SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis

FASEB Journal

Volumn 31, Issue 6, 2017, Pages 2520-2532

  Jablonski, Renea P ^a   Kim, Seok Jo ^a   Cheresh, Paul ^a   Williams, David B ^a   Morales Nebreda, Luisa ^a   Cheng, Yuan ^a   Yeldandi, Anjana ^a   Bhorade, Sangeeta ^a   Pardo, Annie ^b   Selman, Moises ^c   Ridge, Karen ^a   Gius, David ^a   Budinger, G R Scott ^a   Kamp, David W ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

Author keywords

Oxidative stress; Pulmonary fibrosis; Sirtuin 3

Indexed keywords

ASBESTOS; BLEOMYCIN; CASPASE 9; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; SIRTUIN 3; ANTINEOPLASTIC ANTIBIOTIC; OXIDIZING AGENT; SIRT3 PROTEIN, MOUSE;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM CELL; LUNG PARENCHYMA; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; WILD TYPE; A-549 CELL LINE; ANIMAL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PULMONARY FIBROSIS;

A549 CELLS; ALVEOLAR EPITHELIAL CELLS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; ASBESTOS; BLEOMYCIN; DNA DAMAGE; DNA, MITOCHONDRIAL; HUMANS; MICE; MICE, KNOCKOUT; OXIDANTS; PULMONARY FIBROSIS; SIRTUIN 3;

EID: 85020241929     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201601077R     Document Type: Article

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