Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury

Journal of Clinical Investigation

Volumn 125, Issue 2, 2015, Pages 715-726

  Morigi, Marina ^a   Perico, Luca ^a   Rota, Cinzia ^a   Longaretti, Lorena ^a   Conti, Sara ^a   Rottoli, Daniela ^a   Novelli, Rubina ^a   Remuzzi, Giuseppe ^a,b   Benigni, Ariela ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b Azienda Ospedaliera Papa Giovanni XXIII   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CISPLATIN; LEVACECARNINE; SIRTUIN 3; ACETYLCARNITINE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; SIRT3 PROTEIN, HUMAN; SIRT3 PROTEIN, MOUSE; VITAMIN B COMPLEX;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; HUMAN; HUMAN CELL; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; MITOCHONDRIAL DYNAMICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENAL PROTECTION; ANIMAL; CELL LINE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; PATHOLOGY;

ACETYLCARNITINE; ACUTE KIDNEY INJURY; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL LINE; CISPLATIN; HUMANS; KIDNEY TUBULES, PROXIMAL; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; OXIDATIVE STRESS; SIRTUIN 3; VITAMIN B COMPLEX;

EID: 84961291233     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI77632     Document Type: Article

References (35)

1. Lewington AJ, Cerda J, Mehta RL. Raising awareness of acute kidney injury: a global perspective of a silent killer. Kidney Int. 2013;84(3):457-467.
2. Acute kidney injury: prevention, detection and management of acute kidney injury up to the point of renal replacement therapy. NICE Web site. https://www.nice.org.uk/guidance/cg169. Accessed December 11, 2014.
3. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int. 2008;73(9):994-1007.
4. Thadhani R, Pascual M, Bonventre JV. Acute renal failure. N Engl J Med. 1996;334(22):1448-1460.
5. Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 2011;121(11):4210-4221.
6. Zhan M, Brooks C, Liu F, Sun L, Dong Z. Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int. 2013;83(4):568-581.
7. Palmer CS, Osellame LD, Stojanovski D, Ryan MT. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Cell Signal. 2011;23(10):1534-1545.
8. Friedman JR, Nunnari J. Mitochondrial form and function. Nature. 2014;505(7483):335-343.
9. Brooks C, Wei Q, Cho SG, Dong Z. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest. 2009;119(5):1275-1285.
10. Baur JA, Ungvari Z, Minor RK, Le Couteur DG, De Cabo R. Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov. 2012;11(6):443-461.
11. Lombard DB, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007;27(24):8807-8814.
12. Ahn BH, et al. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A. 2008;105(38):14447-14452.
13. Wu YT, Lee HC, Liao CC, Wei YH. Regulation of mitochondrial F (o) F (1) ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA. Biochim Biophys Acta. 2013;1832(1):216-227.
14. Kong X, et al. Sirtuin 3, a new target of PGC-1-alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One. 2010;5(7):e11707.
15. Bell EL, Guarente L. The SirT3 divining rod points to oxidative stress. Mol Cell. 2011;42(5):561-568.
16. Chen CJ, Fu YC, Yu W, Wang W. SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-κB. Biochem Biophys Res Commun. 2013;430(2):798-803.
17. Benigni A, et al. Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest. 2009;119(3):524-530.
18. Morigi M, et al. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol. 2004;15(7):1794-1804.
19. Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des. 2009;15(1):20-28.
20. Costford SR, et al. Skeletal muscle NAMPT is induced by exercise in humans. Am J Physiol Endocrinol Metab. 2010;298(1):E117-E126.
21. Fulco M, et al. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell. 2008;14(5):661-673.
22. Zong H, et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A. 2002;99(25):15983-15987.
23. Canto C, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458(7241):1056-1060.
24. Tufekci O, et al. Evaluation of the effect of acetyl L-carnitine on experimental cisplatin nephrotoxicity. Chemotherapy. 2009;55(6):451-459.
25. Otera H, et al. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol. 2010;191(6):1141-1158.
26. Cipolat S, Martins De Brito O, Dal Zilio B, Scorrano L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A. 2004;101(45):15927-15932.
27. Samant SA, et al. SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Mol Cell Biol. 2014;34(5):807-819.
28. Thomas RL, Gustafsson AB. Mitochondrial autophagy - an essential quality control mechanism for myocardial homeostasis. Circ J. 2013;77(10):2449-2454.
29. Tran M, et al. PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011;121(10):4003-4014.
30. Dugan LL, et al. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest. 2013;123(11):4888-4899.
31. Hoppins S. The regulation of mitochondrial dynamics. Curr Opin Cell Biol. 2014;29:46-52.
32. Twig G, Shirihai OS. The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal. 2011;14(10):1939-1951.
33. Bai A, et al. AMPK agonist downregulates innate and adaptive immune responses in TNBSinduced murine acute and relapsing colitis. Biochem Pharmacol. 2010;80(11):1708-1717.
34. Xia Y, Li Q, Zhong W, Dong J, Wang Z, Wang C. L-carnitine ameliorated fatty liver in highcalorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function. Diabetol Metab Syndr. 2011;3:31.
35. Weibel ER. Practical methods for biological morphometry. In: Stereological Methods. Vol. 1. London, United Kingdom: Academic Press; 1979:40-116.