메뉴 건너뛰기




Volumn 21, Issue 4, 2007, Pages 517-533

DPP-4 inhibitors

Author keywords

dipeptidyl peptidase 4; glucagon like peptide 1; sitagliptin; treatment; type 2 diabetes; vildagliptin

Indexed keywords

6 [[2 [[2 (2 CYANO 1 PYRROLIDINYL) 2 OXOETHYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; ALOGLIPTIN; ALS 2 0426; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIPIZIDE; GLITAZONE DERIVATIVE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GRC 8200; HEMOGLOBIN A1C; INSULIN; METFORMIN; PHX 1149; PIOGLITAZONE; PLACEBO; PSN 9301; R 1438; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SSR 162369; SYR 619; TA 6666; TS 021; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALINE PYRROLIDIDE; VILDAGLIPTIN;

EID: 36549009003     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beem.2007.07.005     Document Type: Review
Times cited : (172)

References (75)
  • 2
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker D.J. The biology of incretin hormones. Cell Metabolism 3 (2006) 153-165
    • (2006) Cell Metabolism , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 3
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M., Stöckmann F., Ebert R., et al. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 29 (1986) 46-54
    • (1986) Diabetologia , vol.29 , pp. 46-54
    • Nauck, M.1    Stöckmann, F.2    Ebert, R.3
  • 4
    • 1842855423 scopus 로고    scopus 로고
    • Incretins, insulin secretion and type-2 diabetes mellitus
    • Vilsboll T., and Holst J.J. Incretins, insulin secretion and type-2 diabetes mellitus. Diabetologia 47 (2004) 357-366
    • (2004) Diabetologia , vol.47 , pp. 357-366
    • Vilsboll, T.1    Holst, J.J.2
  • 5
    • 3242730474 scopus 로고    scopus 로고
    • Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
    • Holst J.J., and Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. American Journal of Physiology 287 (2004) E199-E206
    • (2004) American Journal of Physiology , vol.287
    • Holst, J.J.1    Gromada, J.2
  • 6
    • 15044341261 scopus 로고    scopus 로고
    • What do we know about the secretion and degradation of incretin hormones?
    • Deacon C.F. What do we know about the secretion and degradation of incretin hormones?. Regulatory Peptides 128 (2006) 117-124
    • (2006) Regulatory Peptides , vol.128 , pp. 117-124
    • Deacon, C.F.1
  • 7
    • 12244281855 scopus 로고    scopus 로고
    • Circulation and degradation of GIP and GLP-1
    • Deacon C.F. Circulation and degradation of GIP and GLP-1. Hormone and Metabolic Research 36 (2004) 761-765
    • (2004) Hormone and Metabolic Research , vol.36 , pp. 761-765
    • Deacon, C.F.1
  • 8
    • 12244305595 scopus 로고    scopus 로고
    • New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic β-cells
    • Holz G. New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic β-cells. Hormone and Metabolic Research 36 (2004) 787-794
    • (2004) Hormone and Metabolic Research , vol.36 , pp. 787-794
    • Holz, G.1
  • 9
    • 0033513455 scopus 로고    scopus 로고
    • Exendin 4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
    • Xu G., Stoffers D.A., Habener J.F., et al. Exendin 4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48 (1999) 2270-2276
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3
  • 10
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • Farilla L., Hui H., Bertolotto C., et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 143 (2002) 4397-4408
    • (2002) Endocrinology , vol.143 , pp. 4397-4408
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3
  • 11
    • 12244264206 scopus 로고    scopus 로고
    • The role of GLP-1 in the life and death of pancreatic beta cells
    • Perfetti R., and Hui H. The role of GLP-1 in the life and death of pancreatic beta cells. Hormone and Metabolic Research 36 (2004) 804-810
    • (2004) Hormone and Metabolic Research , vol.36 , pp. 804-810
    • Perfetti, R.1    Hui, H.2
  • 12
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers D.A., Kieffer T.J., Hussain M.A., et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49 (2000) 741-748
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 13
    • 0038574573 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycemia
    • Meier J.J., Gallwitz B., Siepmann N., et al. Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycemia. Diabetologia 46 (2003) 798-801
    • (2003) Diabetologia , vol.46 , pp. 798-801
    • Meier, J.J.1    Gallwitz, B.2    Siepmann, N.3
  • 14
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck M.A., Kleine N., Ørskov C., et al. Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36 (1993) 741-744
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Ørskov, C.3
  • 15
    • 0029829821 scopus 로고    scopus 로고
    • Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1
    • Nakabayashi H., Nishizawa M., Nakagawa A., et al. Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. American Journal of Physiology 271 (1996) E808-E813
    • (1996) American Journal of Physiology , vol.271
    • Nakabayashi, H.1    Nishizawa, M.2    Nakagawa, A.3
  • 16
    • 0033696456 scopus 로고    scopus 로고
    • Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms
    • Balkan B., and Liu X. Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms. American Journal of Physiology 279 (2000) R1449-R1454
    • (2000) American Journal of Physiology , vol.279
    • Balkan, B.1    Liu, X.2
  • 17
    • 0942287326 scopus 로고    scopus 로고
    • Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice
    • Ahrén B. Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice. American Journal of Physiology 286 (2004) R269-R272
    • (2004) American Journal of Physiology , vol.286
    • Ahrén, B.1
  • 18
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with myocardial infarction and left ventricular dysfunction after successful reperfusion
    • Nikolaidis L.A., Mankad S., Sokos G.G., et al. Effects of glucagon-like peptide-1 in patients with myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 109 (2004) 962-965
    • (2004) Circulation , vol.109 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3
  • 19
    • 8544258807 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 on endothelial function in type-2 diabetes patients with stable coronary artery disease
    • Nyström T., Gutniak M., Zhang Q., et al. Effects of glucagon-like peptide-1 on endothelial function in type-2 diabetes patients with stable coronary artery disease. American Journal of Physiology 287 (2004) E1209-E1215
    • (2004) American Journal of Physiology , vol.287
    • Nyström, T.1    Gutniak, M.2    Zhang, Q.3
  • 20
    • 0026596851 scopus 로고
    • Antidiabetic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus
    • Gutniak M., Ørskov C., Holst J.J., et al. Antidiabetic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. The New England Journal of Medicine 326 (1992) 1316-1322
    • (1992) The New England Journal of Medicine , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Ørskov, C.2    Holst, J.J.3
  • 21
    • 0029907680 scopus 로고    scopus 로고
    • Effects of subcutaneous glucagon-like peptide 1 (GLP-1[7-36 amide]) in patients with NIDDM
    • Nauck M.A., Wollschlager D., Werner J., et al. Effects of subcutaneous glucagon-like peptide 1 (GLP-1[7-36 amide]) in patients with NIDDM. Diabetologia 39 (1996) 1546-1553
    • (1996) Diabetologia , vol.39 , pp. 1546-1553
    • Nauck, M.A.1    Wollschlager, D.2    Werner, J.3
  • 22
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type-2 diabetes: a parallel-group study
    • Zander M., Madsbad S., Madsen J.L., et al. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type-2 diabetes: a parallel-group study. Lancet 359 (2002) 824-830
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3
  • 23
    • 16244385334 scopus 로고    scopus 로고
    • Exenatide: a novel treatment of type-2 diabetes
    • Ahrén B. Exenatide: a novel treatment of type-2 diabetes. Therapy 2 (2005) 207-222
    • (2005) Therapy , vol.2 , pp. 207-222
    • Ahrén, B.1
  • 24
    • 33745771673 scopus 로고    scopus 로고
    • Biologic actions and therapeutical potential of the proglucagon-derived peptides
    • Drucker D.J. Biologic actions and therapeutical potential of the proglucagon-derived peptides. Nature Clinical Practice 1 (2005) 22-31
    • (2005) Nature Clinical Practice , vol.1 , pp. 22-31
    • Drucker, D.J.1
  • 25
    • 31844443202 scopus 로고    scopus 로고
    • Glucagon-like ptpide-1: from extract to agent. The Claude Bernard Lecture, 2005
    • Holst J.J. Glucagon-like ptpide-1: from extract to agent. The Claude Bernard Lecture, 2005. Diabetologia 49 (2006) 253-260
    • (2006) Diabetologia , vol.49 , pp. 253-260
    • Holst, J.J.1
  • 26
    • 27744605795 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 (DPP-4) - a novel approach to treat type-2 diabetes
    • Ahrén B. Inhibition of dipeptidyl peptidase-4 (DPP-4) - a novel approach to treat type-2 diabetes. Current Enzyme Inhibition 1 (2005) 65-73
    • (2005) Current Enzyme Inhibition , vol.1 , pp. 65-73
    • Ahrén, B.1
  • 27
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type-2 diabetes
    • Drucker D.J., and Nauck M.A. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type-2 diabetes. Lancet 368 (2006) 1696-1705
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 28
    • 33749834648 scopus 로고    scopus 로고
    • DPP-4 inhibitors and their potential role in the management of type-2 diabetes
    • Barnett A. DPP-4 inhibitors and their potential role in the management of type-2 diabetes. International Journal of Clinical Practice 60 (2006) 1454-1470
    • (2006) International Journal of Clinical Practice , vol.60 , pp. 1454-1470
    • Barnett, A.1
  • 30
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides
    • Mentlein R. Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regulatory Peptides 85 (1999) 9-24
    • (1999) Regulatory Peptides , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 31
    • 0037787851 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV
    • Lambeir A.M., Durinx C., Sharpe S., et al. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Critical Reviews In Clinical Laboratory Sciences 40 (2003) 209-294
    • (2003) Critical Reviews In Clinical Laboratory Sciences , vol.40 , pp. 209-294
    • Lambeir, A.M.1    Durinx, C.2    Sharpe, S.3
  • 33
    • 0031690479 scopus 로고    scopus 로고
    • Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type-2 diabetes
    • Holst J.J., and Deacon C.F. Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type-2 diabetes. Diabetes 47 (1998) 1663-1670
    • (1998) Diabetes , vol.47 , pp. 1663-1670
    • Holst, J.J.1    Deacon, C.F.2
  • 34
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide-1 in anesthetized pigs
    • Deacon C.F., Hughes T.E., and Holst J.J. Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide-1 in anesthetized pigs. Diabetes 47 (1998) 764-769
    • (1998) Diabetes , vol.47 , pp. 764-769
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 35
    • 0034666562 scopus 로고    scopus 로고
    • Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice
    • Ahrén B., Holst J.J., Mårtensson H., et al. Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice. European Journal of Endocrinology 404 (2000) 239-245
    • (2000) European Journal of Endocrinology , vol.404 , pp. 239-245
    • Ahrén, B.1    Holst, J.J.2    Mårtensson, H.3
  • 36
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type-2 diabetes
    • Ahrén B., Landin-Olsson M., Jansson P.A., et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type-2 diabetes. The Journal of Clinical Endocrinology and Metabolism 89 (2004) 2078-2084
    • (2004) The Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 2078-2084
    • Ahrén, B.1    Landin-Olsson, M.2    Jansson, P.A.3
  • 37
    • 0037777695 scopus 로고    scopus 로고
    • 1[[(3-hydroxy-1-adamantyl)amino-]acetyl]-2-cyano-(s)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
    • Villhauer E.B., Brinkman J.A., Naderi G.B., et al. 1[[(3-hydroxy-1-adamantyl)amino-]acetyl]-2-cyano-(s)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. Journal of Medicinal Chemistry 46 (2003) 2774-2789
    • (2003) Journal of Medicinal Chemistry , vol.46 , pp. 2774-2789
    • Villhauer, E.B.1    Brinkman, J.A.2    Naderi, G.B.3
  • 38
    • 19944427998 scopus 로고    scopus 로고
    • (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazol[4,3,a]pyrazi n-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type-2 diabetes
    • Kim D., Wang L., Beconi M., et al. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazol[4,3,a]pyrazi n-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type-2 diabetes. Journal of Medicinal Chemistry 48 (2005) 141-151
    • (2005) Journal of Medicinal Chemistry , vol.48 , pp. 141-151
    • Kim, D.1    Wang, L.2    Beconi, M.3
  • 39
    • 33749851508 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the DPP-4 inhibitor, LAF237, in patients with type-2 diabetes
    • He Y.L., Balch A., and Campestrini J. Pharmacokinetics and pharmacodynamics of the DPP-4 inhibitor, LAF237, in patients with type-2 diabetes. Clinical Pharmacology and Therapy 56 (2005) 19
    • (2005) Clinical Pharmacology and Therapy , vol.56 , pp. 19
    • He, Y.L.1    Balch, A.2    Campestrini, J.3
  • 40
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses
    • Herman G.A., Stevens C., Van Dyck K., et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clinical Pharmacology and Therapy 78 (2005) 675-688
    • (2005) Clinical Pharmacology and Therapy , vol.78 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    Van Dyck, K.3
  • 41
    • 33749838375 scopus 로고    scopus 로고
    • Effect of renal insufficiency on the pharmacokinetics of MK-0431 (sitagliptin), a selective dipeptidyl-peptidase-IV (DPP-IV) inhibitor
    • [abstr 46]
    • Bergman A.J., Coyte J., and Yi B. Effect of renal insufficiency on the pharmacokinetics of MK-0431 (sitagliptin), a selective dipeptidyl-peptidase-IV (DPP-IV) inhibitor. Clinical Pharmacology and Therapy 38 (2006) [abstr 46]
    • (2006) Clinical Pharmacology and Therapy , vol.38
    • Bergman, A.J.1    Coyte, J.2    Yi, B.3
  • 42
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type-2 diabetes
    • Herman G.A., Bergman A., Stevens C., et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type-2 diabetes. The Journal of Clinical Endocrinology and Metabolism 91 (2006) 4612-4619
    • (2006) The Journal of Clinical Endocrinology and Metabolism , vol.91 , pp. 4612-4619
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3
  • 43
  • 44
    • 8844253433 scopus 로고    scopus 로고
    • Acute DPP IV inhibition minimizes glucose and insulin response to a glucose challenge in a diabetic mouse
    • Mika M., Stashko M., Lubben T., et al. Acute DPP IV inhibition minimizes glucose and insulin response to a glucose challenge in a diabetic mouse. Diabetes 52 Suppl 1 (2003) A350
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Mika, M.1    Stashko, M.2    Lubben, T.3
  • 45
    • 3543009434 scopus 로고    scopus 로고
    • The high-fat fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type-2 diabetes
    • Sörhede Winzell M., and Ahrén B. The high-fat fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type-2 diabetes. Diabetes 53 Suppl 3 (2003) S215-S219
    • (2003) Diabetes , vol.53 , Issue.SUPPL. 3
    • Sörhede Winzell, M.1    Ahrén, B.2
  • 46
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic β-cell mass and function in a rodent model of type-2 diabetes
    • Mu J., Woods J., Zhou Y.P., et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic β-cell mass and function in a rodent model of type-2 diabetes. Diabetes 55 (2006) 1695-1704
    • (2006) Diabetes , vol.55 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.P.3
  • 47
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4 week study period in type-2 diabetes
    • Ahrén B., Simonsson E., Larsson H., et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4 week study period in type-2 diabetes. Diabetes Care 25 (2002) 869-875
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahrén, B.1    Simonsson, E.2    Larsson, H.3
  • 48
    • 27744540889 scopus 로고    scopus 로고
    • Improved glucaemic control with dipeptidyl peptidase-4 inhibition in patients with type-2 diabetes: vildagliptin (LAF237) dose response
    • Ristic S., Byiers S., Foley J., et al. Improved glucaemic control with dipeptidyl peptidase-4 inhibition in patients with type-2 diabetes: vildagliptin (LAF237) dose response. Diabetes, Obesity & Metabolism 7 (2005) 692-698
    • (2005) Diabetes, Obesity & Metabolism , vol.7 , pp. 692-698
    • Ristic, S.1    Byiers, S.2    Foley, J.3
  • 49
    • 33745903093 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type-2 diabetes
    • Pratley R.E., Jauffret-Kamel S., Galbreath E., et al. Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type-2 diabetes. Hormone and Metabolic Research 387 (2006) 423-438
    • (2006) Hormone and Metabolic Research , vol.387 , pp. 423-438
    • Pratley, R.E.1    Jauffret-Kamel, S.2    Galbreath, E.3
  • 50
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type-2 diabetes
    • Pi-Sunyer F.X., Schweizer A., Mills D., et al. Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type-2 diabetes. Diabetes Research and Clinical Practice 76 (2007) 132-138
    • (2007) Diabetes Research and Clinical Practice , vol.76 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3
  • 51
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosiglitazone monotherapy in patients with type-2 diabetes: a 24-week, double-blind, randomized trial
    • Rosenstock J., Baron M.A., Dejager S., et al. Comparison of vildagliptin and rosiglitazone monotherapy in patients with type-2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care 30 (2007) 217-223
    • (2007) Diabetes Care , vol.30 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3
  • 52
    • 36549044265 scopus 로고    scopus 로고
    • Couturier A, Foley JE, Dejager S. Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naïve patients with type 2 diabetes. Diabetic Medicine, in press.
  • 53
    • 33645037183 scopus 로고    scopus 로고
    • Effect of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, on glycemic control after 12 weeks in patients with type-2 diabetes
    • Hanefeld M., Herman G., Mickel C., et al. Effect of MK-0431, a dipeptidyl peptidase IV (DPP-IV) inhibitor, on glycemic control after 12 weeks in patients with type-2 diabetes. Diabetologia 49 Suppl 1 (2005) A287
    • (2005) Diabetologia , vol.49 , Issue.SUPPL. 1
    • Hanefeld, M.1    Herman, G.2    Mickel, C.3
  • 54
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type-2 diabetes
    • Scott R., Wu L., Sanchez M., et al. Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type-2 diabetes. International Journal of Clinical Practice 61 (2007) 171-180
    • (2007) International Journal of Clinical Practice , vol.61 , pp. 171-180
    • Scott, R.1    Wu, L.2    Sanchez, M.3
  • 55
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type-2 diabetes mellitus
    • Raz I., Hanefeld M., Xu L., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type-2 diabetes mellitus. Diabetologia 49 (2006) 2564-2571
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3
  • 56
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type-2 diabetes
    • Aschner P., Kipnes M.S., Lunceford J.K., et al. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type-2 diabetes. Diabetes Care 29 (2006) 2632-2637
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3
  • 57
    • 9444285818 scopus 로고    scopus 로고
    • Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type-2 diabetes
    • Ahrén B., Gomis R., Standl E., et al. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type-2 diabetes. Diabetes Care 27 (2004) 2874-2880
    • (2004) Diabetes Care , vol.27 , pp. 2874-2880
    • Ahrén, B.1    Gomis, R.2    Standl, E.3
  • 58
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type-2 diabetes inadequately controlled with metformin
    • Bosi E., Camisaca R.P., Collober C., et al. Effects of vildagliptin on glucose control over 24 weeks in patients with type-2 diabetes inadequately controlled with metformin. Diabetes Care 30 (2007) 890-895
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisaca, R.P.2    Collober, C.3
  • 59
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type-2 diabetes inadequately controlled with metformin alone
    • Charbonnel B., Karasik A., Liu J., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type-2 diabetes inadequately controlled with metformin alone. Diabetes Care 29 (2006) 2638-2643
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3
  • 60
    • 33846817233 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial
    • Nauck M.A., Meininger G., Sheng D., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes, Obesity & Metabolism 9 (2007) 194-205
    • (2007) Diabetes, Obesity & Metabolism , vol.9 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3
  • 61
    • 33846828660 scopus 로고    scopus 로고
    • Vildagliptin in combination with pioglitazeone improves glycaemic control in patients with type-2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study
    • Garber A.J., Schweizer A., Baron M.A., et al. Vildagliptin in combination with pioglitazeone improves glycaemic control in patients with type-2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes, Obesity & Metabolism 9 (2007) 166-174
    • (2007) Diabetes, Obesity & Metabolism , vol.9 , pp. 166-174
    • Garber, A.J.1    Schweizer, A.2    Baron, M.A.3
  • 62
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type-2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Rosenstock J., Brazg R.G., Andryuk P.J., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type-2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clinical Therapeutics 28 (2006) 1556-1568
    • (2006) Clinical Therapeutics , vol.28 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.G.2    Andryuk, P.J.3
  • 63
    • 34247874561 scopus 로고    scopus 로고
    • Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    • Fonseca V., Schweizer A., Albrecht D., et al. Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes. Diabetologia 50 (2007) 1148-1155
    • (2007) Diabetologia , vol.50 , pp. 1148-1155
    • Fonseca, V.1    Schweizer, A.2    Albrecht, D.3
  • 65
    • 25844459084 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition for the treatment of type-2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9
    • Lankas G.R., Leiting B., Roy R.S., et al. Dipeptidyl peptidase IV inhibition for the treatment of type-2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes 54 (2005) 2988-2994
    • (2005) Diabetes , vol.54 , pp. 2988-2994
    • Lankas, G.R.1    Leiting, B.2    Roy, R.S.3
  • 66
    • 23844463766 scopus 로고    scopus 로고
    • Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type-2 diabetes
    • Mari A., Sallas W.M., He Y.L., et al. Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type-2 diabetes. The Journal of Clinical Endocrinology and Metabolic 90 (2005) 4888-4894
    • (2005) The Journal of Clinical Endocrinology and Metabolic , vol.90 , pp. 4888-4894
    • Mari, A.1    Sallas, W.M.2    He, Y.L.3
  • 67
    • 23044487247 scopus 로고    scopus 로고
    • Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type-2 diabetes over 1 year
    • Ahrén B., Pacini G., Foley J.E., et al. Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type-2 diabetes over 1 year. Diabetes Care 28 (2005) 1936-1940
    • (2005) Diabetes Care , vol.28 , pp. 1936-1940
    • Ahrén, B.1    Pacini, G.2    Foley, J.E.3
  • 68
    • 34147189738 scopus 로고    scopus 로고
    • The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single dose administration in type 2 diabetic patients
    • Balas B., Baig M.R., Watson C., et al. The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single dose administration in type 2 diabetic patients. The Journal of Clinical Endocrinology and Metabolism 92 (2007) 1249-1255
    • (2007) The Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 1249-1255
    • Balas, B.1    Baig, M.R.2    Watson, C.3
  • 69
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck M.A., Heimesaat M.M., Behle K., et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. The Journal of Clinical Endocrinology and Metabolism 87 (2002) 1239-1246
    • (2002) The Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3
  • 70
    • 36549018910 scopus 로고    scopus 로고
    • Azuma K., Radikova Z., Mancino J.M., et-al. DPP-4 inhibition improves insulin resistance (IR) in type 2 DM. ADA Session 2006; Late Breaking Abstract 5-LB.
  • 71
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • Pospisilik J.A., Martin J., Doty T., et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes 52 (2003) 741-750
    • (2003) Diabetes , vol.52 , pp. 741-750
    • Pospisilik, J.A.1    Martin, J.2    Doty, T.3
  • 72
    • 34147172248 scopus 로고    scopus 로고
    • The DPP-4 inhibitor vildagliptin increases β-cell mass in rodents
    • Duttaroy A., Voelker F., Zhang X., et al. The DPP-4 inhibitor vildagliptin increases β-cell mass in rodents. Diabetologia 48 Suppl 1 (2005) A178
    • (2005) Diabetologia , vol.48 , Issue.SUPPL. 1
    • Duttaroy, A.1    Voelker, F.2    Zhang, X.3
  • 73
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type-2 diabetes
    • Matikainen N., Mänttäri S., Schweizer A., et al. Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type-2 diabetes. Diabetologia 49 (2006) 2049-2057
    • (2006) Diabetologia , vol.49 , pp. 2049-2057
    • Matikainen, N.1    Mänttäri, S.2    Schweizer, A.3
  • 74
    • 0038497464 scopus 로고    scopus 로고
    • Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type-2 diabetes
    • Kolterman O.G., Buse J.B., Fineman M.S., et al. Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type-2 diabetes. The Journal of Clinical Endocrinology and Metabolism 88 (2003) 3082-3089
    • (2003) The Journal of Clinical Endocrinology and Metabolism , vol.88 , pp. 3082-3089
    • Kolterman, O.G.1    Buse, J.B.2    Fineman, M.S.3
  • 75
    • 34248169217 scopus 로고    scopus 로고
    • Effects of dipeptidyl peptidase 4 inhibition on gastrointestinal function, meal appearance and glucose metabolism in type-2 diabetes
    • Vella A., Bock G., Giesler P.D., et al. Effects of dipeptidyl peptidase 4 inhibition on gastrointestinal function, meal appearance and glucose metabolism in type-2 diabetes. Diabetes 56 (2007) 1475-1480
    • (2007) Diabetes , vol.56 , pp. 1475-1480
    • Vella, A.1    Bock, G.2    Giesler, P.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.