SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

Free Radical Biology and Medicine

Volumn 76, Issue , 2014, Pages 163-172

  Ozden, Ozkan ^a   Park, Seong Hoon ^a   Wagner, Brett A ^b   Song, Ha Yong ^a   Zhu, Yueming ^a   Vassilopoulos, Athanassios ^a   Jung, Barbara ^c   Buettner, Garry R ^b   Gius, David ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Acetylation; Carcinogenesis; Free radicals; PDHA1; Pyruvate dehydrogenase; SIRT3; Warburg

Indexed keywords

ARGININE; GLUTAMINE; LYSINE; OXIDOREDUCTASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE E1 ALPHA; SIRTUIN 3; UNCLASSIFIED DRUG; GLUCOSE; LACTIC ACID; PYRUVATE DEHYDROGENASE E1ALPHA SUBUNIT; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; SIRT3 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; FEMALE; GLYCOLYSIS; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MCF 7 CELL LINE; MUTANT; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PROTEIN ACETYLATION; PROTEIN PROTEIN INTERACTION; WILD TYPE; ACETYLATION; CHEMISTRY; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOPRECIPITATION; METABOLISM; NEOPLASM; OXIDATION REDUCTION REACTION; PATHOLOGY; PROTEIN PROCESSING; TUMOR CELL CULTURE; WESTERN BLOTTING;

ACETYLATION; BLOTTING, WESTERN; CELL PROLIFERATION; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE; GLYCOLYSIS; HUMANS; IMMUNOPRECIPITATION; LACTIC ACID; LYSINE; NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRUVATE DEHYDROGENASE (LIPOAMIDE); PYRUVIC ACID; REACTIVE OXYGEN SPECIES; SIRTUIN 3; TUMOR CELLS, CULTURED;

EID: 84907186695     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.08.001     Document Type: Article

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