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Volumn 17, Issue 18, 2017, Pages 2067-2076

C. Elegans as model for drug discovery

Author keywords

C. elegans; Cancer biology; Drug discovery; HTS; Nematodes; Vertebrate vascular endothelial growth factors

Indexed keywords

AMYLOID BETA PROTEIN; BENOMYL; CLOZAPINE; CYPROHEPTADINE; G PROTEIN COUPLED RECEPTOR; GELDANAMYCIN; LEVAMISOLE; LITHIUM; METFORMIN; NORADRENALIN; OCTOPAMINE; RAPAMYCIN; ROTENONE; TAU PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; MOLECULAR LIBRARY;

EID: 85021051575     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026617666170131114401     Document Type: Article
Times cited : (37)

References (123)
  • 1
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C. elegans as a model organism.
    • Kaletta, T.; Hengartner, M.O. Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov., 2006, 5(5), 387-398.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.5 , pp. 387-398
    • Kaletta, T.1    Hengartner, M.O.2
  • 2
    • 84861666869 scopus 로고    scopus 로고
    • Programmed cell death in C. Elegans, mammals and plants
    • Lord, C.E.; Gunawardena, A.H. Programmed cell death in C. elegans, mammals and plants. Eur. J. Cell. Biol., 2012, 91(8), 603-613.
    • (2012) Eur. J. Cell. Biol. , vol.91 , Issue.8 , pp. 603-613
    • Lord, C.E.1    Gunawardena, A.H.2
  • 4
    • 72949096858 scopus 로고    scopus 로고
    • Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nat. Rev
    • Irazoqui, J.E.; Urbach, J.M.; Ausubel, F.M. Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nat. Rev. Immunol., 2010, 10(1), 47-58.
    • (2010) Immunol. , vol.10 , Issue.1 , pp. 47-58
    • Irazoqui, J.E.1    Urbach, J.M.2    Ausubel, F.M.3
  • 5
    • 0037237117 scopus 로고    scopus 로고
    • C elegans: A model for exploring the genetics of fat storage. Dev
    • McKay, R.M.; McKay, J.P.; Avery, L.; Graff, J.M. C elegans: a model for exploring the genetics of fat storage. Dev. Cell., 2003, 4(1), 131-42.
    • (2003) Cell. , vol.4 , Issue.1 , pp. 131-142
    • McKay, R.M.1    McKay, J.P.2    Avery, L.3    Graff, J.M.4
  • 6
    • 79959459269 scopus 로고    scopus 로고
    • Where do new medicines come from? CBE. Life. Sci
    • Liu, D. Where do new medicines come from? CBE. Life. Sci. Educ., 2011, 10(2), 135-141.
    • (2011) Educ. , vol.10 , Issue.2 , pp. 135-141
    • Liu, D.1
  • 7
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered? Nat. Rev
    • Swinney, D.C.; Anthony, J. How were new medicines discovered? Nat. Rev. Drug Discov., 2011, 10(7), 507-519.
    • (2011) Drug Discov. , vol.10 , Issue.7 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 8
    • 38549131972 scopus 로고    scopus 로고
    • Genomic classification of protein-coding gene families
    • Schwarz, E.M. Genomic classification of protein-coding gene families. WormBook., 2005, 1-23
    • (2005) Wormbook. , pp. 1-23
    • Schwarz, E.M.1
  • 9
    • 0032509302 scopus 로고    scopus 로고
    • Genome sequence of the nematode C. Elegans: A platform for investigating biology
    • Consortium, C.e. S. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science, 1998, 282(5396) , 2012-2018.
    • (1998) Science , vol.282 , Issue.5396 , pp. 2012-2018
    • Consortium, C.S.1
  • 10
    • 0031468610 scopus 로고    scopus 로고
    • Analysis of protein domain families in Caenorhabditis elegans
    • Sonnhammer, E.L.; Durbin, R. Analysis of protein domain families in Caenorhabditis elegans. Genomics, 1997, 46(2) , 200-216;
    • (1997) Genomics , vol.46 , Issue.2 , pp. 200-216
    • Sonnhammer, E.L.1    Durbin, R.2
  • 11
    • 48949116734 scopus 로고    scopus 로고
    • Genome evolution in Caenorhabditis
    • Thomas, J.H. Genome evolution in Caenorhabditis. Brief. Funct. Genomic. Proteomic., 2008, 7(3), 211-6.
    • (2008) Brief. Funct. Genomic. Proteomic. , vol.7 , Issue.3 , pp. 211-216
    • Thomas, J.H.1
  • 12
    • 0034029917 scopus 로고    scopus 로고
    • Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics
    • Lai, C.H.; Chou, C.Y.; Ch'ang, L.Y.; Liu, C.S.; Lin, W. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res., 2000, 10(5), 703-713.
    • (2000) Genome Res. , vol.10 , Issue.5 , pp. 703-713
    • Lai, C.H.1    Chou, C.Y.2    Ch'ang, L.Y.3    Liu, C.S.4    Lin, W.5
  • 13
    • 0034999073 scopus 로고    scopus 로고
    • The use of functional genomics in C. Elegans for studying human development and disease
    • Kuwabara, P.E.; O'Neil, N. The use of functional genomics in C. elegans for studying human development and disease. J. Inherit. Metab. Dis., 2001, 24(2), 127-138.
    • (2001) J. Inherit. Metab. Dis. , vol.24 , Issue.2 , pp. 127-138
    • Kuwabara, P.E.1    O'neil, N.2
  • 14
    • 79957467830 scopus 로고    scopus 로고
    • OrthoList: A compendium of C. elegans genes with human orthologs
    • Shaye, D.D.; Greenwald, I. OrthoList: a compendium of C. elegans genes with human orthologs. PLoS One, 2011, 6(5), e20085.
    • (2011) Plos One , vol.6 , Issue.5
    • Shaye, D.D.1    Greenwald, I.2
  • 16
    • 7444261393 scopus 로고    scopus 로고
    • WormBase as an integrated platform for the C. Elegans ORFeome
    • Chen, N.; Lawson, D.; Bradnam, K.; Harris, T.W.; Stein, L.D. WormBase as an integrated platform for the C. elegans ORFeome. Genome. Res., 2004, 14(10B), 2155-2161.
    • (2004) Genome. Res. , vol.14 , Issue.10B , pp. 2155-2161
    • Chen, N.1    Lawson, D.2    Bradnam, K.3    Harris, T.W.4    Stein, L.D.5
  • 17
    • 78650117774 scopus 로고    scopus 로고
    • Modeling human diseases in Caenorhabditis elegans
    • Markaki, M.; Tavernarakis, N. Modeling human diseases in Caenorhabditis elegans. Biotechnol. J., 2010, 5(12), 1261-1276.
    • (2010) Biotechnol. J. , vol.5 , Issue.12 , pp. 1261-1276
    • Markaki, M.1    Tavernarakis, N.2
  • 18
    • 38549127297 scopus 로고    scopus 로고
    • Interactions with microbial pathogens
    • Darby, C. Interactions with microbial pathogens. WormBook, 2005, 1-15.
    • (2005) Wormbook , pp. 1-15
    • Darby, C.1
  • 19
    • 84880329381 scopus 로고    scopus 로고
    • Caenorhabditis elegans as a model for intracellular pathogen infection
    • Balla, K.M.; Troemel, E.R. Caenorhabditis elegans as a model for intracellular pathogen infection. Cell. Microbiol., 2013, 15(8), 1313-1322.
    • (2013) Cell. Microbiol. , vol.15 , Issue.8 , pp. 1313-1322
    • Balla, K.M.1    Troemel, E.R.2
  • 20
    • 84919392671 scopus 로고    scopus 로고
    • The nematode Caenorhabditis elegans as a model to study viruses
    • Diogo, J.; Bratanich, A. The nematode Caenorhabditis elegans as a model to study viruses. Arch. Virol., 2014, 159(11), 2843-51.
    • (2014) Arch. Virol. , vol.159 , Issue.11 , pp. 2843-2851
    • Diogo, J.1    Bratanich, A.2
  • 21
    • 38449121385 scopus 로고    scopus 로고
    • Chemosensation in C. Elegans
    • Bargmann, C.I. Chemosensation in C. elegans. WormBook, 2006, 1-29.
    • (2006) Wormbook , pp. 1-29
    • Bargmann, C.I.1
  • 22
  • 23
    • 77950244850 scopus 로고    scopus 로고
    • An elegant mind: Learning and memory in Caenorhabditis elegans
    • Ardiel, E.L.; Rankin, C.H. An elegant mind: learning and memory in Caenorhabditis elegans. Learn. Mem., 2010, 17(4) , 191-201.
    • (2010) Learn. Mem , vol.17 , Issue.4 , pp. 191-201
    • Ardiel, E.L.1    Rankin, C.H.2
  • 24
    • 77952923018 scopus 로고    scopus 로고
    • Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age
    • Kauffman, A.L.; Ashraf, J.M.; Corces-Zimmerman, M.R.; Landis, J.N.; Murphy, C.T. Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biol., 2010, 8(5), e1000372.
    • (2010) Plos Biol , vol.8 , Issue.5
    • Kauffman, A.L.1    Ashraf, J.M.2    Corces-Zimmerman, M.R.3    Landis, J.N.4    Murphy, C.T.5
  • 25
    • 84884907989 scopus 로고    scopus 로고
    • Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans. Nat
    • Leinwand, S.G.; Chalasani, S.H. Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans. Nat. Neurosci., 2013, 16(10), 1461-1467.
    • (2013) Neurosci. , vol.16 , Issue.10 , pp. 1461-1467
    • Leinwand, S.G.1    Chalasani, S.H.2
  • 26
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev
    • Sulston, J.E.; Schierenberg, E.; White, J.G.; Thomson, J.N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol., 1983, 100(1), 64-119.
    • (1983) Biol. , vol.100 , Issue.1 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 27
    • 0025752461 scopus 로고
    • Two C. Elegans genes control the programmed deaths of specific cells in the pharynx
    • Ellis, R.E.; Horvitz, H.R. Two C. elegans genes control the programmed deaths of specific cells in the pharynx. Development, 1991, 112(2), 591-603.
    • (1991) Development , vol.112 , Issue.2 , pp. 591-603
    • Ellis, R.E.1    Horvitz, H.R.2
  • 28
    • 0026051936 scopus 로고
    • Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
    • Ellis, R.E.; Jacobson, D.M.; Horvitz, H.R. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics, 1991, 129(1), 79-94.
    • (1991) Genetics , vol.129 , Issue.1 , pp. 79-94
    • Ellis, R.E.1    Jacobson, D.M.2    Horvitz, H.R.3
  • 30
    • 84876003933 scopus 로고    scopus 로고
    • Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans
    • Denning, D.P.; Hatch, V.; Horvitz, H.R. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS Genet., 2013, 9(3), e1003341.
    • (2013) Plos Genet. , vol.9 , Issue.3
    • Denning, D.P.1    Hatch, V.2    Horvitz, H.R.3
  • 31
    • 84908021063 scopus 로고    scopus 로고
    • Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
    • Kobet, R.A.; Pan, X.; Zhang, B.; Pak, S.C.; Asch, A.S.; Lee, M.H. Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification. Biomol. Ther(Seoul), 2014, 22(5), 371-383.
    • (2014) Biomol. Ther(Seoul) , vol.22 , Issue.5 , pp. 371-383
    • Kobet, R.A.1    Pan, X.2    Zhang, B.3    Pak, S.C.4    Asch, A.S.5    Lee, M.H.6
  • 33
    • 0026782145 scopus 로고
    • Molecular analysis of mutations in the Caenorhabditis elegans collagen gene dpy-7
    • Johnstone, I.L.; Shafi, Y.; Barry, J.D. Molecular analysis of mutations in the Caenorhabditis elegans collagen gene dpy-7. EMBO J., 1992, 11(11), 3857-3863.
    • (1992) EMBO J. , vol.11 , Issue.11 , pp. 3857-3863
    • Johnstone, I.L.1    Shafi, Y.2    Barry, J.D.3
  • 36
    • 0032433854 scopus 로고    scopus 로고
    • Lin-35 and lin-53, two genes that antagonize a C. Elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48
    • Lu, X.; Horvitz, H.R. lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell, 1998,. 95(7),. 981-991.
    • (1998) Cell , vol.95 , Issue.7 , pp. 981-991
    • Lu, X.1    Horvitz, H.R.2
  • 37
    • 33644907734 scopus 로고    scopus 로고
    • The C. Elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis.
    • Tarsitano, M.; De Falco, S.; Colonna, V.; McGhee, J.D.; Persico, M.G. The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis. FASEB J., 2006, 20(2), 227-233.
    • (2006) FASEB J. , vol.20 , Issue.2 , pp. 227-233
    • Tarsitano, M.1    De Falco, S.2    Colonna, V.3    McGhee, J.D.4    Persico, M.G.5
  • 39
    • 36549006956 scopus 로고    scopus 로고
    • An antidepressant that extends lifespan in adult Caenorhabditis elegans
    • Petrascheck, M.; Ye, X.; Buck, L.B. An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature, 2007, 450(7169), 553-556.
    • (2007) Nature , vol.450 , Issue.7169 , pp. 553-556
    • Petrascheck, M.1    Ye, X.2    Buck, L.B.3
  • 42
    • 4444279075 scopus 로고    scopus 로고
    • Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality
    • van Haaften, G.; Vastenhouw, N.L.; Nollen, E.A.; Plasterk, R.H.; Tijsterman, M. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proc. Natl. Acad. Sci. USA, 2004, 101(35), 12992-12996.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.35 , pp. 12992-12996
    • Van Haaften, G.1    Vastenhouw, N.L.2    Nollen, E.A.3    Plasterk, R.H.4    Tijsterman, M.5
  • 46
    • 84916878090 scopus 로고    scopus 로고
    • Automated, highthroughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics
    • Buckingham, S.D.; Partridge, F.A.; Sattelle, D.B. Automated, highthroughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics. Int. J. Parasitol. Drugs Drug Resist., 2014, 4(3), 226-232.
    • (2014) Int. J. Parasitol. Drugs Drug Resist. , vol.4 , Issue.3 , pp. 226-232
    • Buckingham, S.D.1    Partridge, F.A.2    Sattelle, D.B.3
  • 47
    • 84858764667 scopus 로고    scopus 로고
    • WormScan: A technique for high-throughput phenotypic analysis of Caenorhabditis elegans
    • Mathew, M.D.; Mathew, N.D.; Ebert, P.R. WormScan: a technique for high-throughput phenotypic analysis of Caenorhabditis elegans. PLoS One, 2012, 7(3), e33483.
    • (2012) Plos One , vol.7 , Issue.3
    • Mathew, M.D.1    Mathew, N.D.2    Ebert, P.R.3
  • 48
    • 79959854438 scopus 로고    scopus 로고
    • Highthroughput behavioral analysis in C. Elegans
    • Swierczek, N.A.; Giles, A.C.; Rankin, C.H.; Kerr, R.A. Highthroughput behavioral analysis in C. elegans. Nat. Methods, 2011, 8(7), 592-598.
    • (2011) Nat. Methods , vol.8 , Issue.7 , pp. 592-598
    • Swierczek, N.A.1    Giles, A.C.2    Rankin, C.H.3    Kerr, R.A.4
  • 50
    • 77951672406 scopus 로고    scopus 로고
    • High-throughput screening and small animal models, where are we?
    • Giacomotto, J.; Segalat, L. High-throughput screening and small animal models, where are we? Br. J. Pharmacol., 2010, 160(2), 204-216.
    • (2010) Br. J. Pharmacol. , vol.160 , Issue.2 , pp. 204-216
    • Giacomotto, J.1    Segalat, L.2
  • 51
    • 84947942460 scopus 로고    scopus 로고
    • Using C. Elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases
    • Chen, X.; Barclay, J.W.; Burgoyne, R.D.; Morgan, A. Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases. Chem. Cent. J., 2015, 9, 65.
    • (2015) Chem. Cent. J. , vol.9 , pp. 65
    • Chen, X.1    Barclay, J.W.2    Burgoyne, R.D.3    Morgan, A.4
  • 55
    • 84876898289 scopus 로고    scopus 로고
    • An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans
    • Leung, C.K.; Wang, Y.; Malany, S.; Deonarine, A.; Nguyen, K.; Vasile, S.; Choe, K.P. An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. PLoS One, 2013, 8(4), e62166.
    • (2013) Plos One , vol.8 , Issue.4
    • Leung, C.K.1    Wang, Y.2    Malany, S.3    Deonarine, A.4    Nguyen, K.5    Vasile, S.6    Choe, K.P.7
  • 59
    • 55449123081 scopus 로고    scopus 로고
    • The anticonvulsant ethosuximide disrupts sensory function to extend C. Elegans lifespan
    • Collins, J.J.; Evason, K.; Pickett, C.L.; Schneider, D.L.; Kornfeld, K. The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan. PLoS Genet., 2008, 4(10), e1000230.
    • (2008) Plos Genet. , vol.4 , Issue.10
    • Collins, J.J.1    Evason, K.2    Pickett, C.L.3    Schneider, D.L.4    Kornfeld, K.5
  • 60
    • 0024792625 scopus 로고
    • Genetic and molecular analysis of a Caenorhabditis elegans betatubulin that conveys benzimidazole sensitivity
    • Driscoll, M.; Dean, E.; Reilly, E.; Bergholz, E.; Chalfie, M. Genetic and molecular analysis of a Caenorhabditis elegans betatubulin that conveys benzimidazole sensitivity. J. Cell. Biol., 1989, 109(6 Pt 1), 2993-3003.
    • (1989) J. Cell. Biol. , vol.109 , Issue.6 , pp. 2993-3003
    • Driscoll, M.1    Dean, E.2    Reilly, E.3    Bergholz, E.4    Chalfie, M.5
  • 61
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman, J.; Movva, N.R.; Hall, M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science, 1991, 253(5022), 905-909.
    • (1991) Science , vol.253 , Issue.5022 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 63
    • 44949143015 scopus 로고    scopus 로고
    • A genetic screen for dihydropyridine(DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels
    • Kwok, T.C.; Hui, K.; Kostelecki, W.; Ricker, N.; Selman, G.; Feng, Z.P.; Roy, P.J. A genetic screen for dihydropyridine(DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels. PLoS Genet., 2008, 4(5), e1000067.
    • (2008) Plos Genet , vol.4 , Issue.5
    • Kwok, T.C.1    Hui, K.2    Kostelecki, W.3    Ricker, N.4    Selman, G.5    Feng, Z.P.6    Roy, P.J.7
  • 64
    • 84884904381 scopus 로고    scopus 로고
    • Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
    • (a) Dickinson, D.J.; Ward, J.D.; Reiner, D.J.; Goldstein, B. Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat. Methods, 2013, 10(10), 1028-34.
    • (2013) Nat. Methods , vol.10 , Issue.10 , pp. 1028-1034
    • Dickinson, D.J.1    Ward, J.D.2    Reiner, D.J.3    Goldstein, B.4
  • 65
    • 84964313213 scopus 로고    scopus 로고
    • Efficient marker-free recovery of custom genetic modifications with CRISPR/Cas9 in Caenorhabditis elegans
    • Arribere, J.A.; Bell, R.T.; Fu, B.X.; Artiles, K.L.; Hartman, P.S.; Fire, A.Z. Efficient marker-free recovery of custom genetic modifications with CRISPR/Cas9 in Caenorhabditis elegans. Genetics, 2014, 198(3), 837-846.
    • (2014) Genetics , vol.198 , Issue.3 , pp. 837-846
    • Arribere, J.A.1    Bell, R.T.2    Fu, B.X.3    Artiles, K.L.4    Hartman, P.S.5    Fire, A.Z.6
  • 66
    • 84979868438 scopus 로고    scopus 로고
    • CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering
    • Dickinson, D.J.; Goldstein, B. CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering. Genetics, 2016, 202(3), 885-901.
    • (2016) Genetics , vol.202 , Issue.3 , pp. 885-901
    • Dickinson, D.J.1    Goldstein, B.2
  • 67
    • 79251511501 scopus 로고    scopus 로고
    • Identification of direct protein targets of small molecules
    • Lomenick, B.; Olsen, R.W.; Huang, J. Identification of direct protein targets of small molecules. ACS Chem. Biol., 2011, 6(1), 34-46.
    • (2011) ACS Chem. Biol. , vol.6 , Issue.1 , pp. 34-46
    • Lomenick, B.1    Olsen, R.W.2    Huang, J.3
  • 72
    • 84960090652 scopus 로고    scopus 로고
    • A network pharmacology approach reveals new candidate caloric restriction mimetics in C. Elegans
    • Calvert, S.; Tacutu, R.; Sharifi, S.; Teixeira, R.; Ghosh, P.; de Magalhaes, J.P. A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell, 2016, 15(2), 256-266.
    • (2016) Aging Cell , vol.15 , Issue.2 , pp. 256-266
    • Calvert, S.1    Tacutu, R.2    Sharifi, S.3    Teixeira, R.4    Ghosh, P.5    De Magalhaes, J.P.6
  • 73
    • 0034666108 scopus 로고    scopus 로고
    • STRING: A webserver to retrieve and display the repeatedly occurring neighbourhood of a gene
    • Snel, B.; Lehmann, G.; Bork, P.; Huynen, M.A. STRING: a webserver to retrieve and display the repeatedly occurring neighbourhood of a gene. Nucleic Acids Res., 2000, 28(18), 3442-3444.
    • (2000) Nucleic Acids Res. , vol.28 , Issue.18 , pp. 3442-3444
    • Snel, B.1    Lehmann, G.2    Bork, P.3    Huynen, M.A.4
  • 77
    • 84862576525 scopus 로고    scopus 로고
    • Interaction of structure-specific and promiscuous G-protein-coupled receptors mediates small-molecule signaling in Caenorhabditis elegans
    • Park, D.; O'Doherty, I.; Somvanshi, R.K.; Bethke, A.; Schroeder, F.C.; Kumar, U.; Riddle, D.L. Interaction of structure-specific and promiscuous G-protein-coupled receptors mediates small-molecule signaling in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA, 2012, 109(25), 9917-9922.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , Issue.25 , pp. 9917-9922
    • Park, D.1    O'doherty, I.2    Somvanshi, R.K.3    Bethke, A.4    Schroeder, F.C.5    Kumar, U.6    Riddle, D.L.7
  • 78
    • 0035799319 scopus 로고    scopus 로고
    • Profiling serine hydrolase activities in complex proteomes
    • Kidd, D.; Liu, Y.; Cravatt, B.F. Profiling serine hydrolase activities in complex proteomes. Biochemistry, 2001, 40(13), 4005-4015.
    • (2001) Biochemistry , vol.40 , Issue.13 , pp. 4005-4015
    • Kidd, D.1    Liu, Y.2    Cravatt, B.F.3
  • 79
    • 3442889367 scopus 로고    scopus 로고
    • OrthoDisease: A database of human disease orthologs
    • O'Brien, K.P.; Westerlund, I.; Sonnhammer, E.L. OrthoDisease: a database of human disease orthologs. Hum. Mutat., 2004, 24(2), 112-119.
    • (2004) Hum. Mutat. , vol.24 , Issue.2 , pp. 112-119
    • O'brien, K.P.1    Westerlund, I.2    Sonnhammer, E.L.3
  • 81
    • 0029449948 scopus 로고
    • Genetic pharmacology: Interactions between drugs and gene products in Caenorhabditis elegans
    • Rand, J.B.; Johnson, C.D. Genetic pharmacology: interactions between drugs and gene products in Caenorhabditis elegans. Methods Cell. Biol., 1995, 48, 187-204.
    • (1995) Methods Cell. Biol. , vol.48 , pp. 187-204
    • Rand, J.B.1    Johnson, C.D.2
  • 83
    • 84905457480 scopus 로고    scopus 로고
    • Culturing Caenorhabditis elegans in axenic liquid media and creation of transgenic worms by microparticle bombardment
    • Samuel, T.K.; Sinclair, J.W.; Pinter, K.L.; Hamza, I. Culturing Caenorhabditis elegans in axenic liquid media and creation of transgenic worms by microparticle bombardment. J. Vis. Exp., 2014, (90), e51796.
    • (2014) J. Vis. Exp , Issue.90
    • Samuel, T.K.1    Sinclair, J.W.2    Pinter, K.L.3    Hamza, I.4
  • 84
    • 0028857865 scopus 로고
    • Estrogens in unexpected places: Possible implications for researchers and consumers
    • Feldman, D.; Krishnan, A. Estrogens in unexpected places: possible implications for researchers and consumers. Environ. Health Perspect., 1995, 103 Suppl 7, 129-133.
    • (1995) Environ. Health Perspect , vol.103 , pp. 129-133
    • Feldman, D.1    Krishnan, A.2
  • 85
    • 80355149174 scopus 로고    scopus 로고
    • Measuring Caenorhabditis elegans life span in 96 well microtiter plates
    • Solis, G.M.; Petrascheck, M. Measuring Caenorhabditis elegans life span in 96 well microtiter plates. J. Vis. Exp., 2011, (49), pii: 2496.
    • (2011) J. Vis. Exp , Issue.49
    • Solis, G.M.1    Petrascheck, M.2
  • 86
    • 80053615320 scopus 로고    scopus 로고
    • The significance of G protein-coupled receptor crystallography for drug discovery
    • Salon, J.A.; Lodowski, D.T.; Palczewski, K. The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol. Rev., 2011, 63(4), 901-937.
    • (2011) Pharmacol. Rev. , vol.63 , Issue.4 , pp. 901-937
    • Salon, J.A.1    Lodowski, D.T.2    Palczewski, K.3
  • 87
    • 21344445234 scopus 로고    scopus 로고
    • TYRA-2(F01E11.5): A Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons
    • Rex, E.; Hapiak, V.; Hobson, R.; Smith, K.; Xiao, H.; Komuniecki, R. TYRA-2(F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons. J. Neurochem., 2005, 94(1), 181-191.
    • (2005) J. Neurochem. , vol.94 , Issue.1 , pp. 181-191
    • Rex, E.1    Hapiak, V.2    Hobson, R.3    Smith, K.4    Xiao, H.5    Komuniecki, R.6
  • 89
    • 0035882491 scopus 로고    scopus 로고
    • Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine
    • Ranganathan, R.; Sawin, E.R.; Trent, C.; Horvitz, H.R. Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine. J. Neurosci., 2001, 21(16), 5871-5884.
    • (2001) J. Neurosci. , vol.21 , Issue.16 , pp. 5871-5884
    • Ranganathan, R.1    Sawin, E.R.2    Trent, C.3    Horvitz, H.R.4
  • 90
    • 84874762077 scopus 로고    scopus 로고
    • A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target
    • Saur, T.; DeMarco, S.E.; Ortiz, A.; Sliwoski, G.R.; Hao, L.; Wang, X.; Cohen, B.M.; Buttner, E.A. A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target. PLoS Genet., 2013, 9(2), e1003313.
    • (2013) Plos Genet , vol.9 , Issue.2
    • Saur, T.1    Demarco, S.E.2    Ortiz, A.3    Sliwoski, G.R.4    Hao, L.5    Wang, X.6    Cohen, B.M.7    Buttner, E.A.8
  • 91
    • 1042268861 scopus 로고    scopus 로고
    • Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis
    • Grad, L.I.; Lemire, B.D. Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis. Hum. Mol. Genet., 2004, 13(3), 303-314.
    • (2004) Hum. Mol. Genet. , vol.13 , Issue.3 , pp. 303-314
    • Grad, L.I.1    Lemire, B.D.2
  • 94
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restrictionlike state and the oxidative stress response to extend C. Elegans Healthspan via AMPK, LKB1, and SKN-1
    • Onken, B.; Driscoll, M. Metformin induces a dietary restrictionlike state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One, 2010, 5(1), e8758.
    • (2010) Plos One , vol.5 , Issue.1
    • Onken, B.1    Driscoll, M.2
  • 95
    • 84892536221 scopus 로고    scopus 로고
    • A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity
    • El-Ami, T.; Moll, L.; Carvalhal Marques, F.; Volovik, Y.; Reuveni, H.; Cohen, E. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell, 2014, 13(1), 165-174.
    • (2014) Aging Cell , vol.13 , Issue.1 , pp. 165-174
    • El-Ami, T.1    Moll, L.2    Carvalhal Marques, F.3    Volovik, Y.4    Reuveni, H.5    Cohen, E.6
  • 96
    • 33748787713 scopus 로고    scopus 로고
    • Both insulin and calcium channel signaling are required for developmental regulation of serotonin synthesis in the chemosensory ADF neurons of Caenorhabditis elegans. Dev
    • Estevez, A.O.; Cowie, R.H.; Gardner, K.L.; Estevez, M. Both insulin and calcium channel signaling are required for developmental regulation of serotonin synthesis in the chemosensory ADF neurons of Caenorhabditis elegans. Dev. Biol., 2006, 298(1), 32-44.
    • (2006) Biol. , vol.298 , Issue.1 , pp. 32-44
    • Estevez, A.O.1    Cowie, R.H.2    Gardner, K.L.3    Estevez, M.4
  • 97
    • 0037359504 scopus 로고    scopus 로고
    • Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans
    • David, C.L.; Smith, H.E.; Raynes, D.A.; Pulcini, E.J.; Whitesell, L. Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans. Cell Stress Chaperones, 2003, 8(1), 93-104.
    • (2003) Cell Stress Chaperones , vol.8 , Issue.1 , pp. 93-104
    • David, C.L.1    Smith, H.E.2    Raynes, D.A.3    Pulcini, E.J.4    Whitesell, L.5
  • 98
    • 39749111800 scopus 로고    scopus 로고
    • Volatile anesthetic preconditioning present in the invertebrate Caenorhabditis elegans
    • Jia, B.; Crowder, C.M. Volatile anesthetic preconditioning present in the invertebrate Caenorhabditis elegans. Anesthesiology, 2008, 108(3), 426-433.
    • (2008) Anesthesiology , vol.108 , Issue.3 , pp. 426-433
    • Jia, B.1    Crowder, C.M.2
  • 99
    • 84959912709 scopus 로고    scopus 로고
    • Angiotensin Converting Enzyme(ACE) Inhibitor Extends Caenorhabditis elegans Life Span
    • Kumar, S.; Dietrich, N.; Kornfeld, K. Angiotensin Converting Enzyme(ACE) Inhibitor Extends Caenorhabditis elegans Life Span. PLoS Genet., 2016, 12(2), e1005866.
    • (2016) Plos Genet , vol.12 , Issue.2
    • Kumar, S.1    Dietrich, N.2    Kornfeld, K.3
  • 103
    • 12844276057 scopus 로고    scopus 로고
    • Neuropeptide G-protein-coupled receptors, their cognate ligands and behavior in Caenorhabditis elegans
    • Geary, T.G.; Kubiak, T.M. Neuropeptide G-protein-coupled receptors, their cognate ligands and behavior in Caenorhabditis elegans. Trends. Pharmacol. Sci., 2005, 26(2), 56-58.
    • (2005) Trends. Pharmacol. Sci. , vol.26 , Issue.2 , pp. 56-58
    • Geary, T.G.1    Kubiak, T.M.2
  • 104
    • 0032894150 scopus 로고    scopus 로고
    • Mechanism-based screening: Discovery of the next generation of anthelmintics depends upon more basic research
    • discussion 113-114
    • Geary, T.G.; Thompson, D.P.; Klein, R.D. Mechanism-based screening: discovery of the next generation of anthelmintics depends upon more basic research. Int. J. Parasitol., 1999, 29(1), 105-112; discussion 113-114.
    • (1999) Int. J. Parasitol. , vol.29 , Issue.1 , pp. 105-112
    • Geary, T.G.1    Thompson, D.P.2    Klein, R.D.3
  • 105
    • 77954580826 scopus 로고    scopus 로고
    • Important helminth infections in Southeast Asia diversity, potential for control and prospects for elimination
    • Utzinger, J.; Bergquist, R.; Olveda, R.; Zhou, X.N. Important helminth infections in Southeast Asia diversity, potential for control and prospects for elimination. Adv. Parasitol., 2010, 72, 1-30.
    • (2010) Adv. Parasitol. , vol.72 , pp. 1-30
    • Utzinger, J.1    Bergquist, R.2    Olveda, R.3    Zhou, X.N.4
  • 108
    • 0035935627 scopus 로고    scopus 로고
    • Caenorhabditis elegans: How good a model for veterinary parasites?
    • Geary, T.G.; Thompson, D.P. Caenorhabditis elegans: how good a model for veterinary parasites? Vet. Parasitol., 2001, 101(3-4), 371-386.
    • (2001) Vet. Parasitol. , vol.101 , Issue.3-4 , pp. 371-386
    • Geary, T.G.1    Thompson, D.P.2
  • 109
    • 84893178251 scopus 로고    scopus 로고
    • Nitazoxanide: Nematicidal mode of action and drug combination studies
    • Somvanshi, V.S.; Ellis, B.L.; Hu, Y.; Aroian, R.V. Nitazoxanide: nematicidal mode of action and drug combination studies. Mol. Biochem. Parasitol., 2014, 193(1), 1-8.
    • (2014) Mol. Biochem. Parasitol , vol.193 , Issue.1 , pp. 1-8
    • Somvanshi, V.S.1    Ellis, B.L.2    Hu, Y.3    Aroian, R.V.4
  • 111
    • 34547613760 scopus 로고    scopus 로고
    • Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi
    • Mylonakis, E.; Casadevall, A.; Ausubel, F.M. Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi. PLoS Pathog., 2007, 3(7), e101.
    • (2007) Plos Pathog. , vol.3 , Issue.7
    • Mylonakis, E.1    Casadevall, A.2    Ausubel, F.M.3
  • 113
    • 84975248873 scopus 로고    scopus 로고
    • A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. Elegans. Cell
    • Martinez, B.A.; Kim, H.; Ray, A.; Caldwell, G.A.; Caldwell, K.A. A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans. Cell. Death Dis., 2015, 6, e1908.
    • (2015) Death Dis. , vol.6
    • Martinez, B.A.1    Kim, H.2    Ray, A.3    Caldwell, G.A.4    Caldwell, K.A.5
  • 115
    • 0036429045 scopus 로고    scopus 로고
    • The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function
    • Eimer, S.; Donhauser, R.; Baumeister, R. The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function. Dev. Biol., 2002, 251(1), 178-192.
    • (2002) Dev. Biol. , vol.251 , Issue.1 , pp. 178-192
    • Eimer, S.1    Donhauser, R.2    Baumeister, R.3
  • 116
    • 12244281810 scopus 로고    scopus 로고
    • Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide(1-42) in a transgenic Caenorhabditis elegans model
    • Drake, J.; Link, C.D.; Butterfield, D.A. Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide(1-42) in a transgenic Caenorhabditis elegans model. Neurobiol. Aging, 2003, 24(3), 415-420.
    • (2003) Neurobiol. Aging , vol.24 , Issue.3 , pp. 415-420
    • Drake, J.1    Link, C.D.2    Butterfield, D.A.3
  • 117
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • Link, C.D. Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA, 1995, 92(20), 9368-9372.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , Issue.20 , pp. 9368-9372
    • Link, C.D.1
  • 120
    • 41949097891 scopus 로고    scopus 로고
    • C. Elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging
    • van Ham, T.J.; Thijssen, K.L.; Breitling, R.; Hofstra, R.M.; Plasterk, R.H.; Nollen, E.A. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet., 2008, 4(3), e1000027.
    • (2008) Plos Genet , vol.4 , Issue.3
    • Van Ham, T.J.1    Thijssen, K.L.2    Breitling, R.3    Hofstra, R.M.4    Plasterk, R.H.5    Nollen, E.A.6
  • 121
    • 0034772838 scopus 로고    scopus 로고
    • Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans
    • Oeda, T.; Shimohama, S.; Kitagawa, N.; Kohno, R.; Imura, T.; Shibasaki, H.; Ishii, N. Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. Hum. Mol. Genet., 2001, 10(19), 2013-2023.
    • (2001) Hum. Mol. Genet , vol.10 , Issue.19 , pp. 2013-2023
    • Oeda, T.1    Shimohama, S.2    Kitagawa, N.3    Kohno, R.4    Imura, T.5    Shibasaki, H.6    Ishii, N.7


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