Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases

Protein Science

Volumn 17, Issue 12, 2008, Pages 2059-2069

  Brucet, Marina ^a   Querol Audí, Jordi ^b   Bertlik, Kamila ^a   Lloberas, Jorge ^a   Fita, Ignacio ^b   Celada, Antonio ^a,c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

Author keywords

DEDDh family; Enzymatic activity; Exonucleases; Structure; TREX1

Indexed keywords

EXONUCLEAS TREX1; EXONUCLEASE; EXONUCLEASE DEDDH; HISTIDINE; LITHIUM; MAGNESIUM; MANGANESE; NUCLEOTIDE; SODIUM; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; METAL BINDING; PRIORITY JOURNAL; PROTEIN INTERACTION; X RAY ANALYSIS;

MAMMALIA;

EID: 56749157701     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.036426.108     Document Type: Article

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