Loss of mitochondrial tumor suppressor genes expression is associated with unfavorable clinical outcome in head and neck squamous cell carcinoma: Data from retrospective study

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Mahjabeen, Ishrat ^a   Kayani, Mahmood Akhtar ^a  

^a COMSATS Institute of Information Technology ^*  (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; DNA GLYCOSYLTRANSFERASE; MITOCHONDRIAL PROTEIN; MTUS1 PROTEIN, HUMAN; OXOGUANINE GLYCOSYLASE 1, HUMAN; SIRT3 PROTEIN, HUMAN; SIRT4 PROTEIN, HUMAN; SIRTUIN; SIRTUIN 3; TUMOR SUPPRESSOR PROTEIN;

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CELL PROLIFERATION; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE LOSS; GENETIC ASSOCIATION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL TUMOR SUPPRESSOR GENE; MTUS1 GENE; OGG1 2A GENE; OUTCOME ASSESSMENT; OXIDATIVE STRESS; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIRT3 GENE; SIRT4 GENE; TUMOR SUPPRESSOR GENE; GENE EXPRESSION; GENETICS; HEAD AND NECK TUMOR; MIDDLE AGED; PATHOLOGY; PROGNOSIS; SQUAMOUS CELL CARCINOMA; SURVIVAL ANALYSIS; TUMOR CELL LINE;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DNA GLYCOSYLASES; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; PROGNOSIS; RETROSPECTIVE STUDIES; SIRTUIN 3; SIRTUINS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 84958191269     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0146948     Document Type: Article

References (32)

1. Carew JS, Huang P. Mitochondrial defects in cancer. Mol Cancer. 2002; Dec 9; 1(9).
2. Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 2010; 17: 41-52. doi: 10.1016/j.ccr.2009.11.023 PMID: 20129246
3. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010; 464(7285): 121-125. doi: 10.1038/nature08778 PMID: 20203611
4. Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibitingmitochondrial glutamine metabolism. Cancer Cell. 2013; 23(4): 450-63. doi: 10.1016/j.ccr.2013.02.024 PMID: 23562301
5. Zhu Y, Yan Y, Principe DR, Zou X, Vassilopoulos A, Gius D. SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer Metab. 2014 Oct 20; 2: 15. doi: 10.1186/2049-3002-2-15 PMID: 25332769
6. Yu W, Dittenhafer-Reed KE, Denu JM. SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem. 2012; 287(17): 14078-14086. doi: 10.1074/jbc. M112.355206 PMID: 22416140
7. Saunders LR, Verdin E. Sirtuins: Critical regulators at the crossroads between cancer and aging. Oncogene. 2007; 26(37): 5489-5504. PMID: 17694089
8. Desouki MM, Doubinskaia I, Gius D, Abdulkadir SA. Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer. Hum Pathol. 2014; 45 (5): 1071-7. doi: 10.1016/j.humpath.2014.01.004 PMID: 24746213
9. Zhang CZ, Liu L, Cai M, Pan Y, Fu J, Cao Y, Yun J. Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. PLoS One. 2012; 7(12): e51703. doi: 10.1371/journal.pone.0051703 PMID: 23272146
10. Xiao K, Jiang J, Wang W, Cao S, Zhu L, Zeng H. Sirt3 is a tumor suppressor in lung adenocarcinoma cells. Oncol Rep. 2013; 30(3):1323-8. doi: 10.3892/or.2013.2604 PMID: 23842789
11. Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013; 23(4): 450-463. doi: 10.1016/j.ccr.2013.02.024 PMID: 23562301
12. Zhu Y, Yan Y, Principe DR, Zou X, Vassilopoulos A, Gius D. SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer & Metabolism. 2014; 2: 15. doi: 10.1186/2049-3002-2-15
13. Seibold S, Rudroff C, Weber M, Galle J, Wanner C, Marx M. Identification of a new tumor suppressor gene located at chromosome 8p21.3e22. Faseb J. 2003; 17: 1180e1182.
14. Yu J, Liu X, Ye H, Zhou X. Genomic characterization of the human mitochondrial tumor suppressor gene 1 (MTUS1): 5' cloning and preliminary analysis of the multiple gene promoters. BMC Res Notes. 2009; 2:109. doi: 10.1186/1756-0500-2-109 PMID: 19545354
15. Rodrigues-Ferreira S, Di Tommaso A, Dimitrov A, Cazaubon S, Gruel N, Colasson H, et al. 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis. PLoS One. 2009; 4: e7239. doi: 10.1371/journal.pone.0007239 PMID: 19794912
16. Ding X, Zhang N, Cai Y, Su Li, Chaoxu Zheng, Yi Jin, et al. Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma. Molecular Oncology. 2012 6(1):73-80.
17. Zhao T, Ding X, Chang B, Zhou X, Wang A. MTUS1/ATIP3a down-regulation is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma. BMC Cancer. 2015; 15: 203. doi: 10.1186/s12885-015-1209-x PMID: 25885343
18. Bacolod MD, Barany F. Gene dysregulations driven by somatic copy number aberrations-biological and clinical implications in colon tumors: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology. J. Mol. Diagn. 2010; 12: 552e561.
19. Zuern C, Heimrich J, Kaufmann R, Richter KK, Settmacher U, Wanner C, et al. Downregulation of MTUS1 in human colon tumors. Oncol Rep. 2010; 23: 183e189.
20. Louis SN, Chow L, Rezmann L, Krezel MA, Catt KJ, Tikellis C, et al. Expression and function of ATIP/ MTUS1 in human prostate cancer cell lines. Prostate. 2010; 70: 1563e1574.
21. Rodrigues-Ferreira S, Di Tommaso A, Dimitrov A, Cazaubon S, Gruel N, Colasson H, et al. 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis. PLoS One. 2009; 4: e7239. doi: 10.1371/journal.pone.0007239 PMID: 19794912
22. Mahjabeen I, Ali K, Zhou X, Kayani MA. Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma. Tumour Biol. 2014; 35(6): 5971-83. doi: 10.1007/s13277-014-1792-5 PMID: 24622884
23. Mahjabeen I, Baig RM, Sabir M, Kayani MA. Genetic and Expressional variations of APEX1 are associated with increased risk of head and neck cancer. Mutagenesis. 2013; 28(2): 213-218. doi: 10.1093/ mutage/ges074 PMID: 23408843
24. Wang Z, Choi S, Lee J, Huang YT, Chen F, Zhao Y. Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival. Cancer Informatics. 2015; 14: 1-9.
25. Sebastian C, Mostoslavsky R. SIRT3 in calorie restriction: can you hear me now? Cell. 2010; 143(5): 667-668. doi: 10.1016/j.cell.2010.11.009 PMID: 21111225
26. Paz-Elizur T, Krupsky M, Blumenstein S, Elinger D, Schechtman E, Livneh Z. DNA repair activity and risk of lung cancer. J Natl Cancer Inst. 2003; 95: 1312-1319. PMID: 12953085
27. Mahjabeen I, Chen Z, Zhou X, Kayani MA Decreased mRNA expression levels of base excision repair (BER) pathway genes is associated with enhanced Ki-67 expression in HNSCC. Medical Oncology. 2012; 29: 3620-3625. doi: 10.1007/s12032-012-0300-2 PMID: 22798271
28. Mambo E, Chatterjee A, Souza-Pinto NC, Mayard S, Hogue BA, O'Hoque M, et al. Oxidized guanine lesions and hOgg1 activity in lung cancer. Oncogene. 2005; 24: 4496-508. PMID: 15856018
29. Cheng Y, Ren X, Gowda AS, Shan Y, Zhang L, Yuan YS, et al. Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Cell Death & Disease. 2013; 4(7): e731. doi: 10.1038/cddis.2013.254
30. Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013; 153(4): 840-854. doi: 10.1016/j.cell.2013.04.023 PMID: 23663782
31. Li H, Feng Z, Wu W, Li J, Zhang J, Xia T. SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2. Int J Oncol. 2013; 43(5): 1420-1430. doi: 10.3892/ijo.2013.2103 PMID: 24042441
32. Petruzzelli GJ. The biology of tumor invasion, angiogenesis and lymph node metastasis. ORL J Otorhinolaryngol Relat Spec. 2000; 62(4):178-185. PMID: 10859518