Novel mechanisms for superoxide-scavenging activity of human manganese superoxide dismutase determined by the K68 key acetylation site

Free Radical Biology and Medicine

Volumn 85, Issue , 2015, Pages 114-126

  Lu, Jiaqi ^a   Cheng, Kuoyuan ^a   Zhang, Bo ^a   Xu, Huan ^a   Cao, Yuanzhao ^a   Guo, Fei ^a   Feng, Xudong ^b   Xia, Qing ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Acetylation; Electrostatic potential; Mitochondria; ROS; Structure; Superoxide; Superoxide dismutase; Tetramerization

Indexed keywords

ANION; ANTIMYCIN A1; LYSINE; MANGANESE SUPEROXIDE DISMUTASE; PARAQUAT; PROTEIN P53; SUPEROXIDE; PROTEIN BINDING; SUPEROXIDE DISMUTASE;

ACETYLATION; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ACETYLATION; AMINO ACID SEQUENCE; ANIMALS; HEK293 CELLS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 84930934967     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.04.011     Document Type: Article

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