Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

Journal of Biological Chemistry

Volumn 292, Issue 18, 2017, Pages 7327-7337

  Brito Moreira, Jordano ^a   Lourenco, Mychael V ^a   Oliveira, Mauricio M ^a   Ribeiro, Felipe C ^a   Ledo, José Henrique ^a   Diniz, Luan P ^a   Vital, Juliana F S ^a   Magdesian, Margaret H ^a   Melo, Helen M ^a   Barros Aragão, Fernanda ^a   De Souza, Jorge M ^a   Alves Leon, Soniza V ^a   Gomes, Flavia C A ^a   Clarke, Julia R ^a   Figueiredo, Cláudia P ^a   De Felice, Fernanda G ^a,b   Ferreira, Sergio T ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; MAMMALS; NEURONS; OLIGOMERS;

ALZHEIMER DISEASE; AMYLOID BETAS; COGNITIVE IMPAIRMENT; HIPPOCAMPAL NEURONS; MEMORY LOSS; NEUROLIGINS; SYNAPSE STRUCTURE; SYNAPTIC INTERACTIONS;

GLYCOPROTEINS;

4 AMINOBUTYRIC ACID A RECEPTOR; AMYLOID BETA PROTEIN; NEUREXIN; NEUREXIN 2ALPHA; NEUROLIGIN 1; OLIGOMER; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN[1-40]; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN; NEUREXIN II; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL DAMAGE; COGNITION; CONTROLLED STUDY; DECLARATIVE MEMORY; DENDRITIC SPINE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MALE; MOUSE; NEOCORTICAL TISSUE; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SYNAPSE; ALZHEIMER DISEASE; ANIMAL; BRAIN; CELL CULTURE; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; PROTEINOSIS; RAT; WISTAR RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CELL ADHESION MOLECULES, NEURONAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; MALE; MICE; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PROTEIN AGGREGATION, PATHOLOGICAL; RATS; RATS, WISTAR; SYNAPSES;

EID: 85018404013     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.761189     Document Type: Article

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