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Volumn 38, Issue , 2017, Pages 117-126

Combinatorial chemistry in drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

COMBINATORIAL CHEMISTRY; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; REVIEW; ANIMAL; HUMAN; PRECLINICAL STUDY; PROCEDURES;

EID: 85018447808     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2017.03.017     Document Type: Review
Times cited : (232)

References (69)
  • 1
    • 0000951677 scopus 로고
    • Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
    • 1 Geysen, H.M., Meloen, R.H., Barteling, S.J., Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. U. S. A. 81 (1984), 3998–4002.
    • (1984) Proc. Natl. Acad. Sci. U. S. A. , vol.81 , pp. 3998-4002
    • Geysen, H.M.1    Meloen, R.H.2    Barteling, S.J.3
  • 2
    • 0000478940 scopus 로고
    • General-method for the rapid solid-phase synthesis of large numbers of peptides—specificity of antigen–antibody interaction at the level of individual amino-acids
    • 2 Houghten, R.A., General-method for the rapid solid-phase synthesis of large numbers of peptides—specificity of antigen–antibody interaction at the level of individual amino-acids. Proc. Natl. Acad. Sci. U. S. A. 82 (1985), 5131–5135.
    • (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , pp. 5131-5135
    • Houghten, R.A.1
  • 3
    • 0026419328 scopus 로고
    • A new type of synthetic peptide library for identifying ligand-binding activity
    • 3 Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V.J., Kazmierski, W.M., Knapp, R.J., A new type of synthetic peptide library for identifying ligand-binding activity. Nature 354 (1991), 82–84.
    • (1991) Nature , vol.354 , pp. 82-84
    • Lam, K.S.1    Salmon, S.E.2    Hersh, E.M.3    Hruby, V.J.4    Kazmierski, W.M.5    Knapp, R.J.6
  • 4
    • 0026419319 scopus 로고
    • Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
    • 4 Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T., Cuervo, J.H., Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 354 (1991), 84–86.
    • (1991) Nature , vol.354 , pp. 84-86
    • Houghten, R.A.1    Pinilla, C.2    Blondelle, S.E.3    Appel, J.R.4    Dooley, C.T.5    Cuervo, J.H.6
  • 5
    • 0027068161 scopus 로고
    • A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives
    • 5 Bunin, B.A., Ellman, J.A., A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives. J. Am. Chem. Soc. 114 (1992), 10997–10998.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 10997-10998
    • Bunin, B.A.1    Ellman, J.A.2
  • 6
    • 0026108692 scopus 로고
    • Light-directed, spatially addressable parallel chemical synthesis
    • 6 Fodor, S.P.A., Read, J.L., Pirrung, M.C., Stryer, L., Lu, A.T., Solas, D., Light-directed, spatially addressable parallel chemical synthesis. Science 251 (1991), 767–773.
    • (1991) Science , vol.251 , pp. 767-773
    • Fodor, S.P.A.1    Read, J.L.2    Pirrung, M.C.3    Stryer, L.4    Lu, A.T.5    Solas, D.6
  • 7
    • 0021818675 scopus 로고
    • Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface
    • 7 Smith, G.P., Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228 (1985), 1315–1317.
    • (1985) Science , vol.228 , pp. 1315-1317
    • Smith, G.P.1
  • 8
    • 0345531149 scopus 로고    scopus 로고
    • Encodamers: unnatural peptide oligomers encoded in RNA
    • 8 Frankel, A., Millward, S.W., Roberts, R.W., Encodamers: unnatural peptide oligomers encoded in RNA. Chem. Biol. 10 (2003), 1043–1050.
    • (2003) Chem. Biol. , vol.10 , pp. 1043-1050
    • Frankel, A.1    Millward, S.W.2    Roberts, R.W.3
  • 10
    • 33646044708 scopus 로고    scopus 로고
    • A highly flexible tRNA acylation method for non-natural polypeptide synthesis
    • 10 Murakami, H., Ohta, A., Ashigai, H., Suga, H., A highly flexible tRNA acylation method for non-natural polypeptide synthesis. Nat. Methods 3 (2006), 357–359.
    • (2006) Nat. Methods , vol.3 , pp. 357-359
    • Murakami, H.1    Ohta, A.2    Ashigai, H.3    Suga, H.4
  • 11
    • 67650305952 scopus 로고    scopus 로고
    • Phage-encoded combinatorial chemical libraries based on bicyclic peptides
    • 11 Heinis, C., Rutherford, T., Freund, S., Winter, G., Phage-encoded combinatorial chemical libraries based on bicyclic peptides. Nat. Chem. Biol. 5 (2009), 502–507.
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 502-507
    • Heinis, C.1    Rutherford, T.2    Freund, S.3    Winter, G.4
  • 12
    • 85018427619 scopus 로고    scopus 로고
    • Combinatorial chemistry: a review
    • 12 Rasheed, A., Farhat, R., Combinatorial chemistry: a review. Int. J. Pharm. Sci. Res. 4 (2013), 2502–2516.
    • (2013) Int. J. Pharm. Sci. Res. , vol.4 , pp. 2502-2516
    • Rasheed, A.1    Farhat, R.2
  • 14
    • 85006414950 scopus 로고    scopus 로고
    • Tumor-targeting peptides from combinatorial libraries
    • Epub ahead of print Extensive review on combinatorial libraries and their successful application in discovery of tumor-targeting peptides.
    • 14• Liu, R., Li, X., Xiao, W., Lam, K.S., Tumor-targeting peptides from combinatorial libraries. Adv. Drug Deliv. Rev., 2016, 10.1016/j.addr.2016.05.009 Epub ahead of print Extensive review on combinatorial libraries and their successful application in discovery of tumor-targeting peptides.
    • (2016) Adv. Drug Deliv. Rev.
    • Liu, R.1    Li, X.2    Xiao, W.3    Lam, K.S.4
  • 15
    • 80052094845 scopus 로고    scopus 로고
    • The rise, fall and reinvention of combinatorial chemistry
    • 15 Kodadek, T., The rise, fall and reinvention of combinatorial chemistry. Chem. Commun. 47 (2011), 9757–9763.
    • (2011) Chem. Commun. , vol.47 , pp. 9757-9763
    • Kodadek, T.1
  • 16
    • 84923030186 scopus 로고    scopus 로고
    • The effects of combinatorial chemistry and technologies on drug discovery and biotechnology—a mini review
    • 16 Seneci, P., Fassina, G., Frecer, V., Miertus, S., The effects of combinatorial chemistry and technologies on drug discovery and biotechnology—a mini review. Nova Biotechnol. Chim. 13 (2014), 87–108.
    • (2014) Nova Biotechnol. Chim. , vol.13 , pp. 87-108
    • Seneci, P.1    Fassina, G.2    Frecer, V.3    Miertus, S.4
  • 17
    • 85003955457 scopus 로고    scopus 로고
    • In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies
    • 17 Lipi, F., Chen, S., Chakravarthy, M., Rakesh, S., Veedu, R.N., In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies. RNA Biol. 13 (2016), 1232–1245.
    • (2016) RNA Biol. , vol.13 , pp. 1232-1245
    • Lipi, F.1    Chen, S.2    Chakravarthy, M.3    Rakesh, S.4    Veedu, R.N.5
  • 19
    • 84874414338 scopus 로고    scopus 로고
    • Fragment-based lead discovery grows up
    • 19 Baker, M., Fragment-based lead discovery grows up. Nat. Rev. Drug Discov. 12 (2013), 5–7.
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 5-7
    • Baker, M.1
  • 21
    • 0037861156 scopus 로고    scopus 로고
    • Computational design strategies for combinatorial libraries
    • 21 Rose, S., Stevens, A., Computational design strategies for combinatorial libraries. Curr. Opin. Chem. Biol. 7 (2003), 331–339.
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 331-339
    • Rose, S.1    Stevens, A.2
  • 22
    • 79952198616 scopus 로고    scopus 로고
    • Molecular library design using multi-objective optimization methods
    • 22 Nicolaou, C.A., Kannas, C.C., Molecular library design using multi-objective optimization methods. Methods Mol. Biol. 685 (2011), 53–69.
    • (2011) Methods Mol. Biol. , vol.685 , pp. 53-69
    • Nicolaou, C.A.1    Kannas, C.C.2
  • 23
    • 79952114386 scopus 로고    scopus 로고
    • Adaptive combinatorial design of focused compound libraries
    • 23 Schneider, G., Schuller, A., Adaptive combinatorial design of focused compound libraries. Methods Mol. Biol. 572 (2010), 135–147.
    • (2010) Methods Mol. Biol. , vol.572 , pp. 135-147
    • Schneider, G.1    Schuller, A.2
  • 24
    • 34547582297 scopus 로고    scopus 로고
    • Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4
    • 24 Evensen, E., Joseph-McCarthy, D., Weiss, G.A., Schreiber, S.L., Karplus, M., Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4. J. Comput. Aid Mol. Des. 21 (2007), 395–418.
    • (2007) J. Comput. Aid Mol. Des. , vol.21 , pp. 395-418
    • Evensen, E.1    Joseph-McCarthy, D.2    Weiss, G.A.3    Schreiber, S.L.4    Karplus, M.5
  • 25
    • 84959341665 scopus 로고    scopus 로고
    • A rapid Python-based methodology for target-focused combinatorial library design
    • 25 Li, S.L., Song, Y.W., Liu, X.F., Li, H.L., A rapid Python-based methodology for target-focused combinatorial library design. Comb. Chem. High Throughput Screen. 19 (2016), 25–35.
    • (2016) Comb. Chem. High Throughput Screen. , vol.19 , pp. 25-35
    • Li, S.L.1    Song, Y.W.2    Liu, X.F.3    Li, H.L.4
  • 26
    • 0025893762 scopus 로고
    • General method for rapid synthesis of multicomponent peptide mixtures
    • 26 Furka, A., Sebestyen, F., Asgedom, M., Dibo, G., General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Pept. Protein Res. 37 (1991), 487–493.
    • (1991) Int. J. Pept. Protein Res. , vol.37 , pp. 487-493
    • Furka, A.1    Sebestyen, F.2    Asgedom, M.3    Dibo, G.4
  • 27
    • 84893118765 scopus 로고    scopus 로고
    • Combinatorial peptide libraries: mining for cell-binding peptides
    • 27 Gray, B.P., Brown, K.C., Combinatorial peptide libraries: mining for cell-binding peptides. Chem. Rev. 114 (2014), 1020–1081.
    • (2014) Chem. Rev. , vol.114 , pp. 1020-1081
    • Gray, B.P.1    Brown, K.C.2
  • 28
    • 84903712331 scopus 로고    scopus 로고
    • Liquid-phase combinatorial library synthesis: recent advances and future perspectives
    • 28 Barot, K.P., Nikolova, S., Ivanov, I., Ghate, M.D., Liquid-phase combinatorial library synthesis: recent advances and future perspectives. Comb. Chem. High Throughput Screen. 17 (2014), 417–438.
    • (2014) Comb. Chem. High Throughput Screen. , vol.17 , pp. 417-438
    • Barot, K.P.1    Nikolova, S.2    Ivanov, I.3    Ghate, M.D.4
  • 29
    • 32644445255 scopus 로고    scopus 로고
    • Combinatorial solid phase peptide synthesis and bioassays
    • 29 Shin, D.S., Kim, D.H., Chung, W.J., Lee, Y.S., Combinatorial solid phase peptide synthesis and bioassays. J. Biochem. Mol. Biol. 38 (2005), 517–525.
    • (2005) J. Biochem. Mol. Biol. , vol.38 , pp. 517-525
    • Shin, D.S.1    Kim, D.H.2    Chung, W.J.3    Lee, Y.S.4
  • 30
    • 0000512227 scopus 로고    scopus 로고
    • Multiple-component condensation strategies for combinatorial library synthesis
    • 30 Armstrong, R.W., Combs, A.P., Tempest, P.A., Brown, S.D., Keating, T.A., Multiple-component condensation strategies for combinatorial library synthesis. Acc. Chem. Res. 29 (1996), 123–131.
    • (1996) Acc. Chem. Res. , vol.29 , pp. 123-131
    • Armstrong, R.W.1    Combs, A.P.2    Tempest, P.A.3    Brown, S.D.4    Keating, T.A.5
  • 31
    • 84964282431 scopus 로고    scopus 로고
    • Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents
    • An excellent paper describing a novel approach to synthesize β-amino acid peptides under mild aqueous conditions without workup. The reaction can be initiated or terminated at any point by choosing an appropriate building block.
    • 31•• Huang, Y.L., Bode, J.W., Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents. Nat. Chem. 6 (2014), 877–884 An excellent paper describing a novel approach to synthesize β-amino acid peptides under mild aqueous conditions without workup. The reaction can be initiated or terminated at any point by choosing an appropriate building block.
    • (2014) Nat. Chem. , vol.6 , pp. 877-884
    • Huang, Y.L.1    Bode, J.W.2
  • 32
    • 84931282152 scopus 로고    scopus 로고
    • Encoded library synthesis using chemical ligation and the discovery of sEH inhibitors from a 334-million member library
    • This paper describes the synthesis of a huge DNA-encoded small-molecule library using Click chemistry ligation and identification of a 2 nM sEH inhibitor from the library.
    • 32• Litovchick, A., Dumelin, C.E., Habeshian, S., Gikunju, D., Guie, M.A., Centrella, P., Zhang, Y., Sigel, E.A., Cuozzo, J.W., Keefe, A.D., et al. Encoded library synthesis using chemical ligation and the discovery of sEH inhibitors from a 334-million member library. Sci. Rep., 5, 2015, 10916 This paper describes the synthesis of a huge DNA-encoded small-molecule library using Click chemistry ligation and identification of a 2 nM sEH inhibitor from the library.
    • (2015) Sci. Rep. , vol.5 , pp. 10916
    • Litovchick, A.1    Dumelin, C.E.2    Habeshian, S.3    Gikunju, D.4    Guie, M.A.5    Centrella, P.6    Zhang, Y.7    Sigel, E.A.8    Cuozzo, J.W.9    Keefe, A.D.10
  • 33
    • 84916235180 scopus 로고    scopus 로고
    • Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies
    • 33 Bashiruddin, N.K., Suga, H., Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies. Curr. Opin. Chem. Biol. 24 (2015), 131–138.
    • (2015) Curr. Opin. Chem. Biol. , vol.24 , pp. 131-138
    • Bashiruddin, N.K.1    Suga, H.2
  • 34
    • 84939805312 scopus 로고    scopus 로고
    • Ribosomal synthesis of macrocyclic peptides in vitro and in vivo mediated by genetically encoded aminothiol unnatural amino acids
    • An elegant method for ribosomal synthesis of side chain-to-tail macrocyclic peptides.
    • 34•• Frost, J.R., Jacob, N.T., Papa, L.J., Owens, A.E., Fasan, R., Ribosomal synthesis of macrocyclic peptides in vitro and in vivo mediated by genetically encoded aminothiol unnatural amino acids. ACS Chem. Biol. 10 (2015), 1805–1816 An elegant method for ribosomal synthesis of side chain-to-tail macrocyclic peptides.
    • (2015) ACS Chem. Biol. , vol.10 , pp. 1805-1816
    • Frost, J.R.1    Jacob, N.T.2    Papa, L.J.3    Owens, A.E.4    Fasan, R.5
  • 35
    • 85010943885 scopus 로고    scopus 로고
    • Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides
    • 35 Jongkees, S.A.K., Umemoto, S., Suga, H., Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides. Chem. Sci. 8 (2017), 1474–1481.
    • (2017) Chem. Sci. , vol.8 , pp. 1474-1481
    • Jongkees, S.A.K.1    Umemoto, S.2    Suga, H.3
  • 36
    • 77956522287 scopus 로고    scopus 로고
    • Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule libraries
    • 36 Townsend, J.B., Shaheen, F., Liu, R., Lam, K.S., Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule libraries. J. Comb. Chem. 12 (2010), 700–712.
    • (2010) J. Comb. Chem. , vol.12 , pp. 700-712
    • Townsend, J.B.1    Shaheen, F.2    Liu, R.3    Lam, K.S.4
  • 37
    • 84957439134 scopus 로고    scopus 로고
    • Advancement and applications of peptide phage display technology in biomedical science
    • 37 Wu, C.H., Liu, I.J., Lu, R.M., Wu, H.C., Advancement and applications of peptide phage display technology in biomedical science. J. Biomed. Sci., 23, 2016, 8.
    • (2016) J. Biomed. Sci. , vol.23 , pp. 8
    • Wu, C.H.1    Liu, I.J.2    Lu, R.M.3    Wu, H.C.4
  • 38
    • 84969612636 scopus 로고    scopus 로고
    • A wide-field fluorescence microscope extension for ultrafast screening of one-bead one-compound libraries using a spectral image subtraction approach
    • 38 Heusermann, W., Ludin, B., Pham, N.T., Auer, M., Weidemann, T., Hintersteiner, M., A wide-field fluorescence microscope extension for ultrafast screening of one-bead one-compound libraries using a spectral image subtraction approach. ACS Comb. Sci. 18 (2016), 209–219.
    • (2016) ACS Comb. Sci. , vol.18 , pp. 209-219
    • Heusermann, W.1    Ludin, B.2    Pham, N.T.3    Auer, M.4    Weidemann, T.5    Hintersteiner, M.6
  • 40
    • 85017505688 scopus 로고    scopus 로고
    • An integrated microfluidic processor for DNA-encoded combinatorial library functional screening
    • 40 MacConnell, A.B., Price, A.K., Paegel, B.M., An integrated microfluidic processor for DNA-encoded combinatorial library functional screening. ACS Comb. Sci. 19 (2017), 181–192.
    • (2017) ACS Comb. Sci. , vol.19 , pp. 181-192
    • MacConnell, A.B.1    Price, A.K.2    Paegel, B.M.3
  • 42
    • 79955841972 scopus 로고    scopus 로고
    • Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods
    • 42 Kumaresan, P.R., Wang, Y., Saunders, M., Maeda, Y., Liu, R., Wang, X., Lam, K.S., Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods. ACS Comb. Sci. 13 (2011), 259–264.
    • (2011) ACS Comb. Sci. , vol.13 , pp. 259-264
    • Kumaresan, P.R.1    Wang, Y.2    Saunders, M.3    Maeda, Y.4    Liu, R.5    Wang, X.6    Lam, K.S.7
  • 43
    • 84922011527 scopus 로고    scopus 로고
    • Design, synthesis, and application of OB2C combinatorial peptide and peptidomimetic libraries
    • 43 Liu, R., Shih, T.C., Deng, X., Anwar, L., Ahadi, S., Kumaresan, P., Lam, K.S., Design, synthesis, and application of OB2C combinatorial peptide and peptidomimetic libraries. Methods Mol. Biol. 1248 (2015), 3–22.
    • (2015) Methods Mol. Biol. , vol.1248 , pp. 3-22
    • Liu, R.1    Shih, T.C.2    Deng, X.3    Anwar, L.4    Ahadi, S.5    Kumaresan, P.6    Lam, K.S.7
  • 44
    • 85018409313 scopus 로고    scopus 로고
    • A novel galectin-1 inhibitor discovered through one-bead two-compound library potentiates the anti-tumor effects of paclitaxel in vivo
    • in press
    • 44 Shih, T.-C., Liu, R., Fung, G., Bhardwaj, G., Ghosh, P.M., Lam, K.S., A novel galectin-1 inhibitor discovered through one-bead two-compound library potentiates the anti-tumor effects of paclitaxel in vivo. Mol. Cancer Ther., 2017 in press.
    • (2017) Mol. Cancer Ther.
    • Shih, T.-C.1    Liu, R.2    Fung, G.3    Bhardwaj, G.4    Ghosh, P.M.5    Lam, K.S.6
  • 45
    • 84898913565 scopus 로고    scopus 로고
    • DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries
    • An excellent review to compare the advantages and limitations of DECLs with conventional small-molecule libraries.
    • 45•• Franzini, R.M., Neri, D., Scheuermann, J., DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries. Acc. Chem. Res. 47 (2014), 1247–1255 An excellent review to compare the advantages and limitations of DECLs with conventional small-molecule libraries.
    • (2014) Acc. Chem. Res. , vol.47 , pp. 1247-1255
    • Franzini, R.M.1    Neri, D.2    Scheuermann, J.3
  • 46
    • 84962232638 scopus 로고    scopus 로고
    • Automated screening for small organic ligands using DNA-encoded chemical libraries
    • This paper describes a generally applicable, inexpensive and fast procedure to automated screen small-molecule ligands against biological targets from DECLs.
    • 46•• Decurtins, W., Wichert, M., Franzini, R.M., Buller, F., Stravs, M.A., Zhang, Y., Neri, D., Scheuermann, J., Automated screening for small organic ligands using DNA-encoded chemical libraries. Nat. Protoc. 11 (2016), 764–780 This paper describes a generally applicable, inexpensive and fast procedure to automated screen small-molecule ligands against biological targets from DECLs.
    • (2016) Nat. Protoc. , vol.11 , pp. 764-780
    • Decurtins, W.1    Wichert, M.2    Franzini, R.M.3    Buller, F.4    Stravs, M.A.5    Zhang, Y.6    Neri, D.7    Scheuermann, J.8
  • 49
    • 0035424887 scopus 로고    scopus 로고
    • Automatic Edman microsequencing of peptides containing multiple unnatural amino acids
    • 49 Liu, R., Lam, K.S., Automatic Edman microsequencing of peptides containing multiple unnatural amino acids. Anal. Biochem. 295 (2001), 9–16.
    • (2001) Anal. Biochem. , vol.295 , pp. 9-16
    • Liu, R.1    Lam, K.S.2
  • 50
    • 0037951325 scopus 로고    scopus 로고
    • A novel and rapid encoding method based on mass spectrometry for one-bead-one-compound small molecule combinatorial libraries
    • 50 Song, A., Zhang, J., Lebrilla, C.B., Lam, K.S., A novel and rapid encoding method based on mass spectrometry for one-bead-one-compound small molecule combinatorial libraries. J. Am. Chem. Soc. 125 (2003), 6180–6188.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 6180-6188
    • Song, A.1    Zhang, J.2    Lebrilla, C.B.3    Lam, K.S.4
  • 51
    • 33749532845 scopus 로고    scopus 로고
    • High-throughput sequence determination of cyclic peptide library members by partial Edman degradation/mass spectrometry
    • 51 Joo, S.H., Xiao, Q., Ling, Y., Gopishetty, B., Pei, D., High-throughput sequence determination of cyclic peptide library members by partial Edman degradation/mass spectrometry. J. Am. Chem. Soc. 128 (2006), 13000–13009.
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 13000-13009
    • Joo, S.H.1    Xiao, Q.2    Ling, Y.3    Gopishetty, B.4    Pei, D.5
  • 52
    • 72949105766 scopus 로고    scopus 로고
    • ‘On-the-fly’ optical encoding of combinatorial peptide libraries for profiling of protease specificity
    • 52 Marcon, L., Battersby, B.J., Ruhmann, A., Ford, K., Daley, M., Lawrie, G.A., Trau, M., ‘On-the-fly’ optical encoding of combinatorial peptide libraries for profiling of protease specificity. Mol. Biosyst. 6 (2010), 225–233.
    • (2010) Mol. Biosyst. , vol.6 , pp. 225-233
    • Marcon, L.1    Battersby, B.J.2    Ruhmann, A.3    Ford, K.4    Daley, M.5    Lawrie, G.A.6    Trau, M.7
  • 53
    • 84930650505 scopus 로고    scopus 로고
    • Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis
    • 53 Kang, H., Jeong, S., Koh, Y., Geun Cha, M., Yang, J.K., Kyeong, S., Kim, J., Kwak, S.Y., Chang, H.J., Lee, H., et al. Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis. Sci. Rep., 5, 2015, 10144.
    • (2015) Sci. Rep. , vol.5 , pp. 10144
    • Kang, H.1    Jeong, S.2    Koh, Y.3    Geun Cha, M.4    Yang, J.K.5    Kyeong, S.6    Kim, J.7    Kwak, S.Y.8    Chang, H.J.9    Lee, H.10
  • 55
    • 84915746858 scopus 로고    scopus 로고
    • DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
    • 55 Daguer, J.P., Zambaldo, C., Ciobanu, M., Morieux, P., Barluenga, S., Winssinger, N., DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules. Chem. Sci. 6 (2015), 739–744.
    • (2015) Chem. Sci. , vol.6 , pp. 739-744
    • Daguer, J.P.1    Zambaldo, C.2    Ciobanu, M.3    Morieux, P.4    Barluenga, S.5    Winssinger, N.6
  • 56
    • 84971324854 scopus 로고    scopus 로고
    • Identification of leishmania donovani topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors
    • 56 Mamidala, R., Majumdar, P., Jha, K.K., Bathula, C., Agarwal, R., Chary, M.T., Mazumdar, H.K., Munshi, P., Sen, S., Identification of leishmania donovani topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors. Sci. Rep., 6, 2016, 26603.
    • (2016) Sci. Rep. , vol.6 , pp. 26603
    • Mamidala, R.1    Majumdar, P.2    Jha, K.K.3    Bathula, C.4    Agarwal, R.5    Chary, M.T.6    Mazumdar, H.K.7    Munshi, P.8    Sen, S.9
  • 57
    • 84856400291 scopus 로고    scopus 로고
    • A biomimetic polyketide-inspired approach to small-molecule ligand discovery
    • This article describes an efficient way to synthesize and screen a novel class of chiral and conformationally constrained pentenoic amide oligomers in OBOC library format.
    • 57• Aquino, C., Sarkar, M., Chalmers, M.J., Mendes, K., Kodadek, T., Micalizio, G.C., A biomimetic polyketide-inspired approach to small-molecule ligand discovery. Nat. Chem. 4 (2011), 99–104 This article describes an efficient way to synthesize and screen a novel class of chiral and conformationally constrained pentenoic amide oligomers in OBOC library format.
    • (2011) Nat. Chem. , vol.4 , pp. 99-104
    • Aquino, C.1    Sarkar, M.2    Chalmers, M.J.3    Mendes, K.4    Kodadek, T.5    Micalizio, G.C.6
  • 59
    • 85002762920 scopus 로고    scopus 로고
    • Discovery and characterization of a peptoid with antifungal activity against Cryptococcus neoformans
    • 59 Corson, A.E., Armstrong, S.A., Wright, M.E., McClelland, E.E., Bicker, K.L., Discovery and characterization of a peptoid with antifungal activity against Cryptococcus neoformans. ACS Med. Chem. Lett. 7 (2016), 1139–1144.
    • (2016) ACS Med. Chem. Lett. , vol.7 , pp. 1139-1144
    • Corson, A.E.1    Armstrong, S.A.2    Wright, M.E.3    McClelland, E.E.4    Bicker, K.L.5
  • 60
    • 84954178710 scopus 로고    scopus 로고
    • Discovery of a sirect Ras inhibitor by screening a combinatorial library of cell-permeable bicyclic peptides
    • 60 Trinh, T.B., Upadhyaya, P., Qian, Z., Pei, D., Discovery of a sirect Ras inhibitor by screening a combinatorial library of cell-permeable bicyclic peptides. ACS Comb. Sci. 18 (2016), 75–85.
    • (2016) ACS Comb. Sci. , vol.18 , pp. 75-85
    • Trinh, T.B.1    Upadhyaya, P.2    Qian, Z.3    Pei, D.4
  • 61
    • 84928473225 scopus 로고    scopus 로고
    • Combinatorial libraries as a tool for the discovery of novel, broad-spectrum antibacterial agents targeting the ESKAPE pathogens
    • Nice story describing the development of in vivo active bis-cyclic guanidines as novel and broad-spectrum antibacterial agents using positional scanning library approach.
    • 61• Fleeman, R., LaVoi, T.M., Santos, R.G., Morales, A., Nefzi, A., Welmaker, G.S., Medina-Franco, J.L., Giulianotti, M.A., Houghten, R.A., Shaw, L.N., Combinatorial libraries as a tool for the discovery of novel, broad-spectrum antibacterial agents targeting the ESKAPE pathogens. J. Med. Chem. 58 (2015), 3340–3355 Nice story describing the development of in vivo active bis-cyclic guanidines as novel and broad-spectrum antibacterial agents using positional scanning library approach.
    • (2015) J. Med. Chem. , vol.58 , pp. 3340-3355
    • Fleeman, R.1    LaVoi, T.M.2    Santos, R.G.3    Morales, A.4    Nefzi, A.5    Welmaker, G.S.6    Medina-Franco, J.L.7    Giulianotti, M.A.8    Houghten, R.A.9    Shaw, L.N.10
  • 62
    • 84923333701 scopus 로고    scopus 로고
    • Fidelity by design: yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery
    • 62 Blakskjaer, P., Heitner, T., Hansen, N.J., Fidelity by design: yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery. Curr. Opin. Chem. Biol. 26 (2015), 62–71.
    • (2015) Curr. Opin. Chem. Biol. , vol.26 , pp. 62-71
    • Blakskjaer, P.1    Heitner, T.2    Hansen, N.J.3
  • 63
    • 84923182115 scopus 로고    scopus 로고
    • Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation
    • The paper describes the use of dual-pharmacophore DECL to identify binding pairs of target proteins. The same approach was also used to improve binding affinity of a known ligand. The authors developed a bidentate ligand that showed potent in vitro binding affinity against carbonic anhydrase IX (Kd = 0.2 nM) and excellent in vivo tumor targeting in a kidney cancer mouse model.
    • 63•• Wichert, M., Krall, N., Decurtins, W., Franzini, R.M., Pretto, F., Schneider, P., Neri, D., Scheuermann, J., Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation. Nat. Chem. 7 (2015), 241–249 The paper describes the use of dual-pharmacophore DECL to identify binding pairs of target proteins. The same approach was also used to improve binding affinity of a known ligand. The authors developed a bidentate ligand that showed potent in vitro binding affinity against carbonic anhydrase IX (Kd = 0.2 nM) and excellent in vivo tumor targeting in a kidney cancer mouse model.
    • (2015) Nat. Chem. , vol.7 , pp. 241-249
    • Wichert, M.1    Krall, N.2    Decurtins, W.3    Franzini, R.M.4    Pretto, F.5    Schneider, P.6    Neri, D.7    Scheuermann, J.8
  • 66
    • 84861322262 scopus 로고    scopus 로고
    • Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
    • 66 Gould, A., Ji, Y.B., Aboye, T.L., Camarero, J.A., Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery. Curr. Pharm. Des. 17 (2011), 4294–4307.
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 4294-4307
    • Gould, A.1    Ji, Y.B.2    Aboye, T.L.3    Camarero, J.A.4
  • 67
    • 85013986653 scopus 로고    scopus 로고
    • Cyclotides as drug design scaffolds
    • 67 Craik, D.J., Du, J., Cyclotides as drug design scaffolds. Curr. Opin. Chem. Biol. 38 (2017), 8–16.
    • (2017) Curr. Opin. Chem. Biol. , vol.38 , pp. 8-16
    • Craik, D.J.1    Du, J.2
  • 68
    • 84982085136 scopus 로고    scopus 로고
    • Substrate-guided design of selective FXIIa inhibitors based on the plant-derived momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold
    • 68 Swedberg, J.E., Mahatmanto, T., Abdul Ghani, H., de Veer, S.J., Schroeder, C.I., Harris, J.M., Craik, D.J., Substrate-guided design of selective FXIIa inhibitors based on the plant-derived momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. J. Med. Chem. 59 (2016), 7287–7292.
    • (2016) J. Med. Chem. , vol.59 , pp. 7287-7292
    • Swedberg, J.E.1    Mahatmanto, T.2    Abdul Ghani, H.3    de Veer, S.J.4    Schroeder, C.I.5    Harris, J.M.6    Craik, D.J.7
  • 69
    • 71049186869 scopus 로고    scopus 로고
    • Biosynthesis and biologicals screening of a genetically encoded library based on the cyclotide MCoTI-I
    • 69 Austin, J., Wang, W., Puttamadappa, S., Shekhtman, A., Camarero, J.A., Biosynthesis and biologicals screening of a genetically encoded library based on the cyclotide MCoTI-I. Chembiochem 10 (2009), 2663–2670.
    • (2009) Chembiochem , vol.10 , pp. 2663-2670
    • Austin, J.1    Wang, W.2    Puttamadappa, S.3    Shekhtman, A.4    Camarero, J.A.5


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