Secreted amyloid precursor protein and holo-APP bind amyloid β through distinct domains eliciting different toxic responses on hippocampal neurons

Journal of Neuroscience Research

Volumn 88, Issue 8, 2010, Pages 1795-1803

  Kedikian, Gabriela ^a   Heredia, Florencia ^a   Salvador, Victoria Rozes ^a   Raimunda, Daniel ^a   Isoardi, Nora ^a,b   Heredia, Lorena ^a   Lorenzo, Alfredo ^a,b  

^a INSTITUTO DE INVESTIGACIÓN MÉDICA MERCEDES Y MARTÍN FERREYRA   (Argentina)

^b UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Alzheimer's disease; Amyloid ; Neurodegeneration; Precursor protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; HOLO AMYLOID PRECURSOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; EXTRACELLULAR JUXTAMEMBRANE; GENE DELETION; HIPPOCAMPUS; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SECRETION; RAT; WESTERN BLOTTING;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CRICETINAE; CRICETULUS; EMBRYO, MAMMALIAN; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HUMANS; IMMUNOPRECIPITATION; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PEPTIDE FRAGMENTS; PROTEIN BINDING; RATS; TRANSFECTION;

EID: 77952404785     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22347     Document Type: Article

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