tissue activity in endurance-trained compared with lean sedentary men. Int J Obes (Lond) 2015; 39(12): 1696–1702.
    • (2015) Int J Obes (Lond) , vol.39 , Issue.12 , pp. 1696-1702
    • Vosselman, M.J.1    Hoeks, J.2    Brans, B.3
  • 78
    • 85021817900 scopus 로고    scopus 로고
    • Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle aged men
    • Motiani P, Virtanen KA, Motiani KK et al. Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle aged men. Diabetes Obes Metab 2017.
    • (2017) Diabetes Obes Metab
    • Motiani, P.1    Virtanen, K.A.2    Motiani, K.K.3
  • 79
    • 77953543325 scopus 로고    scopus 로고
    • Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue
    • Camera DM, Anderson MJ, Hawley JA, Carey AL. Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue. Eur J Appl Physiol 2010; 109(2): 307–316.
    • (2010) Eur J Appl Physiol , vol.109 , Issue.2 , pp. 307-316
    • Camera, D.M.1    Anderson, M.J.2    Hawley, J.A.3    Carey, A.L.4
  • 80
    • 84893452569 scopus 로고    scopus 로고
    • Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
    • Lee P, Linderman JD, Smith S et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab 2014; 19(2): 302–309.
    • (2014) Cell Metab , vol.19 , Issue.2 , pp. 302-309
    • Lee, P.1    Linderman, J.D.2    Smith, S.3
  • 81
    • 84989158706 scopus 로고    scopus 로고
    • Eulogy for the metabolic clinical investigator?
    • Vella A, Jensen MD, Nair KS. Eulogy for the metabolic clinical investigator? Diabetes 2016; 65(10): 2821–2823.
    • (2016) Diabetes , vol.65 , Issue.10 , pp. 2821-2823
    • Vella, A.1    Jensen, M.D.2    Nair, K.S.3
  • 82
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol 2007; 7(2): 118–130.
    • (2007) Nat Rev Immunol , vol.7 , Issue.2 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 83
    • 0024362168 scopus 로고
    • Role of thermogenesis in the regulation of energy balance in relation to obesity
    • Himms-Hagen J. Role of thermogenesis in the regulation of energy balance in relation to obesity. Can J Physiol Pharmacol 1989; 67(4): 394–401.
    • (1989) Can J Physiol Pharmacol , vol.67 , Issue.4 , pp. 394-401
    • Himms-Hagen, J.1
  • 84
    • 84878622198 scopus 로고    scopus 로고
    • Not so hot: optimal housing temperatures for mice to mimic the thermal environment of humans
    • Speakman JR, Keijer J. Not so hot: optimal housing temperatures for mice to mimic the thermal environment of humans. Mol Metab 2012; 2(1): 5–9.
    • (2012) Mol Metab , vol.2 , Issue.1 , pp. 5-9
    • Speakman, J.R.1    Keijer, J.2
  • 85
    • 0018611299 scopus 로고
    • Obesity may be due to a malfunctioning of brown fat
    • Himms-Hagen J. Obesity may be due to a malfunctioning of brown fat. Can Med Assoc J 1979; 121(10): 1361–1364.
    • (1979) Can Med Assoc J , vol.121 , Issue.10 , pp. 1361-1364
    • Himms-Hagen, J.1
  • 86
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
    • Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 1998; 102(2): 412–420.
    • (1998) J Clin Invest , vol.102 , Issue.2 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 87
    • 79952089254 scopus 로고    scopus 로고
    • Brown adipose tissue in morbidly obese subjects
    • Vijgen GH, Bouvy ND, Teule GJ et al. Brown adipose tissue in morbidly obese subjects. PLoS One 2011; 6(2) e17247.
    • (2011) PLoS One , vol.6 , Issue.2
    • Vijgen, G.H.1    Bouvy, N.D.2    Teule, G.J.3
  • 88
    • 84871611304 scopus 로고    scopus 로고
    • Ephedrine activates brown adipose tissue in lean but not obese humans
    • Carey AL, Formosa MF, Van Every B et al. Ephedrine activates brown adipose tissue in lean but not obese humans. Diabetologia 2013; 56(1): 147–155.
    • (2013) Diabetologia , vol.56 , Issue.1 , pp. 147-155
    • Carey, A.L.1    Formosa, M.F.2    Van Every, B.3
  • 89
    • 84887168000 scopus 로고    scopus 로고
    • Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans
    • Orava J, Nuutila P, Noponen T et al. Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans. Obesity (Silver Spring) 2013; 21(11): 2279–2287.
    • (2013) Obesity (Silver Spring) , vol.21 , Issue.11 , pp. 2279-2287
    • Orava, J.1    Nuutila, P.2    Noponen, T.3
  • 90
    • 84862495484 scopus 로고    scopus 로고
    • Increase in brown adipose tissue activity after weight loss in morbidly obese subjects
    • Vijgen GH, Bouvy ND, Teule GJ et al. Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. J Clin Endocrinol Metab 2012; 97(7): E1229–E1233.
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.7 , pp. E1229-E1233
    • Vijgen, G.H.1    Bouvy, N.D.2    Teule, G.J.3
  • 91
    • 85019591578 scopus 로고    scopus 로고
    • Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity
    • Trayhurn P. Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity. Biochimie 2016.
    • (2016) Biochimie
    • Trayhurn, P.1
  • 92
    • 84900544828 scopus 로고    scopus 로고
    • Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability
    • Brondani LA, Assmann TS, de Souza BM et al. Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability. PLoS One 2014; 9(5) e96411.
    • (2014) PLoS One , vol.9 , Issue.5
    • Brondani, L.A.1    Assmann, T.S.2    de Souza, B.M.3
  • 93
    • 84940830979 scopus 로고    scopus 로고
    • FTO obesity variant circuitry and adipocyte browning in humans
    • Claussnitzer M, Dankel SN, Kim KH et al. FTO obesity variant circuitry and adipocyte browning in humans. N Engl J Med 2015; 373(10): 895–907.
    • (2015) N Engl J Med , vol.373 , Issue.10 , pp. 895-907
    • Claussnitzer, M.1    Dankel, S.N.2    Kim, K.H.3
  • 95
    • 77953809603 scopus 로고    scopus 로고
    • Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans)
    • Cannon B, Nedergaard J. Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int J Obes (Lond) 2010; 34(Suppl 1): S7–16.
    • (2010) Int J Obes (Lond) , vol.34 , pp. S7-16
    • Cannon, B.1    Nedergaard, J.2
  • 96
    • 84861845111 scopus 로고    scopus 로고
    • Brown adipose tissue: mechanisms and potential therapeutic targets
    • Tam CS, Lecoultre V, Ravussin E. Brown adipose tissue: mechanisms and potential therapeutic targets. Circulation 2012; 125(22): 2782–2791.
    • (2012) Circulation , vol.125 , Issue.22 , pp. 2782-2791
    • Tam, C.S.1    Lecoultre, V.2    Ravussin, E.3
  • 97
    • 78650098848 scopus 로고    scopus 로고
    • Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    • Ouellet V, Routhier-Labadie A, Bellemare W et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 2011; 96(1): 192–199.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.1 , pp. 192-199
    • Ouellet, V.1    Routhier-Labadie, A.2    Bellemare, W.3
  • 98
    • 84958771871 scopus 로고    scopus 로고
    • The impact of low-protein high-carbohydrate diets on aging and lifespan
    • Le Couteur DG, Solon-Biet S, Cogger VC et al. The impact of low-protein high-carbohydrate diets on aging and lifespan. Cell Mol Life Sci 2016; 73(6): 1237–1252.
    • (2016) Cell Mol Life Sci , vol.73 , Issue.6 , pp. 1237-1252
    • Le Couteur, D.G.1    Solon-Biet, S.2    Cogger, V.C.3
  • 99
    • 84984907972 scopus 로고    scopus 로고
    • Combatting type 2 diabetes by turning up the heat
    • Schrauwen P, van Marken Lichtenbelt WD. Combatting type 2 diabetes by turning up the heat. Diabetologia 2016; 59(11): 2269–2279.
    • (2016) Diabetologia , vol.59 , Issue.11 , pp. 2269-2279
    • Schrauwen, P.1    van Marken Lichtenbelt, W.D.2
  • 100
    • 84906882822 scopus 로고    scopus 로고
    • Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013
    • Ng M, Fleming T, Robinson M et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384(9945): 766–781.
    • (2014) Lancet , vol.384 , Issue.9945 , pp. 766-781
    • Ng, M.1    Fleming, T.2    Robinson, M.3
  • 101
    • 84898470352 scopus 로고    scopus 로고
    • Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice
    • Ravussin Y, Xiao C, Gavrilova O, Reitman ML. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. PLoS One 2014; 9(1) e85876.
    • (2014) PLoS One , vol.9 , Issue.1
    • Ravussin, Y.1    Xiao, C.2    Gavrilova, O.3    Reitman, M.L.4
  • 102
    • 0002467109 scopus 로고
    • Experimentelle beitrage zur lehre von dem taglichen nahrungsbedarf des menschen unter besondere beruckischtigung der not wendigen eiweissmenge
    • Neumman D. Experimentelle beitrage zur lehre von dem taglichen nahrungsbedarf des menschen unter besondere beruckischtigung der not wendigen eiweissmenge. Arch Hyg 1902; 45: 1–87.
    • (1902) Arch Hyg , vol.45 , pp. 1-87
    • Neumman, D.1
  • 103
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Nature 1979; 281(5726): 31–35.
    • (1979) Nature , vol.281 , Issue.5726 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 104
    • 0020540891 scopus 로고
    • Luxuskonsumption, brown fat, and human obesity
    • Garrow JS. Luxuskonsumption, brown fat, and human obesity. Br Med J (Clin Res Ed) 1983; 286(6379): 1684–1686.
    • (1983) Br Med J (Clin Res Ed) , vol.286 , Issue.6379 , pp. 1684-1686
    • Garrow, J.S.1
  • 105
    • 0021954853 scopus 로고
    • Energy expenditure before and during energy restriction in obese patients
    • Ravussin E, Burnand B, Schutz Y, Jequier E. Energy expenditure before and during energy restriction in obese patients. Am J Clin Nutr 1985; 41(4): 753–759.
    • (1985) Am J Clin Nutr , vol.41 , Issue.4 , pp. 753-759
    • Ravussin, E.1    Burnand, B.2    Schutz, Y.3    Jequier, E.4
  • 106
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995; 332(10): 621–628.
    • (1995) N Engl J Med , vol.332 , Issue.10 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 107
    • 78449285027 scopus 로고    scopus 로고
    • Adaptive thermogenesis in humans
    • Rosenbaum M, Leibel RL. Adaptive thermogenesis in humans. Int J Obes (Lond) 2010; 34(Suppl 1): S47–S55.
    • (2010) Int J Obes (Lond) , vol.34 , pp. S47-S55
    • Rosenbaum, M.1    Leibel, R.L.2
  • 109
    • 0014146654 scopus 로고
    • Gluttony. 1. An experimental study of overeating low- or high-protein diets
    • Miller DS, Mumford P. Gluttony. 1. An experimental study of overeating low- or high-protein diets. Am J Clin Nutr 1967; 20(11): 1212–1222.
    • (1967) Am J Clin Nutr , vol.20 , Issue.11 , pp. 1212-1222
    • Miller, D.S.1    Mumford, P.2
  • 110
    • 0021131228 scopus 로고
    • Whole-body calorimetry studies in adult men. 1. The effect of fat over-feeding on 24 h energy expenditure
    • Dallosso HM, James WP. Whole-body calorimetry studies in adult men. 1. The effect of fat over-feeding on 24 h energy expenditure. Br J Nutr 1984; 52(1): 49–64.
    • (1984) Br J Nutr , vol.52 , Issue.1 , pp. 49-64
    • Dallosso, H.M.1    James, W.P.2
  • 111
    • 0033534524 scopus 로고    scopus 로고
    • Role of nonexercise activity thermogenesis in resistance to fat gain in humans
    • Levine JA, Eberhardt NL, Jensen MD. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 1999; 283(5399): 212–214.
    • (1999) Science , vol.283 , Issue.5399 , pp. 212-214
    • Levine, J.A.1    Eberhardt, N.L.2    Jensen, M.D.3
  • 112
    • 0001257550 scopus 로고
    • Adaptation to caloric restriction
    • Taylor HL, Keys A. Adaptation to caloric restriction. Science 1950; 112(2904): 215–218.
    • (1950) Science , vol.112 , Issue.2904 , pp. 215-218
    • Taylor, H.L.1    Keys, A.2
  • 113
    • 84879427668 scopus 로고    scopus 로고
    • Brown adipose tissue activity after a high-calorie meal in humans
    • Vosselman MJ, Brans B, van der Lans AA et al. Brown adipose tissue activity after a high-calorie meal in humans. Am J Clin Nutr 2013; 98(1): 57–64.
    • (2013) Am J Clin Nutr , vol.98 , Issue.1 , pp. 57-64
    • Vosselman, M.J.1    Brans, B.2    van der Lans, A.A.3
  • 114
    • 84981275876 scopus 로고    scopus 로고
    • Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans
    • Hibi M, Oishi S, Matsushita M et al. Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans. Int J Obes (Lond) 2016.
    • (2016) Int J Obes (Lond)
    • Hibi, M.1    Oishi, S.2    Matsushita, M.3
  • 117
    • 84951906454 scopus 로고    scopus 로고
    • The thermogenic responses to overfeeding and cold are differentially regulated
    • Peterson CM, Lecoultre V, Frost EA et al. The thermogenic responses to overfeeding and cold are differentially regulated. Obesity (Silver Spring) 2016; 24(1): 96–101.
    • (2016) Obesity (Silver Spring) , vol.24 , Issue.1 , pp. 96-101
    • Peterson, C.M.1    Lecoultre, V.2    Frost, E.A.3
  • 118
    • 0024384307 scopus 로고
    • Brown adipose tissue, liver, and diet-induced thermogenesis in cafeteria diet-fed rats
    • Ma SW, Foster DO. Brown adipose tissue, liver, and diet-induced thermogenesis in cafeteria diet-fed rats. Can J Physiol Pharmacol 1989; 67(4): 376–381.
    • (1989) Can J Physiol Pharmacol , vol.67 , Issue.4 , pp. 376-381
    • Ma, S.W.1    Foster, D.O.2
  • 120
    • 35948953172 scopus 로고    scopus 로고
    • Individual thermogenic responses to mild cold and overfeeding are closely related
    • Wijers SL, Saris WH, van Marken Lichtenbelt WD. Individual thermogenic responses to mild cold and overfeeding are closely related. J Clin Endocrinol Metab 2007; 92(11): 4299–4305.
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.11 , pp. 4299-4305
    • Wijers, S.L.1    Saris, W.H.2    van Marken Lichtenbelt, W.D.3
  • 121
    • 84889818937 scopus 로고    scopus 로고
    • Overfeeding over 24 hours does not activate brown adipose tissue in humans
    • Schlogl M, Piaggi P, Thiyyagura P et al. Overfeeding over 24 hours does not activate brown adipose tissue in humans. J Clin Endocrinol Metab 2013; 98(12): E1956–E1960.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.12 , pp. E1956-E1960
    • Schlogl, M.1    Piaggi, P.2    Thiyyagura, P.3
  • 122
    • 0020466632 scopus 로고
    • Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma
    • Ricquier D, Nechad M, Mory G. Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma. J Clin Endocrinol Metab 1982; 54(4): 803–807.
    • (1982) J Clin Endocrinol Metab , vol.54 , Issue.4 , pp. 803-807
    • Ricquier, D.1    Nechad, M.2    Mory, G.3
  • 123
    • 0022482362 scopus 로고
    • Brown adipose tissue in patients with phaeochromocytoma
    • Lean ME, James WP, Jennings G, Trayhurn P. Brown adipose tissue in patients with phaeochromocytoma. Int J Obes 1986; 10(3): 219–227.
    • (1986) Int J Obes , vol.10 , Issue.3 , pp. 219-227
    • Lean, M.E.1    James, W.P.2    Jennings, G.3    Trayhurn, P.4
  • 124
    • 0021350359 scopus 로고
    • Ephedrine-induced thermogenesis in man: no role for interscapular brown adipose tissue
    • Astrup A, Bulow J, Christensen NJ, Madsen J. Ephedrine-induced thermogenesis in man: no role for interscapular brown adipose tissue. Clin Sci (Lond) 1984; 66(2): 179–186.
    • (1984) Clin Sci (Lond) , vol.66 , Issue.2 , pp. 179-186
    • Astrup, A.1    Bulow, J.2    Christensen, N.J.3    Madsen, J.4
  • 125
    • 0021844412 scopus 로고
    • Enhanced thermogenic responsiveness during chronic ephedrine treatment in man
    • Astrup A, Lundsgaard C, Madsen J, Christensen NJ. Enhanced thermogenic responsiveness during chronic ephedrine treatment in man. Am J Clin Nutr 1985; 42(1): 83–94.
    • (1985) Am J Clin Nutr , vol.42 , Issue.1 , pp. 83-94
    • Astrup, A.1    Lundsgaard, C.2    Madsen, J.3    Christensen, N.J.4
  • 126
    • 84868206600 scopus 로고    scopus 로고
    • Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans
    • Vosselman MJ, van der Lans AA, Brans B et al. Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans. Diabetes 2012; 61(12): 3106–3113.
    • (2012) Diabetes , vol.61 , Issue.12 , pp. 3106-3113
    • Vosselman, M.J.1    van der Lans, A.A.2    Brans, B.3
  • 127
    • 84994128034 scopus 로고    scopus 로고
    • Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans
    • Saito M, Yoneshiro T, Matsushita M. Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans. Best Pract Res Clin Endocrinol Metab 2016; 30(4): 537–547.
    • (2016) Best Pract Res Clin Endocrinol Metab , vol.30 , Issue.4 , pp. 537-547
    • Saito, M.1    Yoneshiro, T.2    Matsushita, M.3
  • 128
    • 84859046511 scopus 로고    scopus 로고
    • Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans
    • Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012; 95(4): 845–850.
    • (2012) Am J Clin Nutr , vol.95 , Issue.4 , pp. 845-850
    • Yoneshiro, T.1    Aita, S.2    Kawai, Y.3    Iwanaga, T.4    Saito, M.5
  • 129
    • 10544229796 scopus 로고    scopus 로고
    • Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation
    • Tai TA, Jennermann C, Brown KK et al. Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation. J Biol Chem 1996; 271(47): 29909–29914.
    • (1996) J Biol Chem , vol.271 , Issue.47 , pp. 29909-29914
    • Tai, T.A.1    Jennermann, C.2    Brown, K.K.3
  • 130
    • 0031985802 scopus 로고    scopus 로고
    • Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
    • Digby JE, Montague CT, Sewter CP et al. Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes. Diabetes 1998; 47(1): 138–141.
    • (1998) Diabetes , vol.47 , Issue.1 , pp. 138-141
    • Digby, J.E.1    Montague, C.T.2    Sewter, C.P.3
  • 131
    • 7844237506 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression
    • Kelly LJ, Vicario PP, Thompson GM et al. Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology 1998; 139(12): 4920–4927.
    • (1998) Endocrinology , vol.139 , Issue.12 , pp. 4920-4927
    • Kelly, L.J.1    Vicario, P.P.2    Thompson, G.M.3
  • 133
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic N, Walden TB, Shabalina IG et al. Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 2010; 285(10): 7153–7164.
    • (2010) J Biol Chem , vol.285 , Issue.10 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3
  • 134
    • 84858039282 scopus 로고    scopus 로고
    • PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
    • Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 2012; 15(3): 395–404.
    • (2012) Cell Metab , vol.15 , Issue.3 , pp. 395-404
    • Ohno, H.1    Shinoda, K.2    Spiegelman, B.M.3    Kajimura, S.4
  • 135
    • 84877329207 scopus 로고    scopus 로고
    • PPARgamma signaling and metabolism: the good, the bad and the future
    • Ahmadian M, Suh JM, Hah N et al. PPARgamma signaling and metabolism: the good, the bad and the future. Nat Med 2013; 19(5): 557–566.
    • (2013) Nat Med , vol.19 , Issue.5 , pp. 557-566
    • Ahmadian, M.1    Suh, J.M.2    Hah, N.3
  • 137
    • 84855335544 scopus 로고    scopus 로고
    • Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes
    • Lee JY, Takahashi N, Yasubuchi M et al. Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes. Am J Physiol Cell Physiol 2012; 302(2): C463–C472.
    • (2012) Am J Physiol Cell Physiol , vol.302 , Issue.2 , pp. C463-C472
    • Lee, J.Y.1    Takahashi, N.2    Yasubuchi, M.3
  • 138
    • 84892179280 scopus 로고    scopus 로고
    • Hyperthyroidism increases brown fat metabolism in humans
    • Lahesmaa M, Orava J, Schalin-Jantti C et al. Hyperthyroidism increases brown fat metabolism in humans. J Clin Endocrinol Metab 2014; 99(1): E28–E35.
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.1 , pp. E28-E35
    • Lahesmaa, M.1    Orava, J.2    Schalin-Jantti, C.3
  • 139
    • 75149193049 scopus 로고    scopus 로고
    • Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance
    • Skarulis MC, Celi FS, Mueller E et al. Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance. J Clin Endocrinol Metab 2010; 95(1): 256–262.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.1 , pp. 256-262
    • Skarulis, M.C.1    Celi, F.S.2    Mueller, E.3
  • 140
    • 84958213007 scopus 로고    scopus 로고
    • Thyroid hormone activates brown adipose tissue and increases non-shivering thermogenesis – a cohort study in a group of thyroid carcinoma patients
    • Broeders EP, Vijgen GH, Havekes B et al. Thyroid hormone activates brown adipose tissue and increases non-shivering thermogenesis – a cohort study in a group of thyroid carcinoma patients. PLoS One 2016; 11(1) e0145049.
    • (2016) PLoS One , vol.11 , Issue.1
    • Broeders, E.P.1    Vijgen, G.H.2    Havekes, B.3
  • 141
    • 84907367349 scopus 로고    scopus 로고
    • The effects of thyroid hormones on brown adipose tissue in humans: a PET-CT study
    • Zhang Q, Miao Q, Ye H et al. The effects of thyroid hormones on brown adipose tissue in humans: a PET-CT study. Diabetes Metab Res Rev 2014; 30(6): 513–520.
    • (2014) Diabetes Metab Res Rev , vol.30 , Issue.6 , pp. 513-520
    • Zhang, Q.1    Miao, Q.2    Ye, H.3
  • 142
    • 85009060667 scopus 로고    scopus 로고
    • Variable cold-induced brown adipose tissue response to thyroid hormone status
    • Gavrila A, Hasselgren PO, Glasgow A et al. Variable cold-induced brown adipose tissue response to thyroid hormone status. Thyroid 2017; 27(1): 1–10.
    • (2017) Thyroid , vol.27 , Issue.1 , pp. 1-10
    • Gavrila, A.1    Hasselgren, P.O.2    Glasgow, A.3
  • 143
    • 84907221245 scopus 로고    scopus 로고
    • Presence of brown adipose tissue in an adolescent with severe primary hypothyroidism
    • Kim MS, Hu HH, Aggabao PC, Geffner ME, Gilsanz V. Presence of brown adipose tissue in an adolescent with severe primary hypothyroidism. J Clin Endocrinol Metab 2014; 99(9): E1686–E1690.
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.9 , pp. E1686-E1690
    • Kim, M.S.1    Hu, H.H.2    Aggabao, P.C.3    Geffner, M.E.4    Gilsanz, V.5
  • 144
    • 84978969880 scopus 로고    scopus 로고
    • Mechanisms in Endocrinology: brown adipose tissue in humans: regulation and metabolic significance
    • Thuzar M, Ho KK. Mechanisms in Endocrinology: brown adipose tissue in humans: regulation and metabolic significance. Eur J Endocrinol 2016; 175(1): R11–R25.
    • (2016) Eur J Endocrinol , vol.175 , Issue.1 , pp. R11-R25
    • Thuzar, M.1    Ho, K.K.2
  • 145
    • 84921341541 scopus 로고    scopus 로고
    • Effects of glucocorticoids on human brown adipocytes
    • Barclay JL, Agada H, Jang C et al. Effects of glucocorticoids on human brown adipocytes. J Endocrinol 2015; 224(2): 139–147.
    • (2015) J Endocrinol , vol.224 , Issue.2 , pp. 139-147
    • Barclay, J.L.1    Agada, H.2    Jang, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.