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Volumn 36, Issue 48, 2016, Pages 12106-12116

Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer’s amyloid-β oligomers in mice

Author keywords

Alzheimer s; Depression; Inflammation; Microglia; Serotonin

Indexed keywords

MINOCYCLINE; SEROTONIN; TRYPTOPHAN HYDROXYLASE; AMYLOID BETA PROTEIN; TUMOR NECROSIS FACTOR;

EID: 85006049436     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1269-16.2016     Document Type: Article
Times cited : (116)

References (65)
  • 1
    • 54049133277 scopus 로고    scopus 로고
    • The molecular neurobiology of depression
    • Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 455:894-902.
    • (2008) Nature , vol.455 , pp. 894-902
    • Krishnan, V.1    Nestler, E.J.2
  • 4
    • 84884635054 scopus 로고    scopus 로고
    • Promiscuous Alzheimer’s amyloid: Yet another partner
    • Benilova I, De Strooper B (2013) Promiscuous Alzheimer’s amyloid: yet another partner. Science 341:1354-1355.
    • (2013) Science , vol.341 , pp. 1354-1355
    • Benilova, I.1    De Strooper, B.2
  • 5
    • 84893751693 scopus 로고    scopus 로고
    • Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency
    • Bie B, Wu J, Yang H, Xu JJ, Brown DL, Naguib M (2014) Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency. Nat Neurosci 17:223-231.
    • (2014) Nat Neurosci , vol.17 , pp. 223-231
    • Bie, B.1    Wu, J.2    Yang, H.3    Xu, J.J.4    Brown, D.L.5    Naguib, M.6
  • 7
    • 13144258727 scopus 로고    scopus 로고
    • Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer’s disease (DAT): Lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT
    • Bonaccorso S, Lin A, Song C, Verkerk R, Kenis G, Bosmans E, Scharpe S, Vandewoude M, Dossche A, Maes M (1998) Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer’s disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT. Aging (Milano) 10:316-323.
    • (1998) Aging (Milano) , vol.10 , pp. 316-323
    • Bonaccorso, S.1    Lin, A.2    Song, C.3    Verkerk, R.4    Kenis, G.5    Bosmans, E.6    Scharpe, S.7    Vandewoude, M.8    Dossche, A.9    Maes, M.10
  • 10
    • 84859731658 scopus 로고    scopus 로고
    • The immunology of neurodegeneration
    • Czirr E, Wyss-Coray T (2012) The immunology of neurodegeneration. J Clin Invest 122:1156-1163.
    • (2012) J Clin Invest , vol.122 , pp. 1156-1163
    • Czirr, E.1    Wyss-Coray, T.2
  • 12
    • 82355192272 scopus 로고    scopus 로고
    • The A÷ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
    • Ferreira ST, Klein WL (2011) The A÷ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease. Neurobiol Learn Mem 96: 529-543.
    • (2011) Neurobiol Learn Mem , vol.96 , pp. 529-543
    • Ferreira, S.T.1    Klein, W.L.2
  • 14
    • 61449189852 scopus 로고    scopus 로고
    • Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer’s disease
    • Filali M, Lalonde R, Rivest S (2009) Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer’s disease. Genes Brain Behav 8:143-148.
    • (2009) Genes Brain Behav , vol.8 , pp. 143-148
    • Filali, M.1    Lalonde, R.2    Rivest, S.3
  • 16
    • 67349158251 scopus 로고    scopus 로고
    • Progesterone reduces depression-like behavior in a murine model of Alzheimer’s disease
    • Frye CA, Walf AA (2009) Progesterone reduces depression-like behavior in a murine model of Alzheimer’s disease. Age 31:143-153.
    • (2009) Age , vol.31 , pp. 143-153
    • Frye, C.A.1    Walf, A.A.2
  • 17
    • 42049086339 scopus 로고    scopus 로고
    • History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease
    • Geerlings MI, den Heijer T, Koudstaal PJ, Hofman A, Breteler MM (2008) History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease. Neurology 70:1258-1264.
    • (2008) Neurology , vol.70 , pp. 1258-1264
    • Geerlings, M.I.1    Den Heijer, T.2    Koudstaal, P.J.3    Hofman, A.4    Breteler, M.M.5
  • 18
    • 80052184853 scopus 로고    scopus 로고
    • Role of serotonin in Alzheimer’s disease: A new therapeutic target?
    • Geldenhuys WJ, Van der Schyf CJ (2011) Role of serotonin in Alzheimer’s disease: a new therapeutic target? CNS Drugs 25:765-781.
    • (2011) CNS Drugs , vol.25 , pp. 765-781
    • Geldenhuys, W.J.1    Van Der Schyf, C.J.2
  • 21
    • 84903269246 scopus 로고    scopus 로고
    • Innate immune activation in neurodegenerative disease
    • Heneka MT, Kummer MP, Latz E (2014) Innate immune activation in neurodegenerative disease. Nat Rev Immunol 14:463-477.
    • (2014) Nat Rev Immunol , vol.14 , pp. 463-477
    • Heneka, M.T.1    Kummer, M.P.2    Latz, E.3
  • 22
    • 84923444904 scopus 로고    scopus 로고
    • Innate immunity in Alzheimer’s disease
    • Heneka MT, Golenbock DT, Latz E (2015) Innate immunity in Alzheimer’s disease. Nat Immunol 16:229-236.
    • (2015) Nat Immunol , vol.16 , pp. 229-236
    • Heneka, M.T.1    Golenbock, D.T.2    Latz, E.3
  • 29
    • 34248570473 scopus 로고    scopus 로고
    • 5-HT4 receptor and Alzheimer’s disease: The amyloid connection
    • Lezoualc’h F (2007) 5-HT4 receptor and Alzheimer’s disease: the amyloid connection. Exp Neurol 205:325-329.
    • (2007) Exp Neurol , vol.205 , pp. 325-329
    • Lezoualc’H, F.1
  • 30
    • 33847135229 scopus 로고    scopus 로고
    • Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
    • Lorke DE, Lu G, Cho E, Yew DT (2006) Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. BMC Neurosci 7:36.
    • (2006) BMC Neurosci , vol.7 , pp. 36
    • Lorke, D.E.1    Lu, G.2    Cho, E.3    Yew, D.T.4
  • 31
    • 84889656503 scopus 로고    scopus 로고
    • TNF-mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s ÷-amyloid oligomers in mice and monkeys
    • Lourenco MV et al. (2013) TNF-mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s ÷-amyloid oligomers in mice and monkeys. Cell Metab 18:831-843.
    • (2013) Cell Metab , vol.18 , pp. 831-843
    • Lourenco, M.V.1
  • 32
    • 0036669270 scopus 로고    scopus 로고
    • Depression in Alzheimer’s disease: Overview and treatment
    • Lyketsos CG, Olin J (2002) Depression in Alzheimer’s disease: overview and treatment. Biol Psychiatry 52:243-252.
    • (2002) Biol Psychiatry , vol.52 , pp. 243-252
    • Lyketsos, C.G.1    Olin, J.2
  • 33
    • 84880759156 scopus 로고    scopus 로고
    • Neurotoxicity of amyloid ÷-protein: Synaptic and network dysfunction
    • Mucke L, Selkoe DJ (2012) Neurotoxicity of amyloid ÷-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med 2:a006338.
    • (2012) Cold Spring Harb Perspect Med , vol.2
    • Mucke, L.1    Selkoe, D.J.2
  • 34
    • 84884862354 scopus 로고    scopus 로고
    • Serotonin 5-HT2A receptor activation blocks TNF-mediated inflammation in vivo
    • Nau F Jr, Yu B, Martin D, Nichols CD (2013) Serotonin 5-HT2A receptor activation blocks TNF-mediated inflammation in vivo. PLoS One 8:e75426.
    • (2013) Plos One , vol.8
    • Nau, F.1    Yu, B.2    Martin, D.3    Nichols, C.D.4
  • 37
    • 33646923143 scopus 로고    scopus 로고
    • Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis
    • Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D (2006) Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63:530-538.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 530-538
    • Ownby, R.L.1    Crocco, E.2    Acevedo, A.3    John, V.4    Loewenstein, D.5
  • 38
    • 77952291438 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction
    • Park KM, Bowers WJ (2010) Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal 22:977-983.
    • (2010) Cell Signal , vol.22 , pp. 977-983
    • Park, K.M.1    Bowers, W.J.2
  • 40
    • 0017618768 scopus 로고
    • Depression: A new animal model sensitive to antidepressant treatments
    • Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730-732.
    • (1977) Nature , vol.266 , pp. 730-732
    • Porsolt, R.D.1    Le Pichon, M.2    Jalfre, M.3
  • 43
    • 84923675358 scopus 로고    scopus 로고
    • Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress
    • Sachs BD, Ni JR, Caron MG (2015) Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress. Proc Natl Acad Sci U S A 112:2557-2562.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 2557-2562
    • Sachs, B.D.1    Ni, J.R.2    Caron, M.G.3
  • 44
    • 84961194024 scopus 로고    scopus 로고
    • Microglial dysfunction connects depression and Alzheimer’s disease
    • Santos LE, Beckman D, Ferreira ST (2016) Microglial dysfunction connects depression and Alzheimer’s disease. Brain Behav Immun 55:151-165.
    • (2016) Brain Behav Immun , vol.55 , pp. 151-165
    • Santos, L.E.1    Beckman, D.2    Ferreira, S.T.3
  • 45
    • 34548395111 scopus 로고    scopus 로고
    • The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
    • Schmidt HD, Duman RS (2007) The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 18:391-418.
    • (2007) Behav Pharmacol , vol.18 , pp. 391-418
    • Schmidt, H.D.1    Duman, R.S.2
  • 46
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101-1108.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 54
    • 0347604853 scopus 로고    scopus 로고
    • Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder
    • Tuglu C, Kara SH, Caliyurt O, Vardar E, Abay E (2003) Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder. Psychopharmacology (Berl) 170:429-433.
    • (2003) Psychopharmacology (Berl) , vol.170 , pp. 429-433
    • Tuglu, C.1    Kara, S.H.2    Caliyurt, O.3    Vardar, E.4    Abay, E.5
  • 56
    • 77950479716 scopus 로고    scopus 로고
    • Liposomes for specific depletion of macrophages from organs and tissues
    • van Rooijen N, Hendrikx E (2010) Liposomes for specific depletion of macrophages from organs and tissues. Methods Mol Biol 605:189-203.
    • (2010) Methods Mol Biol , vol.605 , pp. 189-203
    • Van Rooijen, N.1    Hendrikx, E.2
  • 58
    • 79959343388 scopus 로고    scopus 로고
    • Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans
    • Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P (2011) Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc Natl Acad Sci U S A 108:9262-9267.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 9262-9267
    • Warner-Schmidt, J.L.1    Vanover, K.E.2    Chen, E.Y.3    Marshall, J.J.4    Greengard, P.5
  • 59
    • 21244495606 scopus 로고    scopus 로고
    • IDO and interferon-alpha-induced depressive symptoms: A shift in hypothesis from tryptophan depletion to neurotoxicity
    • Wichers MC, Koek GH, Robaeys G, Verkerk R, Scharpé S, Maes M (2005) IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. Mol Psychiatry 10: 538-544.
    • (2005) Mol Psychiatry , vol.10 , pp. 538-544
    • Wichers, M.C.1    Koek, G.H.2    Robaeys, G.3    Verkerk, R.4    Scharpé, S.5    Maes, M.6
  • 60
    • 0042811001 scopus 로고    scopus 로고
    • Interferon-gamma-induced conversion of tryptophan: Immunologic and neuropsychiatric aspects
    • Wirleitner B, Neurauter G, Schröcksnadel K, Frick B, Fuchs D (2003) Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. Curr Med Chem 10:1581-1591.
    • (2003) Curr Med Chem , vol.10 , pp. 1581-1591
    • Wirleitner, B.1    Neurauter, G.2    Schröcksnadel, K.3    Frick, B.4    Fuchs, D.5
  • 61
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease-a double-edged sword
    • Wyss-Coray T, Mucke L (2002) Inflammation in neurodegenerative disease-a double-edged sword. Neuron 35:419-432.
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 62
    • 84875655895 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature
    • Wyss-Coray T, Rogers J (2012) Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2:a006346.
    • (2012) Cold Spring Harb Perspect Med , vol.2
    • Wyss-Coray, T.1    Rogers, J.2
  • 63
    • 54349110896 scopus 로고    scopus 로고
    • Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency
    • Yu B, Becnel J, Zerfaoui M, Rohatgi R, Boulares AH, Nichols CD (2008) Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency. J Pharmacol Exp Ther 327:316-323.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 316-323
    • Yu, B.1    Becnel, J.2    Zerfaoui, M.3    Rohatgi, R.4    Boulares, A.H.5    Nichols, C.D.6
  • 64
    • 24144459815 scopus 로고    scopus 로고
    • Serotoninergic impairment and aggressive behavior in Alzheimer’s disease
    • Zarros AC, Kalopita KS, Tsakiris ST (2005) Serotoninergic impairment and aggressive behavior in Alzheimer’s disease. Acta Neurobiol Exp (Wars) 65:277-286.
    • (2005) Acta Neurobiol Exp (Wars) , vol.65 , pp. 277-286
    • Zarros, A.C.1    Kalopita, K.S.2    Tsakiris, S.T.3
  • 65
    • 33748808678 scopus 로고    scopus 로고
    • The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters
    • Zhu CB, Blakely RD, Hewlett WA (2006) The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology 31:2121-2131.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 2121-2131
    • Zhu, C.B.1    Blakely, R.D.2    Hewlett, W.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.