Combinatorial libraries as a tool for the discovery of novel, broad-spectrum antibacterial agents targeting the ESKAPE pathogens

Journal of Medicinal Chemistry

Volumn 58, Issue 8, 2015, Pages 3340-3355

  Fleeman, Renee ^a   Lavoi, Travis M ^b   Santos, Radleigh G ^b   Morales, Angela ^b   Nefzi, Adel ^b   Welmaker, Gregory S ^b   Medina Franco, José L ^c   Giulianotti, Marc A ^a,b   Houghten, Richard A ^b   Shaw, Lindsey N ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [3 (4 CYCLOHEXYLBUTYL) 2 IMINOIMIDAZOLIDIN 4 YL]BUTYL] 4 (CYCLOHEXYLMETHYL) 3 HEXYLIMIDAZOLIDIN 2 IMINE; 1 [4 [3 [2 (ADAMANTAN 1 YL)ETHYL] 2 IMINOIMIDAZOLIDIN 4 YL]BUTYL] 4 BUTYL 3 HEXYLIMIDAZOLIDIN 2 IMINE; 4 (CYCLOHEXYLMETHYL) 3 HEXYL 1 [4 [2 IMINO 3 [3 (TRIFLUOROMETHYL)PHENETHYL]IMIDAZOLIDIN 4 YL]BUTYL]IMIDAZOLIDIN 2 IMINE; 4 BUTYL 3 (4 CYCLOHEXYLBUTYL) 1 [4 [2 IMINO 3 [3 (TRIFLUOROMETHYL)PHENETHYL]IMIDAZOLIDIN 4 YL]BUTYL]IMIDAZOLIDIN 2 IMINE; 4 BUTYL 3 HEXYL 1 [4 [2 IMINO 3 [3 (TRIFLUOROMETHYL)PHENETHYL]IMIDAZOLIDIN 4 YL]BUTYL]IMIDAZOLIDIN 2 IMINE; ANTIBIOTIC AGENT; CIPROFLOXACIN; GUANIDINE DERIVATIVE; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; MOLECULAR LIBRARY;

A549 CELL LINE; ACINETOBACTER BAUMANNII; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL PERITONITIS; BIOFILM; CELL VIABILITY; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG EFFICACY; ENTEROBACTER; ENTEROCOCCUS FAECIUM; EPITHELIUM BASAL CELL; ERYTHROCYTE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; LIPOPHILICITY; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; ANIMAL; BACTERIAL INFECTIONS; BACTERIUM; CELL LINE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; MOLECULAR LIBRARY; PHARMACOLOGY; STAPHYLOCOCCAL INFECTIONS; THERAPEUTIC USE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; CELL LINE; DRUG DISCOVERY; GUANIDINES; HUMANS; MICE; SMALL MOLECULE LIBRARIES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84928473225     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501628s     Document Type: Article

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