Microbial Degradation Products Influence Colon Cancer Risk: The Butyrate Controversy

Journal of Nutrition

Volumn 134, Issue 2, 2004, Pages 479-482

  Lupton, Joanne R ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Butyrate; Colon; Dietary fiber; Omega 3 fatty acids

Indexed keywords

BUTYRIC ACID; SHORT CHAIN FATTY ACID;

CANCER RISK; CARCINOGENICITY; COLON CANCER; COLON FLORA; CONFERENCE PAPER; DIETARY FIBER; DIGESTION; EXPOSURE; FAT INTAKE; HUMAN; HUMAN CELL; LARGE INTESTINE; MICROBIAL DEGRADATION; SMALL INTESTINE;

EID: 0942301264     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.2.479     Document Type: Conference Paper

References (41)

1. IOM (Institute of Medicine). (2002) in: Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. The National Academies Press, Washington, DC.
2. Cummings, J. H. (1984) Microbial digestion of complex carbohydrates in man. Proc. Nutr. Soc. 43: 35-44.
3. Cummings, J. H. & Englyst, H. N. (1987) Fermentation in the human large intestine and the available substrates. Am. J. Clin. Nutr. 45: 1243-1255.
4. McBurney, M. I. & Thompson, L. U. (1990) Fermentative characteristics of cereal brans and vegetable fibers. Nutr. Cancer 13: 271-280.
5. Lupton, J. R. (1995) Butyrate and colonic cytokinetics: differences between in vitro and in vivo studies. Eur. J. Cancer Prev. 4: 373-378.
6. Lupton, J. R. (2000) Is fiber protective against colon cancer? Where the research is leading us. Nutrition 16: 558-561.
7. Gazzaniga, J. M. & Lupton, J. R. (1987) Dilution effect of dietary fiber sources: an in vivo study in the rat. Nutr. Res. 7: 1261-1268.
8. Cummings, J. H. (1993) in: CRC Handbook of Dietary Fiber in Human Nutrition (Spiller, G. A., ed.), pp. 263-349. CRC Press, Boca Raton, FL.
9. Burkitt, D. P., Walker, A.R.P. & Painter, N. S. (1972) Effect of dietary fibre on stools and transit-times, and its role in the causation of disease. Lancet ii 1408-1412.
10. Birkett, A. M., Jones, G. P., de Silva, A. M., Young, G. P. & Muir, J. G. (1997) Dietary intake and faecal excretion of carbohydrate by Australians: Importance of achieving stool weights greater than 150 g to improve faecal markers relevant to colon cancer risk. Eur. J. Clin. Nutr. 51: 625-632.
11. Roediger, W.E.W. (1982) Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 83: 424-429.
12. Hague, A., Manning, A. M., Hanlon, K. A., Huscchtscha, L. I., Hart, D. & Paraskeva, C. (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int. J. Cancer 55: 498-505.
13. Heerdt, B. G., Houston, M. A. & Augenlicht, L. H. (1994) Potentiation by specific short chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines. Cancer Res. 54: 3288-3294.
14. Freeman, H. J. (1986) Effects of differing concentrations of sodium butyrate on 1, 2-dimethylhydrazine-induced rat intestinal neoplasia. Gastroenterology 91: 596-602.
15. Zoran, D. L., Turner, N. D., Taddeo, S. S., Chapkin, R. S. & Lupton, J. R. (1997) Wheat bran reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations. J. Nutr. 127: 2217-2225.
16. Deschner, E. E., Ruperto, J. F. & Lupton, J. R. (1990) Dietary butyrate (tributyrin) does not enhance AOM-induced colon tumorigenesis. Cancer Lett. 53: 79-32.
17. Caderni, G., Luceri, C., Lancioni, L., Tessitore, L. & Dolara, P. (1998) Slow-release pellets of sodium butyrate increase apoptosis in the colon of rats treated with azoxymethane, without affecting aberrant crypt foci and colonic proliferation. Nutr. Cancer 30: 175-181.
18. Caderni, G., Luceri, C., De Filippo, C., Salvadori, M., Giannini, A., Tessitore, L. & Dolara, P. (2001) Slow-release pellets of sodium butyrate do not modify azoxymethane (AOM)-induced intestinal carcinogenesis in F344 rats. Carcinogenesis 22: 525-527.
19. Jacobs, L. R. & Lupton, J. R. (1982) Dietary wheat bran lowers colonic pH in rats. J. Nutr. 112: 592-594.
20. Newmark, H. L. & Lupton, J. R. (1990) Determinants and consequences of colonic luminal pH: implications for colon cancer. Nutr. Cancer 14: 161-173.
21. Sealy, L. & Chalkley, R. (1978) An electron microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells. Cell 14: 115-121.
22. Yoshida (1990) J. Biol. Chem. 265: 1714-1719.
23. Willett, W. C., Stampfer, M. J., Colditz, G. A., Rosner, B. A. & Speizer, F. E. (1990) Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N. Engl. J. Med. 323: 1664-1672.
24. Giovannucci, E., Stampfer, M. J., Colditz, G. A., Rimm, E. B. & Willett, W. C. (1992) Relationship of diet to risk of colorectal adenoma in men. J. Natl. Cancer Inst. 84: 91-98.
25. Fuchs, C. S., Giovannucci, E. L., Colditz, G. A., Hunter, D. J., Stampfer, M. J., Rosner, B., Speizer, F. E. & Willett, W. C. (1999) Dietary fiber and the risk of colorectal cancer and adenoma in women. N. Engl. J. Med. 340: 169-176.
26. Giovannucci, E. & Willett, W. C. (1994) Dietary factors and risk of colon cancer. Ann. Med. 26: 443-452.
27. Alberts, D. S., Martinez, M. E., Roe, D. J., Guillen-Rodriguez, J. M., Marshall, J. R., van Leeuwen, J. B., Reid, M. E., Ritenbaugh, C., Vargas, P. A., Bhatacharyya, A. B., Earnest, D. L. & Sampliner, R. E. (2000) Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. N. Engl. J. Med. 342: 1156-1162.
28. Bonithon-Kopp, C., Kronborg, O., Giacosa, A., Rath, U. & Faivre, J. (2000) Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. Lancet ii 356: 1300-1306.
29. Schatzkin, A., Lanza, E., Corle, D., Lanc, P., Iber, F., Caan, B., Shike, M., Weissfeld, J., Burt, R., Cooper, M. R., Kirkendall, J. W. & Cahill, J. (2000) Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. N. Engl. J. Med. 342: 1149-1155.
30. Le Blay, G., Blottiere, H. M., Ferrier, L., Le Foll, E., Bonnet, C., Galmiche, J. P. & Cherbut, C. (2000) Short-chain fatty acids induce cytoskeletal and extracellular protein modifications associated with modulation of proliferation in primary clture of rat intestinal smooth muscle cells. Dig. Dis. Sci. 45: 1623-1630.
31. Zhang, J., Wu, G., Chapkin, R. S. & Lupton, J. R. (1998) Energy metabolism of rat colonocytes changes during the tumorigenic process and is dependent on diet and carcinogen. J. Nutr. 128: 1262-1269.
32. Fitch, M. D. & Fleming, S. E. (1999) Metabolism of short-chain fatty acids by rat colonic mucosa in vivo. Am. J. Physiol. 277: G31-G40.
33. Chang, W.-C.L., Chapkin, R. S. & Lupton, J. R. (1998) Fish oil blocks azoxymethane-induced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation. J. Nutr. 128: 491-497.
34. Chang, W.-C.L., Turner, N. D., Davidson, L. A., Chapkin, R. S. & Lupton, J. R. (1998) Fish oil depresses the carcinogen-induced expression of cox-2 in rat colonic mucosa. FASEB J. 12: A564.
35. 6 methylguanine DNA adduct levels in rat colon in part by increasing apoptosis during tumor initiation. Cancer Epidemiol. Biomarkers Prev. 9: 819-826.
36. Eberhart, C. E., Coffey, R. J., Radhika, A., Giardiello, F. M., Ferrenbach, S. & Dubois, R. N. (1994) Up-regulation of cyclooxgenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107: 1183-1188.
37. Pasricha, P. J., Bedi, A., O'Connor, K., Rashid, A., Akhtar, A. J., Zahurak, M. L., Piantadosi, S., Hamilton, S. R. & Giardiello, F. M. (1995) The effects of sulindac on colorectal proliferation and apoptosis in familial ademomatous polyposis. Gastroenterology 109: 994-998.
38. Chang, W.-C.L., Turner, N. D., Davidson, L. A., Chapkin, R. S. & Lupton, J. R. (1998) Fish oil depresses the carcinogen-induced expression of cox-2 in rat colonic mucosa. FASEB J. 12: A564.
39. Chapkin, R. S., Hong, M. Y., Fan, Y. Y., Davidson, L. A., Sanders, L. M., Henderson, C. E., Barhoumi, R., Burghardt, R. C., Turner, N. D. & Lupton, J. R. (2002) Dietary n-3 PUFA alter colonocyte mitochondrial membrane composition and function. Lipids 37: 193-199.
40. Hong, M. Y., Chapkin, R. S., Barhoumi, R., Burghardt, R. C., Turner, N. D., Henderson, C. E., Sanders, L. M., Fann, Y. Y., Davidson, L. A., Murphy, M. E., Spinka, C. M., Carroll, R. J. & Lupton, J. R. (2002) Fish oil feeding increases the unsaturation index in mitochondrial phospholipids, enhancing reactive oxygen species generation and initiating apoptosis in rat colonocytes. Carcinogenesis 23: 1919-1925.
41. Covert, K. L., Newton, A. H., Turner, N. D., Sanders, L. M., Popovic, N., Van Velson, C. M., Taddeo, S., Hong, M. Y., Murphy, M. E., Chapkin, R. S. & Lupton, J. R. (2003) The combination of dietary fish oil and butyrate decreases high-multiplicity aberrant crypt foci in experimentally induced colon cancer. FASEB J. 17: 1154.