Activation of Ras-ERK signaling and GSK-3 by amyloid precursor protein and amyloid beta facilitates neurodegeneration in Alzheimer’s disease

eNeuro

Volumn 4, Issue 2, 2017, Pages

  Kirouac, Lisa ^a   Rajic, Alexander J ^b   Cribbs, David H ^b   Padmanabhan, Jaya ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

A beta; Alzheimer s disease; Amyloid precursor protein; GSK3; Protein phosphorylation; Ras MAPK signaling

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; TAU PROTEIN; AMYLOID BETA-PROTEIN (1-42); MAPT PROTEIN, HUMAN; MAPT PROTEIN, RAT; PEPTIDE FRAGMENT;

AGED; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL CYCLE REGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE SILENCING; HUMAN; HUMAN TISSUE; MALE; NERVE DEGENERATION; NEUROBLASTOMA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUNEL ASSAY; UPREGULATION; VERY ELDERLY; WESTERN BLOTTING; ANIMAL; BRAIN; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MAPK SIGNALING; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELL LINE, TUMOR; CYCLIN D1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; NERVE DEGENERATION; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RAS PROTEINS; RATS, SPRAGUE-DAWLEY; TAU PROTEINS;

EID: 85020754168     PISSN: None     EISSN: 23732822     Source Type: Journal    
DOI: 10.1523/ENEURO.0149-16.2017     Document Type: Article

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