Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Okamatsu Ogura, Yuko ^a   Fukano, Keigo ^a   Tsubota, Ayumi ^a   Uozumi, Akihiro ^a   Terao, Akira ^a   Kimura, Kazuhiro ^a   Saito, Masayuki ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TENSHI COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION, PHYSIOLOGICAL; ADIPOCYTES; ANIMALS; COLD TEMPERATURE; ION CHANNELS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; OXYGEN CONSUMPTION; THERMOGENESIS;

EID: 84893586190     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084229     Document Type: Article

References (53)

1. Cannon B, Nedergaard J. (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84(1): 277-359. (Pubitemid 38054374)
2. Frontini A, Cinti S. (2010) Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab 11(4): 253-256.
3. Cinti S. (2012) The adipose organ at a glance. Dis Model Mech 5(5): 588-594.
4. Klingenspor M. (2003) Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 88(1): 141-148.
5. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, et al. (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58(7): 1526-1531.
6. Enerbäck S. (2010) Human brown adipose tissue. Cell Metab 11(4): 248-252.
7. Yoneshiro T, Aita S, Matsushita M, Kayahara T, Kameya T, et al. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 123(8): 3404-3408.
8. Seale P, Kajimura S, Spiegelman BM. (2009) Transcriptional control of brown adipocyte development and physiological function-of mice and men. Genes Dev 23(7): 788-797.
9. Cinti S. (2009) Transdifferentiation properties of adipocytes in the adipose organ. Am J Physiol Endocrinol Metab 297(5): E977-E986.
10. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, et al. (1992) Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 103 (Pt 4): 931-942. (Pubitemid 23042237)
11. Ghorbani M, Himms-Hagen J. (1997) Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int J Obes Relat Metab Disord 21(6): 465-475. (Pubitemid 27236965)
12. Inokuma K, Okamatsu-Ogura Y, Omachi A, Matsushita Y, Kimura K, et al. (2006) Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation. Am J Physiol Endocrinol Metab 290(5): E1014-E1021.
13. Barbatelli G, Murano I, Madsen L, Hao Q, Jimenez M, et al. (2010) The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab 298(6): E1244-E1253.
14. Kajimura S, Seale P, Spiegelman BM. (2010) Transcriptional control of brown fat development. Cell Metab 11(4): 257-262.
15. Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, et al. (2010) Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 285(10): 7153-7164.
16. Seale P, Kajimura S, Yang W, Chin S, Rohas LM, et al. (2007) Transcriptional control of brown fat determination by PRDM16. Cell Metab 6(1): 38-54. (Pubitemid 47008902)
17. Wu J, Boström P, Sparks LM, Ye L, Choi JH, et al. (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150(2): 366-376.
18. Sharp LZ, Shinoda K, Ohno H, Scheel DW, Tomoda E, et al. (2012) Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One 7(11): e49452.
19. Lidell ME, Betz MJ, Dahlqvist Leinhard O, Heglind M, Elander L, et al. (2013) Evidence for two types of brown adipose tissue in humans. Nat Med 19(5): 631-634.
20. Kopecky J, Clarke G, Enerbäck S, Spiegelman B, Kozak LP. (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 96(6): 2914-2923.
21. Soloveva V, Graves RA, Rasenick MM, Spiegelman BM, Ross SR. (1997) Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity. Mol Endocrinol 11(1): 27-38. (Pubitemid 27021251)
22. Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, et al. (2001) Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med 7(10): 1128-1132. (Pubitemid 33010021)
23. Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, et al. (2004) Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc Natl Acad Sci U S A 101(22): 8437-8442. (Pubitemid 38736593)
24. Scimè A, Grenier G, Huh MS, Gillespie MA, Bevilacqua L, et al. (2005) Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab 2(5): 283-295.
25. Auffret J, Viengchareun S, Carré N, Denis RG, Magnan C, et al. (2012) Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity. FASEB J 26(9): 3728-3237.
26. Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, et al. (2011) Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 121(1): 96-105.
27. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. (2012) PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 15(3): 395-404.
28. Lee P, Werner CD, Kebebew E, Celi FS. (2013) Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes (Lond). In press.
29. Okamatsu-Ogura Y, Nio-Kobayashi J, Iwanaga T, Terao A, Kimura K, et al. (2011) Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp Biol Med (Maywood) 236(11): 1274-1281.
30. Nedergaard J, Cannon B. (2013) UCP1 mRNA does not produce heat. Biochim Biophys Acta 1831(5): 943-949.
31. Omachi A, Matsushita Y, Kimura K, Saito M. (2008) Role of uncoupling protein 1 in the anti-obesity effect of beta3-adrenergic agonist in the dog. Res Vet Sci 85(2): 214-219.
32. Shimada K, Ohno Y, Okamatsu-Ogura Y, Suzuki M, Kamikawa A, Terao A, et al. (2012) Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes. Peptides 34(2): 336-342.
33. Collins S, Daniel KW, Petro AE, Surwit RS. (1997) Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology. 138(1): 405-413. (Pubitemid 27009450)
34. Seale P, Bjork B, Yang W, Kajimura S, Chin S,et al. (2008) PRDM16 controls a brown fat/skeletal muscle switch. Nature 454(7207): 961-967.
35. Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, et al. (2011) Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem 286(15): 12983-12990.
36. Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, et al. (2012) FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 26(3): 271-281.
37. Golozoubova V, Hohtola E, Matthias A, Jacobsson A, Cannon B, et al. (2001) Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J 15(11): 2048-2050.
38. Nedergaard J, Golozoubova V, Matthias A, Asadi A, Jacobsson A, et al. (2001) UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta 1504(1): 82-106. (Pubitemid 32179660)
39. Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, et al. (2011) Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A 108(1): 143-148.
40. Tran KV, Gealekman O, Frontini A, Zingaretti MC, Morroni M, et al. (2012) The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab 15(2): 222-229.
41. Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessì-Fulgheri P, et al. (2012) Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest 122(3): 1022-1036.
42. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, et al. (2012) Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481(7382): 463-468.
43. Stefl B, Janovská A, Hodný Z, Rossmeisl M, Horáková M,et al. (1998) Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice. Am J Physiol 274(3 Pt 1): E527-E533.
44. Li B, Nolte LA, Ju JS, Han DH, Coleman T, et al. (2000) Skeletal muscle respiratory unco upling prevents diet-induced obesity and insulin resistance in mice. Nat Med 6(10): 1115-1120.
45. Han DH, Nolte LA, Ju JS, Coleman T, Holloszy JO, et al. (2004) UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. Am J Physiol Endocrinol Metab 286(3): E347-E353. (Pubitemid 38292683)
46. Dupuis L, Gonzalez de Aguilar JL, Echaniz-Laguna A, Eschbach J, Rene F, et al (2009) Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons. PLoS One 4(4): e5390.
47. Baumruk F, Flachs P, Horáková M, Floryk D, Kopecký J. (1999) Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential. FEBS Lett. 444(2-3): 206-210. (Pubitemid 29092803)
48. Flachs P, Rossmeisl M, Kuda O, Kopecky J. (2013) Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: a key to lean phenotype. Biochim Biophys Acta. 1831(5): 986-1003.
49. Lin CS, Klingenberg M. (1982) Characteristics of the isolated purine nucleotide binding protein from brown fat mitochondria. Biochemistry. 21(12): 2950-2956.
50. Nedergaard J. (1982) Catecholamine sensitivity in brown fat cells from cold-acclimated hamsters and rats. Am J Physiol 242(3): C250-C257.
51. Svartengren J, Svoboda P, Cannon B. (1982) Desensitisation of beta-adrenergic responsiveness in vivo. Decreased coupling between receptors and adenylate cyclase in isolated brown-fat cells. Eur J Biochem 128(2-3): 481-488. (Pubitemid 13182607)
52. Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. (1998) Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 102(2): 412-420. (Pubitemid 28335201)
53. Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, et al. (2007) Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 48(1): 41-51. (Pubitemid 46052896)