The Witschi hypothesis revisited after 35 years: Genetic proof from SP-C BRICHOS domain mutations

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 305, Issue 12, 2013, Pages

  Uhal, Bruce D ^a   Nguyen, Hang ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

Alveolar epithelial cells; Epithelial mesenchymal cross talk; Idiopathic pulmonary fibrosis; Lung fibrosis; Type II pneumocyte

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSIN II; AZATHIOPRINE; BLEOMYCIN; BUTYLCRESOL; COLLAGEN; CORTICOSTEROID; DIPHTHERIA TOXIN; FIBRONECTIN; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HYDROGEN PEROXIDE; INTERLEUKIN 10; KERATINOCYTE GROWTH FACTOR; LACTATE DEHYDROGENASE; LAMININ; MATRIX METALLOPROTEINASE; PLACEBO; PLASMINOGEN ACTIVATOR; PREDNISONE; PROSTAGLANDIN E2; PROTEIN; SCATTER FACTOR; SILICON DIOXIDE; SOMATOMEDIN C; SURFACTANT PROTEIN C;

APOPTOSIS; ARTICLE; AUTOPHAGY; BASEMENT MEMBRANE; CELL CULTURE; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CELL VIABILITY; CLINICAL TRIAL (TOPIC); COCULTURE; COMORBIDITY; DEATH; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM STRESS; EPITHELIUM CELL; EPITHELIZATION; FIBROBLAST; FIBROGENESIS; FIBROSING ALVEOLITIS; GENE DELETION; GENE MUTATION; HISTOPATHOLOGY; HOSPITALIZATION; HUMAN; HYPEROXIA; HYPOTHESIS; INFLAMMATION; INFLAMMATORY CELL; INTERSTITIAL LUNG DISEASE; LAMELLAR BODY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG BIOPSY; LUNG FIBROSIS; LUNG INJURY; LUNG LAVAGE; LYMPHOCYTE; MICROENVIRONMENT; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING; TREATMENT FAILURE; UNFOLDED PROTEIN RESPONSE; WITSCHI HYPOTHESIS;

ALVEOLAR EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL CROSS TALK; IDIOPATHIC PULMONARY FIBROSIS; LUNG FIBROSIS; TYPE II PNEUMOCYTE;

ANIMALS; EPITHELIAL CELLS; HUMANS; MUTATION; PROTEIN STRUCTURE, TERTIARY; PULMONARY ALVEOLI; PULMONARY FIBROSIS; PULMONARY SURFACTANT-ASSOCIATED PROTEINS;

EID: 84890371814     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00246.2013     Document Type: Article

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