The genetics of brown adipocyte induction in white fat depots

Frontiers in Endocrinology

Volumn 2, Issue OCT, 2011, Pages

  Kozak, Leslie P ^a  

^a INSTITUTE OF ANIMAL REPRODUCTION AND FOOD RESEARCH   (Poland)

Author keywords

Backcross analysis; Quantitative trait loci; Recombinantinbred strains of mice; Retroperitoneal fat depot; Synergistic interaction of regulatory genes; Transgressive variation; Ucp1 mrna

Indexed keywords

EID: 84874377962     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2011.00064     Document Type: Review

References (51)

1. Almind, K., Manieri, M., Sivitz, W. I., Cinti, S., and Kahn, C. R. (2007). Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syn- drome in mice. Proc. Natl. Acad. Sci. U.S.A. 104, 2366-2371.
2. Anunciado-Koza, R., Zhang, J., Ukropec, J., Bajpeyi, S., Koza, R. A., Rogers, R. C., Cefalu, W. T., Mynatt, R. L., and Kozak, L. P. (2011). Inacti- vation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi trans- porter) reduces physical endurance and metabolic efficiency in mice. J. Biol. Chem. 286, 11659-11671.
3. Bailey, D. W. (1971). Recombinant inbred strains. Transplantation 11, 325-327.
4. Bartness, T. J., and Bamshad, M. (1998). Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am. J. Physiol. 275, R1399-R1411.
5. Berg, F., Gustafson, U., and Anders-son, L. (2006). The uncoupling pro- tein 1 gene (UCP1) is disrupted in the pig lineage: a genetic expla- nation for poor thermoregulation in piglets. PLoS Genet. 2, e129. doi:10.1371/journal.pgen.0020129
6. Brem, R. B., and Kruglyak, L. (2005). The lanscape of genetic complexity across 5,700 gene expression traits in yeast. Proc. Natl. Acad. Sci. U.S.A. 102, 1572-1577.
7. Bukowiecki, L., Collet, A. J., Follea, N., Guay, G., and Jahjah, L. (1982). Brown adipose tissue hyperplasia: a fundamental mechanism of adapta- tion to cold and hyperphagia. Am. J. Physiol. 242, E353-E359.
8. Cannon, B., and Nedergaard, J. (2004). Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359.
9. ′- flanking region. Mol. Endocrinol. 7, 497-506.
10. Cederberg, A., Gronning, L. M., Ahren, B., Tasken, K., Carlsson, P., and Ener-back, S. (2001). FOXC2 is a winged helix gene that counteracts obe- sity, hypertriglyceridemia, and diet- induced insulin resistance. Cell 106, 563-573.
11. Champigny, O., Ricquier, D., Blondel, O., Mayers, R. M., Briscoe, M. G., and Holloway, B. R. (1991). Beta 3-adrenergic receptor stimula- tion restores message and expres-sion of brown-fat mitochondrial uncoupling protein in adult dogs. Proc. Natl. Acad. Sci. U.S.A. 88, 10774-10777.
12. Christian, M., Kiskinis, E., Debevec, D., Leonardsson, G., White, R., and Parker, M. G. (2005). RIP140- targeted repression of gene expres- sion in adipocytes. Mol. Cell. Biol. 25, 9383-9391.
13. Cinti, S. (2002). Adipocyte differentia- tion and transdifferentiation: plas- ticity of the adipose organ. J. Endocrinol. Invest. 25, 823-835.
14. Collins, S., Daniel, K. W., Petro, A. E., and Surwit, R. S. (1997). Strain-specific response to beta 3- adrenergic receptor agonist treat- ment of diet-induced obesity in mice. Endocrinology 138, 405-413.
15. Coulter, A. A., Bearden, C. M., Liu, X., Koza, R. A., and Kozak, L. P. (2003). Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conver- sion of white to brown fat. Physiol. Genomics 14, 139-147.
16. Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y. H., Doria, A., Kolodny, G. M., and Kahn, C. R. (2009). Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360, 1509-1517.
17. Enerback, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M. E., and Kozak, L. P. (1997). Mice lacking mitochondr- ial uncoupling protein are cold- sensitive but not obese. Nature 387, 90-94.
18. Eppig, J. J., Wigglesworth, K., Varnum, D. S., and Nadeau, J. H. (1996). Genetic regulation of traits essen- tial for spontaneous ovarian ter- atocarcinogenesis in strain LT/Sv mice: aberrant meiotic cell cycle, oocyte activation, and partheno- genetic development. Cancer Res. 56, 5047-5054.
19. ′-deiodinase activ- ity is necessary for the response to environmental temperature at birth. Eur. J. Biochem. 193, 297-302.
20. Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., and Kozak, L. P. (1998). Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102, 412-420.
21. Hansen, J. B., Jorgensen, C., Petersen, R. K., Hallenborg, P., De Matteis, R., Boye, H. A., Petrovic, N., Ener-back, S., Nedergaard, J., Cinti, S., Te Riele, H., and Kristiansen, K. (2004). Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte dif- ferentiation. Proc. Natl. Acad. Sci. U.S.A. 101, 4112-4117.
22. Hansen,J. B.,and Kristiansen,K. (2006). Regulatory circuits controlling white versus brown adipocyte differentia- tion. Biochem. J. 398, 153-168.
23. Himms-Hagen, J., Cui, J., Danforth, E. Jr., Taatjes, D. J., Lang, S. S., Waters, B. L., and Claus, T. H. (1994). Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am. J. Physiol. 266, R1371- R1382.
24. Himms-Hagen, J., Melnyk, A., Zin- garetti, M. C., Ceresi, E., Barbatelli, G., and Cinti, S. (2000). Multilocu- lar fat cells in WAT of CL-316243- treated rats derive directly from white adipocytes. Am. J. Physiol. Cell Physiol. 279, C670-C681.
25. Hirning, U., Schmid, P., Schulz, W. A., Kozak, L. P., and Hameister, H. (1989). In developing brown adipose tissue c-myc protooncogene expres- sion is restricted to early differen- tiation stages. Cell Differ. Dev. 27, 243-248.
26. Hofmann, W. E., Liu, X., Bear-den, C. M., Harper, M.-E., and Kozak, L. P. (2001). Effects of genetic background on thermoregu- lation and fatty acid-induced uncou- pling of mitochondria in UCP1- deficient mice. J. Biol. Chem. 276, 12460-12465.
27. Houstek, J., Kopecky, J., Rychter, Z., and Soukup, T. (1988). Uncoupling protein in embryonic brown adi- pose tissue-existence of non ther- mogenic and thermogenic mito- chondria. Biochim. Biophys. Acta 935, 19-25.
28. Kajimura, S., Seale, P., and Spiegelman, B. M. (2010). Transcriptional con- trol of brown fat development. Cell Metab. 11, 257-262.
29. Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., and Spiegelman, B. M. (2008). Regulation of the brown and white fat gene pro- grams through a PRDM16/CtBP transcriptional complex. Genes Dev. 22, 1397-1409.
30. Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., and Wahli, W. (1999). Perox- isome proliferator-activated recep- tor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103, 1489-1498.
31. Koza, R. A., Hohmann, S. M., Guerra, C., Rossmeisl, M., and Kozak, L. P. (2000). Synergistic gene interac- tions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue. J. Biol. Chem. 275, 34486-34492.
32. Kozak, L. P. (2010). Brown fat and the myth of diet-induced thermogene- sis. Cell Metab. 11, 263-267.
33. Kozak, L. P., and Koza, R. A. (2010). The genetics of brown adipose tis- sue. Prog. Mol. Biol. Transl. Sci. 94, 75-123.
34. Kozak, U. C., Kopecky, J., Teisinger, J., Enerback, S., Boyer, B., and Kozak, L. P. (1994). An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol. Cell. Biol. 14, 59-67.
35. Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P. W., Medina-Gomez, G., Vidal-Puig,A.,White, R., and Parker, M. G. (2004). Nuclear receptor corepres- sor RIP140 regulates fat accumula- tion. Proc. Natl. Acad. Sci. U.S.A. 101, 8437-8442.
36. Nogami, S., Ohya, Y., and Yvert, G. (2007). Genetic complexity and quantitative trait loci mapping of yeast morphological traits. PLoS Genet. 3, e31. doi:10.1371/jour- nal.pgen.0030031
37. Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., and Spiegel- man, B. M. (1998). A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839.
38. Rothwell, N. J., and Stock, M. J. (1979). A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31-35.
39. Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scime, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., Tempst, P., Rudnicki, M. A., Beier, D. R., and Spiegelman, B. M. (2008). PRDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961-967.
40. Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tav-ernier, G., Langin, D., and Spiegel-man, B. M. (2007). Transcriptional control of brown fat determina- tion by PRDM16. Cell Metab. 6, 38-54.
41. Sears, I. B., Macginnitie, M. A., Kovacs, L. G., and Graves, R. A. (1996). Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regula-tion by peroxisome proliferator- activated receptor gamma. Mol. Cell. Biol. 16, 3410-3419.
42. Seldin, M. F., Mott, D., Bhat, D., Petro, A., Kuhn, C. M., Kingsmore, S. F., Bogardus, C., Opara, E., Feinglos, M. N., and Surwit, R. S. (1994). Glycogen synthase: a putative locus for diet-induced hyperglycemia. J. Clin. Invest. 94, 269-276.
43. Shockley, K. R., and Churchill, G. A. (2006). Gene expression analy- sis of mouse chromosome substi- tution strains. Mamm. Genome 17, 598-614.
44. Smith, R. E., and Horwitz, B. A. (1969). Brown fat and thermogenesis. Phys- iol. Rev. 49, 330-425.
45. Staszkiewicz, J., Gimble, J., Cain, C., Dietrich, M., Burk, D., Kirk- Ballard, H., and Gawronska-Kozak, B. (2009). Flow cytometric and immunohistochemical detection of in vivo BrdU-labeled cells in mouse fat depots. Biochem. Biophys. Res. Commun. 378, 539-544.
46. Taylor, B. A. (1981). "Recombinant inbred strains," in Genetic Variants and Strains of the Laboratory Mouse, ed. M. C. Green (New York: Gustav Fischer Verlag). 397-407.
47. Trayhurn, P., Temple, N. J., and Van Aerde, J. (1989). Evidence from immunoblotting studies on uncou- pling protein that brown adipose tis- sue is not present in the domestic pig. Can. J. Physiol. Pharmacol. 67, 1480-1485.
48. Van Marken Lichtenbelt, W. D., Van-hommerig, J. W., Smulders, N. M., Drossaerts, J. M., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., and Teule, G. J. (2009). Cold-activated brown adipose tissue in healthy men. N.Engl.J.Med.360, 1500-1508.
49. Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N. J., Enerback, S., and Nuutila, P. (2009). Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518-1525.
50. Xue, B., Coulter, A., Rim, J. S., Koza, R. A., and Kozak, L. P. (2005). Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol. Cell. Biol. 25, 8311-8322.
51. Xue, B., Rim, J. S., Hogan, J. C., Coulter, A. A., Koza, R. A., and Kozak, L. P. (2007). Genetic variability affects the development of brown adipocytes in white fat but not in interscapu- lar brown fat. J. Lipid Res. 48, 41-51.