Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 16, 2015, Pages 5117-5122

  Grieves, Jessica L ^a   Fye, Jason M ^a   Harvey, Scott ^a   Grayson, Jason M ^a   Hollis, Thomas ^a   Perrino, Fred W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; DNA; Lupus; Structure; TREX1

Indexed keywords

AUTOANTIBODY; DOUBLE STRANDED DNA; DOUBLE STRANDED DNA ANTIBODY; EXONUCLEASE; EXONUCLEASE TREX1; MUTANT PROTEIN; POLYNUCLEOTIDE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; ANTIBODY; DNA; EXODEOXYRIBONUCLEASE; PHOSPHOPROTEIN; THREE PRIME REPAIR EXONUCLEASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CATALYSIS; DISEASE ASSOCIATION; DNA DEGRADATION; DNA DENATURATION; DNA STRAND; DNA STRUCTURE; ENZYME ACTIVE SITE; FEMALE; IMMUNE COMPLEX DEPOSITION; IMMUNE RESPONSE; IN VIVO STUDY; INFLAMMATION; INFLAMMATORY DISEASE; KIDNEY; KIDNEY DISEASE; LUPUS LIKE SYNDROME; LYMPHOID HYPERPLASIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; PROTEIN STRUCTURE; VASCULITIS; WILD TYPE; ALLELE; ANIMAL; AUTOIMMUNITY; CHEMISTRY; CHILBLAIN; CONFORMATION; DNA DAMAGE; ENZYMOLOGY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHENOTYPE; PROTEIN SYNTHESIS; SKIN LUPUS ERYTHEMATOSUS;

MUS;

ALLELES; ANIMALS; ANTIBODIES; AUTOIMMUNITY; BASE SEQUENCE; CHILBLAINS; DNA; DNA DAMAGE; EXODEOXYRIBONUCLEASES; HUMANS; INFLAMMATION; LUPUS ERYTHEMATOSUS, CUTANEOUS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PHENOTYPE; PHOSPHOPROTEINS; PROTEIN BIOSYNTHESIS;

EID: 84928243624     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1423804112     Document Type: Article

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