Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue

European Journal of Applied Physiology

Volumn 109, Issue 2, 2010, Pages 307-316

  Camera, Donny M ^a   Anderson, Mitchell J ^a   Hawley, John A ^a   Carey, Andrew L ^a,b  

^a RMIT UNIVERSITY   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Adrenergic; BAT; Brown adipose; Mitochondrial; Obesity; UCP1; WAT; White adipose

Indexed keywords

ABDOMINAL SUBCUTANEOUS FAT; ADULT; ARTICLE; ENDURANCE; EXERCISE; GENE EXPRESSION PROFILING; HUMAN; MALE; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

EXERCISE; GENE EXPRESSION PROFILING; HUMANS; MALE; OXIDATION-REDUCTION; PHYSICAL ENDURANCE; SUBCUTANEOUS FAT, ABDOMINAL; YOUNG ADULT;

EID: 77953543325     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1356-3     Document Type: Article

References (55)

1. Almind K, Manieri M, Sivitz WI, Cinti S, Kahn CR (2007) Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci USA 104:2366-2371
2. Bruce CR, Anderson MJ, Carey AL, Newman DG, Bonen A, Kriketos AD, Cooney GJ, Hawley JA (2003) Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status. J Clin Endocrinol Metab 88:5444-5451
3. Bulow J, Madsen J (1978) Human adipose tissue blood flow during prolonged exercise II. Pflugers Arch 376:41-45
4. Cinti S (2009) Transdifferentiation properties of adipocytes in the adipose organ. Am J Physiol Endocrinol Metab 297: E977-E986
5. Collins S, Surwit RS (2001) The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog Horm Res 56:309-328
6. Crowe S, Turpin SM, Ke F, Kemp BE, Watt MJ (2008) Metabolic remodeling in adipocytes promotes ciliary neurotrophic factormediated fat loss in obesity. Endocrinology 149:2546-2556
7. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509-1517
8. De Matteis R, Arch JR, Petroni ML, Ferrari D, Cinti S, Stock MJ (2002) Immunohistochemical identification of the beta (3)-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine. Int J Obes Relat Metab Disord 26:1442-1450
9. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9:203-209
10. Frayn KN (1998) Regulation of fatty acid delivery in vivo. Adv Exp Med Biol 441:171-179
11. Frayn KN, Langin D, Karpe F (2008) Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased. Diabetologia 51:394-397
12. Gesta S, Tseng Y, Kahn R (2007) Developmental origin of fat: tracking obesity to its source. Cell 131:242-256
13. Gibala MJ, Little JP, van Essen M, Wilkin GP, Burgomaster KA, Safdar A, Raha S, Tarnopolsky MA (2006) Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol 575:901-911
14. Green HJ, Jones S, Ball-Burnett ME, Smith D, Livesey J, Farrance BW (1991) Early muscular and metabolic adaptations to prolonged exercise training in humans. J Appl Physiol 70:2032-2038
15. Green HJ, Jones S, Ball-Burnett M, Farrance B, Ranney D (1995) Adaptations in muscle metabolism to prolonged voluntary exercise and training. J Appl Physiol 78:138-145
16. Hallgren P, Korsback S, Sjostrom L (1986) Measurements of adipose tissue respiration in a closed chamber using an oxygen sensor: methodological considerations. J Lipid Res 27:996-1005
17. Hamosh M, Hamosh P, Bar-Maor JA, Cohen H (1963) Fatty-acid metabolism by human adipose tissues. J Clin Invest 42:1648-1652
18. Hawley JA, Noakes TD (1992) Peak power output predicts maximal oxygen uptake and performance time in trained cyclists. Eur J Appl Physiol Occup Physiol 65:79-83
19. Horowitz JF, Klein S (2000) Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. Am J Physiol Endocrinol Metab 278: E1144-E1152
20. Hotamisligil G (2006) Inflammation and metabolic disorders. Nature 444:860-867
21. Hull D, Segall MM (1965) Sympathetic nervous control of brown adipose tissue and heat production in the new-born rabbit. J Physiol 181:458-467
22. Huttunen P, Hirvonen J, Kinnula V (1981) The occurrence of brown adipose tissue in outdoor workers. Eur J Appl Physiol Occup Physiol 46:339-345
23. Jeukendrup A, Saris W, Schrauwen P, Brouns F, Wagenmakers A (1995) Metabolic availability of medium chain triglycerides coingested with carbohydrates during prolonged exercise. J Appl Physiol 79:756-762
24. Krief S, Lonnqvist F, Raimbault S, Baude B, Van Spronsen A, Arner P, Strosberg AD, Ricquier D, Emorine LJ (1993) Tissue distribution of beta 3-adrenergic receptor mRNA in man. J Clin Invest 91:344-349
25. Larue-Achagiotis C, Goubern M, Laury MC, Louis-Sylvestre J (1994) Energy balance in an inbred strain of rats: comparison with the Wistar strain. Physiol Behav 55:483-487
26. Laye MJ, Rector RS, Warner SO, Naples SP, Perretta AL, Uptergrove GM, Laughlin MH, Thyfault JP, Booth FW, Ibdah JA (2009) Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats. J Physiol 587:3729-3739
27. Lefebvre AM, Laville M, Vega N, Riou JP, van Gaal L, Auwerx J, Vidal H (1998) Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 47:98-103
28. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 270:12953-12956
29. Maassen JA, Romijn JA, Heine RJ (2007) Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus. Diabetologia 50:2036-2041
30. McConell GK, Lee-Young RS, Chen ZP, Stepto NK, Huynh NN, Stephens TJ, Canny BJ, Kemp BE (2005) Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen. J Physiol 568:665-676
31. Nedergaard J, Bengtsson T, Cannon B (2007) Active brown adipose tissue and adult humans. Am J Physiol Endocrinol Metab 293:444-452
32. Oberkofler H, Dallinger G, Liu YM, Hell E, Krempler F, Patsch W (1997) Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans. J Lipid Res 38:2125-2133
33. Ostman J, Arner P, Engfeldt P, Kager L (1979) Regional differences in the control of lipolysis in human adipose tissue. Metabolism 28:1198-1205
34. Peronnet F, Massicotte D (1991) Table of nonprotein respiratory quotient: an update. Can J Sport Sci 16:23-29
35. Peronnet F, Cleroux J, Perrault H, Cousineau D, De Champlain J, Nadeau R (1981) Plasma norepinephrine response to exercise before and after training in humans. J Appl Physiol 51:812-815
36. Petrovic N, Shabalina IG, Timmons JA, Cannon B, Nedergaard J (2008) Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist. Am J Physiol Endocrinol Metab 295: E287-E296
37. Phillips SM, Green HJ, Tarnopolsky MA, Heigenhauser GJ, Grant SM (1996) Progressive effect of endurance training on metabolic adaptations in working skeletal muscle. Am J Physiol 270: E265-E272
38. Puigserver P (2005) Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha. Int J Obes (Lond) 29: S5-S9
39. Ricquier D, Nechad M, Mory G (1982) Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma. Clin Endocrinol Metab 54:803-807
40. Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58:1526-1531
41. Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM (2007) Transcriptional control of brown fat determination by PRDM16. Cell Metab 6:38-54
42. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe H, Erdjument-Bromage H, Tempst P, Rudnick M, Beier D, Spigelman B (2008) PRMD16 controls a brown fat/skeletal muscle switch. Nature 454:21
43. Smith DJ, Deuster PA, Ryan CJ, Doubt TJ (1990) Prolonged whole body immersion in cold water: hormonal and metabolic changes. Undersea Biomed Res 17:139-147
44. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Naslund E, Britton T, Concha H, Hassan M, Ryden M, Frisen J, Arner P (2008) Dynamics of fat cell turnover in humans. Nature 453:783-787
45. Stallknecht B, Vinten J, Ploug T, Galbo H (1991) Increased activities of mitochondrial enzymes in white adipose tissue in trained rats. Am J Physiol 261: E410-E414
46. Sutherland LN, Bomhof MR, Capozzi LC, Basaraba SA, Wright DC (2009) Exercise and adrenaline increase PGC-1{alpha} mRNA expression in rat adipose tissue. J Physiol 587:1607-1617
47. Timmons J, Wennmalm K, Larsson O, Walden T, Lassman T, Petrovic N, Hamilton D, Gimeno R, Wahlestedt C, Baar K, Nedergaard J, Cannon B (2007) Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci USA 104:4401-4406
48. Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D, Langin D (2003) Acquirement of brown fat cell features by human white adipocytes. J Biol Chem 278:33370-33376
49. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR (2008b) New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454:1000-1004
50. Valerio A, Cardile A, Cozzi V, Bracale R, Tedesco L, Pisconti A, Palomba L, Cantoni O, Clementi E, Moncada S, Carruba MO, Nisoli E (2006) TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest 116:2791-2798
51. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500-1508
52. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P (2009) Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518-1525
53. Wilson-Fritch L, Burkart A, Bell G, Mendelson K, Leszyk J, Nicoloro S, Czech M, Corvera S (2003) Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol 23:1085-1094
54. Yang X, Enerback S, Smith U (2003) Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Obes Res 11:1182-1191
55. Youngren JF, Keen S, Kulp JL, Tanner CJ, Houmard JA, Goldfine ID (2001) Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training. Am J Physiol Endocrinol Metab 280: E528-E533