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Volumn 6, Issue OCT, 2015, Pages

The therapeutic potential of brown adipocytes in humans

Author keywords

Adipose tissue; Mitochondria; Obesity; Thermogenesis; Uncoupling protein 1

Indexed keywords

ADENOSINE TRIPHOSPHATE; FATTY ACID; MESSENGER RNA; UNCOUPLING PROTEIN 1;

EID: 84947080064     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2015.00156     Document Type: Review
Times cited : (36)

References (53)
  • 1
    • 84947116041 scopus 로고    scopus 로고
    • Health Unites States, 2013
    • Centers for Disease Control and Prevention/National Center for Health Statistics/Office of Analysis and Epidemiology. Health Unites States, 2013 (2014). Available from: http://www.cdc.gov/nchs/data/hus/hus13.pdf[[x00023]]064
    • (2014)
  • 2
    • 84906882822 scopus 로고    scopus 로고
    • Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013
    • Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2014) 384(9945):766-81. doi: 10.1016/S0140-6736(14)60460-8
    • (2014) Lancet , vol.384 , Issue.9945 , pp. 766-781
    • Ng, M.1    Fleming, T.2    Robinson, M.3    Thomson, B.4    Graetz, N.5    Margono, C.6
  • 3
    • 84906978168 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. National Diabetes Statistics Report (2014). Available from: http://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf
    • (2014) National Diabetes Statistics Report
  • 4
    • 84871055775 scopus 로고    scopus 로고
    • A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    • Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 380(9859):2224-60. doi:10.1016/S0140-6736(12)61766-8
    • (2012) Lancet , vol.380 , Issue.9859 , pp. 2224-2260
    • Lim, S.S.1    Vos, T.2    Flaxman, A.D.3    Danaei, G.4    Shibuya, K.5    Adair-Rohani, H.6
  • 5
    • 34948902196 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study
    • Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation (2007) 116(11):1234-41. doi:10.1161/CIRCULATIONAHA.107.710509
    • (2007) Circulation , vol.116 , Issue.11 , pp. 1234-1241
    • Pou, K.M.1    Massaro, J.M.2    Hoffmann, U.3    Vasan, R.S.4    Maurovich-Horvat, P.5    Larson, M.G.6
  • 6
    • 34547514221 scopus 로고    scopus 로고
    • Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
    • Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology (2007) 133(2):496-506. doi:10.1053/j.gastro.2007.04.068
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 496-506
    • Gastaldelli, A.1    Cusi, K.2    Pettiti, M.3    Hardies, J.4    Miyazaki, Y.5    Berria, R.6
  • 7
    • 0030854715 scopus 로고    scopus 로고
    • Cellular energy utilization and molecular origin of standard metabolic rate in mammals
    • Rolfe D, Brown G. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev (1997) 77:731-58.
    • (1997) Physiol Rev , vol.77 , pp. 731-758
    • Rolfe, D.1    Brown, G.2
  • 8
    • 79961055484 scopus 로고    scopus 로고
    • Implications of nonshivering thermogenesis for energy balance regulation in humans
    • van Marken Lichtenbelt WD, Schrauwen P. Implications of nonshivering thermogenesis for energy balance regulation in humans. Am J Physiol Regul Integr Comp Physiol (2011) 301(2):R285-96. doi:10.1152/ajpregu.00652.2010
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.301 , Issue.2 , pp. R285-R296
    • van Marken Lichtenbelt, W.D.1    Schrauwen, P.2
  • 9
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev (2004) 84(1):277-359. doi:10.1152/physrev.00015.2003
    • (2004) Physiol Rev , vol.84 , Issue.1 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 10
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 360(15):1509-17. doi:10.1056/NEJMoa0810780
    • (2009) N Engl J Med , vol.360 , Issue.15 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3    Tal, I.4    Rodman, D.5    Goldfine, A.B.6
  • 13
    • 0017927437 scopus 로고
    • The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation
    • Nicholls D, Bernson V, Heaton G. The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation. Experientia Suppl (1978) 32:89-93. doi:10.1007/978-3-0348-5559-4_9
    • (1978) Experientia Suppl , vol.32 , pp. 89-93
    • Nicholls, D.1    Bernson, V.2    Heaton, G.3
  • 14
    • 84867564026 scopus 로고    scopus 로고
    • Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria
    • Fedorenko A, Lishko P, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell (2012) 151:400-13. doi:10.1016/j.cell.2012.09.010
    • (2012) Cell , vol.151 , pp. 400-413
    • Fedorenko, A.1    Lishko, P.2    Kirichok, Y.3
  • 15
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab (2009) 9(2):203-9. doi:10.1016/j.cmet.2008.12.014
    • (2009) Cell Metab , vol.9 , Issue.2 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 16
    • 0037314231 scopus 로고    scopus 로고
    • Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
    • Liu X, Rossmeisl M, McClaine J, Riachi M, Harper ME, Kozak LP. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest (2003) 111(3):399-407. doi:10.1172/JCI200315737
    • (2003) J Clin Invest , vol.111 , Issue.3 , pp. 399-407
    • Liu, X.1    Rossmeisl, M.2    McClaine, J.3    Riachi, M.4    Harper, M.E.5    Kozak, L.P.6
  • 17
    • 33646402083 scopus 로고    scopus 로고
    • Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation
    • Inokuma K, Okamatsu-Ogura Y, Omachi A, Matsushita Y, Kimura K, Yamashita H, et al. Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation. Am J Physiol Endocrinol Metab (2006) 290(5):E1014-21. doi:10.1152/ajpendo.00105.2005
    • (2006) Am J Physiol Endocrinol Metab , vol.290 , Issue.5 , pp. E1014-E1021
    • Inokuma, K.1    Okamatsu-Ogura, Y.2    Omachi, A.3    Matsushita, Y.4    Kimura, K.5    Yamashita, H.6
  • 18
    • 77957577776 scopus 로고    scopus 로고
    • A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans
    • Lee P, Greenfield JR, Ho KK, Fulham MJ. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab (2010) 299(4):E601-6. doi:10.1152/ajpendo.00298.2010
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , Issue.4 , pp. E601-E606
    • Lee, P.1    Greenfield, J.R.2    Ho, K.K.3    Fulham, M.J.4
  • 19
    • 78650098848 scopus 로고    scopus 로고
    • Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    • Ouellet V, Routhier-Labadie A, Bellemare W, Lakhal-Chaieb L, Turcotte E, Carpentier AC, et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab (2011) 96(1):192-9. doi:10.1210/jc.2010-0989
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.1 , pp. 192-199
    • Ouellet, V.1    Routhier-Labadie, A.2    Bellemare, W.3    Lakhal-Chaieb, L.4    Turcotte, E.5    Carpentier, A.C.6
  • 20
    • 79959961564 scopus 로고    scopus 로고
    • Association between the presence of brown adipose tissue and non-alcoholic fatty liver disease in adult humans
    • Yilmaz Y, Ones T, Purnak T, Ozguven S, Kurt R, Atug O, et al. Association between the presence of brown adipose tissue and non-alcoholic fatty liver disease in adult humans. Aliment Pharmacol Ther (2011) 34(3):318-23. doi:10.1111/j.1365-2036.2011.04723.x
    • (2011) Aliment Pharmacol Ther , vol.34 , Issue.3 , pp. 318-323
    • Yilmaz, Y.1    Ones, T.2    Purnak, T.3    Ozguven, S.4    Kurt, R.5    Atug, O.6
  • 21
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity
    • Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes (2009) 58(7):1526-31. doi:10.2337/db09-0530
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1526-1531
    • Saito, M.1    Okamatsu-Ogura, Y.2    Matsushita, M.3    Watanabe, K.4    Yoneshiro, T.5    Nio-Kobayashi, J.6
  • 22
    • 84862495484 scopus 로고    scopus 로고
    • Increase in brown adipose tissue activity after weight loss in morbidly obese subjects
    • Vijgen GH, Bouvy ND, Teule GJ, Brans B, Hoeks J, Schrauwen P, et al. Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. J Clin Endocrinol Metab (2012) 97(7):E1229-33. doi:10.1210/jc.2012-1289
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.7 , pp. E1229-E1233
    • Vijgen, G.H.1    Bouvy, N.D.2    Teule, G.J.3    Brans, B.4    Hoeks, J.5    Schrauwen, P.6
  • 23
    • 78650676545 scopus 로고    scopus 로고
    • Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men
    • Yoneshiro TAS, Matsushita M, Kameya T, Nakada K, Kawai Y, Saito M. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity (2011) 19(1):13-6. doi:10.1038/oby.2010.105
    • (2011) Obesity , vol.19 , Issue.1 , pp. 13-16
    • Yoneshiro, T.A.S.1    Matsushita, M.2    Kameya, T.3    Nakada, K.4    Kawai, Y.5    Saito, M.6
  • 24
    • 84911896533 scopus 로고    scopus 로고
    • Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans
    • Chondronikola M, Volpi E, Borsheim E, Porter C, Annamalai P, Enerback S, et al. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes (2014) 63(12):4089-99. doi:10.2337/db14-0746
    • (2014) Diabetes , vol.63 , Issue.12 , pp. 4089-4099
    • Chondronikola, M.1    Volpi, E.2    Borsheim, E.3    Porter, C.4    Annamalai, P.5    Enerback, S.6
  • 25
    • 84856529575 scopus 로고    scopus 로고
    • Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
    • Ouellet V, Labbe SM, Blondin DP, Phoenix S, Guerin B, Haman F, et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest (2012) 122(2):545-52. doi:10.1172/JCI60433
    • (2012) J Clin Invest , vol.122 , Issue.2 , pp. 545-552
    • Ouellet, V.1    Labbe, S.M.2    Blondin, D.P.3    Phoenix, S.4    Guerin, B.5    Haman, F.6
  • 26
    • 84875794383 scopus 로고    scopus 로고
    • 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat
    • Muzik O, Mangner TJ, Leonard WR, Kumar A, Janisse J, Granneman JG. 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat. J Nucl Med (2013) 54(4):523-31. doi:10.2967/jnumed.112.111336
    • (2013) J Nucl Med , vol.54 , Issue.4 , pp. 523-531
    • Muzik, O.1    Mangner, T.J.2    Leonard, W.R.3    Kumar, A.4    Janisse, J.5    Granneman, J.G.6
  • 27
    • 84864087999 scopus 로고    scopus 로고
    • Assessment of oxidative metabolism in brown fat using PET imaging
    • Muzik O, Mangner TJ, Granneman JG. Assessment of oxidative metabolism in brown fat using PET imaging. Front Endocrinol (2012) 3:15. doi:10.3389/fendo.2012.00015
    • (2012) Front Endocrinol , vol.3 , pp. 15
    • Muzik, O.1    Mangner, T.J.2    Granneman, J.G.3
  • 28
    • 84881221754 scopus 로고    scopus 로고
    • Recruited brown adipose tissue as an antiobesity agent in humans
    • Yoneshiro T, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, et al. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest (2013) 123(8):3404-8. doi:10.1172/JCI67803
    • (2013) J Clin Invest , vol.123 , Issue.8 , pp. 3404-3408
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3    Kayahara, T.4    Kameya, T.5    Kawai, Y.6
  • 29
    • 84907973405 scopus 로고    scopus 로고
    • Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans
    • Lee P, Smith S, Linderman J, Courville AB, Brychta RJ, Dieckmann W, et al. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes (2014) 63(11):3686-98. doi:10.2337/db14-0513
    • (2014) Diabetes , vol.63 , Issue.11 , pp. 3686-3698
    • Lee, P.1    Smith, S.2    Linderman, J.3    Courville, A.B.4    Brychta, R.J.5    Dieckmann, W.6
  • 30
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med (2011) 17(2):200-5. doi:10.1038/nm.2297
    • (2011) Nat Med , vol.17 , Issue.2 , pp. 200-205
    • Bartelt, A.1    Bruns, O.T.2    Reimer, R.3    Hohenberg, H.4    Ittrich, H.5    Peldschus, K.6
  • 32
    • 0036384894 scopus 로고    scopus 로고
    • Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region
    • Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging (2002) 29(10):1393-8. doi:10.1007/s00259-002-0902-6
    • (2002) Eur J Nucl Med Mol Imaging , vol.29 , Issue.10 , pp. 1393-1398
    • Hany, T.F.1    Gharehpapagh, E.2    Kamel, E.M.3    Buck, A.4    Himms-Hagen, J.5    von Schulthess, G.K.6
  • 33
    • 84855661101 scopus 로고    scopus 로고
    • The relationship between patients' serum glucose levels and metabolically active brown adipose tissue detected by PET/CT
    • Jacene HA, Cohade CC, Zhang Z, Wahl RL. The relationship between patients' serum glucose levels and metabolically active brown adipose tissue detected by PET/CT. Mol Imaging Biol (2011) 13(6):1278-83. doi:10.1007/s11307-010-0379-9
    • (2011) Mol Imaging Biol , vol.13 , Issue.6 , pp. 1278-1283
    • Jacene, H.A.1    Cohade, C.C.2    Zhang, Z.3    Wahl, R.L.4
  • 34
    • 84902265248 scopus 로고    scopus 로고
    • Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans
    • Matsushita M, Yoneshiro T, Aita S, Kameya T, Sugie H, Saito M. Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans. Int J Obes (Lond) (2013) 38(6): 812-7. doi:10.1038/ijo.2013.206
    • (2013) Int J Obes (Lond) , vol.38 , Issue.6 , pp. 812-817
    • Matsushita, M.1    Yoneshiro, T.2    Aita, S.3    Kameya, T.4    Sugie, H.5    Saito, M.6
  • 35
    • 79960945989 scopus 로고    scopus 로고
    • Different metabolic responses of human brown adipose tissue to activation by cold and insulin
    • Orava J, Nuutila P, Lidell ME, Oikonen V, Noponen T, Viljanen T, et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab (2011) 14(2):272-9. doi:10.1016/j.cmet.2011.06.012
    • (2011) Cell Metab , vol.14 , Issue.2 , pp. 272-279
    • Orava, J.1    Nuutila, P.2    Lidell, M.E.3    Oikonen, V.4    Noponen, T.5    Viljanen, T.6
  • 36
    • 84887168000 scopus 로고    scopus 로고
    • Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans
    • Orava J, Nuutila P, Noponen T, Parkkola R, Viljanen T, Enerback S, et al. Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans. Obesity (Silver Spring) (2013) 21(11): 2279-87. doi:10.1002/oby.20456
    • (2013) Obesity (Silver Spring) , vol.21 , Issue.11 , pp. 2279-2287
    • Orava, J.1    Nuutila, P.2    Noponen, T.3    Parkkola, R.4    Viljanen, T.5    Enerback, S.6
  • 37
    • 0022536596 scopus 로고
    • Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo
    • Ma SW, Foster DO. Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo. Can J Physiol Pharmacol (1986) 64(5):609-14. doi:10.1139/y86-101
    • (1986) Can J Physiol Pharmacol , vol.64 , Issue.5 , pp. 609-614
    • Ma, S.W.1    Foster, D.O.2
  • 38
    • 84924365670 scopus 로고    scopus 로고
    • Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
    • Berbee JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, et al. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun (2015) 6:6356. doi:10.1038/ncomms7356
    • (2015) Nat Commun , vol.6 , pp. 6356
    • Berbee, J.F.1    Boon, M.R.2    Khedoe, P.P.3    Bartelt, A.4    Schlein, C.5    Worthmann, A.6
  • 39
    • 85052358587 scopus 로고    scopus 로고
    • The functional role of brown adipose tissue in whole-body lipid metabolism in humans (1160.3)
    • Chondronikola M, Porter C, Hurren N, Chao T, Yfanti C, Labbé S, et al. The functional role of brown adipose tissue in whole-body lipid metabolism in humans (1160.3). FASEB J (2014) 28(1 Suppl).
    • (2014) FASEB J , vol.28 , Issue.1
    • Chondronikola, M.1    Porter, C.2    Hurren, N.3    Chao, T.4    Yfanti, C.5    Labbé, S.6
  • 41
    • 0021319695 scopus 로고
    • Brown adipose tissue in the parametrial fat pad of the mouse
    • Young P, Arch J, Ashwell M. Brown adipose tissue in the parametrial fat pad of the mouse. FEBS Lett (1984) 167:10-4. doi:10.1016/0014-5793(84)80822-4
    • (1984) FEBS Lett , vol.167 , pp. 10-14
    • Young, P.1    Arch, J.2    Ashwell, M.3
  • 42
    • 0027051199 scopus 로고
    • Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization
    • Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Pénicaud L, et al. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci (1992) 103:931-42.
    • (1992) J Cell Sci , vol.103 , pp. 931-942
    • Cousin, B.1    Cinti, S.2    Morroni, M.3    Raimbault, S.4    Ricquier, D.5    Pénicaud, L.6
  • 43
    • 84890234667 scopus 로고    scopus 로고
    • UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic
    • Shabalina I, Petrovic N, de Jong J, Kalinovich A, Cannon B, Nedergaard J. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Rep (2013) 5:1196-203. doi:10.1016/j.celrep.2013.10.044
    • (2013) Cell Rep , vol.5 , pp. 1196-1203
    • Shabalina, I.1    Petrovic, N.2    de Jong, J.3    Kalinovich, A.4    Cannon, B.5    Nedergaard, J.6
  • 44
    • 84881260642 scopus 로고    scopus 로고
    • Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
    • van der Lans A, Hoeks J, Brans B, Vijgen G, Visser M, Vosselman M, et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest (2013) 123:3395-403. doi:10.1172/JCI68993
    • (2013) J Clin Invest , vol.123 , pp. 3395-3403
    • van der Lans, A.1    Hoeks, J.2    Brans, B.3    Vijgen, G.4    Visser, M.5    Vosselman, M.6
  • 45
    • 0020466632 scopus 로고
    • Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma
    • Ricquier D, Nechad M, Mory G. Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma. J Clin Endocrinol Metab (1982) 54:803-7.
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 803-807
    • Ricquier, D.1    Nechad, M.2    Mory, G.3
  • 46
    • 84875858745 scopus 로고    scopus 로고
    • White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma
    • Frontini A, Vitali A, Perugini J, Murano I, Romiti C, Ricquier D, et al. White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma. Biochim Biophys Acta (2013) 1831:950-9. doi:10.1016/j.bbalip.2013.02.005
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 950-959
    • Frontini, A.1    Vitali, A.2    Perugini, J.3    Murano, I.4    Romiti, C.5    Ricquier, D.6
  • 47
    • 84938568273 scopus 로고    scopus 로고
    • Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress
    • Sidossis L, Porter C, Saraf M, Borsheim E, Radhakrishnan R, Chao T, et al. Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress. Cell Metab (2015) 22:219-27. doi:10.1016/j.cmet.2015.06.022
    • (2015) Cell Metab , vol.22 , pp. 219-227
    • Sidossis, L.1    Porter, C.2    Saraf, M.3    Borsheim, E.4    Radhakrishnan, R.5    Chao, T.6
  • 48
    • 0031870869 scopus 로고    scopus 로고
    • Organ-tissue mass measurement allows modeling of REE and metabolically active tissue mass
    • Gallagher D, Belmonte D, Deurenberg P, Wang Z, Krasnow N, Pi-Sunyer F, et al. Organ-tissue mass measurement allows modeling of REE and metabolically active tissue mass. Am J Physiol (1998) 275:249-58.
    • (1998) Am J Physiol , vol.275 , pp. 249-258
    • Gallagher, D.1    Belmonte, D.2    Deurenberg, P.3    Wang, Z.4    Krasnow, N.5    Pi-Sunyer, F.6
  • 49
    • 0018990649 scopus 로고
    • Systemic responses to injury and the healing wound
    • Wilmore D, Aulick L. Systemic responses to injury and the healing wound. JPEN J Parenter Enteral Nutr (1980) 4:147-51. doi:10.1177/0148607180004002147
    • (1980) JPEN J Parenter Enteral Nutr , vol.4 , pp. 147-151
    • Wilmore, D.1    Aulick, L.2
  • 51
    • 0016292807 scopus 로고
    • Catecholamines: mediator of the hypermetabolic response to thermal injury
    • Wilmore D, Long J, Mason AJ, Skreen R, Pruitt BJ. Catecholamines: mediator of the hypermetabolic response to thermal injury. Ann Surg (1974) 180:653-69. doi:10.1097/00000658-197410000-00031
    • (1974) Ann Surg , vol.180 , pp. 653-669
    • Wilmore, D.1    Long, J.2    Mason, A.J.3    Skreen, R.4    Pruitt, B.J.5
  • 53
    • 0032916518 scopus 로고    scopus 로고
    • The metabolic basis of the increase of the increase in energy expenditure in severely burned patients
    • Yu YM, Tompkins RG, Ryan CM, Young VR. The metabolic basis of the increase of the increase in energy expenditure in severely burned patients. JPEN J Parenter Enteral Nutr (1999) 23:160-8. doi:10.1177/0148607199023003160
    • (1999) JPEN J Parenter Enteral Nutr , vol.23 , pp. 160-168
    • Yu, Y.M.1    Tompkins, R.G.2    Ryan, C.M.3    Young, V.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.