-
1
-
-
84971312731
-
-
Leishmaniasis 2015). (Date of access: 01/02
-
Leishmaniasis, Fact sheet No375: http://www.who.int/mediacentre/factsheets/fs375/en/(2015). (Date of access: 01/02/2015
-
(2015)
Fact Sheet No 375
-
-
-
2
-
-
29144509689
-
Leishmania donovani: Differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase i and in cytotoxicity assays
-
Jean-Moreno, V., Rojas, R., Goyeneche, D., Coombs, G. H., & Walker, J. Leishmania donovani: Differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays. Exp. Parasitol. 112, 21-30 (2006
-
(2006)
Exp. Parasitol
, vol.112
, pp. 21-30
-
-
Jean-Moreno, V.1
Rojas, R.2
Goyeneche, D.3
Coombs, G.H.4
Walker, J.5
-
3
-
-
41149117564
-
Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation
-
Sun, T., & Zhang Y. Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation. Nucleic Acids Res. 36, 1654-64 (2008
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 1654-1664
-
-
Sun, T.1
Zhang, Y.2
-
4
-
-
84879484305
-
Amphotericin b formulations: A comparative review of efficacy and toxicity
-
Hamill, Richard J. Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity. Drugs 73, 919-934 (2013
-
(2013)
Drugs
, vol.73
, pp. 919-934
-
-
Hamill Richard, J.1
-
5
-
-
84867610036
-
Miltefosine: A review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis
-
Dorlo, T. P. C., Balasegaram, M., Beijnen, J. H., & de Vries, P. J. Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis. J. of Antimicrob. Chemother. 67, 2576-2597 (2012
-
(2012)
J. of Antimicrob. Chemother
, vol.67
, pp. 2576-2597
-
-
Dorlo, T.P.C.1
Balasegaram, M.2
Beijnen, J.H.3
De Vries, P.J.4
-
6
-
-
0034234657
-
DNA topoisomerases as targets for antiprotozoal therapy
-
Cheesman, S. J. DNA Topoisomerases as targets for antiprotozoal therapy. Parasitol. Today 16, 277-281 (2000
-
(2000)
Parasitol. Today
, vol.16
, pp. 277-281
-
-
Cheesman, S.J.1
-
7
-
-
0032189942
-
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
-
Nitiss, J. L. Investigating the biological functions of DNA topoisomerases in eukaryotic cells. Biochim. Biophys. Acta 1400, 63-81 (1998
-
(1998)
Biochim. Biophys. Acta
, vol.1400
, pp. 63-81
-
-
Nitiss, J.L.1
-
8
-
-
0032189683
-
Mechanism of action of eukaryotic DNA topoisomerase i and drugs targeted to the enzyme
-
Pommier, Y., Pourquier, P., Fan, Y., & Strumberg, D. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim. Biophys. Acta 1400, 83-106 (1998
-
(1998)
Biochim. Biophys. Acta
, vol.1400
, pp. 83-106
-
-
Pommier, Y.1
Pourquier, P.2
Fan, Y.3
Strumberg, D.4
-
9
-
-
2342501361
-
Reconstitution and functional characterization of the unusual bi-subunit type i topoisomerase from leishmania donovani
-
Das, B. B., Sen, N., Ganguly, A., & Majumder, H. K. Reconstitution and functional characterization of the unusual bi-subunit type I topoisomerase from Leishmania donovani. FEBS Lett. 565, 81-88 (2004
-
(2004)
FEBS Lett
, vol.565
, pp. 81-88
-
-
Das, B.B.1
Sen, N.2
Ganguly, A.3
Majumder, H.K.4
-
10
-
-
34249018852
-
Syn thesis DNA binding, and leishmania topoisomerase inhibition activities of a novel series of anthra[1,2-d]imidazole-6,11-dione derivatives
-
Chaudhuri, P., Majumdar, H. K., & Bhattacharya, S. Synthesis, DNA Binding, and Leishmania Topoisomerase Inhibition Activities of a Novel Series of Anthra[1,2-d]imidazole-6,11-dione Derivatives. J. Med. Chem. 50, 2536-2540 (2007
-
(2007)
J. Med. Chem
, vol.50
, pp. 2536-2540
-
-
Chaudhuri, P.1
Majumdar, H.K.2
Bhattacharya, S.3
-
11
-
-
83155164547
-
Development of derivatives of 3,3′ -diindolylmethane as potent leishmania donovani bi-subunit topoisomerase ib poisons
-
Roy, A., et al. Development of Derivatives of 3,3′ -Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons. PLoS ONE 6, e28493 (2011
-
(2011)
Plos One
, vol.6
, pp. e28493
-
-
Roy, A.1
-
12
-
-
13344284559
-
Scaffold hopping
-
Böhm, H.-J., Flohr, A., & Stahl, M. Scaffold Hopping. Drug Discov. Today: Technologies 1, 217-224 (2004
-
(2004)
Drug Discov. Today: Technologies
, vol.1
, pp. 217-224
-
-
Böhm, H.-J.1
Flohr, A.2
Stahl, M.3
-
13
-
-
0345189564
-
Ligands for the benzodiazepine binding site-a survey
-
Teuber. L., et al. Ligands for the benzodiazepine binding site-a survey. Curr. Pharm. Des. 5, 317-343 (1999
-
(1999)
Curr. Pharm. des
, vol.5
, pp. 317-343
-
-
Teuber, L.1
-
14
-
-
0025368829
-
Dopamine receptor agonists: Selectivity and dopamine D1 receptor efficacy
-
Andersen, P. H. Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. Eur. J. Pharm. 2, 335-347 (1990
-
(1990)
Eur. J. Pharm
, vol.2
, pp. 335-347
-
-
Andersen, P.H.1
-
15
-
-
0030793782
-
Compounds selective for dopamine receptor subtypes
-
Kebabian, J. W. Compounds selective for dopamine receptor subtypes. Drug Discov. Today 2, 333-340 (1999
-
(1999)
Drug Discov. Today
, vol.2
, pp. 333-340
-
-
Kebabian, J.W.1
-
16
-
-
0035992778
-
Tracing the origins of COX-2 inhibitor structures
-
Lednicer, D., Tracing the origins of COX-2 inhibitor structures. Curr. Med. Chem. 9, 1457-1461 (2002
-
(2002)
Curr. Med. Chem
, vol.9
, pp. 1457-1461
-
-
Lednicer, D.1
-
17
-
-
0036653095
-
Designing selective COX-2 inhibitors: Molecular modeling approaches
-
Trummlitz, G., & Van Ryn, J. Designing selective COX-2 inhibitors: molecular modeling approaches. Curr. Opin. Drug. Discov. Dev. 5, 550-561 (2002
-
(2002)
Curr. Opin. Drug. Discov. Dev
, vol.5
, pp. 550-561
-
-
Trummlitz, G.1
Van Ryn, J.2
-
18
-
-
7744243992
-
Bioisosterism: A rational approach in drug design
-
Patani. G. A., & LaVoie, E. J. Bioisosterism: A Rational Approach in Drug Design. Chem. Rev. 96, 3147-3176 (1996
-
(1996)
Chem. Rev
, vol.96
, pp. 3147-3176
-
-
Patani, G.A.1
La Voie, E.J.2
-
19
-
-
84874353612
-
Carboxylic acid (bio)isosteres in drug design
-
Ballatore, C., Huryn, D. M., & Smith, A. B. Carboxylic acid (bio)isosteres in drug design. ChemMedChem. 8, 385-395 (2013
-
(2013)
ChemMedChem
, vol.8
, pp. 385-395
-
-
Ballatore, C.1
Huryn, D.M.2
Smith, A.B.3
-
20
-
-
78751649521
-
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K
-
Isabel, E., et al. Difluoroethylamines as an amide isostere in inhibitors of cathepsin K. Bioorg. Med. Chem. Lett. 21, 920-923 (2011
-
(2011)
Bioorg. Med. Chem. Lett
, vol.21
, pp. 920-923
-
-
Isabel, E.1
-
21
-
-
33749034730
-
Topoisomerase i inhibitors: Camptothecins and beyond
-
Pommier, Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat. Rev. Cancer 6, 789-802 (2006
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 789-802
-
-
Pommier, Y.1
-
22
-
-
0032585548
-
Homocamptothecins: Synthesis and antitumor activity of novel E-ring-modified camptothecin analogues
-
Lavergne, O., et al. Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues. J. Med. Chem. 41, 5410-5419 (1998
-
(1998)
J. Med. Chem
, vol.41
, pp. 5410-5419
-
-
Lavergne, O.1
-
23
-
-
66849113688
-
The indenoisoquinoline noncamptothecin topoisomerase i inhibitors: Update and perspectives
-
Pommier, Y., & Cushman, M. The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives. Mol. Cancer Ther. 8, 1008-1014 (2009
-
(2009)
Mol. Cancer Ther
, vol.8
, pp. 1008-1014
-
-
Pommier, Y.1
Cushman, M.2
-
24
-
-
18944376114
-
Novel tools for visualizing and exploring intermolecular interactions in molecular crystals
-
McKinnon, J. J., Spackman, M. A., & Mitchell, A. S. Novel tools for visualizing and exploring intermolecular interactions in molecular crystals. Acta Crystallogr. Sect. B B60, 627-668 (2004
-
(2004)
Acta Crystallogr. Sect. B
, vol.B60
, pp. 627-668
-
-
McKinnon, J.J.1
Spackman, M.A.2
Mitchell, A.S.3
-
25
-
-
34548810358
-
Towards quantitative analysis of intermolecular interactions with hirshfeld surfaces
-
McKinnon, J. J., Jayatilaka, D., & Spackman, M. A. Towards quantitative analysis of intermolecular interactions with Hirshfeld surfaces. Chem. Commun. 37, 3814-3816 (2007
-
(2007)
Chem. Commun
, vol.37
, pp. 3814-3816
-
-
McKinnon, J.J.1
Jayatilaka, D.2
Spackman, M.A.3
-
27
-
-
0019450420
-
Interaction of Leishmania donovani Promastigotes with Human Monocyte-Derived Macrophages: Parasite Entry, Intracellular Survival, and Multiplication
-
Pearson, R. D., Romito, R., Symes, P. H., & Harcus, J. L. Interaction of Leishmania donovani Promastigotes with Human Monocyte-Derived Macrophages: Parasite Entry, Intracellular Survival, and Multiplication. Infection and Immunity 32, 1249-1253 (1981
-
(1981)
Infection and Immunity
, vol.32
, pp. 1249-1253
-
-
Pearson, R.D.1
Romito, R.2
Symes, P.H.3
Harcus, J.L.4
-
28
-
-
33644862907
-
Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: Activity of flavones against camptothecin-resistant topoisomerase i
-
Das, B. B., et al. Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I. Nucleic Acids Res. 34, 1121-32 (2004
-
(2004)
Nucleic Acids Res
, vol.34
, pp. 1121-1132
-
-
Das, B.B.1
-
29
-
-
33845680773
-
Leish-Man topoisomerase I: An ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase i from Leishmania donovani
-
Ganguly, A., et al. Leish-Man topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani. Nucleic Acids Res. 34, 6286-97 (2006
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 6286-6297
-
-
Ganguly, A.1
-
30
-
-
80053197078
-
Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase
-
Chowdhury, S., et al. Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase. Mol. Pharmacol. 80, 694-703 (2011
-
(2011)
Mol. Pharmacol
, vol.80
, pp. 694-703
-
-
Chowdhury, S.1
-
31
-
-
0029986467
-
Biochemical and biophysical analyses of recombinant forms of human topoisomerase i
-
Stewart, L., Ireton, G. C., Parker, L. H., Madden, K. R., & Champoux, J. J. Biochemical and biophysical analyses of recombinant forms of human topoisomerase I. J. Biol. Chem. 271, 7593-601 (1996
-
(1996)
J. Biol. Chem
, vol.271
, pp. 7593-7601
-
-
Stewart, L.1
Ireton, G.C.2
Parker, L.H.3
Madden, K.R.4
Champoux, J.J.5
-
34
-
-
33744498094
-
Mercury csd 2.0 -new features for the visualization and investigation of crystal structures j
-
Macrae, C. F., et al. Mercury CSD 2.0 -New Features for the Visualization and Investigation of Crystal Structures J. Appl. Cryst. 39, 453-457 (2006
-
(2006)
Appl. Cryst
, vol.39
, pp. 453-457
-
-
Macrae, C.F.1
-
35
-
-
84870488134
-
-
University of Western Australia. URL
-
Wolff, S. K., Grimwood, D. J., Mckinnon, J. J., Turner, M. J., Jayatilaka, D., & Spackman, M. A. Crystal Explorer (version 3.1): A Program for Hirshfeld Surface Analysis. University of Western Australia. URL http://hirshfeldsurface.net/(2012
-
(2012)
Crystal Explorer (Version 3.1): A Program for Hirshfeld Surface Analysis
-
-
Wolff, S.K.1
Grimwood, D.J.2
Mckinnon, J.J.3
Turner, M.J.4
Jayatilaka, D.5
Spackman, M.A.6
|