In Vitro Digestion and Fermentation of Microencapsulated Tributyrin for the Delivery of Butyrate

Journal of Food Science

Volumn 82, Issue 6, 2017, Pages 1491-1499

  Donovan, Joseph D ^a   Bauer, Laura ^a   Fahey, George C ^a   Lee, Youngsoo ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

fermentation; gamma cyclodextrin; in vitro digestion; microencapsulation; tributyrin; whey protein isolate

Indexed keywords

BUTYRIC ACID; TRIACYLGLYCEROL; TRIBUTYRIN;

CHEMISTRY; DIGESTION; DRUG DELIVERY SYSTEM; FERMENTATION; HUMAN; MICROCAPSULE;

BUTYRIC ACID; CAPSULES; DIGESTION; DRUG DELIVERY SYSTEMS; FERMENTATION; HUMANS; TRIGLYCERIDES;

EID: 85019160776     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.13725     Document Type: Article

References (61)

1. Alminger M, Aura A-, Bohn T, Dufour C, SN El, Gomes A, Karakaya S, Martínez-Cuesta MC, McDougall GJ, Requena T, Santos CN. 2014. In vitro models for studying secondary plant metabolite digestion and bioaccessibility. Comp Rev Food Sci Food Safety 13(4):413–36.
2. Bartholome AL, Albin DM, Baker DH, Holst JJ, Tappenden KA. 2004. Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets. J Parenter Enteral Nutr 28(4):210–22.
3. Benedé S, López-Expósito I, Giménez G, Grishina G, Bardina L, Sampson HA, Molina E, López-Fandiño R. 2014. In vitro digestibility of bovine β-casein with simulated and human oral and gastrointestinal fluids. Identification and IgE-reactivity of the resultant peptides. Food Chem 143(0):514–21.
4. Berni CR, Terrin G, Cirillo P, Castaldo G, Salvatore F, Cardillo G, Coruzzo A, Troncone R. 2004. Butyrate as an effective treatment of congenital chloride diarrhea. Gastroenterol 127(2):630–4.
5. Bhandari BR, D'Arc DR, Bich LLT. 1998. Lemon oil to β-cyclodextrin ratio effect on the inclusion efficiency of β-cyclodextrin and the retention of oil volatiles in the complex. J Agric Food Chem 46(4):1494–9.
6. Boisen S. 1991. A model for feed evaluation based on in vitro digestible dry matter and protein. In: Fuller MF, editor. In vitro digestion for pigs and poultry. 1st ed. Slough, UK: CAB International. P 135–45.
7. Boisen S, Eggum BO. 1991. Critical evaluation of in vitro methods for estimating digestibility in simple-stomach animals. Nutr Res Rev 4(1):141–62.
8. Bourquin LD, Garleb KA, Merchen NR, Fahey Jr. GC. 1990. Effects of intake and forage level on site and extent of digestion of plant cell wall monomeric components by sheep. J Anim Sci 68(8):2478–95.
9. Bourquin LD, Titgemeyer EC, Fahey Jr. GC. 1993a. Vegetable fiber fermentation by human fecal bacteria: cell wall polysaccharide disappearance and short-chain fatty acid production during in vitro fermentation and water-holding capacity of unfermented residues. J Nutr 123(5):860–9.
10. Bourquin LD, Titgemeyer EC, Fahey Jr. GC, Garleb KA. 1993b. Fermentation of dietary fiber by human colonic bacteria: disappearance of, short-chain fatty acid production from, and potential water-holding capacity of various substrates. Scand J Gastroenterol 28(3):249–55.
11. Coles LT, Moughan PJ, Darragh AJ. 2005. In vitro digestion and fermentation methods, including gas production techniques, as applied to nutritive evaluation of foods in the hindgut of humans and other simple-stomached animals. Anim Feed Sci Technol 123–124(1):421–44.
12. Cummings JH. 1981. Short chain fatty acids in the human colon. Gut 22(9):763–79.
13. Cummings JH, Macfarlane GT. 1997. Collaborative JPEN-clinical nutrition scientific publications role of intestinal bacteria in nutrient metabolism. J Parenter Enteral Nutr 21(6):357–65.
14. Das SK, Rajabalaya R, David S, Gani N, Khanam J, Nanda A. 2013. Cyclodextrins- the molecular container. Res J Pharm Biol Chem Sci 4(2):1694–720.
15. de Godoy MRC, Bauer LL, Parsons CM, Fahey Jr. GC. 2009. Select corn coproducts from the ethanol industry and their potential as ingredients in pet foods. J Anim Sci 87(1):189–99.
16. Decock G, Landy D, Surpateanu G, Fourmentin S. 2008. Study of the retention of aroma components by cyclodextrins by static headspace gas chromatography. J Incl Phenom Macro 62(3-4):297–302.
17. Del Valle EMM. 2004. Cyclodextrins and their uses: a review. Process Biochem 39(9):1033–46.
18. Desai KGH, Park HJ. 2005. Recent developments in microencapsulation of food ingredients. Drying Technol 23(7):1361–94.
19. Donovan JD, Lee SY, Lee Y. 2016a. R-Index measure of microencapsulated tributyrin in gamma-cyclodextrin influenced by drying method. J Food Sci 81(9):2252–57
20. Donovan JD, Cadwallader KR, Lee Y. 2016b. Volatile retention and morphological properties of microencapsulated tributyrin varied by wall material and drying method. J Food Sci 81(3):653–50.
21. Edelman MJ, Bauer K, Khanwani S, Tait N, Trepel J, Karp J, Nemieboka N, Chung EJ, Echo DV. 2003. Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug. Cancer Chemother Pharmacol 51(5):439–44.
22. Erwin ES, Marco GJ, Emery EM. 1961. Volatile fatty acid analyses of blood and rumen fluid by gas chromatography. J Dairy Sci 44(9):1768–71.
23. Gharsallaoui A, Roudaut G, Chambin O, Voilley A, Saurel R. 2007. Applications of spray drying in microencapsulation of food ingredients: an overview. Food Res Int 40(9):1107–21.
24. Guyton AC, Hall JE. 1996. Digestion and absorption in the gastrointestinal tract. In: Textbook of medical physiology. 9th ed. Philadelphia: W.B. Saunders Co. P 833–44.
25. Hague A, Manning AM, Hanlon KA, Hart D, Paraskeva C, Huschtscha LI. 1993. Sodium butyrate induces apoptosis in human colonic tumor cell lines in a p53-independent pathway: implications for the possible role of dietary fiber in the prevention of large-bowel cancer. Int J Cancer 55(3):498–505.
26. Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. 2008. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther 27(2):104–19.
27. Hawk ET, Levin B. 2005. Colorectal cancer prevention. J Clin Oncol 23(2):378–91.
28. Heerdt BG, Houston MA, Augenlicht LH. 1994. Potentiation by specific short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines. Cancer Res 54(12):3288–94.
29. Hernot DC, Boileau TW, Bauer LL, Swanson KS, Fahey Jr. GC. 2005. In vitro digestion characteristics of unprocessed and processed whole grains and their components. J Agric Food Chem 56(22):10721–6.
30. Hur SJ, Lim BO, Decker EA, McClements DJ. 2011. In vitro human digestion models for food applications. Food Chem 125(1):1–12.
31. Ji YY, Xiao DC. 2006. GIT physicochemical modeling–a critical review. Int J Food Eng 2(4):1–12.
32. Koruda MJ, Rolandelli RH, Bliss DZ, Hastings J, Rombeau JL, Settle RG. 1990. Parenteral nutrition supplemented with short-chain fatty acids: effect on the small-bowel mucosa in normal rats. Am J Clin Nutr 51(4):685–9.
33. Kotunia A, Woliński J, Laubitz D, Jurkowska M, Romé V, Guilloteau P, Zabielski R. 1994. Effect of sodium butyrate on the small intestine development in neonatal piglets fed (correction of feed) by artificial sow. J Physiol Pharmacol 55(2):59–68.
34. Leonel AJ, Alvarez-Leite JI. 2012. Butyrate: implications for intestinal function. Curr Opin Clin Nutr Metab Care 15(5):474–9.
35. Lepage G, Roy C. 1986. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 27(1):114–20.
36. Li M, Bauer LL, Chen X, Wang M, Kuhlenschmidt TB, Kuhlenschmidt MS, Fahey Jr. GC, Donovan SM. 2012. Microbial composition and in vitro fermentation patterns of human milk oligosaccharides and prebiotics differ between formula-fed and sow-reared piglets. J Nutr 142(4):681–9.
37. Lupton JR. 2004. Microbial degradation products influence colon cancer risk: the butyrate controversy. J Nutr 134(2):479–82.
38. Macfarlane GT, Gibson GR, Cummings JH. 1992. Comparison of fermentation reactions in different regions of the human colon. J Appl Bacteriol 72(1):57–64.
39. McClements DJ, Lia Y. 2010. Review of in-vitro digestion models for rapid screening of emulsion-based systems. Food Funct 1(1):32–59.
40. McIntyre A, Gibson PR, Young GP. 1993. Butyrate production from dietary fiber and protection against large bowel cancer in a rat model. Gut 34(3):386–91.
41. Minekus, M., et al. 2014. “A standardized static in vitro digestion method suitable for food–an international consensus.” Food & function 5(6):1113–24.
42. Patz J, Jacobsohn WZ, Gottschalk-Sabag S, Zeides S, Braverman DZ. 1996. Treatment of refractory distal ulcerative colitis with short chain fatty acid enemas. Am J Gastroenterol 91(4):731–4.
43. Picot A, Lacroix C. 2004. Encapsulation of Bifidiobacteria in whey protein-based microcapsules and survival in simulated gastrointestinal conditions and in yogurt. Int Dairy J 14(6):505–15.
44. Rabiu BA, Gibson GR. 2002. Carbohydrates: a limit on bacterial diversity within the colon. Biol Rev 77(3):443–53.
45. Reineccius TA, Reineccius GA, Peppard TL. 2002. Encapsulation of flavors using cyclodextrins: comparison of flavor retention in alpha, beta, and gamma types. J Food Sci 67(9):3271–9.
46. Rosenberg MT. 1996. Microencapsulation of volatiles by spray-drying in whey protein-based wall systems. Int Dairy J 6(3):273–84.
47. Scarpellini E, Lauritano EC, Lupascu A, Petruzzellis C, Novi ML, Roccarina D, Gabrielli M, Serricchio M, Gasbarrini G, Gasbarrini A. 2007. Efficacy of butyrate in the treatment of diarrhea-predominant irritable bowel syndrome. Dig Liver Dis 1(1):19–22.
48. Scheppach W, Sommer H, Kirchner T, Paganelli GM, Bartram P, Christl S, Richter F, Dusel G, Kasper H. 1992. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterol 103(1):51–6.
49. Schonberger BP, Jansen ACA, Janssen LHM. 1988. The acid hydrolysis of cyclodextrins and linear oligosaccharies: a comparative study. In: Huber O, Szejtli J, editors. Proceedings of the 4th International Symposium on Cyclodextrins, Munich, West Germany, April 20–22. 1st ed. AA Dordrecht, the Netherlands: Kluwer Academic Publishers. P 61–3.
50. Shahidi F, Han X. 1993. Encapsulation of food ingredients. Crit Rev Food Sci Nutr 33(6):501–47.
51. Sobel R, Versic R, Gaonkar AG. 2014. Introduction to microencapsulation and controlled delivery in foods. In: Gaonkar AG, Vasisht N, Khare AR, Sobel R, editors. Microencapsulation in the food industry. 1st ed. San Diego, CA: Academic Press. P 3–12.
52. Steinhart AH, Hiruki T, Brzezinski A, Baker JP. 1996. Treatment of left-sided ulcerative colitis with butyrate enemas: a controlled trial. Aliment Pharmacol Ther 10(5):729–36.
53. Szejtli J, Szente L. 2005. Elimination of bitter, disgusting tastes of drugs and foods by cyclodextrins. Eur J Pharm Biopharm 61(3):115–25.
54. Tamamoto LC, Schmidt SJ, Lee S-Y. 2010. Sensory properties of ginseng solutions modified by masking agents. J Food Sci 75(7):S341–S7.
55. Uekama K, Hirayama F, Irie T. 1998. Cyclodextrin drug carrier systems. Chem Rev 98(5):2045–76.
56. Versantvoort CHM, Oomen AG, Van de Kamp E, Rompelberg CJM, Sips AJAM. 2005. Applicability of an in-vitro digestion model in assessing the bioaccessibility of mycotoxins from food. Food Chem Toxicol 43(1):31–40.
57. Vieira ELM, Leonel AJ, Sad AP, Beltrão NRM, Costa TF, Ferreira TMR, Gomes-Santos AC, Faria AMC, Peluzio MCG, Cara DC, Alvarez-Leite JI. 2012. Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis. J Nutr Biochem 23(5):430–6.
58. Wachtershauser A, Stein J. 2000. Rationale for the luminal provision of butyrate in intestinal diseases. Eur J Nutr 39(4):164–71.
59. Whitcomb DC, Lowe ME. 2007. Human pancreatic digestive enzymes. Dig Dis Sci 52(1):1–17.
60. Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ. 2006. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40(3):235–43.
61. Young SL, Sarda X, Rosenberg M. 1993. Microencapsulating properties of whey proteins. 1. Microencapsulation of anhydrous milk fat. J Dairy Sci 76(10):2868–77.