-
1
-
-
0000951677
-
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
-
1 Geysen, H.M., Meloen, R.H., Barteling, S.J., Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. U. S. A. 81 (1984), 3998–4002.
-
(1984)
Proc. Natl. Acad. Sci. U. S. A.
, vol.81
, pp. 3998-4002
-
-
Geysen, H.M.1
Meloen, R.H.2
Barteling, S.J.3
-
2
-
-
0000478940
-
General-method for the rapid solid-phase synthesis of large numbers of peptides—specificity of antigen–antibody interaction at the level of individual amino-acids
-
2 Houghten, R.A., General-method for the rapid solid-phase synthesis of large numbers of peptides—specificity of antigen–antibody interaction at the level of individual amino-acids. Proc. Natl. Acad. Sci. U. S. A. 82 (1985), 5131–5135.
-
(1985)
Proc. Natl. Acad. Sci. U. S. A.
, vol.82
, pp. 5131-5135
-
-
Houghten, R.A.1
-
3
-
-
0026419328
-
A new type of synthetic peptide library for identifying ligand-binding activity
-
3 Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V.J., Kazmierski, W.M., Knapp, R.J., A new type of synthetic peptide library for identifying ligand-binding activity. Nature 354 (1991), 82–84.
-
(1991)
Nature
, vol.354
, pp. 82-84
-
-
Lam, K.S.1
Salmon, S.E.2
Hersh, E.M.3
Hruby, V.J.4
Kazmierski, W.M.5
Knapp, R.J.6
-
4
-
-
0026419319
-
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
-
4 Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T., Cuervo, J.H., Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 354 (1991), 84–86.
-
(1991)
Nature
, vol.354
, pp. 84-86
-
-
Houghten, R.A.1
Pinilla, C.2
Blondelle, S.E.3
Appel, J.R.4
Dooley, C.T.5
Cuervo, J.H.6
-
5
-
-
0027068161
-
A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives
-
5 Bunin, B.A., Ellman, J.A., A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives. J. Am. Chem. Soc. 114 (1992), 10997–10998.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10997-10998
-
-
Bunin, B.A.1
Ellman, J.A.2
-
6
-
-
0026108692
-
Light-directed, spatially addressable parallel chemical synthesis
-
6 Fodor, S.P.A., Read, J.L., Pirrung, M.C., Stryer, L., Lu, A.T., Solas, D., Light-directed, spatially addressable parallel chemical synthesis. Science 251 (1991), 767–773.
-
(1991)
Science
, vol.251
, pp. 767-773
-
-
Fodor, S.P.A.1
Read, J.L.2
Pirrung, M.C.3
Stryer, L.4
Lu, A.T.5
Solas, D.6
-
7
-
-
0021818675
-
Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface
-
7 Smith, G.P., Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228 (1985), 1315–1317.
-
(1985)
Science
, vol.228
, pp. 1315-1317
-
-
Smith, G.P.1
-
8
-
-
0345531149
-
Encodamers: unnatural peptide oligomers encoded in RNA
-
8 Frankel, A., Millward, S.W., Roberts, R.W., Encodamers: unnatural peptide oligomers encoded in RNA. Chem. Biol. 10 (2003), 1043–1050.
-
(2003)
Chem. Biol.
, vol.10
, pp. 1043-1050
-
-
Frankel, A.1
Millward, S.W.2
Roberts, R.W.3
-
9
-
-
23944452871
-
Ribosomal synthesis of unnatural peptides
-
9 Josephson, K., Hartman, M.C.T., Szostak, J.W., Ribosomal synthesis of unnatural peptides. J. Am. Chem. Soc. 127 (2005), 11727–11735.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 11727-11735
-
-
Josephson, K.1
Hartman, M.C.T.2
Szostak, J.W.3
-
10
-
-
33646044708
-
A highly flexible tRNA acylation method for non-natural polypeptide synthesis
-
10 Murakami, H., Ohta, A., Ashigai, H., Suga, H., A highly flexible tRNA acylation method for non-natural polypeptide synthesis. Nat. Methods 3 (2006), 357–359.
-
(2006)
Nat. Methods
, vol.3
, pp. 357-359
-
-
Murakami, H.1
Ohta, A.2
Ashigai, H.3
Suga, H.4
-
11
-
-
67650305952
-
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
-
11 Heinis, C., Rutherford, T., Freund, S., Winter, G., Phage-encoded combinatorial chemical libraries based on bicyclic peptides. Nat. Chem. Biol. 5 (2009), 502–507.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 502-507
-
-
Heinis, C.1
Rutherford, T.2
Freund, S.3
Winter, G.4
-
12
-
-
85018427619
-
Combinatorial chemistry: a review
-
12 Rasheed, A., Farhat, R., Combinatorial chemistry: a review. Int. J. Pharm. Sci. Res. 4 (2013), 2502–2516.
-
(2013)
Int. J. Pharm. Sci. Res.
, vol.4
, pp. 2502-2516
-
-
Rasheed, A.1
Farhat, R.2
-
13
-
-
45149106841
-
Application of combinatorial chemistry science on modern drug discovery
-
13 Kennedy, J.P., Williams, L., Bridges, T.M., Daniels, R.N., Weaver, D., Lindsley, C.W., Application of combinatorial chemistry science on modern drug discovery. J. Comb. Chem. 10 (2008), 345–354.
-
(2008)
J. Comb. Chem.
, vol.10
, pp. 345-354
-
-
Kennedy, J.P.1
Williams, L.2
Bridges, T.M.3
Daniels, R.N.4
Weaver, D.5
Lindsley, C.W.6
-
14
-
-
85006414950
-
Tumor-targeting peptides from combinatorial libraries
-
Epub ahead of print Extensive review on combinatorial libraries and their successful application in discovery of tumor-targeting peptides.
-
14• Liu, R., Li, X., Xiao, W., Lam, K.S., Tumor-targeting peptides from combinatorial libraries. Adv. Drug Deliv. Rev., 2016, 10.1016/j.addr.2016.05.009 Epub ahead of print Extensive review on combinatorial libraries and their successful application in discovery of tumor-targeting peptides.
-
(2016)
Adv. Drug Deliv. Rev.
-
-
Liu, R.1
Li, X.2
Xiao, W.3
Lam, K.S.4
-
15
-
-
80052094845
-
The rise, fall and reinvention of combinatorial chemistry
-
15 Kodadek, T., The rise, fall and reinvention of combinatorial chemistry. Chem. Commun. 47 (2011), 9757–9763.
-
(2011)
Chem. Commun.
, vol.47
, pp. 9757-9763
-
-
Kodadek, T.1
-
16
-
-
84923030186
-
The effects of combinatorial chemistry and technologies on drug discovery and biotechnology—a mini review
-
16 Seneci, P., Fassina, G., Frecer, V., Miertus, S., The effects of combinatorial chemistry and technologies on drug discovery and biotechnology—a mini review. Nova Biotechnol. Chim. 13 (2014), 87–108.
-
(2014)
Nova Biotechnol. Chim.
, vol.13
, pp. 87-108
-
-
Seneci, P.1
Fassina, G.2
Frecer, V.3
Miertus, S.4
-
17
-
-
85003955457
-
In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies
-
17 Lipi, F., Chen, S., Chakravarthy, M., Rakesh, S., Veedu, R.N., In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies. RNA Biol. 13 (2016), 1232–1245.
-
(2016)
RNA Biol.
, vol.13
, pp. 1232-1245
-
-
Lipi, F.1
Chen, S.2
Chakravarthy, M.3
Rakesh, S.4
Veedu, R.N.5
-
18
-
-
84923922485
-
Fragment screening by SPR and advanced application to GPCRs
-
18 Shepherd, C.A., Hopkins, A.L., Navratilova, I., Fragment screening by SPR and advanced application to GPCRs. Prog. Biophys. Mol. Biol. 116 (2014), 113–123.
-
(2014)
Prog. Biophys. Mol. Biol.
, vol.116
, pp. 113-123
-
-
Shepherd, C.A.1
Hopkins, A.L.2
Navratilova, I.3
-
19
-
-
84874414338
-
Fragment-based lead discovery grows up
-
19 Baker, M., Fragment-based lead discovery grows up. Nat. Rev. Drug Discov. 12 (2013), 5–7.
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 5-7
-
-
Baker, M.1
-
20
-
-
84868481873
-
Vemurafenib: the first drug approved for BRAF-mutant cancer
-
20 Bollag, G., Tsai, J., Zhang, J., Zhang, C., Ibrahim, P., Nolop, K., Hirth, P., Vemurafenib: the first drug approved for BRAF-mutant cancer. Nat. Rev. Drug Discov. 11 (2012), 873–886.
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 873-886
-
-
Bollag, G.1
Tsai, J.2
Zhang, J.3
Zhang, C.4
Ibrahim, P.5
Nolop, K.6
Hirth, P.7
-
21
-
-
0037861156
-
Computational design strategies for combinatorial libraries
-
21 Rose, S., Stevens, A., Computational design strategies for combinatorial libraries. Curr. Opin. Chem. Biol. 7 (2003), 331–339.
-
(2003)
Curr. Opin. Chem. Biol.
, vol.7
, pp. 331-339
-
-
Rose, S.1
Stevens, A.2
-
22
-
-
79952198616
-
Molecular library design using multi-objective optimization methods
-
22 Nicolaou, C.A., Kannas, C.C., Molecular library design using multi-objective optimization methods. Methods Mol. Biol. 685 (2011), 53–69.
-
(2011)
Methods Mol. Biol.
, vol.685
, pp. 53-69
-
-
Nicolaou, C.A.1
Kannas, C.C.2
-
23
-
-
79952114386
-
Adaptive combinatorial design of focused compound libraries
-
23 Schneider, G., Schuller, A., Adaptive combinatorial design of focused compound libraries. Methods Mol. Biol. 572 (2010), 135–147.
-
(2010)
Methods Mol. Biol.
, vol.572
, pp. 135-147
-
-
Schneider, G.1
Schuller, A.2
-
24
-
-
34547582297
-
Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4
-
24 Evensen, E., Joseph-McCarthy, D., Weiss, G.A., Schreiber, S.L., Karplus, M., Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4. J. Comput. Aid Mol. Des. 21 (2007), 395–418.
-
(2007)
J. Comput. Aid Mol. Des.
, vol.21
, pp. 395-418
-
-
Evensen, E.1
Joseph-McCarthy, D.2
Weiss, G.A.3
Schreiber, S.L.4
Karplus, M.5
-
25
-
-
84959341665
-
A rapid Python-based methodology for target-focused combinatorial library design
-
25 Li, S.L., Song, Y.W., Liu, X.F., Li, H.L., A rapid Python-based methodology for target-focused combinatorial library design. Comb. Chem. High Throughput Screen. 19 (2016), 25–35.
-
(2016)
Comb. Chem. High Throughput Screen.
, vol.19
, pp. 25-35
-
-
Li, S.L.1
Song, Y.W.2
Liu, X.F.3
Li, H.L.4
-
26
-
-
0025893762
-
General method for rapid synthesis of multicomponent peptide mixtures
-
26 Furka, A., Sebestyen, F., Asgedom, M., Dibo, G., General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Pept. Protein Res. 37 (1991), 487–493.
-
(1991)
Int. J. Pept. Protein Res.
, vol.37
, pp. 487-493
-
-
Furka, A.1
Sebestyen, F.2
Asgedom, M.3
Dibo, G.4
-
27
-
-
84893118765
-
Combinatorial peptide libraries: mining for cell-binding peptides
-
27 Gray, B.P., Brown, K.C., Combinatorial peptide libraries: mining for cell-binding peptides. Chem. Rev. 114 (2014), 1020–1081.
-
(2014)
Chem. Rev.
, vol.114
, pp. 1020-1081
-
-
Gray, B.P.1
Brown, K.C.2
-
28
-
-
84903712331
-
Liquid-phase combinatorial library synthesis: recent advances and future perspectives
-
28 Barot, K.P., Nikolova, S., Ivanov, I., Ghate, M.D., Liquid-phase combinatorial library synthesis: recent advances and future perspectives. Comb. Chem. High Throughput Screen. 17 (2014), 417–438.
-
(2014)
Comb. Chem. High Throughput Screen.
, vol.17
, pp. 417-438
-
-
Barot, K.P.1
Nikolova, S.2
Ivanov, I.3
Ghate, M.D.4
-
29
-
-
32644445255
-
Combinatorial solid phase peptide synthesis and bioassays
-
29 Shin, D.S., Kim, D.H., Chung, W.J., Lee, Y.S., Combinatorial solid phase peptide synthesis and bioassays. J. Biochem. Mol. Biol. 38 (2005), 517–525.
-
(2005)
J. Biochem. Mol. Biol.
, vol.38
, pp. 517-525
-
-
Shin, D.S.1
Kim, D.H.2
Chung, W.J.3
Lee, Y.S.4
-
30
-
-
0000512227
-
Multiple-component condensation strategies for combinatorial library synthesis
-
30 Armstrong, R.W., Combs, A.P., Tempest, P.A., Brown, S.D., Keating, T.A., Multiple-component condensation strategies for combinatorial library synthesis. Acc. Chem. Res. 29 (1996), 123–131.
-
(1996)
Acc. Chem. Res.
, vol.29
, pp. 123-131
-
-
Armstrong, R.W.1
Combs, A.P.2
Tempest, P.A.3
Brown, S.D.4
Keating, T.A.5
-
31
-
-
84964282431
-
Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents
-
An excellent paper describing a novel approach to synthesize β-amino acid peptides under mild aqueous conditions without workup. The reaction can be initiated or terminated at any point by choosing an appropriate building block.
-
31•• Huang, Y.L., Bode, J.W., Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents. Nat. Chem. 6 (2014), 877–884 An excellent paper describing a novel approach to synthesize β-amino acid peptides under mild aqueous conditions without workup. The reaction can be initiated or terminated at any point by choosing an appropriate building block.
-
(2014)
Nat. Chem.
, vol.6
, pp. 877-884
-
-
Huang, Y.L.1
Bode, J.W.2
-
32
-
-
84931282152
-
Encoded library synthesis using chemical ligation and the discovery of sEH inhibitors from a 334-million member library
-
This paper describes the synthesis of a huge DNA-encoded small-molecule library using Click chemistry ligation and identification of a 2 nM sEH inhibitor from the library.
-
32• Litovchick, A., Dumelin, C.E., Habeshian, S., Gikunju, D., Guie, M.A., Centrella, P., Zhang, Y., Sigel, E.A., Cuozzo, J.W., Keefe, A.D., et al. Encoded library synthesis using chemical ligation and the discovery of sEH inhibitors from a 334-million member library. Sci. Rep., 5, 2015, 10916 This paper describes the synthesis of a huge DNA-encoded small-molecule library using Click chemistry ligation and identification of a 2 nM sEH inhibitor from the library.
-
(2015)
Sci. Rep.
, vol.5
, pp. 10916
-
-
Litovchick, A.1
Dumelin, C.E.2
Habeshian, S.3
Gikunju, D.4
Guie, M.A.5
Centrella, P.6
Zhang, Y.7
Sigel, E.A.8
Cuozzo, J.W.9
Keefe, A.D.10
-
33
-
-
84916235180
-
Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies
-
33 Bashiruddin, N.K., Suga, H., Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies. Curr. Opin. Chem. Biol. 24 (2015), 131–138.
-
(2015)
Curr. Opin. Chem. Biol.
, vol.24
, pp. 131-138
-
-
Bashiruddin, N.K.1
Suga, H.2
-
34
-
-
84939805312
-
Ribosomal synthesis of macrocyclic peptides in vitro and in vivo mediated by genetically encoded aminothiol unnatural amino acids
-
An elegant method for ribosomal synthesis of side chain-to-tail macrocyclic peptides.
-
34•• Frost, J.R., Jacob, N.T., Papa, L.J., Owens, A.E., Fasan, R., Ribosomal synthesis of macrocyclic peptides in vitro and in vivo mediated by genetically encoded aminothiol unnatural amino acids. ACS Chem. Biol. 10 (2015), 1805–1816 An elegant method for ribosomal synthesis of side chain-to-tail macrocyclic peptides.
-
(2015)
ACS Chem. Biol.
, vol.10
, pp. 1805-1816
-
-
Frost, J.R.1
Jacob, N.T.2
Papa, L.J.3
Owens, A.E.4
Fasan, R.5
-
35
-
-
85010943885
-
Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides
-
35 Jongkees, S.A.K., Umemoto, S., Suga, H., Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides. Chem. Sci. 8 (2017), 1474–1481.
-
(2017)
Chem. Sci.
, vol.8
, pp. 1474-1481
-
-
Jongkees, S.A.K.1
Umemoto, S.2
Suga, H.3
-
36
-
-
77956522287
-
Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule libraries
-
36 Townsend, J.B., Shaheen, F., Liu, R., Lam, K.S., Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound combinatorial small molecule libraries. J. Comb. Chem. 12 (2010), 700–712.
-
(2010)
J. Comb. Chem.
, vol.12
, pp. 700-712
-
-
Townsend, J.B.1
Shaheen, F.2
Liu, R.3
Lam, K.S.4
-
37
-
-
84957439134
-
Advancement and applications of peptide phage display technology in biomedical science
-
37 Wu, C.H., Liu, I.J., Lu, R.M., Wu, H.C., Advancement and applications of peptide phage display technology in biomedical science. J. Biomed. Sci., 23, 2016, 8.
-
(2016)
J. Biomed. Sci.
, vol.23
, pp. 8
-
-
Wu, C.H.1
Liu, I.J.2
Lu, R.M.3
Wu, H.C.4
-
38
-
-
84969612636
-
A wide-field fluorescence microscope extension for ultrafast screening of one-bead one-compound libraries using a spectral image subtraction approach
-
38 Heusermann, W., Ludin, B., Pham, N.T., Auer, M., Weidemann, T., Hintersteiner, M., A wide-field fluorescence microscope extension for ultrafast screening of one-bead one-compound libraries using a spectral image subtraction approach. ACS Comb. Sci. 18 (2016), 209–219.
-
(2016)
ACS Comb. Sci.
, vol.18
, pp. 209-219
-
-
Heusermann, W.1
Ludin, B.2
Pham, N.T.3
Auer, M.4
Weidemann, T.5
Hintersteiner, M.6
-
39
-
-
83455195323
-
SERS assisted ultra-fast peptidic screening: a new tool for drug discovery
-
39 Perez-Pineiro, R., Correa-Duarte, M.A., Salgueirino, V., Alvarez-Puebla, R.A., SERS assisted ultra-fast peptidic screening: a new tool for drug discovery. Nanoscale 4 (2012), 113–116.
-
(2012)
Nanoscale
, vol.4
, pp. 113-116
-
-
Perez-Pineiro, R.1
Correa-Duarte, M.A.2
Salgueirino, V.3
Alvarez-Puebla, R.A.4
-
40
-
-
85017505688
-
An integrated microfluidic processor for DNA-encoded combinatorial library functional screening
-
40 MacConnell, A.B., Price, A.K., Paegel, B.M., An integrated microfluidic processor for DNA-encoded combinatorial library functional screening. ACS Comb. Sci. 19 (2017), 181–192.
-
(2017)
ACS Comb. Sci.
, vol.19
, pp. 181-192
-
-
MacConnell, A.B.1
Price, A.K.2
Paegel, B.M.3
-
41
-
-
70349964290
-
Iterative in situ click chemistry creates antibody-like protein-capture agents
-
41 Agnew, H.D., Rohde, R.D., Millward, S.W., Nag, A., Yeo, W.S., Hein, J.E., Pitram, S.M., Tariq, A.A., Burns, V.M., Krom, R.J., et al. Iterative in situ click chemistry creates antibody-like protein-capture agents. Angew. Chem. Int. Ed. Engl. 48 (2009), 4944–4948.
-
(2009)
Angew. Chem. Int. Ed. Engl.
, vol.48
, pp. 4944-4948
-
-
Agnew, H.D.1
Rohde, R.D.2
Millward, S.W.3
Nag, A.4
Yeo, W.S.5
Hein, J.E.6
Pitram, S.M.7
Tariq, A.A.8
Burns, V.M.9
Krom, R.J.10
-
42
-
-
79955841972
-
Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods
-
42 Kumaresan, P.R., Wang, Y., Saunders, M., Maeda, Y., Liu, R., Wang, X., Lam, K.S., Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods. ACS Comb. Sci. 13 (2011), 259–264.
-
(2011)
ACS Comb. Sci.
, vol.13
, pp. 259-264
-
-
Kumaresan, P.R.1
Wang, Y.2
Saunders, M.3
Maeda, Y.4
Liu, R.5
Wang, X.6
Lam, K.S.7
-
43
-
-
84922011527
-
Design, synthesis, and application of OB2C combinatorial peptide and peptidomimetic libraries
-
43 Liu, R., Shih, T.C., Deng, X., Anwar, L., Ahadi, S., Kumaresan, P., Lam, K.S., Design, synthesis, and application of OB2C combinatorial peptide and peptidomimetic libraries. Methods Mol. Biol. 1248 (2015), 3–22.
-
(2015)
Methods Mol. Biol.
, vol.1248
, pp. 3-22
-
-
Liu, R.1
Shih, T.C.2
Deng, X.3
Anwar, L.4
Ahadi, S.5
Kumaresan, P.6
Lam, K.S.7
-
44
-
-
85018409313
-
A novel galectin-1 inhibitor discovered through one-bead two-compound library potentiates the anti-tumor effects of paclitaxel in vivo
-
in press
-
44 Shih, T.-C., Liu, R., Fung, G., Bhardwaj, G., Ghosh, P.M., Lam, K.S., A novel galectin-1 inhibitor discovered through one-bead two-compound library potentiates the anti-tumor effects of paclitaxel in vivo. Mol. Cancer Ther., 2017 in press.
-
(2017)
Mol. Cancer Ther.
-
-
Shih, T.-C.1
Liu, R.2
Fung, G.3
Bhardwaj, G.4
Ghosh, P.M.5
Lam, K.S.6
-
45
-
-
84898913565
-
DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries
-
An excellent review to compare the advantages and limitations of DECLs with conventional small-molecule libraries.
-
45•• Franzini, R.M., Neri, D., Scheuermann, J., DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries. Acc. Chem. Res. 47 (2014), 1247–1255 An excellent review to compare the advantages and limitations of DECLs with conventional small-molecule libraries.
-
(2014)
Acc. Chem. Res.
, vol.47
, pp. 1247-1255
-
-
Franzini, R.M.1
Neri, D.2
Scheuermann, J.3
-
46
-
-
84962232638
-
Automated screening for small organic ligands using DNA-encoded chemical libraries
-
This paper describes a generally applicable, inexpensive and fast procedure to automated screen small-molecule ligands against biological targets from DECLs.
-
46•• Decurtins, W., Wichert, M., Franzini, R.M., Buller, F., Stravs, M.A., Zhang, Y., Neri, D., Scheuermann, J., Automated screening for small organic ligands using DNA-encoded chemical libraries. Nat. Protoc. 11 (2016), 764–780 This paper describes a generally applicable, inexpensive and fast procedure to automated screen small-molecule ligands against biological targets from DECLs.
-
(2016)
Nat. Protoc.
, vol.11
, pp. 764-780
-
-
Decurtins, W.1
Wichert, M.2
Franzini, R.M.3
Buller, F.4
Stravs, M.A.5
Zhang, Y.6
Neri, D.7
Scheuermann, J.8
-
47
-
-
77953870958
-
High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries
-
47 Buller, F., Steiner, M., Scheuermann, J., Mannocci, L., Nissen, I., Kohler, M., Beisel, C., Neri, D., High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries. Bioorg. Med. Chem. Lett. 20 (2010), 4188–4192.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 4188-4192
-
-
Buller, F.1
Steiner, M.2
Scheuermann, J.3
Mannocci, L.4
Nissen, I.5
Kohler, M.6
Beisel, C.7
Neri, D.8
-
48
-
-
35548986989
-
From combinatorial chemistry to cancer-targeting peptides
-
48 Aina, O.H., Liu, R., Sutcliffe, J.L., Marik, J., Pan, C.X., Lam, K.S., From combinatorial chemistry to cancer-targeting peptides. Mol. Pharm. 4 (2007), 631–651.
-
(2007)
Mol. Pharm.
, vol.4
, pp. 631-651
-
-
Aina, O.H.1
Liu, R.2
Sutcliffe, J.L.3
Marik, J.4
Pan, C.X.5
Lam, K.S.6
-
49
-
-
0035424887
-
Automatic Edman microsequencing of peptides containing multiple unnatural amino acids
-
49 Liu, R., Lam, K.S., Automatic Edman microsequencing of peptides containing multiple unnatural amino acids. Anal. Biochem. 295 (2001), 9–16.
-
(2001)
Anal. Biochem.
, vol.295
, pp. 9-16
-
-
Liu, R.1
Lam, K.S.2
-
50
-
-
0037951325
-
A novel and rapid encoding method based on mass spectrometry for one-bead-one-compound small molecule combinatorial libraries
-
50 Song, A., Zhang, J., Lebrilla, C.B., Lam, K.S., A novel and rapid encoding method based on mass spectrometry for one-bead-one-compound small molecule combinatorial libraries. J. Am. Chem. Soc. 125 (2003), 6180–6188.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 6180-6188
-
-
Song, A.1
Zhang, J.2
Lebrilla, C.B.3
Lam, K.S.4
-
51
-
-
33749532845
-
High-throughput sequence determination of cyclic peptide library members by partial Edman degradation/mass spectrometry
-
51 Joo, S.H., Xiao, Q., Ling, Y., Gopishetty, B., Pei, D., High-throughput sequence determination of cyclic peptide library members by partial Edman degradation/mass spectrometry. J. Am. Chem. Soc. 128 (2006), 13000–13009.
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 13000-13009
-
-
Joo, S.H.1
Xiao, Q.2
Ling, Y.3
Gopishetty, B.4
Pei, D.5
-
52
-
-
72949105766
-
‘On-the-fly’ optical encoding of combinatorial peptide libraries for profiling of protease specificity
-
52 Marcon, L., Battersby, B.J., Ruhmann, A., Ford, K., Daley, M., Lawrie, G.A., Trau, M., ‘On-the-fly’ optical encoding of combinatorial peptide libraries for profiling of protease specificity. Mol. Biosyst. 6 (2010), 225–233.
-
(2010)
Mol. Biosyst.
, vol.6
, pp. 225-233
-
-
Marcon, L.1
Battersby, B.J.2
Ruhmann, A.3
Ford, K.4
Daley, M.5
Lawrie, G.A.6
Trau, M.7
-
53
-
-
84930650505
-
Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis
-
53 Kang, H., Jeong, S., Koh, Y., Geun Cha, M., Yang, J.K., Kyeong, S., Kim, J., Kwak, S.Y., Chang, H.J., Lee, H., et al. Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis. Sci. Rep., 5, 2015, 10144.
-
(2015)
Sci. Rep.
, vol.5
, pp. 10144
-
-
Kang, H.1
Jeong, S.2
Koh, Y.3
Geun Cha, M.4
Yang, J.K.5
Kyeong, S.6
Kim, J.7
Kwak, S.Y.8
Chang, H.J.9
Lee, H.10
-
54
-
-
84933059417
-
Tankyrase 1 inhibitors with drug-like properties identified by screening a DNA-encoded chemical library
-
54 Samain, F., Ekblad, T., Mikutis, G., Zhong, N., Zimmermann, M., Nauer, A., Bajic, D., Decurtins, W., Scheuermann, J., Brown, P.J., et al. Tankyrase 1 inhibitors with drug-like properties identified by screening a DNA-encoded chemical library. J. Med. Chem. 58 (2015), 5143–5149.
-
(2015)
J. Med. Chem.
, vol.58
, pp. 5143-5149
-
-
Samain, F.1
Ekblad, T.2
Mikutis, G.3
Zhong, N.4
Zimmermann, M.5
Nauer, A.6
Bajic, D.7
Decurtins, W.8
Scheuermann, J.9
Brown, P.J.10
-
55
-
-
84915746858
-
DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
-
55 Daguer, J.P., Zambaldo, C., Ciobanu, M., Morieux, P., Barluenga, S., Winssinger, N., DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules. Chem. Sci. 6 (2015), 739–744.
-
(2015)
Chem. Sci.
, vol.6
, pp. 739-744
-
-
Daguer, J.P.1
Zambaldo, C.2
Ciobanu, M.3
Morieux, P.4
Barluenga, S.5
Winssinger, N.6
-
56
-
-
84971324854
-
Identification of leishmania donovani topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors
-
56 Mamidala, R., Majumdar, P., Jha, K.K., Bathula, C., Agarwal, R., Chary, M.T., Mazumdar, H.K., Munshi, P., Sen, S., Identification of leishmania donovani topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors. Sci. Rep., 6, 2016, 26603.
-
(2016)
Sci. Rep.
, vol.6
, pp. 26603
-
-
Mamidala, R.1
Majumdar, P.2
Jha, K.K.3
Bathula, C.4
Agarwal, R.5
Chary, M.T.6
Mazumdar, H.K.7
Munshi, P.8
Sen, S.9
-
57
-
-
84856400291
-
A biomimetic polyketide-inspired approach to small-molecule ligand discovery
-
This article describes an efficient way to synthesize and screen a novel class of chiral and conformationally constrained pentenoic amide oligomers in OBOC library format.
-
57• Aquino, C., Sarkar, M., Chalmers, M.J., Mendes, K., Kodadek, T., Micalizio, G.C., A biomimetic polyketide-inspired approach to small-molecule ligand discovery. Nat. Chem. 4 (2011), 99–104 This article describes an efficient way to synthesize and screen a novel class of chiral and conformationally constrained pentenoic amide oligomers in OBOC library format.
-
(2011)
Nat. Chem.
, vol.4
, pp. 99-104
-
-
Aquino, C.1
Sarkar, M.2
Chalmers, M.J.3
Mendes, K.4
Kodadek, T.5
Micalizio, G.C.6
-
58
-
-
84858002781
-
Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass
-
58 Guan, M., Yao, W., Liu, R., Lam, K.S., Nolta, J., Jia, J., Panganiban, B., Meng, L., Zhou, P., Shahnazari, M., et al. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat. Med. 18 (2012), 456–462.
-
(2012)
Nat. Med.
, vol.18
, pp. 456-462
-
-
Guan, M.1
Yao, W.2
Liu, R.3
Lam, K.S.4
Nolta, J.5
Jia, J.6
Panganiban, B.7
Meng, L.8
Zhou, P.9
Shahnazari, M.10
-
59
-
-
85002762920
-
Discovery and characterization of a peptoid with antifungal activity against Cryptococcus neoformans
-
59 Corson, A.E., Armstrong, S.A., Wright, M.E., McClelland, E.E., Bicker, K.L., Discovery and characterization of a peptoid with antifungal activity against Cryptococcus neoformans. ACS Med. Chem. Lett. 7 (2016), 1139–1144.
-
(2016)
ACS Med. Chem. Lett.
, vol.7
, pp. 1139-1144
-
-
Corson, A.E.1
Armstrong, S.A.2
Wright, M.E.3
McClelland, E.E.4
Bicker, K.L.5
-
60
-
-
84954178710
-
Discovery of a sirect Ras inhibitor by screening a combinatorial library of cell-permeable bicyclic peptides
-
60 Trinh, T.B., Upadhyaya, P., Qian, Z., Pei, D., Discovery of a sirect Ras inhibitor by screening a combinatorial library of cell-permeable bicyclic peptides. ACS Comb. Sci. 18 (2016), 75–85.
-
(2016)
ACS Comb. Sci.
, vol.18
, pp. 75-85
-
-
Trinh, T.B.1
Upadhyaya, P.2
Qian, Z.3
Pei, D.4
-
61
-
-
84928473225
-
Combinatorial libraries as a tool for the discovery of novel, broad-spectrum antibacterial agents targeting the ESKAPE pathogens
-
Nice story describing the development of in vivo active bis-cyclic guanidines as novel and broad-spectrum antibacterial agents using positional scanning library approach.
-
61• Fleeman, R., LaVoi, T.M., Santos, R.G., Morales, A., Nefzi, A., Welmaker, G.S., Medina-Franco, J.L., Giulianotti, M.A., Houghten, R.A., Shaw, L.N., Combinatorial libraries as a tool for the discovery of novel, broad-spectrum antibacterial agents targeting the ESKAPE pathogens. J. Med. Chem. 58 (2015), 3340–3355 Nice story describing the development of in vivo active bis-cyclic guanidines as novel and broad-spectrum antibacterial agents using positional scanning library approach.
-
(2015)
J. Med. Chem.
, vol.58
, pp. 3340-3355
-
-
Fleeman, R.1
LaVoi, T.M.2
Santos, R.G.3
Morales, A.4
Nefzi, A.5
Welmaker, G.S.6
Medina-Franco, J.L.7
Giulianotti, M.A.8
Houghten, R.A.9
Shaw, L.N.10
-
62
-
-
84923333701
-
Fidelity by design: yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery
-
62 Blakskjaer, P., Heitner, T., Hansen, N.J., Fidelity by design: yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery. Curr. Opin. Chem. Biol. 26 (2015), 62–71.
-
(2015)
Curr. Opin. Chem. Biol.
, vol.26
, pp. 62-71
-
-
Blakskjaer, P.1
Heitner, T.2
Hansen, N.J.3
-
63
-
-
84923182115
-
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation
-
The paper describes the use of dual-pharmacophore DECL to identify binding pairs of target proteins. The same approach was also used to improve binding affinity of a known ligand. The authors developed a bidentate ligand that showed potent in vitro binding affinity against carbonic anhydrase IX (Kd = 0.2 nM) and excellent in vivo tumor targeting in a kidney cancer mouse model.
-
63•• Wichert, M., Krall, N., Decurtins, W., Franzini, R.M., Pretto, F., Schneider, P., Neri, D., Scheuermann, J., Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation. Nat. Chem. 7 (2015), 241–249 The paper describes the use of dual-pharmacophore DECL to identify binding pairs of target proteins. The same approach was also used to improve binding affinity of a known ligand. The authors developed a bidentate ligand that showed potent in vitro binding affinity against carbonic anhydrase IX (Kd = 0.2 nM) and excellent in vivo tumor targeting in a kidney cancer mouse model.
-
(2015)
Nat. Chem.
, vol.7
, pp. 241-249
-
-
Wichert, M.1
Krall, N.2
Decurtins, W.3
Franzini, R.M.4
Pretto, F.5
Schneider, P.6
Neri, D.7
Scheuermann, J.8
-
64
-
-
84929684999
-
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
-
64 Macosko, E.Z., Basu, A., Satija, R., Nemesh, J., Shekhar, K., Goldman, M., Tirosh, I., Bialas, A.R., Kamitaki, N., Martersteck, E.M., et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161 (2015), 1202–1214.
-
(2015)
Cell
, vol.161
, pp. 1202-1214
-
-
Macosko, E.Z.1
Basu, A.2
Satija, R.3
Nemesh, J.4
Shekhar, K.5
Goldman, M.6
Tirosh, I.7
Bialas, A.R.8
Kamitaki, N.9
Martersteck, E.M.10
-
65
-
-
84928125332
-
Increasing the delivery of next generation therapeutics from high throughput screening libraries
-
65 Wigglesworth, M.J., Murray, D.C., Blackett, C.J., Kossenjans, M., Nissink, J.W., Increasing the delivery of next generation therapeutics from high throughput screening libraries. Curr. Opin. Chem. Biol. 26 (2015), 104–110.
-
(2015)
Curr. Opin. Chem. Biol.
, vol.26
, pp. 104-110
-
-
Wigglesworth, M.J.1
Murray, D.C.2
Blackett, C.J.3
Kossenjans, M.4
Nissink, J.W.5
-
66
-
-
84861322262
-
Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery
-
66 Gould, A., Ji, Y.B., Aboye, T.L., Camarero, J.A., Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery. Curr. Pharm. Des. 17 (2011), 4294–4307.
-
(2011)
Curr. Pharm. Des.
, vol.17
, pp. 4294-4307
-
-
Gould, A.1
Ji, Y.B.2
Aboye, T.L.3
Camarero, J.A.4
-
67
-
-
85013986653
-
Cyclotides as drug design scaffolds
-
67 Craik, D.J., Du, J., Cyclotides as drug design scaffolds. Curr. Opin. Chem. Biol. 38 (2017), 8–16.
-
(2017)
Curr. Opin. Chem. Biol.
, vol.38
, pp. 8-16
-
-
Craik, D.J.1
Du, J.2
-
68
-
-
84982085136
-
Substrate-guided design of selective FXIIa inhibitors based on the plant-derived momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold
-
68 Swedberg, J.E., Mahatmanto, T., Abdul Ghani, H., de Veer, S.J., Schroeder, C.I., Harris, J.M., Craik, D.J., Substrate-guided design of selective FXIIa inhibitors based on the plant-derived momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. J. Med. Chem. 59 (2016), 7287–7292.
-
(2016)
J. Med. Chem.
, vol.59
, pp. 7287-7292
-
-
Swedberg, J.E.1
Mahatmanto, T.2
Abdul Ghani, H.3
de Veer, S.J.4
Schroeder, C.I.5
Harris, J.M.6
Craik, D.J.7
-
69
-
-
71049186869
-
Biosynthesis and biologicals screening of a genetically encoded library based on the cyclotide MCoTI-I
-
69 Austin, J., Wang, W., Puttamadappa, S., Shekhtman, A., Camarero, J.A., Biosynthesis and biologicals screening of a genetically encoded library based on the cyclotide MCoTI-I. Chembiochem 10 (2009), 2663–2670.
-
(2009)
Chembiochem
, vol.10
, pp. 2663-2670
-
-
Austin, J.1
Wang, W.2
Puttamadappa, S.3
Shekhtman, A.4
Camarero, J.A.5
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