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Volumn 37, Issue 5, 2017, Pages 198-206

Immune diseases associated with TREX1 and STING dysfunction

Author keywords

Aicardi Gouti res syndrome; Cytosolic DNA sensing; Retinal vasculopathy with cerebral leukodystrophy; STING; STING associated vasculopathy with onset in infancy; TREX1

Indexed keywords

ADAPTOR PROTEIN; ANTINEOPLASTIC AGENT; CELL DNA; DEOXYRIBONUCLEASE; REGULATOR PROTEIN; STING PROTEIN; TREX1 PROTEIN; UNCLASSIFIED DRUG; EXODEOXYRIBONUCLEASE; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; PHOSPHOPROTEIN; THREE PRIME REPAIR EXONUCLEASE 1;

EID: 85019099719     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2016.0086     Document Type: Article
Times cited : (76)

References (72)
  • 1
  • 2
    • 84908120748 scopus 로고    scopus 로고
    • Intrinsic self-DNA triggers inflammatory disease dependent on STING
    • Ahn J, Ruiz P, Barber GN. 2014. Intrinsic self-DNA triggers inflammatory disease dependent on STING. J Immunol 193: 4634-4642.
    • (2014) J Immunol , vol.193 , pp. 4634-4642
    • Ahn, J.1    Ruiz, P.2    Barber, G.N.3
  • 3
    • 80053031961 scopus 로고    scopus 로고
    • STING-dependent signaling
    • Barber GN. 2011. STING-dependent signaling. Nat Immunol 12: 929-930.
    • (2011) Nat Immunol , vol.12 , pp. 929-930
    • Barber, G.N.1
  • 4
    • 84893637182 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing pathways
    • Barber GN. 2014. STING-dependent cytosolic DNA sensing pathways. Trends Immunol 35: 88-93.
    • (2014) Trends Immunol , vol.35 , pp. 88-93
    • Barber, G.N.1
  • 5
    • 84878723890 scopus 로고    scopus 로고
    • High-throughput screening identifies aclacinomycin as a radiosensitizer of EGFR-mutant nonsmall cell lung cancer
    • Bennett DC, Charest J, Sebolt K, Lehrman M, Rehemtulla A, Contessa JN. 2013. High-throughput screening identifies aclacinomycin as a radiosensitizer of EGFR-mutant nonsmall cell lung cancer. Transl Oncol 6: 382-391.
    • (2013) Transl Oncol , vol.6 , pp. 382-391
    • Bennett, D.C.1    Charest, J.2    Sebolt, K.3    Lehrman, M.4    Rehemtulla, A.5    Contessa, J.N.6
  • 6
    • 56749157701 scopus 로고    scopus 로고
    • Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases
    • Brucet M, Querol-Audí J, Bertlik K, Lloberas J, Fita I, Celada A. 2008. Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. Protein Sci 17: 2059-2069.
    • (2008) Protein Sci , vol.17 , pp. 2059-2069
    • Brucet, M.1    Querol-Audí, J.2    Bertlik, K.3    Lloberas, J.4    Fita, I.5    Celada, A.6
  • 12
    • 84921325776 scopus 로고    scopus 로고
    • Targeting of type I interferon in systemic autoimmune diseases
    • Crow MK, Olferiev M, Kirou KA. 2015. Targeting of type I interferon in systemic autoimmune diseases. Transl Res 165: 296-305.
    • (2015) Transl Res , vol.165 , pp. 296-305
    • Crow, M.K.1    Olferiev, M.2    Kirou, K.A.3
  • 14
    • 77950400643 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome and related phenotypes: Linking nucleic acid metabolism with autoimmunity
    • Crow YJ, Rehwinkel J. 2009. Aicardi-Goutieres syndrome and related phenotypes: Linking nucleic acid metabolism with autoimmunity. Hum Mol Genet 18: R130-R136.
    • (2009) Hum Mol Genet , vol.18 , pp. R130-R136
    • Crow, Y.J.1    Rehwinkel, J.2
  • 15
    • 34249848019 scopus 로고    scopus 로고
    • The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering
    • de Silva U, Choudhury S, Bailey SL, Harvey S, Perrino FW, Hollis T. 2007. The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. J Biol Chem 282: 10537-10543.
    • (2007) J Biol Chem , vol.282 , pp. 10537-10543
    • De Silva, U.1    Choudhury, S.2    Bailey, S.L.3    Harvey, S.4    Perrino, F.W.5    Hollis, T.6
  • 16
    • 84959353023 scopus 로고    scopus 로고
    • STING activation by translocation from the ER is associated with infection and autoinflammatory disease
    • Dobbs N, Burnaevskiy N, Chen D, Gonugunta VK, Alto NM, Yan N. 2015. STING activation by translocation from the ER is associated with infection and autoinflammatory disease. Cell Host Microbe 18: 157-168.
    • (2015) Cell Host Microbe , vol.18 , pp. 157-168
    • Dobbs, N.1    Burnaevskiy, N.2    Chen, D.3    Gonugunta, V.K.4    Alto, N.M.5    Yan, N.6
  • 20
    • 84856301080 scopus 로고    scopus 로고
    • Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent Autoimmune Disease
    • Gall A, Treuting P, Elkon KB, Loo, Y-M, Gale M, Barber GN, Stetson DB. 2012. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent Autoimmune Disease. Immunity 36: 120-131.
    • (2012) Immunity , vol.36 , pp. 120-131
    • Gall, A.1    Treuting, P.2    Elkon, K.B.3    Loo, Y.-M.4    Gale, M.5    Barber, G.N.6    Stetson, D.B.7
  • 22
    • 84882896267 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    • Gao D, Wu J, Wu, Y-T, Du F, Aroh C, Yan N, Sun L, Chen ZJ. 2013. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341: 903-906.
    • (2013) Science , vol.341 , pp. 903-906
    • Gao, D.1    Wu, J.2    Wu, Y.-T.3    Du, F.4    Aroh, C.5    Yan, N.6    Sun, L.7    Chen, Z.J.8
  • 23
    • 84940121945 scopus 로고    scopus 로고
    • Cutting edge: CGAS is required for lethal autoimmune disease in the Trex1-deficient mouse model of Aicardi-Goutières syndrome
    • Gray EE, Treuting PM, Woodward JJ, Stetson DB. 2015. Cutting edge: CGAS is required for lethal autoimmune disease in the Trex1-deficient mouse model of Aicardi-Goutières syndrome. J Immunol 195: 1939-1943.
    • (2015) J Immunol , vol.195 , pp. 1939-1943
    • Gray, E.E.1    Treuting, P.M.2    Woodward, J.J.3    Stetson, D.B.4
  • 24
    • 34548046221 scopus 로고    scopus 로고
    • Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis
    • Green RS, Stone EL, Tenno M, Lehtonen E, Farquhar MG, Marth JD. 2007. Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis. Immunity 27: 308-320.
    • (2007) Immunity , vol.27 , pp. 308-320
    • Green, R.S.1    Stone, E.L.2    Tenno, M.3    Lehtonen, E.4    Farquhar, M.G.5    Marth, J.D.6
  • 25
  • 26
    • 84954132420 scopus 로고    scopus 로고
    • Cutting edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in mice
    • Hasan M, Dobbs N, Khan S, White MA, Wakeland EK, Li, Q-Z, Yan N. 2015a. Cutting edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in mice. J Immunol 195: 4573-4577.
    • (2015) J Immunol , vol.195 , pp. 4573-4577
    • Hasan, M.1    Dobbs, N.2    Khan, S.3    White, M.A.4    Wakeland, E.K.5    Li, Q.-Z.6    Yan, N.7
  • 29
    • 84899685774 scopus 로고    scopus 로고
    • Safeguard against DNA sensing: The role of TREX1 in HIV-1 infection and autoimmune diseases
    • Hasan M, Yan N. 2014. Safeguard against DNA sensing: The role of TREX1 in HIV-1 infection and autoimmune diseases. Front Microbiol 5: 193.
    • (2014) Front Microbiol , vol.5 , pp. 193
    • Hasan, M.1    Yan, N.2
  • 30
    • 84979084979 scopus 로고    scopus 로고
    • Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies
    • Hasan M, Yan N. 2016. Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies. Pharmacol Res 111: 336-342.
    • (2016) Pharmacol Res , vol.111 , pp. 336-342
    • Hasan, M.1    Yan, N.2
  • 33
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H, Ma Z, Barber GN. 2009. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461: 788-792.
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 36
    • 33645103490 scopus 로고    scopus 로고
    • An evolving view of the eukaryotic oligosaccharyltransferase
    • Kelleher DJ, Gilmore R. 2006. An evolving view of the eukaryotic oligosaccharyltransferase. Glycobiology 16: 47R-62R.
    • (2006) Glycobiology , vol.16 , pp. 47R-62R
    • Kelleher, D.J.1    Gilmore, R.2
  • 38
    • 84886789626 scopus 로고    scopus 로고
    • Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling
    • Konno H, Konno K, Barber GN. 2013. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155: 688-698.
    • (2013) Cell , vol.155 , pp. 688-698
    • Konno, H.1    Konno, K.2    Barber, G.N.3
  • 40
    • 84884675857 scopus 로고    scopus 로고
    • Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects
    • Li, X-D, Wu J, Gao D, Wang H, Sun L, Chen ZJ. 2013. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341: 1390-1394.
    • (2013) Science , vol.341 , pp. 1390-1394
    • Li, X.-D.1    Wu, J.2    Gao, D.3    Wang, H.4    Sun, L.5    Chen, Z.J.6
  • 41
    • 84938907605 scopus 로고    scopus 로고
    • Genome-wide DNA hypomethylation and RNA: DNA hybrid accumulation in Aicardi-Goutières syndrome
    • Lim YW, Sanz LA, Xu X, Hartono SR, Chedin F. 2015. Genome-wide DNA hypomethylation and RNA: DNA hybrid accumulation in Aicardi-Goutières syndrome. Elife 2015;4: E08007.
    • (2015) Elife , vol.2015 , Issue.4 , pp. e08007
    • Lim, Y.W.1    Sanz, L.A.2    Xu, X.3    Hartono, S.R.4    Chedin, F.5
  • 42
    • 67749084678 scopus 로고    scopus 로고
    • Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease
    • Lindahl T, Barnes DE, Yang, Y-G, Robins P. 2009. Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease. Biochem Soc Trans 37: 535-538.
    • (2009) Biochem Soc Trans , vol.37 , pp. 535-538
    • Lindahl, T.1    Barnes, D.E.2    Yang, Y.-G.3    Robins, P.4
  • 45
    • 0033538461 scopus 로고    scopus 로고
    • Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'/5' exonucleases
    • Mazur DJ, Perrino FW. 1999. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'/5' exonucleases. J Biol Chem 274: 19655-19660.
    • (1999) J Biol Chem , vol.274 , pp. 19655-19660
    • Mazur, D.J.1    Perrino, F.W.2
  • 47
    • 79960203817 scopus 로고    scopus 로고
    • Autoinflammation by endogenous DNA
    • Nagata S, Kawane K. 2011. Autoinflammation by endogenous DNA. Adv Immunol 110: 139-161.
    • (2011) Adv Immunol , vol.110 , pp. 139-161
    • Nagata, S.1    Kawane, K.2
  • 49
    • 79956292569 scopus 로고    scopus 로고
    • Myeloid C-type lectin receptors in pathogen recognition and host defense
    • Osorio F, Reis e Sousa C. 2011. Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 34: 651-664.
    • (2011) Immunity , vol.34 , pp. 651-664
    • Osorio, F.1    Reis, E.2    Sousa, C.3
  • 52
  • 53
    • 0037786682 scopus 로고    scopus 로고
    • A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
    • Robins P, Naven TJ, Pappin DJ, Lindahl T. 1999. A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. EMBO J 18: 3868-3875.
    • (1999) EMBO J , vol.18 , pp. 3868-3875
    • Robins, P.1    Naven, T.J.2    Pappin, D.J.3    Lindahl, T.4
  • 56
    • 84887007032 scopus 로고    scopus 로고
    • Mutations in STT3A and STT3B cause two congenital disorders of glycosylation
    • Shrimal S, Ng BG, Losfeld, M-E, Gilmore R, Freeze HH. 2013. Mutations in STT3A and STT3B cause two congenital disorders of glycosylation. Hum Mol Genet 22: 4638-4645.
    • (2013) Hum Mol Genet , vol.22 , pp. 4638-4645
    • Shrimal, S.1    Ng, B.G.2    Losfeld, M.-E.3    Gilmore, R.4    Freeze, H.H.5
  • 57
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R. 2008. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134: 587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 58
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson DB, Medzhitov R. 2006. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24: 93-103.
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 59
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
    • Sun L, Wu J, Du F, Chen X, Chen ZJ. 2013. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339: 786-791.
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 60
    • 85003010307 scopus 로고    scopus 로고
    • Cytosolic DNA sensing: The field narrows
    • Vance RE. 2016. Cytosolic DNA sensing: The field narrows. Immunity 45: 227-228.
    • (2016) Immunity , vol.45 , pp. 227-228
    • Vance, R.E.1
  • 67
    • 84873724533 scopus 로고    scopus 로고
    • Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    • Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. 2013. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339: 826-830.
    • (2013) Science , vol.339 , pp. 826-830
    • Wu, J.1    Sun, L.2    Chen, X.3    Du, F.4    Shi, H.5    Chen, C.6    Chen, Z.J.7
  • 69
    • 84955365022 scopus 로고    scopus 로고
    • Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis
    • Xia T, Konno H, Ahn J, Barber GN. 2015. Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis. Cell Rep 14: 282-297.
    • (2015) Cell Rep , vol.14 , pp. 282-297
    • Xia, T.1    Konno, H.2    Ahn, J.3    Barber, G.N.4
  • 70
    • 77958114725 scopus 로고    scopus 로고
    • The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    • Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J. 2010. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 11: 1005-1013.
    • (2010) Nat Immunol , vol.11 , pp. 1005-1013
    • Yan, N.1    Regalado-Magdos, A.D.2    Stiggelbout, B.3    Lee-Kirsch, M.A.4    Lieberman, J.5
  • 71
    • 36248988008 scopus 로고    scopus 로고
    • Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    • Yang Y, Lindahl T, Barnes DE. 2007. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131: 873-886.
    • (2007) Cell , vol.131 , pp. 873-886
    • Yang, Y.1    Lindahl, T.2    Barnes, D.E.3
  • 72
    • 84880508067 scopus 로고    scopus 로고
    • Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
    • Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ. 2013. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell 51: 226-235.
    • (2013) Mol Cell , vol.51 , pp. 226-235
    • Zhang, X.1    Shi, H.2    Wu, J.3    Zhang, X.4    Sun, L.5    Chen, C.6    Chen, Z.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.