Nerve growth factor and ras regulate β-amyloid precursor protein gene expression in PC12 cells

Journal of Neurochemistry

Volumn 67, Issue 1, 1996, Pages 98-104

  Cosgaya, José Miguel ^a   Latasa, Maria Jesús ^a   Pascual, Angel ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Amyloid precursor protein; Growth factors; PC12 cells; ras oncogene; Tyrosine kinase receptors

Indexed keywords

AMYLOID PRECURSOR PROTEIN; NERVE GROWTH FACTOR; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTO ONCOGENE; RNA ANALYSIS;

ANIMALIA;

EID: 0029888642     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67010098.x     Document Type: Article

References (45)

1. Allinquant B., Hantraye P., Mailleux P., Moya K., Bouillot C., and Prochiantz A. (1995) Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro. J. Cell Biol. 128, 919-927.
2. Bar-Sagi D. and Feramisco J. R. (1985) Microinjection of the Ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42, 841-848.
3. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
4. Feig L. A. and Cooper G. M. (1988) Inhibition of NIH 3T3 cell proliferation by a mutant Ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8, 3235-3243.
5. Forloni G., Del Bo R., Angeretti N., Smiroldo S., Gabellini N., and Vantini G. (1993) Nerve growth factor does not influence the expression of β-amyloid precursor protein mRNA in rat brain: in vivo and in vitro studies. Brain Res. 620, 292-296.
6. Fucuchi K., Kamino K., Deeb S. S., Smith A. C., Dang T., and Martin G. M. (1992) Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem. Biophys. Res. Commun. 182, 165-173.
7. Fukuyama R., Chandrasekaran K., and Rapoport S. I. (1993) Nerve growth factor-induced neuronal differentiation is accompanied by differential induction and localization of the amyloid precursor protein (APP) in PC12 cells and variant PC12S cells. Mol. Brain Res. 17, 17-22.
8. Games D., Adams D., Alessandrini R., Barbour R., Berthelette P., Blackwell C., Carr T., Clemens J., Donaldson T., Gillespie F., Guido T., Hagoplan S., Johnson-Wood K., Khan K., Lee M., Leibowith P., Lieberburg I., Little S., Masliah E., McConlogue L., Montoya-Zavala M., Mucke L., Paganini L., Penniman E., Power M., Schenk D., Seubert P., Snyder B., Soriano F., Tan H., Vitale J., Wadsworth S., Wolozin B., and Zhao J. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 273, 523-527.
9. Goldgaber D., Harris H. W., Hla T., Maciag T., Donnelly R. J., Jacobsen J. S., Vitek M. P., and Gajdusek D. C. (1989) Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in human endothelial cells. Proc. Natl. Acad. Sci. USA 86, 7606-7610.
10. Greenberg M. E., Greene L. A., and Ziff E. B. (1985) Nerve growth factor and epidermal growth factor induce a rapid transient change in proto-oncogene transcription in PC12 cells. J. Biol. Chem. 260, 14101-14110.
11. Greenberg S. M., Koo E. H., Selkoe D. J., Qiu W. Q., and Kosik K. S. (1994) Secreted β-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances τ phosphorylation. Proc. Natl. Acad. Sci. USA 91, 7104-7108.
12. Greene L. A. and Tischler A. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73, 2424-2428.
13. Guerrero I., Pellicer A., and Burstein D. E. (1988) Dissociation of c-fos from ODC expression and neuronal differentiation in a PC-12 subline stably transfected with an inducible N-ras oncogene. Biochem. Biophys. Res. Commun. 150, 1585-1592.
14. Hagag N., Halegoua S., and Viola M. (1986) Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to Ras p21, Nature 319, 680-682.
15. Halegoua S., Armstrong R. B., and Kremer N. E. (1991) Dissecting the mode of action of a neuronal growth factor. Curr. Top. Microbiol. Immunol. 165, 119-170.
16. Heasly L. E. and Johnson G. L. (1992) The β-PDGF receptor induces neuronal differentiation of PC12 cells. Mol. Biol. Cell 3, 545-553.
17. Hoffman P. W. and Chernak J. M. (1994) The rat amyloid precursor protein promoter contains two DNA regulatory elements which influence high level gene expression. Biochem. Biophys. Res. Commun. 201, 610-617.
18. Huff K., End D., and Guroff G. (1981) Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor. J. Cell Biol. 88, 189-198.
19. König G., Master C. L., and Beyreuther K. (1990) Retinoic acid induced differentiated neuroblastoma cells show increased expression of the A4 amyloid gene of Alzheimer's disease and an altered splicing pattern. FEBS Lett. 269, 305-310.
20. Kremer N. E., D'Arcangelo G., Thomas S. M., De Marco M., Brugge J. S., and Halegoua S. (1991) Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of Src and Ras actions. J. Cell Biol. 115, 809-819.
21. Lahiri D. K. and Robakis N. K. (1991) The promoter activity of the gene encoding Alzheimer β-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences. Mol. Brain Res. 9, 253-257.
22. Levi-Montalcini R. (1987) The nerve growth factor 35 years later. Science 237, 1154-1162.
23. Milward E. A., Papadopoulos R., Fuller S. J., Moir R. D., Small D., Beyreuther K., and Masters C. L. (1992) The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9, 129-137.
24. Mobley W. C., Neve R. L., Prusiner S. B., and McKinley M. P. (1988) Nerve growth factor increases mRNA levels for the prion protein and the β-amyloid protein precursor in developing hamster brain. Proc. Natl. Acad. Sci. USA 85, 9811-9815.
25. ras in rat pheochromocytoma PC12 cells. Oncogene 7, 277-281.
26. Neve R. L., Finch E. A., and Dawes L. R. (1988) Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1, 669-677.
27. Ohyagi Y. and Tabira T. (1993) Effect of growth factors and cytokines on expression of amyloid β-protein precursor mRNAs in cultured neural cells. Mol. Brain Res. 18, 127-132.
28. ras activity and consequent prolonged ERK activity. Neuron 9, 705-717.
29. Quon D., Catalano R., and Cordell B. (1990) Fibroblast growth factor induces β-amyloid precursor mRNA in glial but not neuronal cultured cells. Biochem. Biophys. Res. Commun. 167, 96-102.
30. Quon D., Wang Y., Catalano R., Scardina J. M., Kurakami K., and Cordell B. (1991) Formation of β-amyloid protein deposits in brains of transgenic mice. Nature 352, 239-241.
31. Rabin S. J., Cleghon V., and Kaplan D. R. (1993) SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol. Cell. Biol. 13, 2203-2213.
32. Refolo L. M., Salton S. R. J., Anderson J. P., Mehta P., and Robakis N. K. (1989) Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC12 cell cultures. Biochem. Biophys. Res. Commun. 164, 664-670.
33. Rodriguez-Viciana P., Warne P. H., Dhand R., Vanhaesebroeck B., Gout I., Fry M. J., Waterfield M. D., and Downward J. (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370, 527-532.
34. Salbaum J. M., Weidemann A., Lemaire H., Masters C. L., and Beyreuther K. (1988) The promoter of Alzheimer' disease amyloid A4 precursor gene. EMBO J. 7, 2807-2813.
35. Schlessinger J. (1993) How receptor tyrosine kinases activate Ras. Trends Biochem. Sci. 18, 273-275.
36. Selkoe D. J. (1994) Cell biology of the β-amyloid protein precursor and the mechanism of Alzheimer disease. Annu. Rev. Cell Biol. 10, 373-403.
37. Szeberényi J., Cai H., and Cooper G. M. (1990) Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell. Biol. 10, 5324-5332.
38. Thomas S. M., DeMarco M., D'Arcangelo G., Halegoua S., and Brugge J. S. (1992) Ras is essential for nerve growth factor-and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68, 1031-1040.
39. Togari A., Baker D., Dickens G., and Guroff G. (1983) The neurite-promoting effect of fibroblast growth factor on PC12 cells. Biochem. Biophys. Res. Commun. 114, 1189-1193.
40. Trejo J., Massamiri T., Deng T., Dewji N. N., Bayney R. M., and Brown J. H. (1994) A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's β-amyloid precursor protein gene. J. Biol. Chem. 269, 21682-21690.
41. Troppmair J., Bruder J. T., App H., Cai H., Liptak L., Szeberényi J., Cooper G. M., and Rapp U. R. (1992) Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and b-Raf protein serine kinases in the cytosol. Oncogene 7, 1867-1873.
42. Warne P. H., Rodriguez-Viciana P., and Downward I. (1993) Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature 364, 352-355.
43. Wood K. W., Sarnecki C., Roberts T. M., and Blenis J. (1992) Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68, 1041-1050.
44. Yoshikai S., Sasaki H., Doh-ura K., Furuya H., and Sakaki Y. (1990) Genomic organization of the human amyloid beta-protein precursor gene. Gene 87, 257-263.
45. Yoshikawa K., Aizawa T., and Hayashi Y. (1992) Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359, 64-67.