Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease

Molecular Brain Research

Volumn 109, Issue 1-2, 2002, Pages 45-55

  Pei, Jin Jing ^a   Braak, Heiko ^b   An, Wen Lin ^a   Winblad, Bengt ^a   Cowburn, Richard F ^a   Iqbal, Khalid ^c   Grundke Iqbal, Inge ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GOETHE UNIVERSITY   (Germany)

^c NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Alzheimer's disease; ERK; MEK; Neurofibrillary tangles

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CELL SIZE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DISEASE COURSE; DISEASE SEVERITY; ENTORHINAL CORTEX; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; GRANULE CELL; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; NERVE CELL; NERVE DEGENERATION; NERVE PROJECTION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TEMPORAL CORTEX; TISSUE DISTRIBUTION; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; BRAIN; FEMALE; FLUORESCENT DYES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROFIBRILS; NEURONS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; TAU PROTEINS; UP-REGULATION;

EID: 12244279939     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(02)00488-6     Document Type: Article

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