Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration

Molecular and Cellular Biology

Volumn 26, Issue 11, 2006, Pages 4327-4338

  Chang, Keun A ^a   Kim, Hye Sun ^a   Ha, Tae Young ^a   Ha, Ji Won ^a   Shin, Ki Young ^a   Jeong, Yun Ha ^a   Lee, Jean Pyo ^c   Park, Cheol Hyoung ^a   Kim, Seonghan ^a   Baik, Tae Kyoung ^b   Suh, Yoo Hun ^a  

^a Seoul National University   (South Korea)

^b Eulji University   (South Korea)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN FE65; TAU PROTEIN; THREONINE; TRANSCRIPTION FACTOR CP2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME INDUCTION; HUMAN; HUMAN TISSUE; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

ACTIVE TRANSPORT, CELL NUCLEUS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELL DEATH; CELL NUCLEUS; CELLS, CULTURED; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; NERVE DEGENERATION; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PC12 CELLS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; TAU PROTEINS; THREONINE;

EID: 33646862834     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.02393-05     Document Type: Article

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