Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes

Molecular Neurodegeneration

Volumn 6, Issue 1, 2011, Pages

  Judge, Monique ^b   Hornbeck, Lisa ^a,b   Potter, Huntington ^a,b   Padmanabhan, Jaya ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Amyloid precursor protein; amyloid processing; APP phosphorylation; cell cycle; kinases; mitosis

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CELL CYCLE PROTEIN; CYCLIN D; CYCLIN E; PRESENILIN 1; REGULATOR PROTEIN; THREONINE; TRANSCRIPTION FACTOR E2F1; SMALL INTERFERING RNA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CENTROSOME; CONTROLLED STUDY; DEGENERATIVE DISEASE; IMMUNOHISTOCHEMISTRY; MITOSIS; MOUSE; NERVE CELL; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE; WESTERN BLOTTING; AMYLOID PLAQUE; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENETIC TRANSFECTION; HUMAN; IMMUNOPRECIPITATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING;

MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; BRAIN; CELL CYCLE PROTEINS; CENTROSOME; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOSIS; PHOSPHORYLATION; PLAQUE, AMYLOID; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, SMALL INTERFERING; THREONINE; TRANSFECTION;

EID: 81555234239     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-6-80     Document Type: Article

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