A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function

Neurobiology of Aging

Volumn 36, Issue 12, 2015, Pages 3171-3175

  Tristán Clavijo, Enriqueta ^a,b   Camacho Garcia, Rafael J ^a   Robles Lanuza, Estefanía ^a,b   Ruiz, Agustín ^c   van der Zee, Julie ^d,e   Van Broeckhoven, Christine ^d,e   Hernandez, Isabel ^c   Martinez Mir, Amalia ^a   Scholl, Francisco G ^a,b  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

^c Institut Catala de Neurociencies Aplicades   (Spain)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Alzheimer's disease; Mutation; Neuroligin; NLGN1; Synapse

Indexed keywords

NEUROLIGIN 1; THREONINE; NERVE CELL ADHESION MOLECULE; STOP CODON;

ALLELE; ALZHEIMER DISEASE; ARTICLE; AUTISM; BRAIN DISEASE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; ENDOPLASMIC RETICULUM; FAMILY HISTORY; FEMALE; FRAMESHIFT MUTATION; GENE INACTIVATION; GENE INSERTION; GLUTAMATERGIC SYNAPSE; HIPPOCAMPUS; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; NLGNL3 GENE; NLGNL4 GENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOP CODON; AGED; ANIMAL; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; CYTOLOGY; GENE SILENCING; GENETICS; LONG TERM POTENTIATION; MEMORY; METABOLISM; PHYSIOLOGY; PSYCHOLOGY; RAT; SYNAPSE;

AGED; ALZHEIMER DISEASE; ANIMALS; CELL ADHESION MOLECULES, NEURONAL; CERCOPITHECUS AETHIOPS; CODON, TERMINATOR; COS CELLS; ENDOPLASMIC RETICULUM; FEMALE; FRAMESHIFT MUTATION; GENE SILENCING; HIPPOCAMPUS; HUMANS; LONG-TERM POTENTIATION; MEMORY; RATS; SYNAPSES;

EID: 84947020103     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.09.004     Document Type: Article

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