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56 Chan, L.Y., Gunasekera, S., Henriques, S.T., Worth, N.F., Le, S.J., Clark, R.J., Campbell, J.H., Craik, D.J., Daly, N.L., Engineering pro-angiogenic peptides using stable disulfide-rich cyclic scaffolds. Blood 118 (2011), 6709–6717.
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57
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57 Aboye, T.L., Ha, H., Majumder, S., Christ, F., Debyser, Z., Shekhtman, A., Neamati, N., Camarero, J.A., Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. J Med Chem 55 (2012), 10729–10734.
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58
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58 Eliasen, R., Daly, N.L., Wulff, B.S., Andresen, T.L., Conde-Frieboes, K.W., Craik, D.J., Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1. J Biol Chem 287 (2012), 40493–40501.
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59 Getz, J.A., Cheneval, O., Craik, D.J., Daugherty, P.S., Design of a cyclotide antagonist of neuropilin-1 and -2 that potently inhibits endothelial cell migration. ACS Chem Biol 8 (2013), 1147–1154.
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60 Quimbar, P., Malik, U., Sommerhoff, C.P., Kaas, Q., Chan, L.Y., Huang, Y.-H., Grundhuber, M., Dunse, K., Craik, D.J., Anderson, M.A., et al. High-affinity cyclic peptide matriptase inhibitors. J Biol Chem 288 (2013), 13885–13896.
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61
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61 Wang, C.K., Gruber, C.W., Cěmažar, M., Siatskas, C., Tagore, P., Payne, N., Sun, G., Wang, S., Bernard, C.C., Craik, D.J., Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chem Biol 9 (2014), 156–163.
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62
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62 Chan Lai, Y., Craik David, J., Daly Norelle, L., Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration. Biosci Rep, 35, 2015, e00270.
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63 Huang, Y.-H., Henriques, S.T., Wang, C.K., Thorstholm, L., Daly, N.L., Kaas, Q., Craik, D.J., Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Sci Rep, 5, 2015, 12974.
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64
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64• Jagadish, K., Gould, A., Borra, R., Majumder, S., Mushtaq, Z., Shekhtman, A., Camarero, J.A., Recombinant expression and phenotypic screening of a bioactive cyclotide against α-synuclein-induced cytotoxicity in baker's yeast. Angew Chem Int Ed 54 (2015), 8390–8394 The first paper to report the recombinant expression of cyclotides inside live yeast cells.
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65
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65 Maaß, F., Wustehube-Lausch, J., Dickgiessr, S., Valldorf, B., Reinwarth, M., Schmoldt, H.U., Daneschdar, M., Avrutina, O., Sahin, U., Kolmar, H., Cystine-knot peptides targeting cancer-relevant human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J Pept Sci 21 (2015), 651–660.
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66 Sangphukieo, A., Nawae, W., Laomettachit, T., Supasitthimethee, U., Ruengjitchatchawalya, M., Computational design of hypothetical new peptides based on a cyclotide scaffold as HIV gp120 inhibitor. PLoS One, 10, 2015, e0139562.
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68
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68•• Chan, L.Y., Craik, D.J., Daly, N.L., Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep, 6, 2016, 35347 An example of dual grafting of a cyclotide scaffold- in this case by grafting two anti-angiogenic epitopes targeting cancer.
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70
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70 Swedberg, J.E., Mahatmanto, T., Abdul Ghani, H., de Veer, S.J., Schroeder, C.I., Harris, J.M., Craik, D.J., Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. J Med Chem 59 (2016), 7287–7292.
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71
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A paper reporting oral activity for a cyclotide active in an animal model of multiple sclerosis.
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71• Thell, K., Hellinger, R., Sahin, E., Michenthaler, P., Gold-Binder, M., Haider, T., Kuttke, M., Liutkevičiūtė, Z., Göransson, U., Gründemann, C., et al. Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A 113 (2016), 3960–3965 A paper reporting oral activity for a cyclotide active in an animal model of multiple sclerosis.
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72 Kimura, R.H., Tran, A.-T., Camarero, J.A., Biosynthesis of the cyclotide kalata B1 by using protein splicing. Angew Chem Int Ed 118 (2006), 987–990.
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73 Werle, M., Schmitz, T., Haung, H.-L., Wentzel, A., Kolmar, H., Bernkop-Schnurch, A., The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in organ peptide drug delivery. J Drug Target 14 (2006), 137–146.
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74
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74 Aboye, T.L., Clark, R.J., Craik, D.J., Göransson, U., Ultra stable peptide scaffolds for protein engineering—synthesis and folding of the circular cystine knotted cyclotide cycloviolacin O2. ChemBioChem 9 (2008), 103–113.
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75 Avrutina, O., Schmoldt, H.U., Gabrijelcic-Geiger, D., Wentzel, A., Frauendorf, H., Sommerhoff, C.P., Diederichsen, U., Kolmar, H., Head-to-tail cyclized cystine-knot peptides by a combined recombinant and chemical route of synthesis. ChemBioChem 9 (2008), 33–37.
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76
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76 Austin, J., Wang, W., Puttamadappa, S., Shekhtman, A., Camarero, J.A., Biosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I. ChemBioChem 10 (2009), 2663–2670.
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77 Getz, J.A., Rice, J.J., Daugherty, P.S., Protease-resistant peptide ligands from a knottin scaffold library. ACS Chem Biol 6 (2011), 837–844.
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78 Glotzbach, B., Reinwarth, M., Weber, N., Fabritz, S., Tomaszowski, M., Fittler, H., Christmann, A., Avrutina, O., Kolmar, H., Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1. PLoS One, 8, 2013, e76956.
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79
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79• Jagadish, K., Borra, R., Lacey, V., Majumder, S., Shekhtman, A., Wang, L., Camarero, J.A., Expression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide–protein interactions. Angew Chem Int Ed 52 (2013), 3126–3131 This paper showed that cyclotides containing the non-natural amino acid AziF can be labeled to monitor cyclotide-protein interactions.
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80 Koehbach, J., O'Brien, M., Muttenthaler, M., Miazzo, M., Akcan, M., Elliott, A.G., Daly, N.L., Harvey, P.J., Arrowsmith, S., Gunasekera, S., et al. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc Natl Acad Sci U S A 110 (2013), 21183–21188.
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81
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81 Gray, K., Elghadban, S., Thongyoo, P., Owen, K.A., Szabo, R., Bugge, T.H., Tate, E.W., Leatherbarrow, R.J., Ellis, V., Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II. Thromb Haemost 112 (2014), 402–411.
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82
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82 Senthilkumar, B., Kumar, P., Rajasekaran, R., In-silico template selection of in-vitro evolved kalata B1 of Oldenlandia affinis for scaffolding peptide-based drug design. J Cell Biochem 117 (2016), 66–73.
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