The crystal structure of TREX1 explains the 3′ nucleotide specificity and reveals a polyproline II helix for protein partnering

Journal of Biological Chemistry

Volumn 282, Issue 14, 2007, Pages 10537-10543

  De Silva, Udesh ^a   Choudhury, Sumana ^a   Bailey, Suzanna L ^a   Harvey, Scott ^a   Perrino, Fred W ^a   Hollis, Thomas ^a,b  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXONUCLEASE ACTIVITY; POLYPROLINES; PROTEIN PARTNERING;

DNA; ENZYME ACTIVITY; NEUROLOGY; NUCLEOTIDES; PHOSPHATES; PROTEINS;

CRYSTAL STRUCTURE;

DEOXYADENOSINE PHOSPHATE; EXONUCLEASE; HELIX LOOP HELIX PROTEIN; PROLINE DERIVATIVE; SINGLE STRANDED DNA; THREE PRIME REPAIR EXONUCLEASE 1; UNCLASSIFIED DRUG; EXODEOXYRIBONUCLEASE; PHOSPHOPROTEIN; TREX1 PROTEIN, HUMAN; TREX1 PROTEIN, MOUSE;

AICARDI GOUTIERES SYNDROME; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE IDENTIFICATION; GENE INTERACTION; GENE MUTATION; GENE STRUCTURE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING SITE; BRAIN DISEASE; CHEMISTRY; ENZYMOLOGY; GENETIC DISORDER; GENETICS; MOUSE; MUTATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; SYNDROME;

ANIMALS; APOPTOSIS; AUTOIMMUNITY; BINDING SITES; BRAIN DISEASES; CRYSTALLOGRAPHY, X-RAY; DNA, SINGLE-STRANDED; EXODEOXYRIBONUCLEASES; GENETIC DISEASES, INBORN; HUMANS; MICE; MUTATION; PHOSPHOPROTEINS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; SYNDROME;

EID: 34249848019     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700039200     Document Type: Article

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