Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  de Bock, Martin ^a   Derraik, José G B ^a   Brennan, Christine M ^a   Biggs, Janene B ^a   Morgan, Philip E ^b   Hodgkinson, Steven C ^a   Hofman, Paul L ^a,c   Cutfield, Wayne S ^a,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACTEOSIDE; APIGENIN; C REACTIVE PROTEIN; CAFFEIC ACID; FLAVONOID; GLUCOSE; HYDROXYTYROSOL; INSULIN; INTERLEUKIN 6; INTERLEUKIN 8; KAEMPFEROL; LUTEOLIN; OLEA EUROPAEA EXTRACT; OLEIC ACID; OLEUROPEIN; PLACEBO; PLANT EXTRACT; POLYPHENOL DERIVATIVE; QUERCETIN; RUTOSIDE; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACNE; ADULT; AREA UNDER THE CURVE; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD PRESSURE MONITORING; BODY COMPOSITION; BODY MASS; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; LIPID ANALYSIS; LIVER FUNCTION; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NEW ZEALAND; OLIVE TREE; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PANCREAS ISLET BETA CELL; PATIENT COMPLIANCE; PLANT LEAF; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SIDE EFFECT; SUPPLEMENTATION;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CROSS-OVER STUDIES; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; MIDDLE AGED; NEW ZEALAND; OLEA; OVERWEIGHT; PLANT EXTRACTS; PLANT LEAVES; POLYPHENOLS; TREATMENT OUTCOME;

EID: 84874848268     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057622     Document Type: Article

References (35)

1. Fisher P, Ward A, (1994) Medicine in Europe: complementary medicine in Europe. BMJ 309: 107-111.
2. Schmidt K, Jacobs P, Barton A, (2002) Cross-cultural differences in GPs' attitudes towards complementary and alternative medicine: a survey comparing regions of the UK and Germany. Complement Ther Med 10: 141-147.
3. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS, (2003) Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 26: 1277-1294.
4. Komaki E, Yamaguchi S, Maru I, Kinoshita M, Kakehi K, et al. (2003) Identification of anti-α-amylase components from olive leaf extracts. Food Sci Technol Res 9: 35-39.
5. El SN, Karakaya S, (2009) Olive tree (Olea europaea) leaves: potential beneficial effects on human health. Nutr Rev 67: 632-638.
6. de Bock M, Derraik JGB, Cutfield W, (2012) Polyphenols and glucose homeostasis in humans. Journal of the Academy of Nutrition and Dietetics 112: 808-815.
7. Keys A, (1995) Mediterranean diet and public health: personal reflections. Am J Clin Nutr 61: 1321S-1323S.
8. Agostoni CV, (2011) Scientific Opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage (ID 1333, 1638, 1639, 1696, 2865), maintenance of normal blood HDL-cholesterol concentrations (ID 1639), maintenance of normal blood pressure (ID 3781), anti-inflammatory properties (ID 1882), contributes to the upper respiratory tract health (ID 3468), can help to maintain a normal function of gastrointestinal tract (3779), and contributes to body defences against external agents (ID 3467) pursuant to Article 13 (1) of Regulation (EC) No 1924/2006. EFSA journal 9: 2033.2031-2033.2025.
9. EFSA Panel on Dietetic Products Nutrition, (2012) Allergies (2012) Guidance on the scientific requirements for health claims related to appetite ratings, weight management, and blood glucose concentrations. EFSA Journal 10: 2604.
10. Matsuda M, DeFronzo RA, (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470.
11. Lorenzo C, Haffner SM, Stančáková A, Laakso M, (2010) Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic finnish offspring of type 2 diabetic individuals. J Clin Endocrinol Metab 95: 5082-5090.
12. Maki KC, Rains TM, Dicklin MR, Bell M, (2010) Repeatability of indices of insulin sensitivity and secretion from standard liquid meal tests in subjects with type 2 diabetes mellitus or normal or impaired fasting glucose. Diabetes Technol Ther 12: 895-900.
13. Kahn S, Prigeon R, McCulloch D, Boyko E, Bergman R, et al. (1993) Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42: 1663-1672.
14. Novotny R, Going S, Teegarden D, Van Loan M, McCabe G, et al. (2007) Hispanic and Asian pubertal girls have higher android/gynoid fat ratio than whites. Obesity 15: 1565-1570.
15. Wühl E, Witte K, Soergel M, Mehls O, Schaefer F, (2002) Distribution of 24-h ambulatory blood pressure in children: normalized reference values and role of body dimensions. J Hypertens 20: 1995.
16. Tardif JC, Lesage F, Harel F, Romeo P, Pressacco J, (2011) Imaging biomarkers in atherosclerosis trials. Circ Cardiovasc Imaging 4: 319-333.
17. Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, et al. (2003) Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood. JAMA 290: 2277-2283.
18. Hagstromer M, Oja P, Sjostrom M, (2006) The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity. Public Health Nutr 9: 755-762.
19. Brazier J, Harper R, Jones N, O'cathain A, Thomas K, et al. (1992) Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ 305: 160.
20. Maki KC, McKenney JM, Farmer MV, Reeves MS, Dicklin MR, (2009) Indices of insulin sensitivity and secretion from a standard liquid meal test in subjects with type 2 diabetes, impaired or normal fasting glucose. Nutr J 8: 22.
21. Ou H, Cheng J, Yu E, Wu T, (2006) Metformin increases insulin sensitivity and plasma beta-endorphin in human subjects. Horm Metab Res 38: 106.
22. Miyazaki Y, Matsuda M, DeFronzo RA, (2002) Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes. Diabetes Care 25: 517-523.
23. Ferrannini E, (1998) Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 19: 477-490.
24. Gerich JE, (1998) The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 19: 491-503.
25. Derosa G, Franzetti IG, Querci F, Carbone A, Caccarelli L, et al. (2012) Exenatide plus metformin compared with metformin alone on β-cell function in patients with Type 2 diabetes. Diabet Med 29: 1515-1523.
26. Degn KB, Juhl CB, Sturis J, Jakobsen G, Brock B, et al. (2004) One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and α-and β-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes 53: 1187-1194.
27. Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, et al. (2012) Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. J Med Food 15: 605-610.
28. Kim JH, Bachmann RA, Chen J, (2009) Interleukin-6 and Insulin Resistance. Vitam Horm 80: 613-633.
29. Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, et al. (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 55: 2688-2697.
30. Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, et al. (2006) Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J Biol Chem 281: 7060-7067.
31. Wheatcroft SB, Kearney MT, Shah AM, Ezzat VA, Miell JR, et al. (2007) IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes 56: 285-294.
32. Heald A, Cruickshank J, Riste L, Cade J, Anderson S, et al. (2001) Close relation of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in two populations. Diabetologia 44: 333-339.
33. Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, et al. (2008) Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res 22: 1239-1242.
34. Susalit E, Agus N, Effendi I, Tjandrawinata RR, Nofiarny D, et al. (2011) Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine 18: 251-258.
35. Fonolla J, Diaz-Ropero P, de la Fuente E, Quintela J (2010) One-month consumpotion of an olive leaf extract enhances cardivascular status in hypercholesterolemic subjects [abstract]. Atheroscler Suppl 11: 182 (MS358).