Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

Immunity

Volumn 43, Issue 3, 2015, Pages 463-474

  Hasan, Maroof ^a,e   Fermaintt, Charles S ^a   Gao, Ningguo ^a,f   Sakai, Tomomi ^b   Miyazaki, Takuya ^b,g   Jiang, Sixin ^a,h   Li, Quan Zhen ^c   Atkinson, John P ^d   Morse, Herbert C ^b   Lehrman, Mark A ^a   Yan, Nan ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

^f Xbiotech   (United States)

^g YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACLACINOMYCIN; AUTOANTIBODY; GLYCAN; NUCLEASE; OLIGOSACCHARYLTRANSFERASE; TRANSFERASE; TREX1 PROTEIN; UNCLASSIFIED DRUG; ACLACINOMYCINS; ACLARUBICIN; DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE - PROTEIN GLYCOTRANSFERASE; EXODEOXYRIBONUCLEASE; GLYCOSYLTRANSFERASE; MEMBRANE PROTEIN; PHOSPHOPROTEIN; POLYSACCHARIDE; PROTEIN BINDING; THREE PRIME REPAIR EXONUCLEASE 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CONCENTRATION AT STEADY-STATE; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANE; ENZYME ACTIVITY; FRAMESHIFT MUTATION; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GLYCOSYLATION; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOGENICITY; INNATE IMMUNITY; LYMPHOBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; FIBROBLAST; FLUORESCENCE MICROSCOPY; GENETICS; HEK293 CELL LINE; HELA CELL LINE; IMMUNOBLOTTING; KNOCKOUT MOUSE; MAMMALIAN EMBRYO; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSGENIC MOUSE;

ACLARUBICIN; ANIMALS; CELLS, CULTURED; CYTOSOL; EMBRYO, MAMMALIAN; EXODEOXYRIBONUCLEASES; FIBROBLASTS; FRAMESHIFT MUTATION; HEK293 CELLS; HELA CELLS; HEXOSYLTRANSFERASES; HUMANS; IMMUNITY, INNATE; IMMUNOBLOTTING; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; PHOSPHOPROTEINS; POLYSACCHARIDES; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

EID: 84941628442     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.07.022     Document Type: Article

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