TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion

EMBO Journal

Volumn 35, Issue 2, 2016, Pages 121-142

  Xia, Qin ^a   Wang, Hongfeng ^a   Hao, Zongbing ^a   Fu, Cheng ^b   Hu, Qingsong ^a   Gao, Feng ^a   Ren, Haigang ^a   Chen, Dong ^a   Han, Junhai ^c   Ying, Zheng ^a,d   Wang, Guanghui ^a,b  

^a SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c SOUTHEAST UNIVERSITY   (China)

^d MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

ALS; Autophagy; mTORC1; TDP 43; TFEB

Indexed keywords

ADAPTOR PROTEIN; DYNACTIN; DYNACTIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN; TAR DNA BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TCFEB PROTEIN, MOUSE; TFEB PROTEIN, HUMAN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGOSOME LYSOSOME FUSION; AUTOPHAGY; BIOACCUMULATION; CELL FUSION; CONTROLLED STUDY; DOWN REGULATION; DROSOPHILA; EXPERIMENTAL MODEL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LOSS OF FUNCTION MUTATION; LYSOSOME; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; ORGANELLE BIOGENESIS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; FRONTOTEMPORAL DEMENTIA; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; DROSOPHILA; FRONTOTEMPORAL LOBAR DEGENERATION; HEK293 CELLS; HELA CELLS; HUMANS; LYSOSOMES; MICE; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; RATS; TOR SERINE-THREONINE KINASES;

EID: 84955311292     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201591998     Document Type: Article

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