Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics

International Journal for Parasitology: Drugs and Drug Resistance

Volumn 4, Issue 3, 2014, Pages 226-232

  Buckingham, Steven D ^a   Partridge, Frederick A ^a   Sattelle, David B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Anthelmintic drug discovery; Automated drug screening; C. elegans; Nematode parasites

Indexed keywords

ANTHELMINTIC AGENT;

ALGORITHM; ANTIBIOTIC RESISTANCE; ASCARIASIS; AUTOMATION; CAENORHABDITIS ELEGANS; DRUG DETERMINATION; DRUG SCREENING; FASCIOLA HEPATICA; HIGH THROUGHPUT SCREENING; HOOKWORM; HUMAN; NEMATODIASIS; NONHUMAN; REVIEW; STRONGYLOIDIASIS; TRICHURIASIS;

EID: 84916878090     PISSN: None     EISSN: 22113207     Source Type: Journal    
DOI: 10.1016/j.ijpddr.2014.10.004     Document Type: Review

References (52)

1. Atkinson H.J., Lilley C.J., Urwin P.E. Strategies for transgenic nematode control in developed and developing world crops. Curr. Opin. Biotechnol. 2012, 23:251-256.
2. Baek J.H., Cosman P., Feng Z., Silver J., Schafer W.R. Using machine vision to analyze and classify Caenorhabditis elegans behavioral phenotypes quantitatively. J. Neurosci. Methods 2002, 118:9-21.
3. Ben Arous J., Laffont S., Chatenay D. Molecular and sensory basis of a food related two-state behaviour in C. elegans. PLoS ONE 2009, 4:e7584.
4. Boyd W.A., McBride S.J., Rice R.J., Snyder D.W., Freedman J.H. A highthroughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. Toxicol. Appl. Pharmacol. 2010, 245:153-159.
5. Buckingham S.D., Sattelle D.B. Strategies for automated analysis of C. elegans locomotion. Invert. Neurosci. 2008, 8:121-131.
6. Buckingham S.D., Sattelle D.B. Fast automated measurement of nematode swimming (thrashing) without morphometry. BMC Neurosci. 2009, 10:84.
7. Byrne J.T., Maher N.J., Jones P.W. Comparative responses of Globodera rostochiensis and G. pallida to hatching chemicals. J. Nematol. 2001, 33:195-202.
8. Cronin C.J., Mendel J.E., Mukhtar S., Kim Y.M., Stirbl R.C., Bruck J., Sternberg P.W. An automated system for measuring parameters of nematode sinusoidal movement. BMC Genet. 2005, 6:5.
9. Culetto E., Sattelle D.B. A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes. Hum. Mol. Genet. 2000, 9:869-877.
10. Eder J., Sedrani R., Wiesman C. The discovery of first-in-class drugs: origins and evolution. Nat. Rev. Drug Discov. 2014, 13:577-587.
11. Evans T., Chapple N. The animal health market. Nat. Rev. Drug. Discov. 2002, 1:937-938.
12. Fahmy M.A. An investigation of the life cycle of Trichuris muris. Parasitology 1954, 44:5057.
13. Fairbairn D., Wertheim G., Harpur R.P., Schiller E.L. Biochemistry of normal and irradiated strains of Hymenolepsis diminuta. Exp. Parasitol. 1961, 11:248-263.
14. Feng Z., Cronin C.J., Wittig J.H., Sternberg P.W., Schafer W.R. An imaging system for standardized quantitative analysis of C. elegans behavior. BMC Bioinform. 2004, 5:115.
15. Flavell S.W., Pokala N., Macosko E.Z., Albrecht D.R., Larsch J., Bargman C. Serotonin and the neuropeptide PDF initiate and extend opposing behavioural states in C. elegans. Cell 2013, 154:1023-1025.
16. Geng W., Cosman P.C., Palm M., Schafer W.R. Caenorhabditis elegans egg-laying detection and behavior study using image analysis. EURASIP J. Adv. Sig. Proc. 2005, 14:2229-2240.
17. Geng W., Cosman P., Baek J.H., Berry C.C., Schafer W.R. Quantitative classification and natural clustering of Caenorhabditis elegans behavioral phenotypes. Genetics 2003, 165:1117-1126.
18. Greenblum A., Sznitzman R., Fua P., Arratia P.E., Snitzman J. Caenorhabditis elegans segmentation using texture-based models for motility phenotyping. IEEE Trans. Biomed. Eng. 2014, 61:2278-2289.
19. Hardaker L.A., Singer E., Kerr R., Zhou G., Schafer W.R. Serotonin modulates locomotory behavior and coordinates egg-laying and movement in Caenorhabditis elegans. J. Neurobiol. 2001, 49:303-313.
20. Hoshi K., Shingai R. Computer-driven automatic identification of locomotion states in Caenorhabditis elegans. J. Neurosci. Methods 2006, 157:355-363.
21. Hotez P.J., Brindley P.J., Bethony J.M., King C.H., Pearce E.J., Jacobson J. Helminth infections: the great neglected tropical diseases. J. Clin. Invest. 2008, 118:1311-1321.
22. Hubert J., Kerboeuf D. A microlarval development assay for the detection of anthelmintic resistance in sheep nematodes. Vet. Rec. 1992, 130:442-446.
23. Hurst R.J.M., Hopwood T., Gallagher A.L., Partridge F., Kagechika H., Sattelle D.B., Else K.J. Blocking the retinoid X receptor reduces the viability of Trichuris muris in vitro. BMC Infect. Dis. 2014, 14:520.
24. Husson, S.J., Costa, W.S., Schmitt, C., Gottschalk, A., 2013. Keeping track of worm trackers. In: WormBook, (ed.), The C. elegans Research Community. WormBook, doi/10.1895/wormbook.1.7.1 http://www.wormbook.org.
25. Jadhav K.B., Rajini P.S. Neurophysiological alterations in Caenorhabditis elegans exposed to dichlorvos, an organophosphorus insecticide. Pestic. Biochem. Physiol. 2009, 94:79-85.
26. Kaletta T., Hengartner M.O. Finding function in novel targets; C. elegans as a model organism. Nat. Rev. Drug Discov. 2006, 5:387-398.
27. Kaplan R.M. Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol. 2004, 10:477-481.
28. Marcellino C., Gut J., Lim K.C., Sigh R., McKerrow J., Sakanari J. WormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasites. PLoS Negl. Trop. Dis. 2014, 6:e1494.
29. McCarty T.R., Turkeltaub J.A., Hoetz P.J. Global progress towards eliminating gastrointestinal helminth infections. Curr. Opin. Gastroenterol. 2014, 30:18-24.
30. Mitchell P., Mould R., Dillon J., Glautier S., Andrianakis I., James C., Pugh A., Holden-Dye L. A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans. PLoS ONE 2010, 5(5):e10422. 10.1371/journal.pone.001042.
31. Murray C.J., et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012, 380:2197-2223.
32. Nicol J.M., Turner S.J., Coyne D.L., den Nijs L., Hockland S., Maafi T. Current Nematode Threats to World Agriculture. Genomics and Molecular Genetics of PlantNematode interactions 2011, 21-43. Springer, Dordrecht,The Netherlands. J.T. Jones, G. Gheysen, C. Fenoll (Eds.).
33. Ponce-Macotela M., Rodgriguez-Caballero A., Peralta-Abarca G.E., Martinez-Gordillo M.N. A simplified method for hatching and isolating Toxocara canis larvae to facilitate excretory-secretory antigen collection in vitro. Vet. Parasitol. 2011, 175:382-385.
34. Ramot D., Johnson B.E., Berry T.L., Carnell L., Goodman M.B. The parallel worm tracker: a platform for measuring average speed and drug-induced paralysis in nematodes. PLoS ONE 2008, 3:e2208. 10.1371/journal.pone.0002208.
35. Reiss D., Harrison L.M., Bungiro R., Cappello M. Short report: an agar plate method for culturing hookworm larvae: analysis of growth kinetics and infectivity compared with standard coproculture techniques. Am. J. Trop. Med. Hyg. 2007, 77:1087-1090.
36. Restif C., Ibáñez-Ventoso C., Vora M.M., Guo S., Metaxas D., Driscoll M. CeleST: computer vision software for quantitative analysis of C. elegans swim behavior reveals novel features of locomotion. PLoS Comput. Biol. 2014, 10(7):e1003702. 10.1371/journal.pcbi.1003702.
37. Scott I., Pomroy W.E., Kenyon P.R., Smith G., Adlington B., Moss A. Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis. Vet. Parasitol. 2013, 198:166-171.
38. Shingai R. Durations and frequencies of free locomotion in wild type and GABAergic mutants of Caenorhabditis elegans. Neurosci. Res. 2000, 38:71-83.
39. Simonetta S.H., Golombek D.A. An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies application. J. Neurosci. Methods 2007, 161:273-280.
40. Storey B., Marcellino C., Millera M., Macleana M., Mostafa E., Howell S., Sakanaric J., Wolstenholme A., Kaplan R. Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: "The Worminator". Int. J. Parasitol. 2014, Available online 28 August 2014, ISSN 2211-3207. 10.1016/j.ijpddr.2014.08.003.
41. Stroustrup N., Ulmschneider B.E., Nash Z.M., Lopez-Moyado I.F., Apfield J., Fontana W. The Caenorhabditis elegans lifespan machine. Nat. Methods 2013, 10:665-670.
42. Sutherland I.A., Leathwick D.M. Anthelmintic resistance in nematode parasites of cattle: a global issue?. Trends Parasitol. 2011, 27:176-181.
43. Swinney D.C., Anthony J. How were new medicines discovered?. Nat. Drug. Discov. Rev. 2011, 10:507-519.
44. Sznitman R., Gupta M., Hager G.D., Arratia P.E., Sznitman J. Multi-environment model estimation for motility analysis of Caenorhabditis elegans. PLoS ONE 2010, 5(7):e11631. 10.1371/journal.pone.0011631.
45. Tsibidis G.D., Tavernarakis N. Nemo: a computational tool for analysing nematode locomotion. BMC Neurosci. 2007, 8:86.
46. Urban J.F., Douvres F.W. In vitro development of Ascaris suum from third-to fourth -stage larvae and detection of metabolic antigens in multi-well culture systems. J. Parasitol. 1981, 67:800-806.
47. Vos T., Flaxman A.D., Naghavi M., et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1999-2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012, 380:2163-2196.
48. Waller P.J. International approaches to the concept of integrated control of nematode parasites of livestock. Int. J. Parasitol. 1999, 29:155-164.
49. Woods D.J., Vaillancourt V.A., Wendt J.A., Meeus P. Discovery and development of veterinary antiparasitic drugs: past, present and future. Future Med. Chem. 2011, 3:887-896.
50. Xian B., Shen J., Chen W., Sun N., Qiao N., Jiang D., Yu T., Men Y., Han Z., Pang Y., Kaweberlein M., Huang Y., Han J.D. WormFarm: a quantitative control and measurement device towards automated Caenorhabditis elegans aging analysis. Aging Cell 2013, 12:398-409.
51. Yemini E., Jucikas T., Grundy L.J., Brown A.E., Schafer W.R. A database of Caenorhabditis elegans behavioural phenotypes. Nat. Methods 2013, 10:877-879.
52. Zheng M., Gorelenkova O., Yang J., Feng Z. A liquid phase based C. elegans behavioural analysis system identifies motor activity loss in a nematode Parkinson's disease model. J. Neurosci. Methods 2012, 204:234-237.