TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Neuron

Volumn 95, Issue 2, 2017, Pages 297-308.e6

  Paolicelli, Rosa C ^a   Jawaid, Ali ^a   Henstridge, Christopher M ^b   Valeri, Andrea ^a   Merlini, Mario ^a   Robinson, John L ^c   Lee, Edward B ^c   Rose, Jamie ^d   Appel, Stanley ^e   Lee, Virginia M Y ^c   Trojanowski, John Q ^c   Spires Jones, Tara ^b   Schulz, Paul E ^f   Rajendran, Lawrence ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e HOUSTON METHODIST HOSPITAL   (United States)

^f UNIVERSITY OF TEXAS   (United States)

Author keywords

Alzheimer's Disease; Amyloid; Amyotrophic Lateral Sclerosis; Clearance; Frontotemporal Lobar Degeneration; Microglia; Phagocytosis; Synapse Loss; Synaptic Pruning; Tardbp; TDP 43

Indexed keywords

AMYLOID; TAR DNA BINDING PROTEIN; DNA BINDING PROTEIN; TDP-43 PROTEIN, MOUSE;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MICROGLIA; MOUSE; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN METABOLISM; SYNAPSE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; BRAIN; COGNITION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

AMYLOID; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BRAIN; COGNITION; DNA-BINDING PROTEINS; MICE, TRANSGENIC; MICROGLIA; SYNAPSES;

EID: 85021321620     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2017.05.037     Document Type: Article

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