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Volumn 22, Issue 6, 2017, Pages

The antidiabetic mechanisms of polyphenols related to increased glucagon-like peptide-1 (GLP1) and insulin signaling

Author keywords

Beta cells; Diabetes; DPP4 inhibition; GLP1; Insulin; L cells; Pancreas; Polyphenols

Indexed keywords


EID: 85020655656     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules22060903     Document Type: Review
Times cited : (103)

References (52)
  • 1
    • 84892659350 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • Association, A.A.D. [CrossRef] [PubMed]
    • Association, A.A.D. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2014, 37, S81-S90. [CrossRef] [PubMed]
    • (2014) Diabetes Care , vol.37 , pp. S81-S90
  • 2
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • [CrossRef] [PubMed]
    • Shaw, J.E.; Sicree, R.A.; Zimmet, P.Z. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 2010, 87, 4-14. [CrossRef] [PubMed]
    • (2010) Diabetes Res. Clin. Pract. , vol.87 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 3
    • 82955247909 scopus 로고    scopus 로고
    • IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
    • [CrossRef] [PubMed]
    • Whiting, D.R.; Guariguata, L.;Weil, C.; Shaw, J. IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract. 2011, 94, 311-321. [CrossRef] [PubMed]
    • (2011) Diabetes Res. Clin. Pract. , vol.94 , pp. 311-321
    • Whiting, D.R.1    Guariguata, L.2    Weil, C.3    Shaw, J.4
  • 4
    • 85027055277 scopus 로고    scopus 로고
    • (accessed on 11 January)
    • World Health Organization. W.H.O. Global Report On Diabetes. Available online: apps.who.int/iris/bitstream/10665/204871/1/9789241565257-eng.pdf (accessed on 11 January 2017).
    • (2017) W.H.O. Global Report on Diabetes
  • 5
    • 84938420461 scopus 로고    scopus 로고
    • The economic costs of type 2 diabetes: A global systematic review
    • [CrossRef] [PubMed]
    • Seuring, T.; Archangelidi, O.; Suhrcke, M. The Economic Costs of Type 2 Diabetes: A Global Systematic Review. Pharmacoeconomics 2015, 33, 811-831. [CrossRef] [PubMed]
    • (2015) Pharmacoeconomics , vol.33 , pp. 811-831
    • Seuring, T.1    Archangelidi, O.2    Suhrcke, M.3
  • 6
    • 79960181204 scopus 로고    scopus 로고
    • 4th ed.;Wiley-Blackwell: Chichester,West Sussex, UK; Hoboken, NJ, USA
    • Holt, R.I.G. Textbook of Diabetes, 4th ed.;Wiley-Blackwell: Chichester,West Sussex, UK; Hoboken, NJ, USA, 2010; p. 1119.
    • (2010) Textbook of Diabetes , pp. 1119
    • Holt, R.I.G.1
  • 7
    • 84873410142 scopus 로고    scopus 로고
    • High fructose corn syrup and diabetes prevalence: A global perspective
    • [CrossRef] [PubMed]
    • Goran, M.I.; Ulijaszek, S.J.; Ventura, E.E. High fructose corn syrup and diabetes prevalence: A global perspective. Glob. Public Health 2013, 8, 55-64. [CrossRef] [PubMed]
    • (2013) Glob. Public Health , vol.8 , pp. 55-64
    • Goran, M.I.1    Ulijaszek, S.J.2    Ventura, E.E.3
  • 8
    • 84902493910 scopus 로고    scopus 로고
    • The effect of Mediterranean diet on the development of type 2 diabetes mellitus: A meta-analysis of 10 prospective studies and 136,846 participants
    • [CrossRef] [PubMed]
    • Koloverou, E.; Esposito, K.; Giugliano, D.; Panagiotakos, D. The effect of Mediterranean diet on the development of type 2 diabetes mellitus: A meta-analysis of 10 prospective studies and 136,846 participants. Metabolism 2014, 63, 903-911. [CrossRef] [PubMed]
    • (2014) Metabolism , vol.63 , pp. 903-911
    • Koloverou, E.1    Esposito, K.2    Giugliano, D.3    Panagiotakos, D.4
  • 9
    • 85017657564 scopus 로고    scopus 로고
    • A novel synthetic pathway enables microbial production of polyphenols independent from the endogenous aromatic amino acid metabolism
    • [CrossRef] [PubMed]
    • Kallscheuer, N.; Vogt, M.; Marienhagen, J. A Novel Synthetic Pathway Enables Microbial Production of Polyphenols Independent from the Endogenous Aromatic Amino Acid Metabolism. ACS Synth. Biol. 2017, 6, 410-415. [CrossRef] [PubMed]
    • (2017) ACS Synth Biol. , vol.6 , pp. 410-415
    • Kallscheuer, N.1    Vogt, M.2    Marienhagen, J.3
  • 10
    • 84946491882 scopus 로고    scopus 로고
    • Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effect-A review
    • [CrossRef]
    • Shahidi, F.; Ambigaipalan, P. Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effect-A review. J. Funct. Foods 2015, 18, 820-897. [CrossRef]
    • (2015) J. Funct. Foods , vol.18 , pp. 820-897
    • Shahidi, F.1    Ambigaipalan, P.2
  • 11
    • 84976299785 scopus 로고    scopus 로고
    • Polyphenol-and fibre-rich dried fruits with green tea attenuate starch-derived postprandial blood glucose and insulin: A randomised, controlled, single-blind, cross-over intervention
    • [CrossRef] [PubMed]
    • Nyambe-Silavwe, H.; Williamson, G. Polyphenol-and fibre-rich dried fruits with green tea attenuate starch-derived postprandial blood glucose and insulin: A randomised, controlled, single-blind, cross-over intervention. Br. J. Nutr. 2016, 116, 443-450. [CrossRef] [PubMed]
    • (2016) Br. J. Nutr. , vol.116 , pp. 443-450
    • Nyambe-Silavwe, H.1    Williamson, G.2
  • 12
    • 84962498419 scopus 로고    scopus 로고
    • Cocoa and whey protein differentially affect markers of lipid and glucose metabolism and satiety
    • [CrossRef] [PubMed]
    • Campbell, C.L.; Foegeding, E.A.; Harris, G.K. Cocoa and Whey Protein Differentially Affect Markers of Lipid and Glucose Metabolism and Satiety. J. Med. Food 2016, 19, 219-227. [CrossRef] [PubMed]
    • (2016) J. Med. Food , vol.19 , pp. 219-227
    • Campbell, C.L.1    Foegeding, E.A.2    Harris, G.K.3
  • 13
    • 84976449644 scopus 로고    scopus 로고
    • Inhibition of advanced glycation end-product formation and antioxidant activity by extracts and polyphenols from scutellaria alpina L. and S. Altissima L
    • [CrossRef] [PubMed]
    • Grzegorczyk-Karolak, I.; Golab, K.; Gburek, J.; Wysokinska, H.; Matkowski, A. Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. Molecules 2016, 21, 1-10. [CrossRef] [PubMed]
    • (2016) Molecules , vol.21 , pp. 1-10
    • Grzegorczyk-Karolak, I.1    Golab, K.2    Gburek, J.3    Wysokinska, H.4    Matkowski, A.5
  • 14
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • [CrossRef] [PubMed]
    • Holst, J.J. The physiology of glucagon-like peptide 1. Physiol. Rev. 2007, 87, 1409-1439. [CrossRef] [PubMed]
    • (2007) Physiol. Rev. , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 15
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • [CrossRef] [PubMed]
    • Baggio, L.L.; Drucker, D.J. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007, 132, 2131-2157. [CrossRef] [PubMed]
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 16
    • 84920095184 scopus 로고    scopus 로고
    • Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors
    • [CrossRef] [PubMed]
    • Mulvihill, E.E.; Drucker, D.J. Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors. Endocr. Rev. 2014, 35, 992-1019. [CrossRef] [PubMed]
    • (2014) Endocr. Rev. , vol.35 , pp. 992-1019
    • Mulvihill, E.E.1    Drucker, D.J.2
  • 17
    • 84940009221 scopus 로고    scopus 로고
    • INS-gene mutations: From genetics and beta cell biology to clinical disease
    • [CrossRef] [PubMed]
    • Liu, M.; Sun, J.H.; Cui, J.Q.; Chen, W.; Guo, H.; Barbetti, F.; Arvan, P. INS-gene mutations: From genetics and beta cell biology to clinical disease. Mol. Asp. Med. 2015, 42, 3-18. [CrossRef] [PubMed]
    • (2015) Mol. Asp. Med. , vol.42 , pp. 3-18
    • Liu, M.1    Sun, J.H.2    Cui, J.Q.3    Chen, W.4    Guo, H.5    Barbetti, F.6    Arvan, P.7
  • 18
    • 84894046601 scopus 로고    scopus 로고
    • Proinsulin Entry and Transit through the Endoplasmic Reticulum in Pancreatic Beta Cells
    • [PubMed]
    • Liu, M.; Wright, J.; Guo, H.; Xiong, Y.; Arvan, P. Proinsulin Entry and Transit through the Endoplasmic Reticulum in Pancreatic Beta Cells. Vitam. Horm. 2014, 95, 35-62. [PubMed]
    • (2014) Vitam. Horm. , vol.95 , pp. 35-62
    • Liu, M.1    Wright, J.2    Guo, H.3    Xiong, Y.4    Arvan, P.5
  • 19
    • 84891648237 scopus 로고    scopus 로고
    • Insulin receptor signaling in normal and insulin-resistant states
    • [CrossRef] [PubMed]
    • Boucher, J.; Kleinridders, A.; Kahn, C.R. Insulin Receptor Signaling in Normal and Insulin-Resistant States. CSH Perspect. Biol. 2014, 6, 1-23. [CrossRef] [PubMed]
    • (2014) CSH Perspect. Biol. , vol.6 , pp. 1-23
    • Boucher, J.1    Kleinridders, A.2    Kahn, C.R.3
  • 20
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • [CrossRef] [PubMed]
    • Kahn, S.E.; Hull, R.L.; Utzschneider, K.M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006, 444, 840-846. [CrossRef] [PubMed]
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 21
    • 36549009003 scopus 로고    scopus 로고
    • DPP-4 inhibitors
    • [CrossRef] [PubMed]
    • Ahren, B. DPP-4 inhibitors. Best Pract. Res. Clin. Endocrinol. 2007, 21, 517-533. [CrossRef] [PubMed]
    • (2007) Best Pract. Res. Clin. Endocrinol. , vol.21 , pp. 517-533
    • Ahren, B.1
  • 22
    • 84995559883 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors: Novel mechanism of actions
    • [CrossRef] [PubMed]
    • Singh, A.K. Dipeptidyl peptidase-4 inhibitors: Novel mechanism of actions. Indian J. Endocr. Metab. 2014, 18, 753-759. [CrossRef] [PubMed]
    • (2014) Indian J. Endocr. Metab. , vol.18 , pp. 753-759
    • Singh, A.K.1
  • 23
    • 84870054636 scopus 로고    scopus 로고
    • GLP-1 receptor agonists for individualized treatment of type 2 diabetesmellitus
    • [CrossRef] [PubMed]
    • Meier, J.J. GLP-1 receptor agonists for individualized treatment of type 2 diabetesmellitus. Natr. Rev. Endocrinol. 2012, 8, 728-742. [CrossRef] [PubMed]
    • (2012) Natr. Rev. Endocrinol. , vol.8 , pp. 728-742
    • Meier, J.J.1
  • 25
    • 84920850372 scopus 로고    scopus 로고
    • Pharmacogenomics of glinides
    • [CrossRef] [PubMed]
    • Chen, M.; Hu, C.; Jia, W.P. Pharmacogenomics of glinides. Pharmacogenomics 2015, 16, 45-60. [CrossRef] [PubMed]
    • (2015) Pharmacogenomics , vol.16 , pp. 45-60
    • Chen, M.1    Hu, C.2    Jia, W.P.3
  • 28
    • 84906562305 scopus 로고    scopus 로고
    • Dietary sweet potato (Ipomoea batatas L) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1)
    • [CrossRef] [PubMed]
    • Nagamine, R.; Ueno, S.; Tsubata, M.; Yamaguchi, K.; Takagaki, K.; Hira, T.; Hara, H.; Tsuda, T. Dietary sweet potato (Ipomoea batatas L.) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1). Food Funct. 2014, 5, 2309-2316. [CrossRef] [PubMed]
    • (2014) Food Funct. , vol.5 , pp. 2309-2316
    • Nagamine, R.1    Ueno, S.2    Tsubata, M.3    Yamaguchi, K.4    Takagaki, K.5    Hira, T.6    Hara, H.7    Tsuda, T.8
  • 29
    • 85010858927 scopus 로고    scopus 로고
    • Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 (GLP-1(7-36)) amide in C57BL/6J mice
    • [CrossRef] [PubMed]
    • Fujii, Y.; Osaki, N.; Hase, T.; Shimotoyodome, A. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 (GLP-1(7-36)) amide in C57BL/6J mice. J. Nutr. Sci. 2015, 4, 1-9. [CrossRef] [PubMed]
    • (2015) J. Nutr. Sci. , vol.4 , pp. 1-9
    • Fujii, Y.1    Osaki, N.2    Hase, T.3    Shimotoyodome, A.4
  • 30
    • 36949030842 scopus 로고    scopus 로고
    • The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people
    • [CrossRef] [PubMed]
    • Thom, E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J. Int. Med. Res. 2007, 35, 900-908. [CrossRef] [PubMed]
    • (2007) J. Int. Med. Res. , vol.35 , pp. 900-908
    • Thom, E.1
  • 31
    • 85013977931 scopus 로고    scopus 로고
    • Flavanol concentrations do not predict dipeptidyl peptidase-IV inhibitory activities of four cocoas with different processing histories
    • [CrossRef] [PubMed]
    • Ryan, C.M.; Khoo,W.; Stewart, A.C.; O'Keefe, S.F.; Lambert, J.D.; Neilson, A.P. Flavanol concentrations do not predict dipeptidyl peptidase-IV inhibitory activities of four cocoas with different processing histories. Food Funct. 2017, 8, 746-756. [CrossRef] [PubMed]
    • (2017) Food Funct. , vol.8 , pp. 746-756
    • Ryan, C.M.1    Khoo, W.2    Stewart, A.C.3    O'Keefe, S.F.4    Lambert, J.D.5    Neilson, A.P.6
  • 33
    • 84899441839 scopus 로고    scopus 로고
    • Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells
    • [CrossRef] [PubMed]
    • González-Abuín, N.; Martinez-Micaelo, N.; Blay, M.; Green, B.D.; Pinent, M.; Ardevol, A. Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. Am. J. Physiol. Cell Physiol. 2014, 306, C485-C492. [CrossRef] [PubMed]
    • (2014) Am. J. Physiol. Cell Physiol. , vol.306 , pp. C485-C492
    • González-Abuín, N.1    Martinez-Micaelo, N.2    Blay, M.3    Green, B.D.4    Pinent, M.5    Ardevol, A.6
  • 34
    • 84956604510 scopus 로고    scopus 로고
    • Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent
    • [CrossRef] [PubMed]
    • Serrano, J.; Casanova-Marti, A.; Gil-Cardoso, K.; Blay, M.T.; Terra, X.; Pinent, M.; Ardevol, A. Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent. Food Funct. 2016, 7, 483-490. [CrossRef] [PubMed]
    • (2016) Food Funct. , vol.7 , pp. 483-490
    • Serrano, J.1    Casanova-Marti, A.2    Gil-Cardoso, K.3    Blay, M.T.4    Terra, X.5    Pinent, M.6    Ardevol, A.7
  • 35
    • 84900661735 scopus 로고    scopus 로고
    • By-product from decoction process of Hibiscus sabdariffa L. Calyces as a source of polyphenols and dietary fiber
    • [CrossRef] [PubMed]
    • Sayago-Ayerdi, S.G.; Velazquez-Lopez, C.; Montalvo-Gonzalez, E.; Goni, I. By-product from decoction process of Hibiscus sabdariffa L. calyces as a source of polyphenols and dietary fiber. J. Sci. Food Agric. 2014, 94, 898-904. [CrossRef] [PubMed]
    • (2014) J. Sci. Food Agric. , vol.94 , pp. 898-904
    • Sayago-Ayerdi, S.G.1    Velazquez-Lopez, C.2    Montalvo-Gonzalez, E.3    Goni, I.4
  • 36
    • 84907942461 scopus 로고    scopus 로고
    • Hibiscus sabdariffa Polyphenols Alleviate Insulin Resistance and Renal Epithelial to Mesenchymal Transition: A Novel Action Mechanism Mediated by Type 4 Dipeptidyl Peptidase
    • [CrossRef] [PubMed]
    • Peng, C.H.; Yang, Y.S.; Chan, K.C.; Wang, C.J.; Chen, M.L.; Huang, C.N. Hibiscus sabdariffa Polyphenols Alleviate Insulin Resistance and Renal Epithelial to Mesenchymal Transition: A Novel Action Mechanism Mediated by Type 4 Dipeptidyl Peptidase. J. Agric. Food Chem. 2014, 62, 9736-9743. [CrossRef] [PubMed]
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 9736-9743
    • Peng, C.H.1    Yang, Y.S.2    Chan, K.C.3    Wang, C.J.4    Chen, M.L.5    Huang, C.N.6
  • 37
    • 84964769158 scopus 로고    scopus 로고
    • Flaked sorghum biscuits increase postprandial GLP-1 and GIP levels and extend subjective satiety in healthy subjects
    • [CrossRef] [PubMed]
    • Stefoska-Needham, A.; Beck, E.J.; Johnson, S.K.; Chu, J.Y.; Tapsell, L.C. Flaked sorghum biscuits increase postprandial GLP-1 and GIP levels and extend subjective satiety in healthy subjects. Mol. Nutr. Food Res. 2016, 60, 1118-1128. [CrossRef] [PubMed]
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 1118-1128
    • Stefoska-Needham, A.1    Beck, E.J.2    Johnson, S.K.3    Chu, J.Y.4    Tapsell, L.C.5
  • 38
    • 84934451277 scopus 로고    scopus 로고
    • A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. Population in the gut microbiota of mice
    • [CrossRef] [PubMed]
    • Anhê, F.F.; Roy, D.; Pilon, G.; Dudonné, S.; Matamoros, S.; Varin, T.V.; Garofalo, C.; Moine, Q.; Desjardins, Y.; Levy, E.; et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 2015, 64, 872-883. [CrossRef] [PubMed]
    • (2015) Gut , vol.64 , pp. 872-883
    • Anhê, F.F.1    Roy, D.2    Pilon, G.3    Dudonné, S.4    Matamoros, S.5    Varin, T.V.6    Garofalo, C.7    Moine, Q.8    Desjardins, Y.9    Levy, E.10
  • 39
    • 84960253261 scopus 로고    scopus 로고
    • Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: Relationship with gut microbiome richness and ecology
    • [CrossRef] [PubMed]
    • Dao, M.C.; Everard, A.; Aron-Wisnewsky, J.; Sokolovska, N.; Prifti, E.; Verger, E.O.; Kayser, B.D.; Levenez, F.; Chilloux, J.; Hoyles, L.; et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: Relationship with gut microbiome richness and ecology. Gut 2016, 65, 426-436. [CrossRef] [PubMed]
    • (2016) Gut , vol.65 , pp. 426-436
    • Dao, M.C.1    Everard, A.2    Aron-Wisnewsky, J.3    Sokolovska, N.4    Prifti, E.5    Verger, E.O.6    Kayser, B.D.7    Levenez, F.8    Chilloux, J.9    Hoyles, L.10
  • 40
    • 84867212574 scopus 로고    scopus 로고
    • Cinnamon polyphenols regulate multiple metabolic pathways involved in insulin signaling and intestinal lipoprotein metabolism of small intestinal enterocytes
    • [CrossRef] [PubMed]
    • Qin, B.L.; Dawson, H.D.; Schoene, N.W.; Polansky, M.M.; Anderson, R.A. Cinnamon polyphenols regulate multiple metabolic pathways involved in insulin signaling and intestinal lipoprotein metabolism of small intestinal enterocytes. Nutrition 2012, 28, 1172-1179. [CrossRef] [PubMed]
    • (2012) Nutrition , vol.28 , pp. 1172-1179
    • Qin, B.L.1    Dawson, H.D.2    Schoene, N.W.3    Polansky, M.M.4    Anderson, R.A.5
  • 41
    • 84878774732 scopus 로고    scopus 로고
    • Cinnamtannin A2, a Tetrameric Procyanidin, Increases GLP-1 and Insulin Secretion in Mice
    • [CrossRef] [PubMed]
    • Yamashita, Y.; Okabe, M.; Natsume, M.; Ashida, H. Cinnamtannin A2, a Tetrameric Procyanidin, Increases GLP-1 and Insulin Secretion in Mice. Biosci. Biotechnol. Biochem. 2013, 77, 888-891. [CrossRef] [PubMed]
    • (2013) Biosci. Biotechnol. Biochem. , vol.77 , pp. 888-891
    • Yamashita, Y.1    Okabe, M.2    Natsume, M.3    Ashida, H.4
  • 42
    • 84896321557 scopus 로고    scopus 로고
    • Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding
    • [CrossRef] [PubMed]
    • Dorenkott, M.R.; Griffin, L.E.; Goodrich, K.M.; Thompson-Witrick, K.A.; Fundaro, G.; Ye, L.Y.; Stevens, J.R.; Ali, M.; O'Keefe, S.F.; Hulver, M.W.; et al. Oligomeric Cocoa Procyanidins Possess Enhanced Bioactivity Compared to Monomeric and Polymeric Cocoa Procyanidins for Preventing the Development of Obesity, Insulin Resistance, and Impaired Glucose Tolerance during High-Fat Feeding. J. Agric. Food Chem. 2014, 62, 2216-2227. [CrossRef] [PubMed]
    • (2014) J. Agric. Food Chem. , vol.62 , pp. 2216-2227
    • Dorenkott, M.R.1    Griffin, L.E.2    Goodrich, K.M.3    Thompson-Witrick, K.A.4    Fundaro, G.5    Ye, L.Y.6    Stevens, J.R.7    Ali, M.8    O'Keefe, S.F.9    Hulver, M.W.10
  • 43
    • 84901358924 scopus 로고    scopus 로고
    • Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats
    • [CrossRef]
    • Muthukumaran, J.; Srinivasan, S.; Venkatesan, R.S.; Ramachandran, V.; Muruganathan, U. Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats. J. Acute Dis. 2013, 2, 304-309. [CrossRef]
    • (2013) J. Acute Dis. , vol.2 , pp. 304-309
    • Muthukumaran, J.1    Srinivasan, S.2    Venkatesan, R.S.3    Ramachandran, V.4    Muruganathan, U.5
  • 45
    • 85007574673 scopus 로고    scopus 로고
    • Apple polyphenol extract improves insulin sensitivity in vitro and in vivo in animal models of insulin resistance
    • [CrossRef] [PubMed]
    • Manzano, M.; Giron, M.D.; Vilchez, J.D.; Sevillano, N.; El-Azem, N.; Rueda, R.; Salto, R.; Lopez-Pedrosa, J.M. Apple polyphenol extract improves insulin sensitivity in vitro and in vivo in animal models of insulin resistance. Nutr. Metab. 2016, 13, 1-10. [CrossRef] [PubMed]
    • (2016) Nutr. Metab. , vol.13 , pp. 1-10
    • Manzano, M.1    Giron, M.D.2    Vilchez, J.D.3    Sevillano, N.4    El-Azem, N.5    Rueda, R.6    Salto, R.7    Lopez-Pedrosa, J.M.8
  • 46
    • 84863587286 scopus 로고    scopus 로고
    • Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects
    • [CrossRef] [PubMed]
    • Törrönen, R.; Sarkkinen, E.; Niskanen, T.; Tapola, N.; Kilpi, K.; Niskanen, L. Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects. Br. J. Nutr. 2012, 107, 1445-1451. [CrossRef] [PubMed]
    • (2012) Br. J. Nutr. , vol.107 , pp. 1445-1451
    • Törrönen, R.1    Sarkkinen, E.2    Niskanen, T.3    Tapola, N.4    Kilpi, K.5    Niskanen, L.6
  • 47
    • 84874848268 scopus 로고    scopus 로고
    • Olive (olea europaea l) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: A randomized, placebo-controlled, crossover trial
    • [CrossRef] [PubMed]
    • De Bock, M.; Derraik, J.G.B.; Brennan, C.M.; Biggs, J.B.; Morgan, P.E.; Hodgkinson, S.C.; Hofman, P.L.; Cutfield, W.S. Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial. PLoS ONE 2013, 8, 1-8. [CrossRef] [PubMed]
    • (2013) PLoS ONE , vol.8 , pp. 1-8
    • De Bock, M.1    Derraik, J.G.B.2    Brennan, C.M.3    Biggs, J.B.4    Morgan, P.E.5    Hodgkinson, S.C.6    Hofman, P.L.7    Cutfield, W.S.8
  • 48
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing-Comparison with the euglycemic insulin clamp
    • [CrossRef] [PubMed]
    • Matsuda, M.; DeFronzo, R.A. Insulin sensitivity indices obtained from oral glucose tolerance testing-Comparison with the euglycemic insulin clamp. Diabetes Care 1999, 22, 1462-1470. [CrossRef] [PubMed]
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 49
    • 84931560412 scopus 로고    scopus 로고
    • Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: A controlled randomised intervention trial
    • [CrossRef] [PubMed]
    • Bozzetto, L.; Annuzzi, G.; Pacini, G.; Costabile, G.; Vetrani, C.; Vitale, M.; Griffo, E.; Giacco, A.; De Natale, C.; Cocozza, S.; et al. Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: A controlled randomised intervention trial. Diabetologia 2015, 58, 1551-1560. [CrossRef] [PubMed]
    • (2015) Diabetologia , vol.58 , pp. 1551-1560
    • Bozzetto, L.1    Annuzzi, G.2    Pacini, G.3    Costabile, G.4    Vetrani, C.5    Vitale, M.6    Griffo, E.7    Giacco, A.8    De Natale, C.9    Cocozza, S.10
  • 50
    • 84978160182 scopus 로고    scopus 로고
    • Plant-based dietary patterns and incidence of type 2 diabetes in US men and women: Results from three prospective cohort studies
    • [CrossRef] [PubMed]
    • Satija, A.; Bhupathiraju, S.N.; Rimm, E.B.; Spiegelman, D.; Chiuve, S.E.; Borgi, L.; Willett, W.C.; Manson, J.E.; Sun, Q.; Hu, F.B. Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies. PLoS Med. 2016, 13, 1-18. [CrossRef] [PubMed]
    • (2016) PLoS Med. , vol.13 , pp. 1-18
    • Satija, A.1    Bhupathiraju, S.N.2    Rimm, E.B.3    Spiegelman, D.4    Chiuve, S.E.5    Borgi, L.6    Willett, W.C.7    Manson, J.E.8    Sun, Q.9    Hu, F.B.10
  • 51
    • 84963795554 scopus 로고    scopus 로고
    • Intake of total polyphenols and some classes of polyphenols is inversely associated with diabetes in elderly people at high cardiovascular disease risk
    • [CrossRef] [PubMed]
    • Tresserra-Rimbau, A.; Guasch-Ferre, M.; Salas-Salvado, J.; Toledo, E.; Corella, D.; Castaner, O.; Guo, X.H.; Gomez-Gracia, E.; Lapetra, J.; Aros, F.; et al. Intake of Total Polyphenols and Some Classes of Polyphenols Is Inversely Associated with Diabetes in Elderly People at High Cardiovascular Disease Risk. J. Nutr. 2016, 146, 767-777. [CrossRef] [PubMed]
    • (2016) J. Nutr. , vol.146 , pp. 767-777
    • Tresserra-Rimbau, A.1    Guasch-Ferre, M.2    Salas-Salvado, J.3    Toledo, E.4    Corella, D.5    Castaner, O.6    Guo, X.H.7    Gomez-Gracia, E.8    Lapetra, J.9    Aros, F.10
  • 52
    • 84924975340 scopus 로고    scopus 로고
    • Effect of lyophilized grapefruit juice on P-glycoprotein-mediated drug transport in-vitro and in-vivo
    • [CrossRef] [PubMed]
    • Ahmed, I.S.; Hassan, M.A.; Kondo, T. Effect of lyophilized grapefruit juice on P-glycoprotein-mediated drug transport in-vitro and in-vivo. Drug Dev. Ind. Pharm. 2015, 41, 375-381. [CrossRef] [PubMed]
    • (2015) Drug Dev. Ind. Pharm. , vol.41 , pp. 375-381
    • Ahmed, I.S.1    Hassan, M.A.2    Kondo, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.