Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 310, Issue 8, 2016, Pages H962-H972

  Pillai, Vinodkumar B ^a   Bindu, Samik ^a   Sharp, Will ^a   Fang, Yong Hu ^a   Kim, Gene ^a   Gupta, Madhu ^b   Samant, Sadhana ^a   Gupta, Mahesh P ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Doxorubicin; Mitochondria; ROS; Sirt3

Indexed keywords

DNA GLYCOSYLTRANSFERASE; DOXORUBICIN; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; OXOGUANINE DNA GLYCOSYLASE 1; REACTIVE OXYGEN METABOLITE; SIRTUIN 3; UNCLASSIFIED DRUG; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; DNA ADDUCT; OGG1 PROTEIN, MOUSE; SIRT-3 PROTEIN, RAT; SIRT3 PROTEIN, MOUSE; SIRTUIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC MUSCLE CELL; CARDIOMYOPATHY; CELL DEATH; CONTROLLED STUDY; DISEASE COURSE; FEMALE; MALE; MITOCHONDRIAL DNA DISORDER; MOUSE; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN DEPLETION; ANALOGS AND DERIVATIVES; ANIMAL; CARDIOMEGALY; CARDIOMYOPATHIES; CELL CULTURE; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; DNA ADDUCT; DNA DAMAGE; ENZYMOLOGY; FIBROBLAST; GENETICS; HEART MITOCHONDRION; HYDROLYSIS; KNOCKOUT MOUSE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME FACTOR;

ANIMALS; CARDIOMEGALY; CARDIOMYOPATHIES; CELL DEATH; CELLS, CULTURED; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; DNA ADDUCTS; DNA DAMAGE; DNA GLYCOSYLASES; DNA, MITOCHONDRIAL; DOXORUBICIN; FEMALE; FIBROBLASTS; HYDROLYSIS; MALE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIRTUIN 3; SIRTUINS; TIME FACTORS;

EID: 84979033838     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00832.2015     Document Type: Article

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