Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans

Cell Metabolism

Volumn 23, Issue 4, 2016, Pages 602-609

  Lee, Paul ^a,b,d   Bova, Ron ^b   Schofield, Lynne ^a,b   Bryant, Wendy ^b   Dieckmann, William ^c   Slattery, Anthony ^b   Govendir, Matt A ^a   Emmett, Louise ^b   Greenfield, Jerry R ^a,b,d  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

beige adipose; circadian; GLUT4; Rev erb; UCP1

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCOSYLATED HEMOGLOBIN; INDINAVIR; NUCLEAR RECEPTOR NR1D1; UNCOUPLING PROTEIN 1; NR1D1 PROTEIN, HUMAN; SLC2A4 PROTEIN, HUMAN; UCP1 PROTEIN, HUMAN;

ADULT; ARTICLE; BIOLOGICAL RHYTHM; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; CORE TEMPERATURE; DIABETES MELLITUS; ENVIRONMENTAL TEMPERATURE; EX VIVO STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; INSULIN TREATMENT; MALE; MIDDLE AGED; MOLECULAR INTERACTION; NONSHIVERING THERMOGENESIS; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SKIN TEMPERATURE; THERMOGENESIS; CELL CULTURE; CIRCADIAN RHYTHM; METABOLISM; PHYSIOLOGY; YOUNG ADULT;

ADIPOCYTES, BROWN; ADIPOSE TISSUE, BROWN; ADULT; CELLS, CULTURED; CIRCADIAN RHYTHM; FEMALE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; MALE; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; THERMOGENESIS; UNCOUPLING PROTEIN 1; YOUNG ADULT;

EID: 84962028277     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.02.007     Document Type: Article

References (27)

1. A. Bartelt, O.T. Bruns, R. Reimer, H. Hohenberg, H. Ittrich, K. Peldschus, M.G. Kaul, U.I. Tromsdorf, H. Weller, C. Waurisch, and et al. Brown adipose tissue activity controls triglyceride clearance Nat. Med. 17 2011 200 205
2. E.E. Blaak, J.M. Antoine, D. Benton, I. Björck, L. Bozzetto, F. Brouns, M. Diamant, L. Dye, T. Hulshof, J.J. Holst, and et al. Impact of postprandial glycaemia on health and prevention of disease Obes. Rev. 13 2012 923 984
3. M.R. Boon, L.E. Bakker, R.A. van der Linden, L. Pereira Arias-Bouda, F. Smit, H.J. Verberne, W.D. van Marken Lichtenbelt, I.M. Jazet, and P.C. Rensen Supraclavicular skin temperature as a measure of 18F-FDG uptake by BAT in human subjects PLoS ONE 9 2014 e98822
4. M. Chondronikola, E. Volpi, E. Børsheim, C. Porter, P. Annamalai, S. Enerbäck, M.E. Lidell, M.K. Saraf, S.M. Labbe, N.M. Hurren, and et al. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans Diabetes 63 2014 4089 4099
5. A.M. Cypess, Y.C. Chen, C. Sze, K. Wang, J. English, O. Chan, A.R. Holman, I. Tal, M.R. Palmer, G.M. Kolodny, and C.R. Kahn Cold but not sympathomimetics activates human brown adipose tissue in vivo Proc. Natl. Acad. Sci. USA 109 2012 10001 10005
6. Z. Gerhart-Hines, D. Feng, M.J. Emmett, L.J. Everett, E. Loro, E.R. Briggs, A. Bugge, C. Hou, C. Ferrara, P. Seale, and et al. The nuclear receptor Rev-erbα controls circadian thermogenic plasticity Nature 503 2013 410 413
7. T. Gnad, S. Scheibler, I. von Kügelgen, C. Scheele, A. Kilić, A. Glöde, L.S. Hoffmann, L. Reverte-Salisa, P. Horn, S. Mutlu, and et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors Nature 516 2014 395 399
8. J. Himms-Hagen Brown adipose tissue thermogenesis and obesity Prog. Lipid Res. 28 1989 67 115
9. Himms-Hagen, J. (1995). Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats: a new hypothesis that links thermostatic and glucostatic hypotheses for control of food intake. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 208, 159-169.
10. D. Isler, H.P. Hill, and M.K. Meier Glucose metabolism in isolated brown adipocytes under beta-adrenergic stimulation. Quantitative contribution of glucose to total thermogenesis Biochem. J. 245 1987 789 793
11. C. Jang, S. Jalapu, M. Thuzar, P.W. Law, S. Jeavons, J.L. Barclay, and K.K. Ho Infrared thermography in the detection of brown adipose tissue in humans Physiol. Rep. 2 2014 2
12. N.Z. Jespersen, T.J. Larsen, L. Peijs, S. Daugaard, P. Homøe, A. Loft, J. de Jong, N. Mathur, B. Cannon, J. Nedergaard, and et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans Cell Metab. 17 2013 798 805
13. S. Kajimura, B.M. Spiegelman, and P. Seale Brown and beige fat: physiological roles beyond heat generation Cell Metab. 22 2015 546 559
14. D. Konrad, P.J. Bilan, Z. Nawaz, G. Sweeney, W. Niu, Z. Liu, C.N. Antonescu, A. Rudich, and A. Klip Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice Diabetes 51 2002 2719 2726
15. P. Lee, J.R. Greenfield, K.K. Ho, and M.J. Fulham A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans Am. J. Physiol. Endocrinol. Metab. 299 2010 E601 E606
16. P. Lee, K.K. Ho, P. Lee, J.R. Greenfield, K.K. Ho, and J.R. Greenfield Hot fat in a cool man: infrared thermography and brown adipose tissue Diabetes Obes. Metab. 13 2011 92 93
17. P. Lee, J.D. Linderman, S. Smith, R.J. Brychta, J. Wang, C. Idelson, R.M. Perron, C.D. Werner, G.Q. Phan, U.S. Kammula, and et al. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans Cell Metab. 19 2014 302 309
18. P. Lee, S. Smith, J. Linderman, A.B. Courville, R.J. Brychta, W. Dieckmann, C.D. Werner, K.Y. Chen, and F.S. Celi Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans Diabetes 63 2014 3686 3698
19. M. Matsushita, T. Yoneshiro, S. Aita, T. Kameya, H. Sugie, and M. Saito Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans Int. J. Obes. 38 2014 812 817
20. J. Nedergaard, and B. Cannon UCP1 mRNA does not produce heat Biochim. Biophys. Acta 1831 2013 943 949
21. J. Orava, P. Nuutila, M.E. Lidell, V. Oikonen, T. Noponen, T. Viljanen, M. Scheinin, M. Taittonen, T. Niemi, S. Enerbäck, and K.A. Virtanen Different metabolic responses of human brown adipose tissue to activation by cold and insulin Cell Metab. 14 2011 272 279
22. V. Ouellet, S.M. Labbé, D.P. Blondin, S. Phoenix, B. Guérin, F. Haman, E.E. Turcotte, D. Richard, and A.C. Carpentier Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans J. Clin. Invest. 122 2012 545 552
23. M. Saito, Y. Okamatsu-Ogura, M. Matsushita, K. Watanabe, T. Yoneshiro, J. Nio-Kobayashi, T. Iwanaga, M. Miyagawa, T. Kameya, K. Nakada, and et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity Diabetes 58 2009 1526 1531
24. P. Schrauwen, W.D. van Marken Lichtenbelt, and B.M. Spiegelman The future of brown adipose tissues in the treatment of type 2 diabetes Diabetologia 58 2015 1704 1707
25. B.M. Spiegelman Banting Lecture 2012: Regulation of adipogenesis: toward new therapeutics for metabolic disease Diabetes 62 2013 1774 1782
26. M.J. Vosselman, A.A. van der Lans, B. Brans, R. Wierts, M.A. van Baak, P. Schrauwen, and W.D. van Marken Lichtenbelt Systemic β-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans Diabetes 61 2012 3106 3113
27. Yamamoto, N., Ueda, M., Sato, T., Kawasaki, K., Sawada, K., Kawabata, K., and Ashida, H. (2011). Measurement of glucose uptake in cultured cells. Current Protocols in Pharmacology, ed. S.J. Enna Chapter 12, Unit 12 14 11-22.