Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells

American Journal of Physiology - Cell Physiology

Volumn 273, Issue 5 42-5, 1997, Pages

  Dabrowski, Andrzej ^a,b   Groblewski, Guy E ^a   Schäfer, Claus ^a   Guan, Kun Liang ^a   Williams, John A ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b School of Medicine   (Poland)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Epidermal growth factor; Mitogen activated protein kinase kinase; Protein kinase C; Raf; Ras

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE;

ACINAR CELL; ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030720786     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1997.273.5.c1472     Document Type: Article

References (12)

1. 2-adrenergic receptors expressed in fibroblasts. J. Biol. Chem. 268: 22235-22238, 1993.
2. Alessi, D. R. The protein kinase C inhibitors R0318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1B (Rsk-2) and p70S6K. FEBS Lett. 402: 121-123, 1997.
3. Barnier, J. V., C. Papin, A. Eychène, O. Lecoq, and G. Calothy. The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression. J. Biol. Chem. 270: 23381-23889, 1995.
4. Bogoyevitch, M. A., C. J. Marshall, and P. H. Sugden. Hypertrophic agonists stimulate the activities of the protein kinases c-raf and A-raf in cultured ventricular myocytes. J. Biol. Chem. 270: 26303-26310, 1995.
5. rsk in rat pancreatic acini through protein kinase C. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G401-G407, 1997.
6. Burgering, B. M. T., and J. L. Bos. Regulation of Ras-mediated signaling: more than one way to skin a cat. Trends Biochem. Sci. 20: 18-22, 1995.
7. Cano, E., and L. C. Mahadevan. Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20: 117-122, 1995.
8. Dabrowski, A., T. Grady, C. D. Logsdon, and J. A. Williams. Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo. J. Biol. Chem. 271: 5686-5690, 1996.
9. Dabrowski, A., J. VanderKuur, C. Carter-Su, and J. A. Williams. Cholecystokinin stimulates formation of a Shc-Grb2 complex in rat pancreatic acinar cells through a protein kinase C-dependent mechanism. J. Biol. Chem. 271: 27125-27129, 1996.
10. Davis, R. J. MAPKs: new JNK expands the group. Trends Biochem Sci. 19: 470-473, 1994.
11. Dent, P., W. Haser, T. A. J. Haystead, L. A. Vincent, T. M. Roberts, and T. W. Sturgill. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science 257: 1404-1407, 1992.
12. Dent, P., T. Jelinek, D. K. Morrison, M. J. Weber, and T. W. Sturgill. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. Science 268: 1902-1906, 1995.